Adapt and shape: metabolic features within the metastatic niche

Authors: Pranzini, Erica ^{1, 2, @}, Ippolito, Luigi ^{1, 2, @}, Pardella, Elisa ^{1, 2, @}, Giannoni, Elisa ¹, Chiarugi, Paola ^{1, ⁎}

Source: In Trends in Endocrinology & Metabolism March 2025 36(3):205-218

Nutritional and metabolic signalling through GPCRs

Authors: Pardella, Elisa, Ippolito, Luigi, Giannoni, Elisa, Chiarugi, Paola

Source: FEBS letters. 596(18):2364-2381

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163061832.0x000001&indx=1&recIds=ETOCvdc_100163061832.0x000001

Unconventional roles of lactate along the tumor and immune landscape

Authors: Ippolito, Luigi, Sonveaux, Pierre, Chiarugi, Paola

Source: Trends in endocrinology and metabolism. 33(4):231-235

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157024584.0x000001&indx=1&recIds=ETOCvdc_100157024584.0x000001

SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis

Authors: Pranzini, Erica, Pardella, Elisa, Muccillo, Livio, Leo, Angela, Nesi, Ilaria, Santi, Alice, Parri, Matteo, Zhang, Tong, Uribe, Alejandro Huerta, Lottini, Tiziano, Sabatino, Lina, Caselli, Anna, Arcangeli, Annarosa, Raugei, Giovanni, Colantuoni, Vittorio, Cirri, Paolo, Chiarugi, Paola, Maddocks, Oliver D.K., Paoli, Paolo, Taddei, Maria Letizia

Source: In Cell Reports 16 August 2022 40(7)

Mitochondrial oxidative metabolism contributes to a cancer stem cell phenotype in cholangiocarcinoma

Authors: Raggi, Chiara, Taddei, Maria Letizia, Sacco, Elena, Navari, Nadia, Correnti, Margherita, Piombanti, Benedetta, Pastore, Mirella, Campani, Claudia, Pranzini, Erica, Iorio, Jessica, Lori, Giulia, Lottini, Tiziano, Peano, Clelia, Cibella, Javier, Lewinska, Monika, Andersen, Jesper B., di Tommaso, Luca, Viganò, Luca, Di Maira, Giovanni, Madiai, Stefania, Ramazzotti, Matteo, Orlandi, Ivan, Arcangeli, Annarosa, Chiarugi, Paola, Marra, Fabio

Source: In Journal of Hepatology June 2021 74(6):1373-1385

DNMT3A epigenetically regulates key microRNAs involved in epithelial-to-mesenchymal transition in prostate cancer

Authors: Mancini, Monica, Grasso, Margherita, Muccillo, Livio, Babbio, Federica, Precazzini, Francesca, Castiglioni, Ilaria, Zanetti, Valentina, Rizzo, Francesca, Pistore, Christian, De Marino, Maria Giovanna, Zocchi, Michele, Del Vescovo, Valerio, Licursi, Valerio, Giurato, Giorgio, Weisz, Alessandro, Chiarugi, Paola, Sabatino, Lina, Denti, Michela Alessandra, Bonapace, Ian Marc

Source: Carcinogenesis. 42(12):1449-1460

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139152461.0x000001&indx=1&recIds=ETOCvdc_100139152461.0x000001

Stromal-induced mitochondrial re-education: Impact on epithelial-to-mesenchymal transition and cancer aggressiveness

Authors: Bacci, Marina, Ippolito, Luigi, Magnelli, Lucia, Giannoni, Elisa ^*, Chiarugi, Paola

Source: In Seminars in Cell and Developmental Biology February 2020 98:71-79

Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer

Authors: Bacci, Marina, Lorito, Nicla, Ippolito, Luigi, Ramazzotti, Matteo, Luti, Simone, Romagnoli, Simone, Parri, Matteo, Bianchini, Francesca, Cappellesso, Federica, Virga, Federico, Gao, Qiong, Simões, Bruno M., Marangoni, Elisabetta, Martin, Lesley-Ann, Comito, Giuseppina, Ferracin, Manuela, Giannoni, Elisa, Mazzone, Massimiliano, Chiarugi, Paola, Morandi, Andrea

Source: In Cell Reports 2 July 2019 28(1):104-118

Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer.

Authors: Ippolito, Luigi, Duatti, Assia, Iozzo, Marta, Comito, Giuseppina, Pardella, Elisa, Lorito, Nicla, Bacci, Marina, Pranzini, Erica, Santi, Alice, Sandrini, Giada, Catapano, Carlo V, Serni, Sergio, Spatafora, Pietro, Morandi, Andrea, Giannoni, Elisa, Chiarugi, Paola

Source: EMBO Reports; Aug2024, Vol. 25 Issue 8, p3506-3531, 26p

FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer.

