Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer

Authors: Pippione, Agnese Chiara, Kovachka, Sandra, Vigato, Chiara, Bertarini, Laura, Mannella, Iole, Sainas, Stefano, Rolando, Barbara, Denasio, Enrica, Piercy-Mycock, Helen, Romalho, Linda, Salladini, Edoardo, Adinolfi, Salvatore, Zonari, Daniele, Peraldo-Neia, Caterina, Chiorino, Giovanna, Passoni, Alice, Mirza, Osman Asghar, Frydenvang, Karla, Pors, Klaus, Lolli, Marco Lucio, Spyrakis, Francesca, Oliaro-Bosso, Simonetta, Boschi, Donatella

Source: In European Journal of Medicinal Chemistry 15 March 2024 268

Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication

Authors: Luganini, Anna, Sibille, Giulia, Pavan, Marta, Mello Grand, Maurizia, Sainas, Stefano, Boschi, Donatella, Lolli, Marco L., Chiorino, Giovanna, Gribaudo, Giorgio

Source: In Antiviral Research November 2023 219

TRF2 cooperates with CTCF for controlling the oncomiR-193b-3p in colorectal cancer

Authors: Dinami, Roberto, Petti, Eleonora, Porru, Manuela, Rizzo, Angela, Ganci, Federica, Sacconi, Andrea, Ostano, Paola, Chiorino, Giovanna, Trusolino, Livio, Blandino, Giovanni, Ciliberto, Gennaro, Zizza, Pasquale, Biroccio, Annamaria

Source: In Cancer Letters 1 May 2022 533

Plasma microRNA ratios associated with breast cancer detection in a nested case–control study from a mammography screening cohort.

Authors: Chiorino, Giovanna¹ (AUTHOR), Petracci, Elisabetta² (AUTHOR), Sehovic, Emir^1,3 (AUTHOR) emir.sehovic@fondazionetempia.org, Gregnanin, Ilaria¹ (AUTHOR), Camussi, Elisa⁴ (AUTHOR), Mello-Grand, Maurizia¹ (AUTHOR), Ostano, Paola¹ (AUTHOR), Riggi, Emilia⁴ (AUTHOR), Vergini, Viviana⁴ (AUTHOR), Russo, Alessia⁵ (AUTHOR), Berrino, Enrico^5,6 (AUTHOR), Ortale, Andrea⁴ (AUTHOR), Garena, Francesca⁴ (AUTHOR), Venesio, Tiziana⁶ (AUTHOR), Gallo, Federica⁷ (AUTHOR), Favettini, Elisabetta⁸ (AUTHOR), Frigerio, Alfonso⁴ (AUTHOR), Matullo, Giuseppe⁵ (AUTHOR), Segnan, Nereo⁴ (AUTHOR) nereo.segnan@cpo.it, Giordano, Livia⁴ (AUTHOR)

Source: Scientific Reports. 7/25/2023, Vol. 13 Issue 1, p1-14. 14p.

Subject Terms: *MEDICAL screening, *EARLY detection of cancer, *BREAST cancer, *MAMMOGRAMS, *CASE-control method

Evaluation of Left Ventricular Volumes and Ejection Fraction from Gated Myocardial Perfusion SPECT Processed with 'Myovation Evolution': Comparison of Three Automated Software Packages using Cardiac Magnetic Resonance as Reference

Authors: Calandri, Enrico, Guana, Francesca, Pultrone, Mirco, Leuzzi, Stefano, Chiorino, Giovanna, Soligo, Eleonora, Frantellizzi, Viviana, Gallina, Sonya, Liberatore, Mauro, De Vincentis, Giuseppe

Source: Current Radiopharmaceuticals. 14(2):112-120

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129474547.0x000001&indx=1&recIds=ETOCvdc_100129474547.0x000001

Confirmation of previously identified plasma microRNA ratios for breast cancer detection in a nested case‐control study within a screening setting.

Authors: Sehovic, Emir, Gregnanin, Ilaria, Mello‐Grand, Maurizia, Ostano, Paola, Vergini, Viviana, Ortale, Andrea, Amoruso, Angela, Favettini, Elisabetta, Segnan, Nereo, Chiorino, Giovanna, Giordano, Livia, Petracci, Elisabetta

Source: Clinical & Translational Medicine; Nov2024, Vol. 14 Issue 11, p1-7, 7p

Subject Terms: REVERSE transcriptase polymerase chain reaction, EARLY detection of cancer, RECEIVER operating characteristic curves, HORMONE therapy, LOGISTIC regression analysis, ADOLESCENT smoking, CANCER education

