Novel Inhibitory Actions of Neuroactive Steroid [3α,5α]-3-Hydroxypregnan-20-One on Toll-like Receptor 4-Dependent Neuroimmune Signaling.

Authors: Lopez, Alejandro G.^1,2 (AUTHOR) alopezsf@live.unc.edu, Chirasani, Venkat R.^1,3 (AUTHOR) venkatr@med.unc.edu, Balan, Irina² (AUTHOR), O'Buckley, Todd K.² (AUTHOR), Adelman, Makayla R.² (AUTHOR), Morrow, A. Leslie^2,4,5 (AUTHOR) morrow@med.unc.edu

Source: Biomolecules (2218-273X). Nov2024, Vol. 14 Issue 11, p1441. 16p.

Subject Terms: *SURFACE plasmon resonance, *MOLECULAR docking, *BINDING sites, *PROTEIN-lipid interactions, *PROTEIN-protein interactions, *INFLAMMATORY mediators

Structural and functional interactions between the EF hand domain and S2–S3 loop in the type-1 ryanodine receptor ion channel

Authors: Chirasani, Venkat R., Elferdink, Millar, Kral, MacKenzie, Carter, Jordan S., Heitmann, Savannah, Meissner, Gerhard, Yamaguchi, Naohiro

Source: In Journal of Biological Chemistry February 2024 300(2)

Mapping co‐regulatory interactions among ligand‐binding sites in ryanodine receptor 1

Authors: Chirasani, Venkat R., Popov, Konstantin I., Meissner, Gerhard, Dokholyan, Nikolay V.

Source: Proteins. 90(2):385-394

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100146539409.0x000001&indx=1&recIds=ETOCvdc_100146539409.0x000001

Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition

Authors: Huynh, Minh V., Parsonage, Derek, Forshaw, Tom E., Chirasani, Venkat R., Hobbs, G. Aaron, Wu, Hanzhi, Lee, Jingyun, Furdui, Cristina M., Poole, Leslie B., Campbell, Sharon L.

Source: In Journal of Biological Chemistry August 2022 298(8)

Whole proteome mapping of compound-protein interactions

Authors: Chirasani, Venkat R., Wang, Jian, Sha, Congzhou, Raup-Konsavage, Wesley, Vrana, Kent, Dokholyan, Nikolay V.

Source: In Current Research in Chemical Biology 2022 2

Identifying crucial E-protein residues responsible for unusual stability of Zika virus envelope

Authors: Pindi, Chinmai, Chirasani, Venkat R., Senapati, Sanjib

Source: In Biophysical Journal 21 September 2021 120(18):4041-4054

Structural and functional interactions between the Ca2+-, ATP-, and caffeine-binding sites of skeletal muscle ryanodine receptor (RyR1)

Authors: Chirasani, Venkat R., Pasek, Daniel A., Meissner, Gerhard

Source: In Journal of Biological Chemistry September 2021 297(3)

Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis

Authors: Chen, Yu-Chi, Dinavahi, Saketh S., Feng, Qilong, Gowda, Raghavendra, Ramisetti, Srinivasa, Xia, Xinghai, LaPenna, Kyle B., Chirasani, Venkat R., Cho, Sung Hyun, Hafenstein, Susan L., Battu, Madhu Babu, Berg, Arthur, Sharma, Arun K., Kirchhausen, Tom, Dokholyan, Nikolay V., Amin, Shantu, He, Pingnian, Robertson, Gavin P.

Source: In Cancer Letters 28 May 2021 506:107-119

Single-channel properties of skeletal muscle ryanodine receptor pore Δ4923FF4924 in two brothers with a lethal form of fetal akinesia

Authors: Xu, Le, Harms, Frederike L., Chirasani, Venkat R., Pasek, Daniel A., Kortüm, Fanny, Meinecke, Peter, Dokholyan, Nikolay V., Kutsche, Kerstin ^*, Meissner, Gerhard ^*

Source: In Cell Calcium May 2020 87

Ca2+-mediated activation of the skeletal-muscle ryanodine receptor ion channel

Authors: Xu, Le, Chirasani, Venkat R., Carter, Jordan S., Pasek, Daniel A., Dokholyan, Nikolay V., Yamaguchi, Naohiro, Meissner, Gerhard

Source: In Journal of Biological Chemistry 14 December 2018 293(50):19501-19509

G4941K substitution in the pore-lining S6 helix of the skeletal muscle ryanodine receptor increases RyR1 sensitivity to cytosolic and luminal Ca2+

Authors: Xu, Le, Mowrey, David D., Chirasani, Venkat R., Wang, Ying, Pasek, Daniel A., Dokholyan, Nikolay V., Meissner, Gerhard

