TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation

Authors: Chiramel, Abhilash I., Meyerson, Nicholas R., McNally, Kristin L., Broeckel, Rebecca M., Montoya, Vanessa R., Méndez-Solís, Omayra, Robertson, Shelly J., Sturdevant, Gail L., Lubick, Kirk J., Nair, Vinod, Youseff, Brian H., Ireland, Robin M., Bosio, Catharine M., Kim, Kyusik, Luban, Jeremy, Hirsch, Vanessa M., Taylor, R. Travis, Bouamr, Fadila, Sawyer, Sara L., Best, Sonja M.

Source: In Cell Reports 11 June 2019 27(11):3269-3283

AP3B1 Has Type I Interferon-Independent Antiviral Function against SARS-CoV-2.

Authors: Subramanian, Gayatri, Hage, Adam, Feldmann, Friederike, Chiramel, Abhilash I., McNally, Kristin L., Sturdevant, Gail L., Beare, Paul A., Best, Sonja M.

Source: Viruses (1999-4915); Sep2024, Vol. 16 Issue 9, p1377, 11p

Subject Terms: SARS-CoV-2, VIRAL genes, VIRAL proteins, VIRAL replication

Role of autophagy in Zika virus infection and pathogenesis

Authors: Chiramel, Abhilash I., Best, Sonja M.

Source: In Virus Research 2 August 2018 254:34-40

Alisporivir Has Limited Antiviral Effects Against Ebola Virus Strains Makona and Mayinga

Authors: Chiramel, Abhilash I., Banadyga, Logan, Dougherty, Jonathan D., Falzarano, Darryl, Martellaro, Cynthia, Brees, Dominique, Taylor, R. Travis, Ebihara, Hideki, Best, Sonja M.

Source: The Journal of Infectious Diseases, 2016 Oct . 214, S355-S359.

Access URL: http://www.jstor.org/stable/44007300

FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum Turnover, Inhibits Replication of Ebola Virus Strains Makona and Mayinga

Authors: Chiramel, Abhilash I., Dougherty, Jonathan D., Nair, Vinod, Robertson, Shelly J., Best, Sonja M.

Source: The Journal of Infectious Diseases, 2016 Oct . 214, S319-S325.

Access URL: http://www.jstor.org/stable/44007296

Flavivirus Antagonism of Type I Interferon Signaling Reveals Prolidase as a Regulator of IFNAR1 Surface Expression

Authors: Lubick, Kirk J., Robertson, Shelly J., McNally, Kristin L., Freedman, Brett A., Rasmussen, Angela L., Taylor, R. Travis, Walts, Avram D., Tsuruda, Seitaro, Sakai, Mizuki, Ishizuka, Mariko, Boer, Elena F., Foster, Erin C., Chiramel, Abhilash I., Addison, Conrad B., Green, Richard, Kastner, Daniel L., Katze, Michael G., Holland, Steven M., Forlino, Antonella, Freeman, Alexandra F., Boehm, Manfred, Yoshii, Kentaro, Best, Sonja M.

Source: In Cell Host & Microbe 8 July 2015 18(1):61-74

A pigtailed macaque model of Kyasanur Forest disease virus and Alkhurma hemorrhagic disease virus pathogenesis.

Authors: Broeckel, Rebecca M.¹, Feldmann, Friederike², McNally, Kristin L.¹, Chiramel, Abhilash I.¹, Sturdevant, Gail L.¹, Leung, Jacqueline M.³, Hanley, Patrick W.², Lovaglio, Jamie², Rosenke, Rebecca², Scott, Dana P.², Saturday, Greg², Bouamr, Fadila⁴, Rasmussen, Angela L.^5,6, Robertson, Shelly J.¹, Best, Sonja M.¹, sbest@niaid.nih.gov

Source: PLoS Pathogens; 12/2/2021, Vol. 17 Issue 12, p1-25, 25p

Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19.

Authors: Robertson, Shelly J., Bedard, Olivia, McNally, Kristin L., Shaia, Carl, Clancy, Chad S., Lewis, Matthew, Broeckel, Rebecca M., Chiramel, Abhilash I., Shannon, Jeffrey G., Sturdevant, Gail L., Rosenke, Rebecca, Anzick, Sarah L., Forte, Elvira, Preuss, Christoph, Baker, Candice N., Harder, Jeffrey M., Brunton, Catherine, Munger, Steven, Bruno, Daniel P., Lack, Justin B.

Source: Nature Communications; 7/25/2023, Vol. 14 Issue 1, p1-13, 13p

Subject Terms: COVID-19 pandemic, TYPE I interferons, SARS-CoV-2, INTERFERONS, COVID-19, LABORATORY mice, TRANSGENIC mice

Rapalogs downmodulate intrinsic immunity and promote cell entry of SARS-CoV-2.