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer

Authors: Di Mitri, Diletta, Mirenda, Michela, Vasilevska, Jelena, Calcinotto, Arianna, Delaleu, Nicolas, Revandkar, Ajinkya, Gil, Veronica, Boysen, Gunther, Losa, Marco, Mosole, Simone, Pasquini, Emiliano, D’Antuono, Rocco, Masetti, Michela, Zagato, Elena, Chiorino, Giovanna, Ostano, Paola, Rinaldi, Andrea, Gnetti, Letizia, Graupera, Mariona, Martins Figueiredo Fonseca, Ana Raquel, Pereira Mestre, Ricardo, Waugh, David, Barry, Simon, De Bono, Johann, Alimonti, Andrea

Source: In Cell Reports 20 August 2019 28(8):2156-2168

ABCC3 is a novel target for the treatment of pancreatic cancer

Authors: Adamska, Aleksandra, Ferro, Riccardo, Lattanzio, Rossano, Capone, Emily, Domenichini, Alice, Damiani, Verena, Chiorino, Giovanna, Akkaya, Begum Gokcen, Linton, Kenneth J., De Laurenzi, Vincenzo, Sala, Gianluca, Falasca, Marco

Source: In Advances in Biological Regulation August 2019 73

Epigenetic Regulation of iASPP-p63 Feedback Loop in Cutaneous Squamous Cell Carcinoma

Authors: Robinson, Deborah J., Patel, Ankit, Purdie, Karin J., Wang, Jun, Rizvi, Hasan, Hufbauer, Martin, Ostano, Paola, Akgül, Baki, Chiorino, Giovanna, Harwood, Catherine A., Bergamaschi, Daniele

Source: In Journal of Investigative Dermatology August 2019 139(8):1658-1671

SOMAscan Proteomics Identifies Novel Plasma Proteins in Amyotrophic Lateral Sclerosis Patients.

Authors: Berrone, Elena¹ (AUTHOR), Chiorino, Giovanna² (AUTHOR), Guana, Francesca² (AUTHOR), Benedetti, Valerio¹ (AUTHOR), Palmitessa, Claudia¹ (AUTHOR), Gallo, Marina¹ (AUTHOR), Calvo, Andrea^3,4 (AUTHOR), Casale, Federico³ (AUTHOR), Manera, Umberto^3,4 (AUTHOR), Favole, Alessandra¹ (AUTHOR) alessandra.favole@izsto.it, Crociara, Paola^1,5 (AUTHOR), Testori, Camilla¹ (AUTHOR), Carta, Valerio¹ (AUTHOR), Tessarolo, Carlotta¹ (AUTHOR), D'Angelo, Antonio⁶ (AUTHOR), De Marco, Giovanni^3,4 (AUTHOR), Caramelli, Maria¹ (AUTHOR), Chiò, Adriano^3,4 (AUTHOR) alessandra.favole@izsto.it, Casalone, Cristina¹ (AUTHOR), Corona, Cristiano¹ (AUTHOR)

Source: International Journal of Molecular Sciences. Feb2023, Vol. 24 Issue 3, p1899. 24p.

Subject Terms: *AMYOTROPHIC lateral sclerosis, *BLOOD proteins, *APTAMERS, *PROTEOMICS, *ENZYME-linked immunosorbent assay, *PROTEIN expression

Extracellular vesicles miR-574-5p and miR-181a-5p as prognostic markers in NSCLC patients treated with nivolumab.

Authors: Genova, Carlo, Marconi, Silvia, Chiorino, Giovanna, Guana, Francesca, Ostano, Paola, Santamaria, Sara, Rossi, Giovanni, Vanni, Irene, Longo, Luca, Tagliamento, Marco, Zullo, Lodovica, Dal Bello, Maria Giovanna, Dellepiane, Chiara, Alama, Angela, Rijavec, Erika, Ludovini, Vienna, Barletta, Giulia, Passiglia, Francesco, Metro, Giulio, Baglivo, Sara

Source: Clinical & Experimental Medicine; 8/6/2024, Vol. 24 Issue 1, p1-14, 14p

Subject Terms: IMMUNE checkpoint inhibitors, NON-small-cell lung carcinoma, EXTRACELLULAR vesicles, OVERALL survival, PROGNOSIS

Development and validation of a clinical decision support system based on PSA, microRNAs, and MRI for the detection of prostate cancer.

Authors: Mazzetti, Simone, Defeudis, Arianna, Nicoletti, Giulia, Chiorino, Giovanna, De Luca, Stefano, Faletti, Riccardo, Gatti, Marco, Gontero, Paolo, Manfredi, Matteo, Mello-Grand, Maurizia, Peraldo-Neia, Caterina, Zitella, Andrea, Porpiglia, Francesco, Regge, Daniele, Giannini, Valentina

Source: European Radiology; Aug2024, Vol. 34 Issue 8, p5108-5117, 10p

Subject Terms: CLINICAL decision support systems, PROSTATE cancer, RECEIVER operating characteristic curves, MAGNETIC resonance imaging, PROSTATE-specific antigen

Negative Control of Keratinocyte Differentiation by Rho/CRIK Signaling Coupled with Up-Regulation of KyoT1/2 (FHL1) Expression

Authors: Grossi, Maddalena, Hiou-Feige, Agnès, Di Vignano, Alice Tommasi, Calautti, Enzo, Ostano, Paola, Lee, Sam, Chiorino, Giovanna, Dotto, G. Paolo, Gross, Jerome

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Aug 01. 102(32), 11313-11318.

