Role of CDK4 as prognostic biomarker in Soft Tissue Sarcoma and synergistic effect of its inhibition in dedifferentiated liposarcoma sequential treatment

Authors: Silvia Vanni, Giacomo Miserocchi, Graziana Gallo, Valentina Fausti, Sofia Gabellone, Chiara Liverani, Chiara Spadazzi, Claudia Cocchi, Chiara Calabrese, Giovanni De Luca, Massimo Bassi, Manlio Gessaroli, Nicola Tomasetti, Angelo Campobassi, Federica Pieri, Giorgio Ercolani, Davide Cavaliere, Lorena Gurrieri, Nada Riva, Federica Recine, Toni Ibrahim, Laura Mercatali, Robin Jones, Alessandro De Vita

Source: Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-4 (2024)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2162-3619

Access URL: https://doaj.org/article/67e47af7cc474fdabff1ecf9d66a2bd6

Exploring nanotechnology solutions for improved outcomes in gastrointestinal stromal tumors

Authors: Sofia Gabellone, Silvia Vanni, Valentina Fausti, Giacomo Miserocchi, Chiara Liverani, Chiara Spadazzi, Claudia Cocchi, Chiara Calabrese, Davide Cavaliere, Carlo Alberto Pacilio, Giorgio Ercolani, Federica Pieri, Lorena Gurrieri, Nada Riva, Robin Jones, Alessandro De Vita

Source: Heliyon, Vol 10, Iss 23, Pp e40596- (2024)

Subject Terms: GIST, c-Kit, DOG1, Imatinib, TKI inhibitors, Nanotechnology, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024166273; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/da6fe95f84b94863ac7f39c8a2a24d44

Orthogonal proteogenomic analysis identifies the druggable PA2G4-MYC axis in 3q26 AML

Authors: Matteo Marchesini, Andrea Gherli, Elisa Simoncini, Lucas Moron Dalla Tor, Anna Montanaro, Natthakan Thongon, Federica Vento, Chiara Liverani, Elisa Cerretani, Anna D’Antuono, Luca Pagliaro, Raffaella Zamponi, Chiara Spadazzi, Elena Follini, Benedetta Cambò, Mariateresa Giaimo, Angela Falco, Gabriella Sammarelli, Giannalisa Todaro, Sabrina Bonomini, Valentina Adami, Silvano Piazza, Claudia Corbo, Bruno Lorusso, Federica Mezzasoma, Costanza Anna Maria Lagrasta, Maria Paola Martelli, Roberta La Starza, Antonio Cuneo, Franco Aversa, Cristina Mecucci, Federico Quaini, Simona Colla, Giovanni Roti

Source: Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c30fb1e8744340988d7fe56036a89ecf

Xenografting Human Musculoskeletal Sarcomas in Mice, Chick Embryo, and Zebrafish: How to Boost Translational Research

Authors: Veronica Giusti, Giacomo Miserocchi, Giulia Sbanchi, Micaela Pannella, Claudia Maria Hattinger, Marilena Cesari, Leonardo Fantoni, Ania Naila Guerrieri, Chiara Bellotti, Alessandro De Vita, Chiara Spadazzi, Davide Maria Donati, Monica Torsello, Enrico Lucarelli, Toni Ibrahim, Laura Mercatali

Source: Biomedicines, Vol 12, Iss 8, p 1921 (2024)

Subject Terms: patient-derived xenografts (PDX), cell-derived xenografts (CDX), murine models, zebrafish, chorioallantoic membrane (CAM), musculoskeletal sarcomas, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/12/8/1921; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/b62b69d1957b47d4ae7db370d746fddf

High-grade transformation of a polymorphous adenocarcinoma of the salivary gland: a case report and review of the literature

Authors: Giacomo Miserocchi, Massimo Bassi, Giovanni De Luca, Sebastiano Calpona, Francesco De Rosa, Alberto Bongiovanni, Elisabetta Parisi, Giandomenico Di Menna, Alessandro De Vita, Chiara Liverani, Chiara Spadazzi, Claudia Cocchi, Silvia Vanni, Laura Capelli, Massimo Magnani, Giuseppe Meccariello, Claudio Vicini, Angelo Campobassi, Laura Mercatali, Toni Ibrahim

