Integrated spatial multiomics reveals fibroblast fate during tissue repair

Authors: Foster, Deshka S., Januszyk, Michael, Yost, Kathryn E., Chinta, Malini S., Gulati, Gunsagar S., Nguyen, Alan T., Burcham, Austin R., Salhotra, Ankit, Ransom, R. Chase, Henn, Dominic, Chen, Kellen, Mascharak, Shamik, Tolentino, Karen, Titan, Ashley L., Jones, R. Ellen, da Silva, Oscar, Leavitt, W. Tripp, Marshall, Clement D., des Jardins-Park, Heather E., Hu, Michael S., Wan, Derrick C., Wernig, Gerlinde, Wagh, Dhananjay, Coller, John, Norton, Jeffrey A., Gurtner, Geoffrey C., Newman, Aaron M., Chang, Howard Y., Longaker, Michael T.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 Oct 01. 118(41), 1-10.

Access URL: https://www.jstor.org/stable/27093407

Multiomic analysis reveals conservation of cancer-associated fibroblast phenotypes across species and tissue of origin

Authors: Foster, Deshka S., Januszyk, Michael, Delitto, Daniel, Yost, Kathryn E., Griffin, Michelle, Guo, Jason, Guardino, Nicholas, Delitto, Andrea E., Chinta, Malini, Burcham, Austin R., Nguyen, Alan T., Bauer-Rowe, Khristian E., Titan, Ashley L., Salhotra, Ankit, Jones, R. Ellen, da Silva, Oscar, Lindsay, Hunter G., Berry, Charlotte E., Chen, Kellen, Henn, Dominic, Mascharak, Shamik, Talbott, Heather E., Kim, Alexia, Nosrati, Fatemeh, Sivaraj, Dharshan, Ransom, R. Chase, Matthews, Michael, Khan, Anum, Wagh, Dhananjay, Coller, John, Gurtner, Geoffrey C., Wan, Derrick C., Wapnir, Irene L., Chang, Howard Y., Norton, Jeffrey A., Longaker, Michael T.

Source: In Cancer Cell 14 November 2022 40(11):1392-1406

Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing

Authors: Mascharak, Shamik, Talbott, Heather E., Januszyk, Michael, Griffin, Michelle, Chen, Kellen, Davitt, Michael F., Demeter, Janos, Henn, Dominic, Bonham, Clark A., Foster, Deshka S., Mooney, Nancie, Cheng, Ran, Jackson, Peter K., Wan, Derrick C., Gurtner, Geoffrey C., Longaker, Michael T.

Source: In Cell Stem Cell 3 February 2022 29(2):315-327

Endothelial‐specific CXCL12 regulates neovascularization during tissue repair and tumor progression.

Authors: Hostler, Andrew C., Hahn, William W., Hu, Michael S., Rennert, Robert, Fischer, Katharina S., Barrera, Janos A., Duscher, Dominik, Januszyk, Michael, Henn, Dominic, Sivaraj, Dharshan, Yasmeh, Jonathan P., Kussie, Hudson C., Granoski, Maia B., Padmanabhan, Jagannath, Vial, Ivan N., Riegler, Johannes, Wu, Joseph C., Longaker, Michael T., Chen, Kellen, Maan, Zeshaan N.

Source: FASEB Journal; 12/31/2024, Vol. 38 Issue 24, p1-17, 17p

Elevated Shear Stress Modulates Heterogenous Cellular Subpopulations to Induce Vascular Remodeling.

Authors: Fischer, Katharina S., Henn, Dominic, Zhao, Eric T., Sivaraj, Dharshan, Litmanovich, Ben, Hahn, William W., Hostler, Andrew C., Mojadidi, Sultana M., Gonzalez, Javier, Knochel, Amelia B., Mora Pinos, Maria Gracia, Holley, Jared, Kussie, Hudson, Granoski, Maia, Yasmeh, Jonathan P., Kneser, Ulrich, Chen, Kellen, Gurtner, Geoffrey C.

