Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development

Authors: Christina J. F. Courreges, Elizabeth C. M. Davenport, Benoit Bilanges, Elena Rebollo-Gomez, Jens Hukelmann, Priya Schoenfelder, James R. Edgar, David Sansom, Cheryl L. Scudamore, Rahul Roychoudhuri, Oliver A. Garden, Bart Vanhaesebroeck, Klaus Okkenhaug

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: PI3K, Treg, VPS34, autophagy, endocytosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1374621/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/76c0dafb2bb54d09976bae31a2ce382f

Spi1 R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice

Authors: Natalie Brown, Rosemary Finnon, Paul Finnon, Roisin McCarron, Lourdes Cruz-Garcia, Grainne O’Brien, Eleanor Herbert, Cheryl L. Scudamore, Edouard Morel, Christophe Badie

Source: iScience, Vol 26, Iss 9, Pp 107530- (2023)

Subject Terms: Cancer, Genetics, Molecular Genetics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223016073; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/3a11095d3f2342bdb9b60e049777d4d7

Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?

Authors: Tsvetana Petrova, Kyle Bennett, Sambit Nanda, Sam Strickson, Cheryl L. Scudamore, Alan R. Prescott, Philip Cohen

Source: PLoS ONE, Vol 17, Iss 2 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843210/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/9aa94b8e1ece4432939106c9866a2b7e

Comprehensive phenotypic analysis of the Dp1Tyb mouse strain reveals a broad range of Down syndrome-related phenotypes

Authors: Eva Lana-Elola, Heather Cater, Sheona Watson-Scales, Simon Greenaway, Jennifer Müller-Winkler, Dorota Gibbins, Mihaela Nemes, Amy Slender, Tertius Hough, Piia Keskivali-Bond, Cheryl L. Scudamore, Eleanor Herbert, Gareth T. Banks, Helene Mobbs, Tara Canonica, Justin Tosh, Suzanna Noy, Miriam Llorian, Patrick M. Nolan, Julian L. Griffin, Mark Good, Michelle Simon, Ann-Marie Mallon, Sara Wells, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz

Source: Disease Models & Mechanisms, Vol 14, Iss 10 (2021)

Subject Terms: down syndrome, mouse model, craniofacial development, memory, sleep, hearing, diabetes, haematopoiesis, Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/14/10/dmm049157; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/2e0de4e621364f88bbb0ae2f68e17fe9

Hypoxia-sensing CAR T cells provide safety and efficacy in treating solid tumors

Authors: Paris Kosti, James W. Opzoomer, Karen I. Larios-Martinez, Rhonda Henley-Smith, Cheryl L. Scudamore, Mary Okesola, Mustafa Y.M. Taher, David M. Davies, Tamara Muliaditan, Daniel Larcombe-Young, Natalie Woodman, Cheryl E. Gillett, Selvam Thavaraj, John Maher, James N. Arnold

Source: Cell Reports Medicine, Vol 2, Iss 4, Pp 100227- (2021)

Subject Terms: chimeric antigen receptor, T cell, hypoxia, HIF1α, cytokine release syndrome, toxicity, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666379121000434; https://doaj.org/toc/2666-3791

Access URL: https://doaj.org/article/bf080dc78d404bfaadbb38beeca753ca

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

Authors: Inma M. Berenjeno, Roberto Piñeiro, Sandra D. Castillo, Wayne Pearce, Nicholas McGranahan, Sally M. Dewhurst, Valerie Meniel, Nicolai J. Birkbak, Evelyn Lau, Laurent Sansregret, Daniele Morelli, Nnennaya Kanu, Shankar Srinivas, Mariona Graupera, Victoria E. R. Parker, Karen G. Montgomery, Larissa S. Moniz, Cheryl L. Scudamore, Wayne A. Phillips, Robert K. Semple, Alan Clarke, Charles Swanton, Bart Vanhaesebroeck

Source: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ef3433ccebdb4fec8e066692342a604d

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Authors: Benoit Bilanges, Samira Alliouachene, Wayne Pearce, Daniele Morelli, Gyorgy Szabadkai, Yuen-Li Chung, Gaëtan Chicanne, Colin Valet, Julia M. Hill, Peter J. Voshol, Lucy Collinson, Christopher Peddie, Khaled Ali, Essam Ghazaly, Vinothini Rajeeve, Georgios Trichas, Shankar Srinivas, Claire Chaussade, Rachel S. Salamon, Jonathan M. Backer, Cheryl L. Scudamore, Maria A. Whitehead, Erin P. Keaney, Leon O. Murphy, Robert K. Semple, Bernard Payrastre, Sharon A. Tooze, Bart Vanhaesebroeck

Source: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/555f2b0adcb149a18a070a3da3035320

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

Authors: Samira Alliouachene, Benoit Bilanges, Gaëtan Chicanne, Karen E. Anderson, Wayne Pearce, Khaled Ali, Colin Valet, York Posor, Pei Ching Low, Claire Chaussade, Cheryl L. Scudamore, Rachel S. Salamon, Jonathan M. Backer, Len Stephens, Phill T. Hawkins, Bernard Payrastre, Bart Vanhaesebroeck

Source: Cell Reports, Vol 13, Iss 9, Pp 1881-1894 (2015)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124715012413; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/be1d1c3eb7fa418d859629465770509e

Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance

Authors: Alison J. Hugill, Michelle E. Stewart, Marianne A. Yon, Fay Probert, I. Jane Cox, Tertius A. Hough, Cheryl L. Scudamore, Liz Bentley, Gary Wall, Sara E. Wells, Roger D. Cox