Source: In Journal of Biological Chemistry 9 February 2018 293(6):2015-2028

Structural Plasticity of Cholesteryl Ester Transfer Protein Assists the Lipid Transfer Activity

Authors: Chirasani, Venkat R., Revanasiddappa, Prasanna D., Senapati, Sanjib

Source: In Journal of Biological Chemistry 9 September 2016 291(37):19462-19473

Regulation of intestinal SGLT1 by catestatin in hyperleptinemic type 2 diabetic mice

Authors: Dominguez Rieg, Jessica A, Chirasani, Venkat R, Koepsell, Hermann, Senapati, Sanjib, Mahata, Sushil K, Rieg, Timo

Source: In Laboratory Investigation January 2016 96(1):98-111

Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin

Authors: Tewari, Debanjan, Ahmed, Tofayel, Chirasani, Venkat R., Singh, Pradeep K., Maji, Samir K., Senapati, Sanjib, Bera, Amal Kanti

Source: In BBA - Biomembranes January 2015 1848(1) Part A:151-158

Molecular Basis of Differential Stability and Temperature Sensitivity of ZIKA versus Dengue Virus Protein Shells.

Authors: Pindi, Chinmai¹, Chirasani, Venkat R.¹, Rahman, Mohammad Homaidur¹, Ahsan, Mohd¹, Revanasiddappa, Prasanna D.¹, Senapati, Sanjib¹ sanjibs@iitm.ac.in

Source: Scientific Reports. 5/21/2020, Vol. 10 Issue 1, p1-10. 10p.

Subject Terms: *ZIKA virus, *TEMPERATURE sensitive mutated bacteria, *FLAVIVIRUSES, *MOLECULAR dynamics, *MEMBRANE fusion

Naturally Occurring Variants of the Dysglycemic Peptide Pancreastatin: DIFFERENTIAL POTENCIES FOR MULTIPLE CELLULAR FUNCTIONS AND STRUCTURE-FUNCTION CORRELATION

Authors: Allu, Prasanna K.R. ^{‡, 1}, Chirasani, Venkat R. ^‡, Ghosh, Dhiman ^§, Mani, Anitha ^‡, Bera, Amal K. ^‡, Maji, Samir K. ^§, Senapati, Sanjib ^‡, Mullasari, Ajit S. ^¶, Mahapatra, Nitish R. ^{‡, 2}

Source: In Journal of Biological Chemistry 14 February 2014 289(7):4455-4469

Catestatin Gly364Ser Variant Alters Systemic Blood Pressure and the Risk for Hypertension in Human Populations via Endothelial Nitric Oxide Pathway

Authors: Kiranmayi, Malapaka, Chirasani, Venkat R., Allu, Prasanna K.R., Subramanian, Lakshmi, Martelli, Elizabeth E., Sahu, Bhavani S., Vishnuprabu, Durairajpandian, Kumaragurubaran, Rathnakumar, Sharma, Saurabh, Bodhini, Dhanasekaran, Dixit, Madhulika, Munirajan, Arasambattu K., Khullar, Madhu, Radha, Venkatesan, Mohan, Viswanathan, Mullasari, Ajit S., Naga Prasad, Sathyamangla V., Senapati, Sanjib, Mahapatra, Nitish R.

Source: Hypertension. 68(2):334-347

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100035341621.0x000001&indx=1&recIds=ETOCvdc_100035341621.0x000001

Molecular basis and cellular functions of vinculin-actin directional catch bonding.

Authors: Chirasani, Venkat R., Khan, Mohammad Ashhar I., Malavade, Juilee N., Dokholyan, Nikolay V., Hoffman, Brenton D., Campbell, Sharon L.

Source: Nature Communications; 12/14/2023, Vol. 14 Issue 1, p1-20, 20p

Subject Terms: CELL physiology, CELL migration, VINCULIN, CELL anatomy, CYTOSKELETAL proteins, MICROFILAMENT proteins

Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins

Authors: Bonfanti, Silvia, Lionetti, Maria Chiara, Fumagalli, Maria Rita, Chirasani, Venkat R., Tiana, Guido, Dokholyan, Nikolay V., Zapperi, Stefano, La Porta, Caterina A. M.

Source: Scientific reports. 9(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131479046.0x000001&indx=1&recIds=ETOCvdc_100131479046.0x000001

Exploring the interplay between the EF hand domain and S2-S3 loop in RYR1: Implications for Ca2+/Mg2+ inhibition

Authors: Elferdink, Millar, Kral, MacKenzie, Chirasani, Venkat R., Carter, Jordan S., Heitmann, Savannah, Yamaguchi, Naohiro

Source: In Biophysical Journal 8 February 2024 123(3) Supplement 1:104a-104a