Authors: Guoli Shi¹, Chiramel, Abhilash I.², Tiansheng Li³, Kin Kui Lai¹, Kenney, Adam D.⁴, Zani, Ashley⁴, Eddy, Adrian C.⁴, Majdoul, Saliha¹, Lizhi Zhang⁴, Dempsey, Tirhas¹, Beare, Paul A.⁵, Kar, Swagata⁶, Yewdell, Jonathan W.³, Best, Sonja M.², Yount, Jacob S.⁴, Compton, Alex A.¹ alex.compton@nih.gov

Source: Journal of Clinical Investigation. 12/15/2022, Vol. 132 Issue 24, p1-16. 16p.

Subject Terms: *SARS-CoV-2, *EVEROLIMUS, *MTOR inhibitors, *VIRUS diseases

Company/Entity: UNITED States. Food & Drug Administration

Roles of ESCRT Proteins ALIX and CHMP4A and Their Interplay with Interferon-Stimulated Gene 15 during Tick-Borne Flavivirus Infection.

Authors: Tran, Pham-Tue-Hung¹, Chiramel, Abhilash I.², Johansson, Magnus¹, Melika, Wessam¹ wessam.melik@oru.se

Source: Journal of Virology. Feb2022, Vol. 96 Issue 3, p1-15. 15p.

Subject Terms: *FLAVIVIRAL diseases, *VIRAL proteins, *VIRUS-like particles, *PROTEINS, *GENE silencing

Genome-Wide CRISPR Screen Identifies RACK1 as a Critical Host Factor for Flavivirus Replication.

Authors: Shue, Byron¹, Chiramel, Abhilash I.², Cerikan, Berati³, Thu-Hien To⁴, Frölich, Sonja¹, Pederson, Stephen M.⁴, Kirby, Emily N.¹, Eyre, Nicholas S.¹, Bartenschlager, Ralf F. W.³, Best, Sonja M.², Beard, Michael R.¹ michael.beard@adelaide.edu.au

Source: Journal of Virology. Dec2021, Vol. 95 Issue 24, p1-18. 18p.

Subject Terms: *WEST Nile virus, *CRISPRS, *DENGUE viruses, *ZIKA virus, *COVID-19, *PROTEIN kinases

The liver X receptor agonist LXR 623 restricts flavivirus replication.

Authors: Mlera, Luwanika, Offerdahl, Danielle K., Dorward, David W., Carmody, Aaron, Chiramel, Abhilash I., Best, Sonja M., Bloom, Marshall E.

Source: Emerging Microbes & Infections; Dec 2021, Vol. 10 Issue 1, p1378-1389, 12p

Divergent Roles of Autophagy in Virus Infection.

Authors: Chiramel, Abhilash I.¹ Abhilash_Chiramel@med.uni-heidelberg.de, Brady, Nathan R.² n.brady@dkfz.de, Bartenschlager, Ralf¹ Ralf_Bartenschlager@med.uni-heidelberg.de

Source: Cells (2073-4409). Mar2013, Vol. 2 Issue 1, p83-104. 22p.

Subject Terms: *AUTOPHAGY, *HUMAN evolution, *INTRACELLULAR pathogens, *ANTIVIRAL agents, *VIRUS diseases, *LYSOSOMAL storage diseases

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Disruption of the Golgi Apparatus and Contribution of the Endoplasmic Reticulum to the SARS-CoV-2 Replication Complex.

Authors: Hackstadt, Ted¹ (AUTHOR) cdooley@niaid.nih.gov, Chiramel, Abhilash I.² (AUTHOR) abhilash.chiramel@gmail.com, Hoyt, Forrest H.³ (AUTHOR) forrest.hoyt@nih.gov, Williamson, Brandi N.⁴ (AUTHOR) Brandi.Williamson@nih.gov, Dooley, Cheryl A.¹ (AUTHOR), Beare, Paul A.⁵ (AUTHOR) pbeare@niaid.nih.gov, de Wit, Emmie⁴ (AUTHOR) emmie.dewit@nih.gov, Best, Sonja M.² (AUTHOR) sbest@niaid.nih.gov, Fischer, Elizabeth R.³ (AUTHOR) EFISCHER@niaid.nih.gov

Source: Viruses (1999-4915). Sep2021, Vol. 13 Issue 9, p1798. 1p.

Subject Terms: *SARS-CoV-2, *ENDOPLASMIC reticulum, *VIRAL proteins, *ELECTRON microscopy, *MICROSCOPY, *COVID-19, *GOLGI apparatus

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