Unique challenges required reassessment and alterations to critical reagents to rescue a neutralizing antibody assay.

Authors: Rowe, Blake A, Medina-Carle, Katie, Chen, Keguan, Reese, Kimberly J, McCarthy, Kenneth M, Concannon, Amy A, Gunn, George R, Gehman, Andrew P, Jiang, Yong, Meyer, Erik

Source: Bioanalysis; 2024, Vol. 16 Issue 14, p735-745, 11p

Anti‐IL‐7 receptor α monoclonal antibody (GSK2618960) in healthy subjects – a randomized, double‐blind, placebo‐controlled study

Authors: Ellis, Joanne, Maurik, Andre, Fortunato, Lea, Gisbert, Sophie, Chen, Keguan, Schwartz, Ann, McHugh, Simon, Want, Andrew, Santos Franco, Sara, Oliveira, Joao‐Joaquim, Price, Jeffrey, Coles, Alasdair, Brown, Kim, Su, Donggang, Craigen, Jenny L., Yang, Jiansong, Brett, Sara, Davis, Bill, Cheriyan, Joseph, Kousin‐Ezewu, Onajite, Gray, Frank, Thompson, Paul W., Fernando, Disala

Source: British journal of clinical pharmacology. 85(2):304-315

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100090534805.0x000001&indx=1&recIds=ETOCvdc_100090534805.0x000001

A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of ^1^8F-FB-A20FMDV2 for Imaging the Integrin α~vβ~6

Authors: Keat, Nicholas, Kenny, Julia, Chen, Keguan, Onega, Mayca, Garman, Nadia, Slack, Robert J., Parker, Christine A., Lumbers, R. Thomas, Hallett, Will, Saleem, Azeem

Source: Journal of nuclear medicine technology. 46(2):136-143

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN616148149&indx=1&recIds=ETOCRN616148149

Characterization of the robust humoral immune response to GSK2618960, a humanized anti-IL-7 receptor monoclonal antibody, observed in healthy subjects in a Phase 1 study.

Authors: Liao, Karen¹ (AUTHOR) karen.x.liao@gsk.com, Chen, Keguan¹ (AUTHOR), Brett, Sara² (AUTHOR), Gehman, Andrew³ (AUTHOR), Schwartz, Ann M.¹ (AUTHOR), Gunn, George R.¹ (AUTHOR), DeWall, Stephen L.¹ (AUTHOR)

Source: PLoS ONE. 3/23/2021, Vol. 16 Issue 3, p1-18. 18p.

Subject Terms: *MONONUCLEAR leukocytes, *HUMORAL immunity, *RECEPTOR antibodies, *IMMUNOLOGIC memory, *MONOCLONAL antibodies, *DENDRITIC cells

False-positive immunogenicity responses are caused by CD20+ B cell membrane fragments in an anti-ofatumumab antibody bridging assay

Authors: Chen, Keguan, Page, Jerry G., Schwartz, Ann M., Lee, Thomas N., DeWall, Stephen L., Sikkema, Daniel J., Wang, Catherine

Source: In Journal of Immunological Methods 30 August 2013 394(1-2):22-31

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A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of ¹⁸F-FB-A20FMDV2 for Imaging the Integrin αvβ6.

Authors: Keat, Nicholas, Kenny, Julia, Keguan Chen, Onega, Mayca, Garman, Nadia, Slack, Robert J., Parker, Christine A., Lumbers, R. Thomas, Hallett, Will, Saleem, Azeem, Passchier, Jan, Lukey, Pauline T., Chen, Keguan

Source: Journal of Nuclear Medicine Technology; Jun2018, Vol. 46 Issue 2, p136-143, 8p, 2 Color Photographs, 3 Charts, 1 Graph

Development and validation of a cell-based SEAP reporter assay for the detection of neutralizing antibodies against an anti-IL-13 therapeutic antibody

Authors: Liao, Karen, Sikkema, Dan, Wang, Catherine, Chen, Keguan, DeWall, Stephen, Lee, Thomas N.

Source: In Journal of Immunological Methods 31 January 2012 375(1-2):258-263

Peripheral lymph node stromal cells can promote growth and tumorigenicity of breast carcinoma cells through the release of IGF-I and EGF.

Authors: LeBedis, Christina, Chen, Keguan, Fallavollita, Lucia, Boutros, Tarek, Brodt, Pnina

Source: International Journal of Cancer; Jul2002, Vol. 100 Issue 1, p2-8, 7p