Source: Tissue Engineering Part A: Tissue Engineering; Dec2024, Vol. 30 Issue 23/24, p752-765, 14p

Macrophage Subpopulation Dynamics Shift following Intravenous Infusion of Mesenchymal Stromal Cells

Authors: Kosaric, Nina, Srifa, Waracharee, Bonham, Clark A., Kiwanuka, Harriet, Chen, Kellen, Kuehlmann, Britta A., Maan, Zeshaan N., Noishiki, Chikage, Porteus, Matthew H., Longaker, Michael T., Gurtner, Geoffrey C.

Source: In Molecular Therapy 2 September 2020 28(9):2007-2022

Role of boundary conditions in determining cell alignment in response to stretch

Authors: Chen, Kellen, Vigliotti, Andrea, Bacca, Mattia, McMeeking, Robert M., Deshpande, Vikram S., Holmes, Jeffrey W.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2018 Jan . 115(5), 986-991.

Access URL: https://www.jstor.org/stable/26507262

Oat-Derived Bioactives (Avenanthramide and Beta-glucan) Increase the Velocity of and Accelerate Wound Healing

Authors: Li, William W ¹, Miller, Abigail A ¹, Kussie, Hudson C ², Chen, Kellen ², Gurtner, Geoffrey C ², Li, Vincent W ¹

Source: In Current Developments in Nutrition July 2024 8 Supplement 2

Pullulan-Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings.

Authors: Chen, Kellen¹, Sivaraj, Dharshan¹, Davitt, Michael F.¹, Leeolou, Melissa C.¹, Henn, Dominic¹, Steele, Sydney R.¹, Huskins, Savana L.¹, Trotsyuk, Artem A.¹, Kussie, Hudson C.¹, Greco, Autumn H.¹, Padmanabhan, Jagannath¹, Perrault, David P.¹, Zamaleeva, Alsu I.¹, Longaker, Michael T.¹, Gurtner, Geoffrey C.¹ ggurtner@stanford.edu

Source: Wound Repair & Regeneration. May/Jun2022, Vol. 30 Issue 3, p397-408. 12p.

Subject Terms: *COLLAGEN, *WOUND healing, *BIOLOGICAL models, *HYDROCOLLOID surgical dressings, *ANIMAL experimentation, *WOUND care, *MICE

Skin grafts for burns injuries can lead to crippling scars – a drug that blocks the skin’s ability to respond to physical stimuli could promote healing, new research in pigs finds (May 2022)

Authors: Chen Kellen

Source: The Conversation: An Independent Source of Analysis from Academic Researchers.

Availability: https://search.credoreference.com/content/entry/conversqauq/skin_grafts_for_burns_injuries_can_lead_to_crippling_scars_a_drug_that_blocks_the_skins_ability_to_respond_to_physical_stimuli_could_promote_healing_new_research_in_pigsfinds/0

31 - Implants and biomaterials

Authors: Sivaraj, Dharshan, Henn, Dominic, King, Timothy W., Chen, Kellen

Source: In Plastic Surgery Edition: Fifth Edition. 2024:544

Deferoxamine topical cream superior to patch in rescuing radiation‐induced fibrosis of unwounded and wounded skin.

Authors: Berry, Charlotte E., Abbas, Darren B., Griffin, Michelle, Lintel, Hendrik, Guo, Jason, Kameni, Lionel, Churukian, Andrew A., Fazilat, Alexander Z., Chen, Kellen, Gurtner, Geoffrey C., Longaker, Michael T., Momeni, Arash, Wan, Derrick C.

Source: Journal of Cellular & Molecular Medicine; Apr2024, Vol. 28 Issue 8, p1-15, 15p

Subject Terms: OINTMENTS, DEFEROXAMINE, FIBROSIS, LABORATORY mice, WOUND healing

Avenanthramide and β-Glucan Therapeutics Accelerate Wound Healing Via Distinct and Nonoverlapping Mechanisms.