Authors: Lorito, Nicla, Subbiani, Angela, Smiriglia, Alfredo, Bacci, Marina, Bonechi, Francesca, Tronci, Laura, Romano, Elisabetta, Corrado, Alessia, Longo, Dario Livio, Iozzo, Marta, Ippolito, Luigi, Comito, Giuseppina, Giannoni, Elisa, Meattini, Icro, Avgustinova, Alexandra, Chiarugi, Paola, Bachi, Angela, Morandi, Andrea

Source: EMBO Molecular Medicine; Jul2024, Vol. 16 Issue 7, p1533-1559, 27p

Lactate: A Metabolic Driver in the Tumour Landscape

Authors: Ippolito, Luigi, Morandi, Andrea, Giannoni, Elisa, Chiarugi, Paola

Source: In Trends in Biochemical Sciences February 2019 44(2):153-166

Kv1.3 potassium channel of myeloid cells controls tumor growth in vivo

Authors: Varanita, Tatiana, Angi, Beatrice, Bonesso, Daniele, Tosi, Anna, Albiero, Mattia, Calura, Enrica, Parri, Matteo, Chiarugi, Paola, Fadini, Gian Paolo, Rosato, Antonio, Zoltán, Máté, Erdelyi, Ferenc, Szabo, Ildiko

Source: In BBA - Molecular Basis of Disease December 2024 1870(8)

Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

Authors: Apicella, Maria, Giannoni, Elisa, Fiore, Stephany, Ferrari, Karin Johanna, Fernández-Pérez, Daniel, Isella, Claudio, Granchi, Carlotta, Minutolo, Filippo, Sottile, Antonino, Comoglio, Paolo Maria, Medico, Enzo, Pietrantonio, Filippo, Volante, Marco, Pasini, Diego, Chiarugi, Paola, Giordano, Silvia, Corso, Simona

Source: In Cell Metabolism 4 December 2018 28(6):848-865

Redox cycler based therapeutic option against mitochondrial pathologies linked to respiratory chain dysfunction

Authors: Bonesso, Daniele, Donadon, Michael, Rossa, Andrea, Biasutto, Lucia, Favero, Marta, Mattarei, Andrea, Iozzo, Marta, Santi, Alice, Purhonen, Janne, Giannoni, Elisa, Chiarugi, Paola, Kalljarvi, Jukka, Calura, Enrica, Zeviani, Massimo, Viscomi, Carlo, Szabo, Ildiko

Source: In BBA - Bioenergetics 1 September 2024 1865 Supplement

Stromal‐induced downregulation of miR‐1247 promotes prostate cancer malignancy

Authors: Taddei, Maria Letizia, Cavallini, Lorenzo, Ramazzotti, Matteo, Comito, Giuseppina, Pietrovito, Laura, Morandi, Andrea, Giannoni, Elisa, Raugei, Giovanni, Chiarugi, Paola

Source: Journal of cellular physiology. 234(6):8274-8285

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123623030.0x000001&indx=1&recIds=ETOCvdc_100123623030.0x000001

Β3‐Adrenoceptor as a potential immuno‐suppressor agent in melanoma

Authors: Calvani, Maura, Bruno, Gennaro, Dal Monte, Massimo, Nassini, Romina, Fontani, Filippo, Casini, Arianna, Cavallini, Lorenzo, Becatti, Matteo, Bianchini, Francesca, De Logu, Francesco, Forni, Giulia, Marca, Giancarlo, Calorini, Lido, Bagnoli, Paola, Chiarugi, Paola, Pupi, Alberto, Azzari, Chiara, Geppetti, Pierangelo, Favre, Claudio, Filippi, Luca

Source: British journal of pharmacology. 176(14):2509-2524

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112306728.0x000001&indx=1&recIds=ETOCvdc_100112306728.0x000001

Zoledronic Acid Inhibits the RhoA-mediated Amoeboid Motility of Prostate Cancer Cells

Authors: Pietrovito, Laura, Comito, Giuseppina, Parri, Matteo, Giannoni, Elisa, Chiarugi, Paola, Taddei, Maria Letizia

Source: Current cancer drug targets. 19(10):807-816

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100100000618.0x000001&indx=1&recIds=ETOCvdc_100100000618.0x000001

Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer

Authors: Ippolito, Luigi, Morandi, Andrea, Taddei, Maria, Parri, Matteo, Comito, Giuseppina, Iscaro, Alessandra, Raspollini, Maria, Magherini, Francesca, Rapizzi, Elena, Masquelier, Julien, Muccioli, Giulio, Sonveaux, Pierre, Chiarugi, Paola, Giannoni, Elisa

Source: Oncogene. 38(27):5339-5355

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184151014.0x000001&indx=1&recIds=ETOCvdc_100184151014.0x000001

Reactive Oxygen Species as Essential Mediators of Cell Adhesion: The Oxidative Inhibition of a FAK Tyrosine Phosphatase Is Required for Cell Adhesion

Authors: Chiarugi, Paola, Pani, Giovambattista, Giannoni, Elisa, Taddei, Letizia, Colavitti, Renata, Raugei, Giovanni, Symons, Mark, Borrello, Silvia, Galeotti, Tommaso, Ramponi, Giampietro

Source: The Journal of Cell Biology, 2003 Jun 01. 161(5), 933-944.

Access URL: https://www.jstor.org/stable/1621557

Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer

Authors: Chen, Jingjing, Guccini, Ilaria, Mitri, Diletta Di, Brina, Daniela, Revandkar, Ajinkya, Sarti, Manuela, Pasquini, Emiliano, Alajati, Abdullah, Pinton, Sandra, Losa, Marco, Civenni, Gianluca, Catapano, Carlo, Sgrignani, Jacopo, Cavalli, Andrea, D'Antuono, Rocco, Asara, John, Morandi, Andrea, Chiarugi, Paola, Crotti, Sara, Agostini, Marco, Montopoli, Monica, Masgras, Ionica, Rasola, Andrea, Garcia-Escudero, Ramon, Delaleu, Nicolas, Rinaldi, Andrea, Bertoni, Francesco, Bono, Johann de, Carracedo, Arkaitz, Alimonti, Andrea

Source: Nature genetics. 50(2):219-228

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171355244.0x000001&indx=1&recIds=ETOCvdc_100171355244.0x000001