Source: Biology Open, Vol 4, Iss 11, Pp 1367-1375 (2015)

Subject Terms: Arylformamidase, Kynurenine, Tryptophan, Diabetes, Insulin secretion, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://bio.biologists.org/content/4/11/1367; https://doaj.org/toc/2046-6390

Access URL: https://doaj.org/article/0d46b7420e604bf78174db331289ed60

Integrating pathology into human disease modelling – how to eat the elephant

Authors: Cheryl L. Scudamore

Source: Disease Models & Mechanisms, Vol 7, Iss 5, Pp 495-497 (2014)

Subject Terms: Pathology, Phenotyping, Mouse, IMPC, Medicine, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/7/5/495; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/991a793e897040cc8bbeff5cb0c352c6

Why are the phenotypes of TRAF6 knock-in and TRAF6 knock-out mice so different?

Authors: Tsvetana Petrova, Kyle Bennett, Sambit Nanda, Sam Strickson, Cheryl L Scudamore, Alan R Prescott, Philip Cohen

Source: PLoS ONE, Vol 17, Iss 2, p e0263151 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/5231f41ba28a4996abcc543715a58fad

The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities.

Authors: Eleanor Herbert, Michelle Stewart, Marie Hutchison, Ann M Flenniken, Dawei Qu, Lauryl M J Nutter, Colin McKerlie, Liane Hobson, Brenda Kick, Bonnie Lyons, Jean-Paul Wiegand, Rosalinda Doty, Juan Antonio Aguilar-Pimentel, Martin Hrabe de Angelis, Mary Dickinson, John Seavitt, Jacqueline K White, Cheryl L Scudamore, Sara Wells

Source: PLoS ONE, Vol 15, Iss 6, p e0230162 (2020)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/080643f202ae48d1931d33a2f5d1884e

Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare.

Authors: Gail F Davies, Beth J Greenhough, Pru Hobson-West, Robert G W Kirk, Ken Applebee, Laura C Bellingan, Manuel Berdoy, Henry Buller, Helen J Cassaday, Keith Davies, Daniela Diefenbacher, Tone Druglitrø, Maria Paula Escobar, Carrie Friese, Kathrin Herrmann, Amy Hinterberger, Wendy J Jarrett, Kimberley Jayne, Adam M Johnson, Elizabeth R Johnson, Timm Konold, Matthew C Leach, Sabina Leonelli, David I Lewis, Elliot J Lilley, Emma R Longridge, Carmen M McLeod, Mara Miele, Nicole C Nelson, Elisabeth H Ormandy, Helen Pallett, Lonneke Poort, Pandora Pound, Edmund Ramsden, Emma Roe, Helen Scalway, Astrid Schrader, Chris J Scotton, Cheryl L Scudamore, Jane A Smith, Lucy Whitfield, Sarah Wolfensohn

Source: PLoS ONE, Vol 11, Iss 7, p e0158791 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/5d4d2534dba34d3ea79fb6452d4540cb

Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles.

Authors: Amany K Elshorbagy, Fredrik Jernerén, Cheryl L Scudamore, Fiona McMurray, Heather Cater, Tertius Hough, Roger Cox, Helga Refsum

Source: PLoS ONE, Vol 11, Iss 10, p e0163214 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/00ce75a619414a8bbd718d62d5935192

Pharmacological inhibition of FTO.

Authors: Fiona McMurray, Marina Demetriades, WeiShen Aik, Myrte Merkestein, Holger Kramer, Daniel S Andrew, Cheryl L Scudamore, Tertius A Hough, Sara Wells, Frances M Ashcroft, Michael A McDonough, Christopher J Schofield, Roger D Cox

Source: PLoS ONE, Vol 10, Iss 4, p e0121829 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c9068305748e4c1b8eed30081056f2db

Targeting of Slc25a21 is associated with orofacial defects and otitis media due to disrupted expression of a neighbouring gene.

Authors: Simon Maguire, Jeanne Estabel, Neil Ingham, Selina Pearson, Edward Ryder, Damian M Carragher, Nicolas Walker, Sanger MGP Slc25a21 Project Team, James Bussell, Wai-In Chan, Thomas M Keane, David J Adams, Cheryl L Scudamore, Christopher J Lelliott, Ramiro Ramírez-Solis, Natasha A Karp, Karen P Steel, Jacqueline K White, Anna-Karin Gerdin

Source: PLoS ONE, Vol 9, Iss 3, p e91807 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24642684/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/7985cf02c3584cebbd464cdb2fb6225b

Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

Authors: Rebecca E McIntyre, Pavithra Lakshminarasimhan Chavali, Ozama Ismail, Damian M Carragher, Gabriela Sanchez-Andrade, Josep V Forment, Beiyuan Fu, Martin Del Castillo Velasco-Herrera, Andrew Edwards, Louise van der Weyden, Fengtang Yang, Sanger Mouse Genetics Project, Ramiro Ramirez-Solis, Jeanne Estabel, Ferdia A Gallagher, Darren W Logan, Mark J Arends, Stephen H Tsang, Vinit B Mahajan, Cheryl L Scudamore, Jacqueline K White, Stephen P Jackson, Fanni Gergely, David J Adams

Source: PLoS Genetics, Vol 8, Iss 11, p e1003022 (2012)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003022&type=printable; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/59c11391f61449a4aa008d3e380c5a64