Furazanopyrazine-based novel promising anticancer agents interfering with the eicosanoid biosynthesis pathways by dual mPGES-1 and sEH inhibition

Authors: Lauro, Gianluigi ^{a, 1}, Aliberti, Michela ^{a, 1}, De Nisco, Mauro ^b, Pedatella, Silvana ^c, Pepe, Giacomo ^a, Basilicata, Manuela Giovanna ^d, Chini, Maria Giovanna ^e, Fischer, Katrin ^f, Hofstetter, Robert K. ^f, Werz, Oliver ^f, Ferraro, Maria Grazia ^g, Piccolo, Marialuisa ^h, Irace, Carlo ^h, Saviano, Anella ⁱ, Campiglia, Pietro ^a, Bertamino, Alessia ^a, Ostacolo, Carmine ^a, Ciaglia, Tania ^a, Manfra, Michele ^{b, ⁎}, Bifulco, Giuseppe ^{a, ⁎⁎}

Source: In European Journal of Medicinal Chemistry 5 May 2025 289

Protection conferred by booster vaccine doses in hospitalized patients with COVID-19 during the SARS-CoV-2 Omicron BA.2 and BA.5 epidemics from 2022 to 2023 in Greece

Authors: Maltezou, Helena C., Gamaletsou, Maria N., Chini, Maria, Petrakis, Vasileios, Rapti, Vasiliki, Giannouchos, Theodoros V., Karantoni, Eleni, Kounouklas, Konstantinos, Stamou, Panagiota, Karapanou, Αmalia, Basoulis, Dimitrios, Verykokkou, Andrianna-Chrysovalanto, Souliotis, Kyriakos, Panagopoulos, Periklis, Hatzigeorgiou, Dimitrios, Poulakou, Garyfalia, Syrigos, Konstantinos N., Sipsas, Nikolaos V.

Source: In Infectious Medicine December 2024 3(4)

In situ HEXRD experimental study and prediction of microstructures and internal stresses during heat treatment of carburized and carbonitrided low-alloyed steels

Authors: Teixeira, Julien, Jeyabalan, Karthikeyan, Geandier, Guillaume, Dulcy, Jacky, Denand, Benoît, Chini, Maria-Rita, Catteau, Simon D., Courteaux, Marc, Denis, Sabine

Source: In Acta Materialia 15 August 2024 275

Candida auris in Greek healthcare facilities: Active surveillance results on first cases and outbreaks from eleven hospitals within Attica region

Authors: Politi, Lida, Vrioni, Georgia, Hatzianastasiou, Sofia, Lada, Malvina, Martsoukou, Maria, Sipsas, Nikolaos V., Chini, Maria, Baka, Vasiliki, Kafkoula, Eleni, Masgala, Aikaterini, Pirounaki, Maria, Michailidis, Christos, Chrysos, Georgios, Zarkotou, Olympia, Mamali, Vasiliki, Papastamopoulos, Vasileios, Saroglou, Georgios, Pournaras, Spyros, Meletiadis, Joseph, Karakasiliotis, Ioannis, Karachalios, Stefanos, Smilakou, Stavroula, Skandami, Vasiliki, Orfanidou, Maria, Argyropoulou, Athina, Tsakris, Athanassios, Kontopidou, Flora

Source: In Journal of Medical Mycology June 2024 34(2)

Effectiveness of full (booster) COVID-19 vaccination against severe outcomes and work absenteeism in hospitalized patients with COVID-19 during the Delta and Omicron waves in Greece

Authors: Maltezou, Helena C., Basoulis, Dimitrios, Bonelis, Konstantinos, Gamaletsou, Maria N., Giannouchos, Theodoros V., Karantoni, Eleni, Karapanou, Αmalia, Kounouklas, Konstantinos, Livanou, Maria Effrosyni, Zotou, Maria, Rapti, Vasiliki, Stamou, Panagiota, Loulakis, Dimitrios, Souliotis, Kyriakos, Chini, Maria, Panagopoulos, Periklis, Poulakou, Garyfalia, Syrigos, Konstantinos N., Hatzigeorgiou, Dimitrios, Sipsas, Nikolaos V.

