Assessing the stoichiometric efficacy of mammalian expressed paraoxonase-1 variant I-F11 to afford protection against G-type nerve agents

Authors: Mata, David G., Sabnekar, Praveena, Watson, Cetara A., Rezk, Peter E., Chilukuri, Nageswararao

Source: In Chemico-Biological Interactions 25 November 2016 259 Part B:233-241

Investigation of Evolved Paraoxonase-1 Variants for Prevention of Organophosphorous Pesticide Compound Intoxication

Authors: Mata, David G., Rezk, Peter E. ¹, Sabnekar, Praveena, Cerasoli, Douglas M., Chilukuri, Nageswararao ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics June 2014 349(3):549-558

Assessing protection against OP pesticides and nerve agents provided by wild-type HuPON1 purified from Trichoplusia ni larvae or induced via adenoviral infection

Authors: Hodgins, Sean M., Kasten, Shane A., Harrison, Joshua, Otto, Tamara C., Oliver, Zeke P., Rezk, Peter, Reeves, Tony E., Chilukuri, Nageswararao, Cerasoli, Douglas M.

Source: In Chemico-Biological Interactions 25 March 2013 203(1):177-180

Persistent and high-level expression of human liver prolidase in vivo in mice using adenovirus

Authors: Aleti, Vineela, Reddy, Gireesh B., Parikh, Kalpana, Arun, Peethambaran, Chilukuri, Nageswararao

Source: In Chemico-Biological Interactions 25 March 2013 203(1):191-195

An in vitro and in vivo evaluation of the efficacy of recombinant human liver prolidase as a catalytic bioscavenger of chemical warfare nerve agents

Authors: Rezk, Peter E., Zdenka, Pierre, Sabnekar, Praveena, Kajih, Takwen, Mata, David G., Wrobel, Chester, Cerasoli, Douglas M., Chilukuri, Nageswararao

Source: Drug and chemical toxicology. 38(1):37-43

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100105355118.0x000001&indx=1&recIds=ETOCvdc_100105355118.0x000001

Gene-Delivered Butyrylcholinesterase Is Prophylactic against the Toxicity of Chemical Warfare Nerve Agents and Organophosphorus Compounds

Authors: Parikh, Kalpana, Duysen, Ellen G., Snow, Benjamin, Jensen, Neil S., Manne, Veeraswamy, Lockridge, Oksana, Chilukuri, Nageswararao ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics April 2011 337(1):92-101

Demonstration of in vivo stability and lack of immunogenicity of a polyethyleneglycol-conjugated recombinant CHO-derived butyrylcholinesterase bioscavenger using a homologous macaque model

Authors: Rosenberg, Yvonne J., Saxena, Ashima, Sun, Wei, Jiang, Xiaoming, Chilukuri, Nageswararao, Luo, Chunjuan, Doctor, Bhupendra P., Lee, Keunmyoung D.

Source: In Chemico-Biological Interactions 2010 187(1):279-286

Adenovirus-Transduced Human Butyrylcholinesterase in Mouse Blood Functions as a Bioscavenger of Chemical Warfare Nerve Agents

Authors: Chilukuri, Nageswararao ^*, Duysen, Ellen G., Parikh, Kalpana, diTargiani, Robert, Doctor, Bhupendra P., Lockridge, Oksana, Saxena, Ashima

Source: In Molecular Pharmacology September 2009 76(3):612-617

A repeated injection of polyethyleneglycol-conjugated recombinant human butyrylcholinesterase elicits immune response in mice

Authors: Chilukuri, Nageswararao, Sun, Wei, Parikh, Kalpana, Naik, Ramachandra S., Tang, Lin, Doctor, Bhupendra P., Saxena, Ashima

Source: In Toxicology and Applied Pharmacology 2008 231(3):423-429

Effect of polyethylene glycol modification on the circulatory stability and immunogenicity of recombinant human butyrylcholinesterase

Authors: Chilukuri, Nageswararao, Sun, Wei, Naik, Ramachandra S., Parikh, Kalpana, Tang, Lin, Doctor, Bhupendra P., Saxena, Ashima

