Probing BRD Inhibition Substituent Effects in Bulky Analogues of (+)‐JQ1

Authors: Hassell‐Hart, Storm, Picaud, Sarah, Lengacher, Raphael, Csucker, Joshua, Millet, Regis, Gasser, Gilles, Alberto, Roger, Maple, Hannah, Felix, Robert, Leśnikowski, Zbigniew J., Stewart, Helen J. S., Chevassut, Timothy J., Morley, Simon, Filippakopoulos, Panagis, Spencer, John

Source: Helvetica chimica acta. 104(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116440052.0x000001&indx=1&recIds=ETOCvdc_100116440052.0x000001

BRD4-mediated repression of p53 is a target for combination therapy in AML

Authors: Latif, Anne-Louise, Newcombe, Ashley, Li, Sha, Gilroy, Kathryn, Robertson, Neil A., Lei, Xue, Stewart, Helen J. S., Cole, John, Terradas, Maria Terradas, Rishi, Loveena, McGarry, Lynn, McKeeve, Claire, Reid, Claire, Clark, William, Campos, Joana, Kirschner, Kristina, Davis, Andrew, Lopez, Jonathan, Sakamaki, Jun-ichi, Morton, Jennifer P., Ryan, Kevin M., Tait, Stephen W. G., Abraham, Sheela A., Holyoake, Tessa, Higgins, Brian, Huang, Xu, Blyth, Karen, Copland, Mhairi, Chevassut, Timothy J. T., Keeshan, Karen, Adams, Peter D.

Source: Nature communications. 12(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194144044.0x000001&indx=1&recIds=ETOCvdc_100194144044.0x000001

High INR on warfarin

Authors: Reddy, Udaya, Mallepaddi, Nageswara Rao, Chevassut, Timothy J

Source: BMJ: British Medical Journal, 2015 Apr 01. 350

Access URL: https://www.jstor.org/stable/26520673

Acute myeloid leukemia cells exhibit selective down-regulation of DNMT3A isoform 2

Authors: Stewart, Helen J. S., Shalit, Ella, Halliday, Loryn, Morey, Dominic, Chevassut, Timothy J.

Source: Leukemia & lymphoma. 56(12):3445-3448

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100048283349.0x000001&indx=1&recIds=ETOCvdc_100048283349.0x000001

The polo-like kinase inhibitor BI 2536 exhibits potent activity against malignant plasma cells and represents a novel therapy in multiple myeloma

Authors: Stewart, Helen J., Kishikova, Lyudmila, Powell, Fiona L., Wheatley, Sally P., Chevassut, Timothy J.

Source: In Experimental Hematology 2011 39(3):330-338

Immunohistochemical prognostication in diffuse large B-cell lymphoma: a single center 6-year retrospective analysis

Authors: Robinson, Stephen D., Gabriel, Joseph, Webb, Andrew, Corbett, Timothy, Johnston, Rosalynd, Wright, David, Chevassut, Timothy J.

Source: Leukemia & lymphoma. 56(10):2975-2977

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100048283186.0x000001&indx=1&recIds=ETOCvdc_100048283186.0x000001

Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis.

Authors: Chaudry, Sabah F.¹, Chevassut, Timothy J. T.¹

Source: BioMed Research International. 2/14/2017, Vol. 2017, p1-13. 13p.

Subject Terms: *GENETIC techniques, *HEMATOPOIESIS, *GENETIC mutation, *TRANSFERASES, *DNA methylation, *ACUTE myeloid leukemia, *HEMATOLOGIC malignancies, *EPIGENOMICS, *GENETICS, *PROGNOSIS

Chloroquine and COVID-19 -- a potential game changer?

Authors: Sturrock, Beattie R. H.^1,2, Chevassut, Timothy J. T.^3,4 t.chevassut@bsms.ac.uk

Source: Clinical Medicine. May2020, Vol. 20 Issue 3, p278-281. 4p.

Subject Terms: *CHLOROQUINE, *CORONAVIRUSES, *COST effectiveness, *EPIDEMICS, *TREATMENT effectiveness, *COVID-19

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Bromodomain inhibition by JQ1 suppresses lipopolysaccharide-stimulated interleukin-6 secretion in multiple myeloma cells

Authors: Ghurye, Rohit R., Stewart, Helen J.S., Chevassut, Timothy J.

Source: In Cytokine February 2015 71(2):415-417

BET Inhibition Suppresses S100A8 and S100A9 Expression in Acute Myeloid Leukemia Cells and Synergises with Daunorubicin in Causing Cell Death.

Authors: Stewart, Helen J. S., Chaudry, Sabah, Crichlow, Asante, Luiling Feilding, Freya, Chevassut, Timothy J. T.

Source: Bone Marrow Research; 5/31/2018, p1-9, 9p

Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor

Authors: Hassell-Hart, Storm, Runcie, Andrew, Krojer, Tobias, Doyle, Jordan, Lineham, Ella, Ocasio, Cory A., Neto, Brenno A. D., Fedorov, Oleg, Marsh, Graham, Maple, Hannah, Felix, Robert, Banks, Rebecca, Ciulli, Alessio, Picaud, Sarah, Filippakopoulos, Panagis, von Delft, Frank, Brennan, Paul, Stewart, Helen J. S., Chevassut, Timothy J., Walker, Martin, Austin, Carol, Morley, Simon, Spencer, John

Source: Organometallics; February 2020, Vol. 39 Issue: 3 p408-416, 9p

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The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease.

Authors: Robinson, Sophie R., Oliver, Antony W., Chevassut, Timothy J., Newbury, Sarah F.

Source: Biomolecules (2218-273X); 2015, Vol. 5 Issue 3, p1515-1539, 25p

Subject Terms: EXORIBONUCLEASES, EXOSOMES, PROTEIN structure

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The Genetic Architecture of Multiple Myeloma.

Authors: Prideaux, Steven M., O'Brien, Emma Conway, Chevassut, Timothy J.

Source: Advances in Hematology; 2014, p1-16, 16p

Subject Terms: MULTIPLE myeloma, BLOOD cells, HYPERCALCEMIA, BLOOD diseases, IMMUNOGLOBULINS, LOCUS (Genetics), GENETICS

The RAG Model: A New Paradigm for Genetic Risk Stratification in Multiple Myeloma.

Authors: Prideaux, Steven M., O'Brien, Emma Conway, Chevassut, Timothy J.

Source: Bone Marrow Research; 2014, p1-9, 9p