Source: Vaccine. 41(14):2343-2348

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186473489.0x000001&indx=1&recIds=ETOCvdc_100186473489.0x000001

Mapping frailty in people living with HIV: A nationwide study in Greece

Authors: Tsakona, Dimitra, Kapetanakis, Anargyros, Kyrou, Dimitrios, Vrontaras, Nikolaos, Xochelli, Aliki, Metallidis, Simeon, Tsachouridou, Olga, Chini, Maria, Meliou, Maria, Psichogiou, Mina, Basoulis, Dimitrios, Antoniadou, Anastasia, Protopapas, Konstantinos, Panagopoulos, Periklis, Petrakis, Vasilis, Gogos, Charalambos, Leonidou, Leonidia, Karamanidou, Christina

Source: HIV medicine. 24(2):170-179

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173648090.0x000001&indx=1&recIds=ETOCvdc_100173648090.0x000001

2-Substituted 1,5-benzothiazepine-based HDAC inhibitors exert anticancer activities on human solid and acute myeloid leukemia cell lines

Authors: De Vita, Simona, Meninno, Sara, Capasso, Lucia, Colarusso, Ester, Chini, Maria Giovanna, Lauro, Gianluigi, Rinaldi, Romolo, De Cicco, Annalisa, Sian, Veronica, Terracciano, Stefania, Nebbioso, Angela, Lattanzi, Alessandra, Bifulco, Giuseppe

Source: In Bioorganic & Medicinal Chemistry 1 October 2023 93

Exploring the chemical space of functionalized [1,2,4]triazolo[4,3-a]quinoxaline-based compounds targeting the bromodomain of BRD9

Authors: Gazzillo, Erica, Pierri, Martina, Colarusso, Ester, Chini, Maria Giovanna, Ferraro, Maria Grazia, Piccolo, Marialuisa, Irace, Carlo, Bruno, Ines, Bifulco, Giuseppe, Terracciano, Stefania, Lauro, Gianluigi

Source: In Bioorganic Chemistry October 2023 139

Target identification by structure-based computational approaches: Recent advances and perspectives

Authors: De Vita, Simona, Chini, Maria Giovanna, Bifulco, Giuseppe, Lauro, Gianluigi

Source: In Bioorganic & Medicinal Chemistry Letters 1 March 2023 83

Efficacy and safety of early soluble urokinase plasminogen receptor plasma-guided anakinra treatment of COVID-19 pneumonia: a subgroup analysis of the SAVE-MORE randomised trial

Authors: Akinosoglou, Karolina, Kotsaki, Antigone, Gounaridi, Ioanna-Maria, Christaki, Eirini, Metallidis, Simeon, Adamis, Georgios, Fragkou, Archontoula, Fantoni, Massimo, Rapti, Aggeliki, Kalomenidis, Ioannis, Chrysos, Georgios, Boni, Gloria, Kainis, Ilias, Alexiou, Zoi, Castelli, Francesco, Serino, Francesco Saverio, Bakakos, Petros, Nicastri, Emanuele, Tzavara, Vassiliki, Safarika, Asimina, Ioannou, Sofia, Dagna, Lorenzo, Dimakou, Katerina, Tzatzagou, Glykeria, Chini, Maria, Bassetti, Matteo, Kotsis, Vasileios, Angheben, Andrea, Tsoukalas, George, Selmi, Carlo, Spiropoulou, Olga-Maria, Samarkos, Michael, Doumas, Michael, Damoraki, Georgia, Masgala, Aikaterini, Papanikolaou, Ilias, Argyraki, Aikaterini, Negri, Marcantonio, Leventogiannis, Konstantinos, Sympardi, Styliani, Gatselis, Nikolaos K., Petrakis, Vasileios, Netea, Mihai G., Panagopoulos, Periklis, Sakka, Vissaria, Milionis, Haralampos, Dalekos, George N., Giamarellos-Bourboulis, Evangelos J.

Source: In eClinicalMedicine February 2023 56

Interferon gamma-induced protein 10 (IP-10) for the early prognosis of the risk for severe respiratory failure and death in COVID-19 pneumonia

Authors: Samaras, Charilaos, Kyriazopoulou, Evdoxia, Poulakou, Garyfallia, Reiner, Eran, Kosmidou, Maria, Karanika, Ioanna, Petrakis, Vasileios, Adamis, George, Gatselis, Nikolaos K., Fragkou, Archontoula, Rapti, Aggeliki, Taddei, Eleonora, Kalomenidis, Ioannis, Chrysos, George, Bertoli, Giulia, Kainis, Ilias, Alexiou, Zoi, Castelli, Francesco, Saverio Serino, Francesco, Bakakos, Petros, Nicastri, Emanuele, Tzavara, Vassiliki, Kostis, Evangelos, Dagna, Lorenzo, Koukidou, Sofia, Tzatzagou, Glykeria, Chini, Maria, Bassetti, Matteo, Trakatelli, Christina, Tsoukalas, George, Selmi, Carlo, Samarkos, Michael, Pyrpasopoulou, Athina, Masgala, Aikaterini, Antonakis, Emmanouil, Argyraki, Aikaterini, Akinosoglou, Karolina, Sympardi, Styliani, Panagopoulos, Periklis, Milionis, Haralampos, Metallidis, Simeon, Syrigos, Konstantinos N., Angel, Alon, Dalekos, George N., Netea, Mihai G., Giamarellos-Bourboulis, Evangelos J.