Source: In Chemico-Biological Interactions 2008 175(1):255-260

Adenovirus-mediated gene transfer of human butyrylcholinesterase results in persistent high-level transgene expression in vivo

Authors: Chilukuri, Nageswararao, Duysen, Ellen G., Parikh, Kalpana, Sun, Wei, Doctor, Bhupendra P., Lockridge, Oksana, Saxena, Ashima

Source: In Chemico-Biological Interactions 2008 175(1):327-331

An In Vitro Comparative Study on the Reactivation of Nerve Agent-Inhibited Guinea Pig and Human Acetylcholinesterases by Oximes.

Authors: Luo, Chunyuan, Tong, Min, Chilukuri, Nageswararao

Source: Biochemistry; October 23 2007, Vol. 46 Issue 42, p11771-11779, 9p

Gene therapy delivering a paraoxonase 1 variant offers long-term prophylactic protection against nerve agents in mice.

Authors: Betapudi, Venkaiah, Goswami, Reena, Silayeva, Liliya, Doctor, Deborah M., Chilukuri, Nageswararao

Source: Science Translational Medicine; 1/22/2020, Vol. 12 Issue 527, p1-13, 13p

Subject Terms: GENE therapy, CHEMICAL warfare agents, CHEMICAL warfare, ACETYLCHOLINESTERASE, ORGANOPHOSPHORUS compounds, NERVES

Gene Therapy Leaves a Vicious Cycle.

Authors: Goswami, Reena, Subramanian, Gayatri, Silayeva, Liliya, Newkirk, Isabelle, Doctor, Deborah, Chawla, Karan, Chattopadhyay, Saurabh, Chandra, Dhyan, Chilukuri, Nageswararao, Betapudi, Venkaiah

Source: Frontiers in Oncology; 4/24/2019, pN.PAG-N.PAG, 25p

Subject Terms: GENE therapy, GENETIC code, PROTEIN synthesis, CLINICAL trials, PHARMACEUTICAL industry

A strategy for the production of soluble human senescence marker protein-30 in Escherichia coli

Authors: Choi, Moonsuk S., Saxena, Ashima, Chilukuri, Nageswararao

Source: In Biochemical and Biophysical Research Communications 2010 393(3):509-513

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Protective Effects of Recombinant Kunitz-Domain 1 of Human Tissue Factor Pathway Inhibitor-2 Against 2-Chloroethyl Ethyl Sulfide Toxicity In Vitro.

Authors: Choi, Moonsuk S., Parikh, Kalpana, Saxena, Ashima, Chilukuri, Nageswararao

Source: ePlasty: Open Access Journal of Plastic Surgery; 2008, Vol. 8, p23-35, 13p

An In Vitro Comparative Study on the Reactivation of Nerve Agent-Inhibited Guinea Pig and Human Acetylcholinesterases by Oximes.

Authors: Chunyuan Luo, Min Tong, Chilukuri, Nageswararao, Brecht, Karen, Maxwell, Donald M., Saxena, Ashima

Source: Biochemistry; 10/23/2007, Vol. 46 Issue 42, p11771-11779, 9p

Protective Effects of Recombinant Kunitz-Domain 1 of Human Tissue Factor Pathway Inhibitor-2 Against 2-Chloroethyl Ethyl Sulfide Toxicity In Vitro.

Authors: Choi, Moonsuk S., Parikh, Kalpana, Saxena, Ashima, Chilukuri, Nageswararao

Source: Journal of Burns & Wounds; 2007, Vol. 7, p12-24, 13p

(26) Species-related differences in the oxime-induced reactivation of organophosphate-inhibited acetylcholinesterases

Authors: Luo, Chunyuan, Dawson, Maureen, Chambers, Carolyn, Chilukuri, Nageswararao, Radić, Zoran, Taylor, Palmer, Doctor, Bhupendra P., Saxena, Ashima

Source: In Chemico-Biological Interactions 2005 157:393-394