The BR-body proteome contains a complex network of protein-protein and protein-RNA interactions

Authors: Nandana, Vidhyadhar, Rathnayaka-Mudiyanselage, Imalka W., Muthunayake, Nisansala S., Hatami, Ali, Mousseau, C. Bruce, Ortiz-Rodríguez, Luis A., Vaishnav, Jamuna, Collins, Michael, Gega, Alisa, Mallikaarachchi, Kaveendya S., Yassine, Hadi, Ghosh, Aishwarya, Biteen, Julie S., Zhu, Yingxi, Champion, Matthew M., Childers, W. Seth, Schrader, Jared M.

Source: In Cell Reports 31 October 2023 42(10)

Biomolecular condensates as stress sensors and modulators of bacterial signaling.

Authors: Sasazawa, Moeka¹, Tomares, Dylan T.², Childers, W. Seth², wschild@pitt.edu, Saurabh, Saumya¹, saumya@nyu.edu

Source: PLoS Pathogens; 8/15/2024, Vol. 20 Issue 8, p1-25, 25p

Regulation of the activity of the bacterial histidine kinase PleC by the scaffolding protein PodJ

Authors: Zhang, Chao, Zhao, Wei, Duvall, Samuel W., Kowallis, Kimberly A., Childers, W. Seth

Source: In Journal of Biological Chemistry April 2022 298(4)

BR-Bodies Provide Selectively Permeable Condensates that Stimulate mRNA Decay and Prevent Release of Decay Intermediates

Authors: Al-Husini, Nadra, Tomares, Dylan T., Pfaffenberger, Zechariah J., Muthunayake, Nisansala S., Samad, Mohammad A., Zuo, Tiancheng, Bitar, Obaidah, Aretakis, James R., Bharmal, Mohammed-Husain M., Gega, Alisa, Biteen, Julie S., Childers, W. Seth, Schrader, Jared M.

Source: In Molecular Cell 21 May 2020 78(4):670-682

Manipulation of Bacterial Signaling Using Engineered Histidine Kinases

Authors: Kowallis, Kimberly A., Duvall, Samuel W., Zhao, Wei, Childers, W. Seth

Source: Methods in molecular biology. 2077:141-164

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN622328367&indx=1&recIds=ETOCRN622328367

Biomolecular Condensates: From Bacterial Compartments to Incubator Spaces of Emergent Chemical Systems in Matter‐to‐Life Transitions.

Authors: Schnorr, Wade E.¹, Childers, W. Seth¹ wschild@pitt.edu

Source: ChemSystemsChem. Jul2024, Vol. 6 Issue 4, p1-15. 15p.

Subject Terms: *INCUBATORS, *BACTERIAL cells, *PREBIOTICS, *CYTOLOGY, *LIPOSOMES

α-Proteobacterial RNA Degradosomes Assemble Liquid-Liquid Phase-Separated RNP Bodies

Authors: Al-Husini, Nadra, Tomares, Dylan T., Bitar, Obaidah, Childers, W. Seth, Schrader, Jared M.

Source: In Molecular Cell 20 September 2018 71(6):1027-1039

Dynamic translation regulation in Caulobacter cell cycle control

Authors: Schrader, Jared M., Li, Gene-Wei, Childers, W. Seth, Perez, Adam M., Weissman, Jonathan S., Shapiro, Lucy, McAdams, Harley H.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Nov 01. 113(44), E6859-E6867.

Access URL: https://www.jstor.org/stable/26472341

Uncovering supramolecular chirality codes for the design of tunable biomaterials.