Source: In Cytokine February 2023 162

Identification and Development of BRD9 Chemical Probes.

Authors: Colarusso, Ester¹ (AUTHOR) ecolarusso@unisa.it, Chini, Maria Giovanna² (AUTHOR) mariagiovanna.chini@unimol.it, Bifulco, Giuseppe¹ (AUTHOR) bifulco@unisa.it, Lauro, Gianluigi¹ (AUTHOR) glauro@unisa.it, Giordano, Assunta³ (AUTHOR) assunta.giordano@cnr.it

Source: Pharmaceuticals (14248247). Mar2024, Vol. 17 Issue 3, p392. 31p.

Subject Terms: *STRUCTURE-activity relationships, *DRUG discovery, *CARRIER proteins, *SMALL molecules, *GENE expression, *CHROMATIN-remodeling complexes

HIV continuum of care: bridging cross-sectional and longitudinal analyses

Authors: Touloumi, Giota, Thomadakis, Christos, Pantazis, Nikos, Papastamopoulos, Vasileios, Paparizos, Vasilios, Metallidis, Simeon, Adamis, Georgios, Chini, Maria, Psichogiou, Mina, Chrysos, Georgios, Sambatakou, Helen, Barbunakis, Emmanouil, Vourli, Georgia, Antoniadou, Anastasia

Source: AIDS. 36(4):583-591

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194406613.0x000001&indx=1&recIds=ETOCvdc_100194406613.0x000001

Estimation of the determinants for HIV late presentation using the traditional definition and molecular clock‐inferred dates: Evidence that older age, heterosexual risk group and more recent diagnosis are prognostic factors

Authors: Kostaki, Evangelia Georgia, Limnaios, Stefanos, Adamis, Georgios, Xylomenos, Georgios, Chini, Maria, Mangafas, Nikos, Lazanas, Marios, Patrinos, Stavros, Metallidis, Simeon, Tsachouridou, Olga, Papastamopoulos, Vasileios, Chatzidimitriou, Dimitrios, Antoniadou, Anastasia, Papadopoulos, Antonios, Protopapas, Konstantinos, Tsiara, Chrysa, Psichogiou, Mina, Basoulis, Dimitrios, Pilalas, Dimitrios, Paraskeva, Dimitra, Chrysos, Georgios, Paparizos, Vasileios, Kourkounti, Sofia, Sambatakou, Helen, Bolanos, Vasileios, Sipsas, Nikolaos V., Lada, Malvina, Barbounakis, Emmanouil, Kantzilaki, Evrikleia, Panagopoulos, Periklis, Petrakis, Vasilis, Drimis, Stelios, Katsarolis, Ioannis, Lagiou, Pagona, Hatzakis, Angelos, Magiorkinis, Gkikas, Skoura, Lemonia, Paraskevis, Dimitrios

Source: HIV medicine. 23(11):1143-1152

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167016976.0x000001&indx=1&recIds=ETOCvdc_100167016976.0x000001

Vaccination coverage rates and attitudes towards mandatory vaccinations among healthcare personnel in tertiary-care hospitals in Greece

Authors: Maltezou, Helena C., Tseroni, Maria, Drositis, Ioannis, Gamaletsou, Maria N., Koukou, Dimitra Maria, Bolikas, Emmanouil, Peskelidou, Emmanuela, Daflos, Charalambos, Panagiotaki, Evangelia, Ledda, Caterina, Pavli, Androula, Moussas, Nikolaos, Kontogianni, Stavroula, Svarna, Eftychia, Ploumidis, Michalis, Spyrou, Andronikos, Chini, Maria, Adamis, Georgios, Lourida, Athanasia, Hatzigeorgiou, Dimitrios, Gargalianos, Panagiotis, Syrogiannopoulos, George, Sipsas, Nikolaos V.

Source: Expert review of vaccines. 21(6):853-859

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152577221.0x000001&indx=1&recIds=ETOCvdc_100152577221.0x000001

Thiazolidin-4-one-based compounds interfere with the eicosanoid biosynthesis pathways by mPGES-1/sEH/5-LO multi-target inhibition

Authors: Colarusso, Ester, Potenza, Marianna, Lauro, Gianluigi, Chini, Maria Giovanna, Sepe, Valentina, Zampella, Angela, Fischer, Katrin, Hofstetter, Robert K., Werz, Oliver, Bifulco, Giuseppe

Source: In European Journal of Medicinal Chemistry Reports August 2022 5

5‐methyl‐2‐carboxamidepyrrole‐based novel dual mPGES‐1/sEH inhibitors as promising anticancer candidates.