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: polymorphous adenocarcinoma, high-grade transformation, minor salivary gland, gene expression profiling, oral floor, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1245043/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/19e129d9ff6f4b87b4d70f581ba99204

Lineage‐specific mechanisms and drivers of breast cancer chemoresistance revealed by 3D biomimetic culture

Authors: Chiara Liverani, Alessandro De Vita, Chiara Spadazzi, Giacomo Miserocchi, Claudia Cocchi, Alberto Bongiovanni, Anna De Lucia, Federico La Manna, Francesco Fabbri, Michela Tebaldi, Dino Amadori, Ennio Tasciotti, Giovanni Martinelli, Laura Mercatali, Toni Ibrahim

Source: Molecular Oncology, Vol 16, Iss 4, Pp 921-939 (2022)

Subject Terms: 3D models, breast cancer, DNA repair, doxorubicin, drug resistance, lysosomes, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/7f50673868da47039920d747cb127b18

HRAS overexpression predicts response to Lenvatinib treatment in gastroenteropancreatic neuroendocrine tumors

Authors: Chiara Liverani, Chiara Spadazzi, Toni Ibrahim, Federica Pieri, Flavia Foca, Chiara Calabrese, Alessandro De Vita, Giacomo Miserocchi, Claudia Cocchi, Silvia Vanni, Giorgio Ercolani, Davide Cavaliere, Nicoletta Ranallo, Elisa Chiadini, Giovanna Prisinzano, Stefano Severi, Maddalena Sansovini, Giovanni Martinelli, Alberto Bongiovanni, Laura Mercatali

Source: Frontiers in Endocrinology, Vol 13 (2023)

Subject Terms: nen, primary cultures, Lenvatinib efficacy, HRAS overexpression, predictive marker, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2022.1045038/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/6702750d458546d594d1121a5c66b84f

The emerging role of cancer nanotechnology in the panorama of sarcoma

Authors: Laura Mercatali, Silvia Vanni, Giacomo Miserocchi, Chiara Liverani, Chiara Spadazzi, Claudia Cocchi, Chiara Calabrese, Lorena Gurrieri, Valentina Fausti, Nada Riva, Damiano Genovese, Enrico Lucarelli, Maria Letizia Focarete, Toni Ibrahim, Luana Calabrò, Alessandro De Vita

Source: Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)

Subject Terms: sarcoma, nanotechnology, lipid-based nanocarriers, polymeric nanoparticles, smart materials, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fbioe.2022.953555/full; https://doaj.org/toc/2296-4185

Access URL: https://doaj.org/article/f885ba5b521043b3ab3517835c5c98b4

The potential role of the extracellular matrix in the activity of trabectedin in UPS and L-sarcoma: evidences from a patient‐derived primary culture case series in tridimensional and zebrafish models

Authors: Alessandro De Vita, Federica Recine, Giacomo Miserocchi, Federica Pieri, Chiara Spadazzi, Claudia Cocchi, Silvia Vanni, Chiara Liverani, Anna Farnedi, Francesco Fabbri, Valentina Fausti, Roberto Casadei, Francesca Brandolini, Giorgio Ercolani, Davide Cavaliere, Alberto Bongiovanni, Nada Riva, Lorena Gurrieri, Giandomenico Di Menna, Sebastiano Calpona, Silvia Angela Debonis, Laura Mercatali, Toni Ibrahim

Source: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-12 (2021)

Subject Terms: Trabectedin, Extracellular matrix, Undifferentiated pleomorphic sarcoma and L-sarcoma, Patient‐derived primary cultures, 3D scaffold, Chemotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/31e3db4f0cf24657932c820ed97f9c7f

Three-dimensional collagen-based scaffold model to study the microenvironment and drug-resistance mechanisms of oropharyngeal squamous cell carcinomas

Authors: Giacomo Miserocchi, Claudia Cocchi, Alessandro De Vita, Chiara Liverani, Chiara Spadazzi, Sebastiano Calpona, Giandomenico Di Menna, Massimo Bassi, Giuseppe Meccariello, Giovanni De Luca, Angelo Campobassi, Maria Maddalena Tumedei, Alberto Bongiovanni, Valentina Fausti, Franco Cotelli, Toni Ibrahim, Laura Mercatali

