Transporters and Toxicity: Insights From the International Transporter Consortium Workshop 4

Authors: Hafey, Michael J., Aleksunes, Lauren M., Bridges, Christy C., Brouwer, Kenneth R., Chien, Huan‐Chieh, Leslie, Elaine M., Hu, Shuiying, Li, Yang, Shen, Jinshan, Sparreboom, Alex, Sprowl, Jason, Tweedie, Donald, Lai, Yurong

Source: Clinical pharmacology & therapeutics. 112(3):527-539

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100158381744.0x000001&indx=1&recIds=ETOCvdc_100158381744.0x000001

Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives

Authors: Zou, Ling, Spanogiannopoulos, Peter, Pieper, Lindsey M., Chien, Huan-Chieh, Cai, Wenlong, Khuri, Natalia, Pottel, Joshua, Vora, Bianca, Ni, Zhanglin, Tsakalozou, Eleftheria, Zhang, Wenjun, Shoichet, Brian K., Giacomini, Kathleen M., Turnbaugh, Peter J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Jul 01. 117(27), 16009-16018.

Access URL: https://www.jstor.org/stable/26935167

Considerations in Kp,uu,brain-based Strategy for Selecting CNS-targeted Drug Candidates with Sufficient Target Coverage and Substantial Pharmacodynamic Effect.

Authors: Zou, Ling, Chien, Huan-Chieh, Pade, Devendra, Li, Yanfei, Nguyen, Minhkhoi, Bhamidipati, Ravi Kanth, Wang, Zhe, Enogieru, Osatohanmwen Jessica, Wahlstrom, Jan

Source: AAPS Journal; Apr2025, Vol. 27 Issue 2, p1-13, 13p

The Effects of Prodrug Size and a Carbonyl Linker on l‐Type Amino Acid Transporter 1‐Targeted Cellular and Brain Uptake

Authors: Venteicher, Brooklynn, Merklin, Kasey, Ngo, Huy X., Chien, Huan‐Chieh, Hutchinson, Keino, Campbell, Jerome, Way, Hannah, Griffith, Joseph, Alvarado, Cesar, Chandra, Surabhi, Hill, Evan, Schlessinger, Avner, Thomas, Allen A.

Source: ChemMedChem. 16(5):869-880

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115859870.0x000001&indx=1&recIds=ETOCvdc_100115859870.0x000001

Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies

Authors: Yee, Sook Wah, Buitrago, Dina, Stecula, Adrian, Ngo, Huy X., Chien, Huan‐Chieh, Zou, Ling, Koleske, Megan L., Giacomini, Kathleen M.

Source: FASEB journal. 34(12):15734-15752

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163874192.0x000001&indx=1&recIds=ETOCvdc_100163874192.0x000001

Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity

Authors: Zou, Ling, Stecula, Adrian, Gupta, Anshul, Prasad, Bhagwat, Chien, Huan-Chieh, Yee, Sook Wah, Wang, Li, Unadkat, Jashvant D., Stahl, Simone H., Fenner, Katherine S., Giacomini, Kathleen M. ^*

Source: In Molecular Pharmacology July 2018 94(1):689-699

L-Type amino acid transporter 1 activity of 1, 2, 3-triazolyl analogs of l-histidine and l-tryptophan

Authors: Hall, Colton, Wolfe, Hannah, Wells, Alyssa, Chien, Huan-Chieh, Colas, Claire, Schlessinger, Avner, Giacomini, Kathleen M., Thomas, Allen A.

Source: Bioorganic & medicinal chemistry letters. 29(16):2254-2258

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100090306768.0x000001&indx=1&recIds=ETOCvdc_100090306768.0x000001

A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568

Authors: Yang, Peng, Wang, Yixuan, Hoang, Don, Tinkham, Matthew, Patel, Anamika, Sun, Ming-An, Wolf, Gernot, Baker, Mairead, Chien, Huan-Chieh, Lai, Kuan-Yu Nick, Cheng, Xiaodong, Shen, Che-Kun James, Macfarlan, Todd S.

Source: Science, 2017 May . 356(6339), 757-760.

Access URL: https://www.jstor.org/stable/26399053

Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates.

Authors: Yee, Sook Wah, Ferrández-Peral, Luis, Alentorn-Moron, Pol, Fontsere, Claudia, Ceylan, Merve, Koleske, Megan L., Handin, Niklas, Artegoitia, Virginia M., Lara, Giovanni, Chien, Huan-Chieh, Zhou, Xujia, Dainat, Jacques, Zalevsky, Arthur, Sali, Andrej, Brand, Colin M., Wolfreys, Finn D., Jia Yang, Gestwicki, Jason E., Capra, John A., Artursson, Per

Source: Nature Communications; 5/23/2024, Vol. 15 Issue 1, p1-17, 17p, 5 Graphs

Rapid Method To Determine Intracellular Drug Concentrations in Cellular Uptake Assays: Application to Metformin in Organic Cation Transporter 1–Transfected Human Embryonic Kidney 293 Cells