Access URL: https://www.jstor.org/stable/3376264

Systematic evaluation of the microRNAome through miR-CATCHv2.0 identifies positive and negative regulators of BRAF-X1 mRNA

Authors: Marranci, Andrea, D'Aurizio, Romina, Vencken, Sebastian, Mero, Serena, Guzzolino, Elena, Rizzo, Milena, Pitto, Letizia, Pellegrini, Marco, Chiorino, Giovanna, Greene, Catherine M., Poliseno, Laura

Source: RNA biology. 16(7):865-878

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100081987362.0x000001&indx=1&recIds=ETOCvdc_100081987362.0x000001

Development of a yeast-based system to identify new hBRAFV600E functional interactors

Authors: Lubrano, Simone, Comelli, Laura, Piccirilli, Chiara, Marranci, Andrea, Dapporto, Francesca, Tantillo, Elena, Gemignani, Federica, Gutkind, J., Salvetti, Alessandra, Chiorino, Giovanna, Cozza, Giorgio, Chiariello, Mario, Galli, Alvaro, Poliseno, Laura, Cervelli, Tiziana

Source: Oncogene. 38(8):1355-1366

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112260672.0x000001&indx=1&recIds=ETOCvdc_100112260672.0x000001

Cholangiocarcinoma stem-like subset shapes tumor-initiating niche by educating associated macrophages

Authors: Raggi, Chiara, Correnti, Margherita, Sica, Antonio, Andersen, Jesper B., Cardinale, Vincenzo, Alvaro, Domenico, Chiorino, Giovanna, Forti, Elisa, Glaser, Shannon, Alpini, Gianfranco, Destro, Annarita, Sozio, Francesca, Di Tommaso, Luca, Roncalli, Massimo, Banales, Jesus M., Coulouarn, Cédric, Bujanda, Luis, Torzilli, Guido, Invernizzi, Pietro

Source: In Journal of Hepatology January 2017 66(1):102-115

Cells with stemness features are generated from in vitro transformed human fibroblasts

Authors: Bono, Bartolo, Ostano, Paola, Peritore, Martina, Gregnanin, Ilaria, Belgiovine, Cristina, Liguori, Manuela, Allavena, Paola, Chiorino, Giovanna, Chiodi, Ilaria, Mondello, Chiara

Source: Scientific reports. 8(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182723021.0x000001&indx=1&recIds=ETOCvdc_100182723021.0x000001

Circulating microRNAs combined with PSA for accurate and non-invasive prostate cancer detection

Authors: Mello-Grand, Maurizia, Gregnanin, Ilaria, Sacchetto, Lidia, Ostano, Paola, Zitella, Andrea, Bottoni, Giulia, Oderda, Marco, Marra, Giancarlo, Munegato, Stefania, Pardini, Barbara, Naccarati, Alessio, Gasparini, Mauro, Gontero, Paolo, Chiorino, Giovanna

Source: Carcinogenesis. 40(2):246-253

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100094665949.0x000001&indx=1&recIds=ETOCvdc_100094665949.0x000001

HSD17B7 gene in self‐renewal and oncogenicity of keratinocytes from Black versus White populations

Authors: Xu, Xiaoying, Tassone, Beatrice, Ostano, Paola, Katarkar, Atul, Proust, Tatiana, Joseph, Jean‐Marc, Riganti, Chiara, Chiorino, Giovanna, Kutalik, Zoltan, Lefort, Karine, Dotto, Gian Paolo

Source: EMBO molecular medicine. 13(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125407077.0x000001&indx=1&recIds=ETOCvdc_100125407077.0x000001

PARP1 expression drives the synergistic antitumor activity of trabectedin and PARP1 inhibitors in sarcoma preclinical models

Authors: Pignochino, Ymera, Capozzi, Federica, D'Ambrosio, Lorenzo, Dell'Aglio, Carmine, Basiricò, Marco, Canta, Marta, Lorenzato, Annalisa, Vignolo Lutati, Francesca, Aliberti, Sandra, Palesandro, Erica, Boccone, Paola, Galizia, Danilo, Miano, Sara, Chiabotto, Giulia, Napione, Lucia, Gammaitoni, Loretta, Sangiolo, Dario, Benassi, Maria, Pasini, Barbara, Chiorino, Giovanna, Aglietta, Massimo, Grignani, Giovanni

Source: Molecular cancer. 16(1):1-15

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128900343.0x000001&indx=1&recIds=ETOCvdc_100128900343.0x000001