Source: Cancer Biology & Medicine, Vol 18, Iss 2, Pp 502-516 (2021)

Subject Terms: oropharyngeal squamous cell carcinoma, collagen, biomimetic scaffold, zebrafish, drug-resistance, primary culture, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.cancerbiomed.org/index.php/cocr/article/view/1836; https://doaj.org/toc/2095-3941

Access URL: https://doaj.org/article/b2b4a83cf3894a17815a4a8558ec3d76

Lysyl oxidase engineered lipid nanovesicles for the treatment of triple negative breast cancer

Authors: Alessandro De Vita, Chiara Liverani, Roberto Molinaro, Jonathan O. Martinez, Kelly A. Hartman, Chiara Spadazzi, Giacomo Miserocchi, Francesca Taraballi, Michael Evangelopoulos, Federica Pieri, Alberto Bongiovanni, Laura Mercatali, Ennio Tasciotti, Toni Ibrahim

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/f3592b74807643ad8fc46e879476242d

Myxofibrosarcoma landscape: diagnostic pitfalls, clinical management and future perspectives

Authors: Silvia Vanni, Alessandro De Vita, Lorena Gurrieri, Valentina Fausti, Giacomo Miserocchi, Chiara Spadazzi, Chiara Liverani, Claudia Cocchi, Chiara Calabrese, Alberto Bongiovanni, Nada Riva, Laura Mercatali, Federica Pieri, Roberto Casadei, Enrico Lucarelli, Toni Ibrahim

Source: Therapeutic Advances in Medical Oncology, Vol 14 (2022)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1758-8359

Access URL: https://doaj.org/article/4aa06f9cbc64417c87a8626b0e56f7e8

Case Report: Adult NTRK-Rearranged Spindle Cell Neoplasm: Early Tumor Shrinkage in a Case With Bone and Visceral Metastases Treated With Targeted Therapy

Authors: Federica Recine, Alessandro De Vita, Valentina Fausti, Federica Pieri, Alberto Bongiovanni, Eugenia Franchini, Roberto Casadei, Maria Cristina Falasconi, Devil Oboldi, Federica Matteucci, Maria Caterina Pallotti, Laura Mercatali, Nada Riva, Lorena Gurrieri, Silvia Vanni, Chiara Liverani, Giacomo Miserocchi, Chiara Spadazzi, Claudia Cocchi, Toni Ibrahim

Source: Frontiers in Oncology, Vol 11 (2022)

Subject Terms: NTRK-rearranged spindle cell neoplasm, NTRK fusions, oncogenic driver alterations, targeted therapies, visceral and bone involvement, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.740676/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/eeb397f448b948948aa77c11b4e57337

Immune Checkpoint Inhibitors With or Without Bone-Targeted Therapy in NSCLC Patients With Bone Metastases and Prognostic Significance of Neutrophil-to-Lymphocyte Ratio

Authors: Alberto Bongiovanni, Flavia Foca, Jessica Menis, Stefania Luigia Stucci, Fabrizio Artioli, Valentina Guadalupi, Maria Rosachiara Forcignanò, Manuela Fantini, Federica Recine, Laura Mercatali, Chiara Spadazzi, Marco Angelo Burgio, Valentina Fausti, Anna Miserocchi, Toni Ibrahim

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: immune checkpoint inhibitors, NSCLC, bone metastases, zoledronate, denosumab, lung cancer, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.697298/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/efaf44bda0a24525b2e67623d8a9d899

Phase-II Trials of Pazopanib in Metastatic Neuroendocrine Neoplasia (mNEN): A Systematic Review and Meta-Analysis

Authors: Alberto Bongiovanni, Chiara Liverani, Federica Recine, Valentina Fausti, Laura Mercatali, Alessandro Vagheggini, Chiara Spadazzi, Giacomo Miserocchi, Claudia Cocchi, Giandomenico Di Menna, Alessandro De Vita, Stefano Severi, Silvia Nicolini, Toni Ibrahim

