Lipid domain boundary triggers membrane damage and protein folding of human islet amyloid polypeptide in the early pathogenesis of amyloid diseases

Authors: Lewis, Amber, Pham, Thuong, Nguyen, Ngoc, Graf, Angela, Cheng, Kwan H.

Source: In Biophysical Chemistry May 2023 296

Exploring the binding kinetics and behaviors of self-aggregated beta-amyloid oligomers to phase-separated lipid rafts with or without ganglioside-clusters

Authors: Pham, Thuong, Cheng, Kwan H.

Source: In Biophysical Chemistry November 2022 290

Coarse-grained MD simulations reveal beta-amyloid fibrils of various sizes bind to interfacial liquid-ordered and liquid-disordered regions in phase separated lipid rafts with diverse membrane-bound conformational states

Authors: Cheng, Sara Y., Cao, Yiyi, Rouzbehani, Marzieh, Cheng, Kwan H.

Source: In Biophysical Chemistry May 2020 260

Exploring Membrane Binding Targets of Disordered Human Tau Aggregates on Lipid Rafts Using Multiscale Molecular Dynamics Simulations.

Authors: Cheng, Kwan H.^1,2 (AUTHOR) kcheng1@trinity.edu, Graf, Angela² (AUTHOR), Lewis, Amber¹ (AUTHOR), Pham, Thuong² (AUTHOR), Acharya, Aakriti² (AUTHOR)

Source: Membranes. Nov2022, Vol. 12 Issue 11, p1098. 22p.

Examination of the Interplay between Membrane Tension and the Tight Junction Protein, ZO‐1

Authors: Wilkinson, Nancy J., Peng, Lindsey N., Doran, John E., Cheng, Kwan H., King, Jonathan M.

Source: FASEB journal. 36

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196443793.0x000001&indx=1&recIds=ETOCvdc_100196443793.0x000001

Exploring Tau Fibril-Disaggregating and Antioxidating Molecules Binding to Membrane-Bound Amyloid Oligomers Using Machine Learning-Enhanced Docking and Molecular Dynamics.

Authors: Segura, Luthary, Santos, Natalia, Flores, Rafael, Sikazwe, Donald, McGibbon, Miles, Blay, Vincent, Cheng, Kwan H.

Source: Molecules; Jun2024, Vol. 29 Issue 12, p2818, 27p

Subject Terms: TAU proteins, MOLECULAR dynamics, ALZHEIMER'S disease, AMYLOID, OLIGOMERS, DRUG discovery

Maximally asymmetric transbilayer distribution of anionic lipids alters the structure and interaction with lipids of an amyloidogenic protein dimer bound to the membrane surface

Authors: Cheng, Sara Y., Chou, George, Buie, Creighton, Vaughn, Mark W., Compton, Campbell, Cheng, Kwan H.

Source: In Chemistry and Physics of Lipids March 2016 196:33-51

Multiscale Modeling of Macromolecular Interactions between Tau-Amylin Oligomers and Asymmetric Lipid Nanodomains That Link Alzheimer's and Diabetic Diseases.

Authors: Santos, Natalia, Segura, Luthary, Lewis, Amber, Pham, Thuong, Cheng, Kwan H.

Source: Molecules; Feb2024, Vol. 29 Issue 3, p740, 29p

Subject Terms: ALZHEIMER'S disease, MULTISCALE modeling, LIPIDS, PROTEIN folding, HYDROPHILIC interactions, OLIGOMERS, LECITHIN

Characterization of 3D Voronoi tessellation nearest neighbor lipid shells provides atomistic lipid disruption profile of protein containing lipid membranes

Authors: Cheng, Sara Y., Duong, Hai V., Compton, Campbell, Vaughn, Mark W., Nguyen, Hoa, Cheng, Kwan H.

Source: In Biophysical Chemistry March 2015 198:22-35

Data supporting beta-amyloid dimer structural transitions and protein–lipid interactions on asymmetric lipid bilayer surfaces using MD simulations on experimentally derived NMR protein structures

Authors: Cheng, Sara Y., Chou, George, Buie, Creighton, Vaughn, Mark W., Compton, Campbell, Cheng, Kwan H.

Source: Data in brief. 7:658-672

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141202278.0x000001&indx=1&recIds=ETOCvdc_100141202278.0x000001

Molecular Mechanisms of Protein–Lipid Interactions and Protein Folding of Heterogeneous Amylin and Tau Oligomers on Lipid Nanodomains That Link to Alzheimer's.

Authors: Santos, Natalia¹, nsantos@trinity.edu, Segura, Luthary¹, lsegura1@trinity.edu, Lewis, Amber¹, alewis2@trinity.edu, Pham, Thuong², tpham3@trinity.edu, Cheng, Kwan H.^1,2, kcheng1@trinity.edu

Source: Macromol; Dec2023, Vol. 3 Issue 4, p805-827, 23p

Data showing the lipid conformations and membrane binding behaviors of beta-amyloid fibrils in phase-separated cholesterol-enriched lipid domains with and without glycolipid and oxidized cholesterol from coarse-grained molecular dynamics simulations

Authors: Cheng, Sara Y., Cao, Yiyi, Rouzbehani, Marzieh, Cheng, Kwan H.

Source: Data in brief. 30

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116144488.0x000001&indx=1&recIds=ETOCvdc_100116144488.0x000001

Exploring the Role of Anionic Lipid Nanodomains in the Membrane Disruption and Protein Folding of Human Islet Amyloid Polypeptide Oligomers on Lipid Membrane Surfaces Using Multiscale Molecular Dynamics Simulations.

Authors: Nguyen, Ngoc, Lewis, Amber, Pham, Thuong, Sikazwe, Donald, Cheng, Kwan H.

Source: Molecules; May2023, Vol. 28 Issue 10, p4191, 27p

Subject Terms: AMYLIN, PROTEIN folding, MOLECULAR dynamics, MEMBRANE proteins, OLIGOMERS, MEMBRANE lipids

Effect of quinone on the fluorescence decay dynamics of endogenous flavin bound to bacterial luciferase

Authors: Vetrova, Elena V., Kudryasheva, Nadezhda S., Cheng, Kwan H.

Source: In Biophysical Chemistry 2009 141(1):59-65

The superlattice model of lateral organization of membranes and its implications on membrane lipid homeostasis

Authors: Somerharju, Pentti ^⁎, Virtanen, Jorma A., Cheng, Kwan H., Hermansson, Martin

Source: In BBA - Biomembranes 2009 1788(1):12-23

Design and Synthesis of New Acyl Urea Analogs as Potential σ1R Ligands.

Authors: Thapa, Rajesh, Flores, Rafael, Cheng, Kwan H., Mochona, Bereket, Sikazwe, Donald

Source: Molecules; Mar2023, Vol. 28 Issue 5, p2319, 13p

Subject Terms: UREA derivatives, ISOXAZOLES, UREA compounds, LIGANDS (Biochemistry), ALZHEIMER'S disease, UREA

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