Authors: Chien, Huan-Chieh, Zur, Arik A, Maurer, Tristan S, Yee, Sook Wah, Tolsma, John, Jasper, Paul, Scott, Dennis O, Giacomini, Kathleen M ^*

Source: In Drug Metabolism and Disposition March 2016 44(3):356-364

OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin

Authors: Chen, Ligong, Shu, Yan, Liang, Xiaomin, Chen, Eugene C., Yee, Sook Wah, Zur, Arik A., Li, Shuanglian, Xu, Lu, Keshari, Kayvan R., Lin, Michael J., Chien, Huan-Chieh, Zhang, Youcai, Morrissey, Kari M., Liu, Jason, Ostrem, Jonathan, Younger, Noah S., Kurhanewicz, John, Shokat, Keven M., Ashrafi, Kaveh, Giacomini, Kathleen M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2014 Jul 01. 111(27), 9983-9988.

Access URL: https://www.jstor.org/stable/23802698

LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates

Authors: Zur, Arik A., Chien, Huan-Chieh, Augustyn, Evan, Flint, Andrew, Heeren, Nathan, Finke, Karissa, Hernandez, Christopher, Hansen, Logan, Miller, Sydney, Lin, Lawrence, Giacomini, Kathleen M., Colas, Claire, Schlessinger, Avner, Thomas, Allen A.

Source: Bioorganic & medicinal chemistry letters. 26(20):5000-5006

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100069966666.0x000001&indx=1&recIds=ETOCvdc_100069966666.0x000001

LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs

Authors: Augustyn, Evan, Finke, Karissa, Zur, Arik A., Hansen, Logan, Heeren, Nathan, Chien, Huan-Chieh, Lin, Lawrence, Giacomini, Kathleen M., Colas, Claire, Schlessinger, Avner, Thomas, Allen A.

Source: Bioorganic & medicinal chemistry letters. 26(11):2616-2621

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100065907104.0x000001&indx=1&recIds=ETOCvdc_100065907104.0x000001

Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools

Authors: Lin, Ting-Yu, Mai, Quynh N., Zhang, Hao, Wilson, Emily, Chien, Huan-Chieh, Yee, Sook Wah, Giacomini, Kathleen M., Olgin, Jeffrey E., Irannejad, Roshanak

Source: Nature Chemical Biology; January 2024, Vol. 20 Issue: 1 p62-73, 12p

Metformin Is a Substrate and Inhibitor of the Human Thiamine Transporter, THTR-2 (SLC19A3)

Authors: Liang, Xiaomin, Chien, Huan-Chieh, Yee, Sook Wah, Giacomini, Marilyn M., Chen, Eugene C., Piao, Meiling, Hao, Jia, Twelves, Jolyn, Lepist, Eve-Irene, Ray, Adrian S.

Source: Molecular pharmaceutics. 12(12):4301-4310

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN604116064&indx=1&recIds=ETOCRN604116064

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.

Authors: Yee, Sook Wah¹, Stecula, Adrian¹, Chien, Huan-Chieh¹, Zou, Ling¹, Feofanova, Elena V.², van Borselen, Marjolein¹, Cheung, Kit Wun Kathy¹, kathy.giacomini@ucsf.edu, Yousri, Noha A.^3,4, Suhre, Karsten⁵, Kinchen, Jason M.⁶, Boerwinkle, Eric^2,7, Irannejad, Roshanak⁸, Yu, Bing², Giacomini, Kathleen M.^1,9

Source: PLoS Genetics; 9/25/2019, Vol. 15 Issue 9, p1-38, 38p

l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan

Authors: Hall, Colton, Wolfe, Hannah, Wells, Alyssa, Chien, Huan-Chieh, Colas, Claire, Schlessinger, Avner, Giacomini, Kathleen M., Thomas, Allen A.

Source: In Bioorganic & Medicinal Chemistry Letters 15 August 2019 29(16):2254-2258

Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.

Authors: Liang, Xiaomin¹, Yee, Sook Wah¹, Chien, Huan-Chieh¹, Chen, Eugene C.¹, Luo, Qi^1,2, Zou, Ling¹, Piao, Meiling^1,2, Mifune, Arias¹, Chen, Ligong^1,2, Calvert, Meredith E.³, King, Sarah⁴, Norheim, Frode⁵, Abad, Janna³, Krauss, Ronald M.⁴, Giacomini, Kathleen M.^1,6, Kathy.giacomini@ucsf.edu

Source: PLoS Biology; 4/16/2018, Vol. 16 Issue 4, p1-33, 33p, 1 Chart, 6 Graphs

Rate of Evolution in Brain-Expressed Genes in Humans and Other Primates.

Authors: Wang, Hurng-Yi, Chien, Huan-Chieh, Osada, Naoki

Source: PLoS Biology; February 2007, Vol. 5 Issue 2, p335-342, 8p

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