Source: Frontiers in Oncology, Vol 10 (2020)

Subject Terms: pazopanib, neuroendocrine neoplasia, neuroendocrine tumours, review, carcinoid, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2020.00414/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/4b1b34e9a54d4ffeba6e151454ff1b8e

Metastatic neuroendocrine neoplasia treatments in patients over 70 years of age

Authors: Alberto Bongiovanni, Federica Recine, Flavia Foca, Valentina Fausti, Nada Riva, Greta Fabbri, Stefano Severi, Chiara Liverani, Alessandro De Vita, Chiara Spadazzi, Giacomo Miserocchi, Laura Mercatali, Dino Amadori, Toni Ibrahim

Source: Endocrine Connections, Vol 7, Iss 12, Pp 1535-1541 (2018)

Subject Terms: neuroendocrine tumors, neuroendocrine neoplasia, elderly patients, neuroendocrine carcinoma, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://ec.bioscientifica.com/view/journals/ec/7/12/EC-18-0478.xml; https://doaj.org/toc/2049-3614

Access URL: https://doaj.org/article/ff98511a34394123b075e9563e09b048

A Rationale for the Activity of Bone Target Therapy and Tyrosine Kinase Inhibitor Combination in Giant Cell Tumor of Bone and Desmoplastic Fibroma: Translational Evidences

Authors: Alessandro De Vita, Silvia Vanni, Giacomo Miserocchi, Valentina Fausti, Federica Pieri, Chiara Spadazzi, Claudia Cocchi, Chiara Liverani, Chiara Calabrese, Roberto Casadei, Federica Recine, Lorena Gurrieri, Alberto Bongiovanni, Toni Ibrahim, Laura Mercatali

Source: Biomedicines, Vol 10, Iss 2, p 372 (2022)

Subject Terms: bone sarcoma, giant cell tumor of bone, desmoplastic fibroma, primary culture, 3D scaffold, gene expression profiling, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/2/372; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/ad70c2dfa9ca44d0b9cbb16c726fa991

Management and potentialities of primary cancer cultures in preclinical and translational studies

Authors: Giacomo Miserocchi, Laura Mercatali, Chiara Liverani, Alessandro De Vita, Chiara Spadazzi, Federica Pieri, Alberto Bongiovanni, Federica Recine, Dino Amadori, Toni Ibrahim

Source: Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-16 (2017)

Subject Terms: Primary culture, Cancer microenvironment, Management, Patient-derived xenograft, Zebrafish, Medicine

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12967-017-1328-z; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/f516f2822d7b4353a7a355b67c83925a

mTOR inhibitor and bone-targeted drugs break the vicious cycle between clear-cell renal carcinoma and osteoclasts in an in vitro co-culture model

Authors: Chiara Spadazzi, Federica Recine, Laura Mercatali, Giacomo Miserocchi, Chiara Liverani, Alessandro De Vita, Alberto Bongiovanni, Valentina Fausti, Toni Ibrahim

Source: Journal of Bone Oncology, Vol 16, Iss , Pp - (2019)

Subject Terms: Diseases of the musculoskeletal system, RC925-935, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212137418303105; https://doaj.org/toc/2212-1374

Access URL: https://doaj.org/article/30c15128f0c04caab0c324260ea07d63

Innovative approaches to establish and characterize primary cultures: an ex vivo 3D system and the zebrafish model

Authors: Chiara Liverani, Federico La Manna, Arwin Groenewoud, Laura Mercatali, Gabri Van Der Pluijm, Federica Pieri, Davide Cavaliere, Alessandro De Vita, Chiara Spadazzi, Giacomo Miserocchi, Alberto Bongiovanni, Federica Recine, Nada Riva, Dino Amadori, Ennio Tasciotti, Ewa Snaar-Jagalska, Toni Ibrahim

Source: Biology Open, Vol 6, Iss 2, Pp 133-140 (2017)

Subject Terms: Primary cultures, Collagen scaffolds, Zebrafish, Near-patient models, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://bio.biologists.org/content/6/2/133; https://doaj.org/toc/2046-6390

Access URL: https://doaj.org/article/b041616b805f44658bdba1de95196424