Authors: Colarusso, Ester, Lauro, Gianluigi, Potenza, Marianna, Galatello, Paola, Garigliota, Maria Luisa d'Aulisio, Ferraro, Maria Grazia, Piccolo, Marialuisa, Chini, Maria Giovanna, Irace, Carlo, Campiglia, Pietro, Hoffstetter, Robert Klaus, Werz, Oliver, Ramunno, Anna, Bifulco, Giuseppe

Source: Archiv der Pharmazie; Jan2025, Vol. 358 Issue 1, p1-14, 14p

Introducing structure-based three-dimensional pharmacophore models for accelerating the discovery of selective BRD9 binders

Authors: Pierri, Martina, Gazzillo, Erica, Chini, Maria Giovanna, Ferraro, Maria Grazia, Piccolo, Marialuisa, Maione, Francesco, Irace, Carlo, Bifulco, Giuseppe, Bruno, Ines, Terracciano, Stefania, Lauro, Gianluigi

Source: In Bioorganic Chemistry January 2022 118

Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways

Authors: Potenza, Marianna, Sciarretta, Martina, Chini, Maria Giovanna, Saviano, Anella, Maione, Francesco, D'Auria, Maria Valeria, De Marino, Simona, Giordano, Assunta, Hofstetter, Robert Klaus, Festa, Carmen, Werz, Oliver, Bifulco, Giuseppe

Source: In European Journal of Medicinal Chemistry 15 November 2021 224

Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

Authors: Kyriazopoulou, Evdoxia, Huet, Thomas, Cavalli, Giulio, Gori, Andrea, Kyprianou, Miltiades, Pickkers, Peter, Eugen-Olsen, Jesper, Clerici, Mario, Veas, Francisco, Chatellier, Gilles, Kaplanski, Gilles, Netea, Mihai G., Pontali, Emanuele, Gattorno, Marco, Cauchois, Raphael, Kooistra, Emma, Kox, Matthijs, Bandera, Alessandra, Beaussier, Hélène, Mangioni, Davide, Dagna, Lorenzo, van der Meer, Jos W.M., Giamarellos-Bourboulis, Evangelos J., Hayem, Gilles, Volpi, Stefano, Sormani, Maria Pia, Signori, Alessio, Bozzi, Giorgio, Minoia, Francesca, Aliberti, Stefano, Grasselli, Giacomo, Alagna, Laura, Lombardi, Andrea, Ungaro, Riccardo, Agostoni, Carlo, Blasi, Francesco, Costantino, Giorgio, Fracanzani, Anna Ludovica, Montano, Nicola, Peyvandi, Flora, Sottocorno, Marcello, Muscatello, Antonio, Filocamo, Giovanni, Papadopoulos, Antonios, Mouktaroudi, Maria, Karakike, Eleni, Saridaki, Maria, Gkavogianni, Theologia, Katrini, Konstantina, Vechlidis, Nikolaos, Avgoustou, Christina, Chalvatzis, Stamatios, Marantos, Theodoros, Damoulari, Christina, Damoraki, Georgia, Ktena, Sofia, Tsilika, Maria, Koufargyris, Panagiotis, Karageorgos, Athanasios, Droggiti, Dionysia-Irene, Koliakou, Aikaterini, Poulakou, Garyfallia, Tsiakos, Konstantinos, Myrodia, Dimitra-Melia, Gravvani, Areti, Trontzas, Ioannis P., Syrigos, Konstantinos, Kalomenidis, Ioannis, Kranidioti, Eleftheria, Panagopoulos, Periklis, Petrakis, Vasileios, Metallidis, Simeon, Loli, Georgia, Tsachouridou, Olga, Dalekos, George N., Gatselis, Nikolaos, Stefos, Aggelos, Georgiadou, Sarah, Lygoura, Vassiliki, Milionis, Haralampos, Kosmidou, Maria, Papanikolaou, Ilias C., Akinosoglou, Karolina, Giannitsioti, Efthymia, Chrysos, Georgios, Mavroudis, Panagiotis, Sidiropoulou, Chrysanthi, Adamis, Georgios, Fragkou, Archontoula, Rapti, Aggeliki, Alexiou, Zoi, Symbardi, Styliani, Masgala, Aikaterini, Kostaki, Konstantina, Kostis, Evangelos, Samarkos, Michael, Bakakos, Petros, Tzavara, Vassiliki, Dimakou, Katerina, Tzatzagou, Glykeria, Chini, Maria, Kotsis, Vasileios, Tsoukalas, George, Bliziotis, Ioannis, Doumas, Michael, Argyraki, Aikaterini, Kainis, Ilias, Fantoni, Massimo, Cingolani, Antonella, Angheben, Andrea, Cardellino, Chiara Simona, Castelli, Francesco, Serino, Francesco Saverio, Nicastri, Emanuele, Ippolito, Giuseppe, Bassetti, Matteo, Selmi, Carlo, Netea, Mihai G, van der Meer, Jos W M, Giamarellos-Bourboulis, Evangelos J ^*

Source: In The Lancet Rheumatology October 2021 3(10):e690-e697