Authors: Klawa, Stephen J., Lee, Michelle, Riker, Kyle D., Jian, Tengyue, Wang, Qunzhao, Gao, Yuan, Daly, Margaret L., Bhonge, Shreeya, Childers, W. Seth, Omosun, Tolulope O., Mehta, Anil K., Lynn, David G., Freeman, Ronit

Source: Nature Communications; 1/26/2024, Vol. 15 Issue 1, p1-16, 16p

Subject Terms: CHIRALITY, PEPTIDE derivatives, ACTIVATION energy, AMYLOID beta-protein, DISEASE progression, NEURODEGENERATION

Branched Signal Wiring of an Essential Bacterial Cell-Cycle Phosphotransfer Protein

Authors: Blair, Jimmy A., Xu, Qingping, Childers, W. Seth, Mathews, Irimpan I., Kern, Justin W., Eckart, Michael, Deacon, Ashley M., Shapiro, Lucy

Source: In Structure 3 September 2013 21(9):1590-1601

Cover Image

Authors: Muthunayake, Nisansala S., Tomares, Dylan T., Childers, W. Seth, Schrader, Jared M.

Source: Wiley interdisciplinary reviews.RNA. 11(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108011152.0x000001&indx=1&recIds=ETOCvdc_100108011152.0x000001

Phase‐separated bacterial ribonucleoprotein bodies organize mRNA decay

Authors: Muthunayake, Nisansala S., Tomares, Dylan T., Childers, W. Seth, Schrader, Jared M.

Source: Wiley interdisciplinary reviews.RNA. 11(6)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108011120.0x000001&indx=1&recIds=ETOCvdc_100108011120.0x000001

RNase E biomolecular condensates stimulate PNPase activity.

Authors: Collins, Michael J., Tomares, Dylan T., Nandana, Vidhyadhar, Schrader, Jared M., Childers, W. Seth

Source: Scientific Reports; 8/9/2023, Vol. 13 Issue 1, p1-15, 15p

Subject Terms: CAULOBACTER crescentus, PROTEIN-protein interactions, CATALYTIC activity, RIBONUCLEASES, PHASE separation, RNA

Chapter Ten - Protein engineering strategies to stimulate the functions of bacterial pseudokinases

Authors: Yang, Xiaole, Kowallis, Kimberly A., Childers, W. Seth

Source: In Methods in Enzymology 2022 667:275-302

Engineering Metal Ion Coordination to Regulate Amyloid Fibril Assembly and Toxicity

Authors: Dong, Jijun, Canfield, Jeffrey M., Mehta, Anil K., Shokes, Jacob E., Tian, Bo, Childers, W. Seth, Simmons, James A., Mao, Zixu, Scott, Robert A., Warncke, Kurt, Lynn, David G.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2007 Aug . 104(33), 13313-13318.

Access URL: https://www.jstor.org/stable/25436481

Peptide membranes in chemical evolution

Authors: Childers, W Seth, Ni, Rong, Mehta, Anil K, Lynn, David G

Source: In Current Opinion in Chemical Biology 2009 13(5):652-659

Phase separation modulates the assembly and dynamics of a polarity-related scaffold-signaling hub.

Authors: Tan, Wei, Cheng, Sihua, Li, Yingying, Li, Xiao-Yang, Lu, Ning, Sun, Jingxian, Tang, Guiyue, Yang, Yujiao, Cai, Kezhu, Li, Xuefei, Ou, Xijun, Gao, Xiang, Zhao, Guo-Ping, Childers, W. Seth, Zhao, Wei

Source: Nature Communications; 11/23/2022, Vol. 13 Issue 1, p1-14, 14p

Subject Terms: PHASE separation, CAULOBACTER crescentus, SCAFFOLD proteins

Imaging Nucleation, Growth and Heterogeneity in Self-Assembled Amyloid Phases

Authors: Anthony, Neil R, Berland, Keith M, Mehta, Anil K, Lynn, David G, Childers, W. Seth

Source: Bio-Nanoimaging: Protein Misfolding and Aggregation. 2014, p27-36.

Templating Molecular Arrays in Amyloid's Cross-β Grooves.

Authors: Childers, W. Seth, Mehta, Anil K., Lu, Kun

Source: Journal of the American Chemical Society; July 29 2009, Vol. 131 Issue 29, p10165-10172, 8p

Facial Symmetry in Protein Self-Assembly.

Authors: Mehta, Anil K., Lu, Kun, Childers, W. Seth

Source: Journal of the American Chemical Society; July 30 2008, Vol. 130 Issue 30, p9829-9835, 7p