Authors: Kussie, Hudson C., Hahn, William, Sivaraj, Dharshan, Quintero, Filiberto, Knochel, Amelia, Alfsharif, Abdelrahman M., Yasmeh, Jonathan P., Fischer, Katharina, Mojadidi, Sultana, Hostler, Andrew, Granoski, Maia, McKenna, Eamonn, Henn, Dominic, Litmanovich, Ben, Miller, Abigail A., Schurr, Delaney K., Li, Vincent W., Li, William W., Gurtner, Geoffrey C., Chen, Kellen

Source: Advances in Wound Care (2162-1918); Apr2024, Vol. 13 Issue 4, p155-166, 12p

Skin wound healing measured remotely through molecular flux.

Authors: Chen, Kellen, Gurtner, Geoffrey C.

Source: Nature; Apr2025, Vol. 640 Issue 8058, p321-322, 2p

Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells.

Authors: Padmanabhan, Jagannath, Chen, Kellen, Sivaraj, Dharshan, Henn, Dominic, Kuehlmann, Britta A., Kussie, Hudson C., Zhao, Eric T., Kahn, Anum, Bonham, Clark A., Dohi, Teruyuki, Beck, Thomas C., Trotsyuk, Artem A., Stern-Buchbinder, Zachary A., Than, Peter A., Hosseini, Hadi S., Barrera, Janos A., Magbual, Noah J., Leeolou, Melissa C., Fischer, Katharina S., Tigchelaar, Seth S.

Source: Nature Biomedical Engineering; Nov2023, Vol. 7 Issue 11, p1419-1436, 18p

Blockchain, Information Security, Control, and Integrity: Who Is in Charge?

Authors: Barrera, Janos A., Trotsyuk, Artem A., Henn, Dominic, Sivaraj, Dharshan, Chen, Kellen, Mittal, Smiti, Mermin-Bunnell, Alana M., Larson, Madelyn R., Padmanabhan, Jagannath, Kinney, Brian, Nachbar, James, Sacks, Justin, Terkonda, Sarvam P., Jeffers, Lynn, Gurtner, Geoffrey C.

Source: Plastic & Reconstructive Surgery; Oct2023, Vol. 152 Issue 4, p751e-758e, 8p

Deferoxamine Intradermal Delivery Patch for Treatment of a Beta-Thalassemia Wound.

Authors: Perrault, David, Chattopadhyay, Arhana, Sivaraj, Dharshan, Wan, Derrick, Chen, Kellen, Gurtner, Geoffrey, Sen, Subhro

Source: Annals of Surgery Open; Mar2024, Vol. 5 Issue 1, p1-3, 3p

Cas9-mediated knockout of Ndrg2 enhances the regenerative potential of dendritic cells for wound healing.

Authors: Henn, Dominic, Zhao, Dehua, Sivaraj, Dharshan, Trotsyuk, Artem, Bonham, Clark Andrew, Fischer, Katharina S., Kehl, Tim, Fehlmann, Tobias, Greco, Autumn H., Kussie, Hudson C., Moortgat Illouz, Sylvia E., Padmanabhan, Jagannath, Barrera, Janos A., Kneser, Ulrich, Lenhof, Hans-Peter, Januszyk, Michael, Levi, Benjamin, Keller, Andreas, Longaker, Michael T., Chen, Kellen

Source: Nature Communications; 8/7/2023, Vol. 14 Issue 1, p1-16, 16p

Subject Terms: WOUND healing, DENDRITIC cells, CHRONIC wounds & injuries, CELL populations, GENOME editing, SKIN regeneration, PROGENITOR cells

Robotics in Plastic Surgery: It's Here.

Authors: Henn, Dominic, Trotsyuk, Artem A., Barrera, Janos A., Sivaraj, Dharshan, Chen, Kellen, Mittal, Smiti, Mermin-Bunnell, Alana M., Chattopadhyay, Arhana, Larson, Madelyn R., Kinney, Brian M., Nachbar, James, TerKonda, Sarvam P., Reddy, Sashank, Jeffers, Lynn, Sacks, Justin M., Gurtner, Geoffrey C.

Source: Plastic & Reconstructive Surgery; Jul2023, Vol. 152 Issue 1, p239-249, 11p

Panchromatic photosensitizers and dye-sensitized solar cell using the same