The synthetic opioid fentanyl increases HIV replication in macrophages.

Authors: Madhuravasal Krishnan, Janani¹ (AUTHOR), Kong, Ling¹ (AUTHOR), Meeds, Heidi L.¹ (AUTHOR), Roskin, Krishna M.^2,3 (AUTHOR), Medvedovic, Mario⁴ (AUTHOR), Sherman, Kenneth E.^1,5 (AUTHOR), Blackard, Jason T.^1,5 (AUTHOR) jason.blackard@uc.edu

Source: PLoS ONE. 2/27/2025, Vol. 20 Issue 2, p1-17. 17p.

Subject Terms: *OPIOID abuse, *CHEMOKINE receptors, *GENE expression, *HIV infections, *STATISTICAL significance

Radiation Retinopathy: Microangiopathy-Inflammation-Neurodegeneration.

Authors: Davids, Anja-Maria¹ (AUTHOR) inga.pompoes@charite.de, Pompös, Inga-Marie¹ (AUTHOR) norbert.kociok@charite.de, Kociok, Norbert¹ (AUTHOR) antonia.joussen@charite.de, Heufelder, Jens² (AUTHOR) jens.heufelder@charite.de, Skosyrski, Sergej¹ (AUTHOR), Reichhart, Nadine¹ (AUTHOR), Joussen, Antonia M.¹ (AUTHOR), Wolf, Susanne A.^1,3 (AUTHOR) susanne.wolf@charite.de

Source: Cells (2073-4409). Feb2025, Vol. 14 Issue 4, p298. 23p.

Subject Terms: *UVEAL melanoma, *CHEMOKINE receptors, *CELL physiology, *LABORATORY mice, *RETINA, *PROTON beams

SELP⁺ TEC:CD8⁺ T cell crosstalk associates with improved radiotherapy efficacy in cervical cancer.

Authors: Huang, Qingyu¹ (AUTHOR), Yang, Wenhui² (AUTHOR), Wang, Fuhao¹ (AUTHOR), Huang, Rui³ (AUTHOR), Wang, Qian² (AUTHOR), Li, Xiaohui⁴ (AUTHOR), Lei, Tianyu² (AUTHOR), Yue, Shengqin² (AUTHOR), Zou, Wenxue^1,5 (AUTHOR), An, Qi² (AUTHOR), Yue, Jinbo¹ (AUTHOR) jbyue@sdfmu.edu.cn, Hu, Qinyong^1,2 (AUTHOR) rm001223@whu.edu.cn, Liu, Chao¹ (AUTHOR) charles.liu@whu.edu.cn

Source: Molecular Cancer. 2/3/2025, Vol. 24 Issue 1, p1-7. 7p.

Subject Terms: *MEDICAL sciences, *CHEMOKINE receptors, *T cells, *EPITHELIAL cells, *ENDOTHELIAL cells

Oral Cancer-Derived miR-762 Suppresses T-Cell Infiltration and Activation by Horizontal Inhibition of CXCR3 Expression.

Authors: Peng, Hsuan-Yu^1,2,3 (AUTHOR) a03776@tmu.edu.tw, Chang, Chia-Wei⁴ (AUTHOR) 153054@h.tmu.edu.tw, Wu, Ping-Hsiu^5,6,7,8 (AUTHOR) wupinghsiu@tmu.edu.tw, Li, Li-Jie^9,10 (AUTHOR) xu3xu4ru56lily@gmail.com, Lin, Yu-Lung¹¹ (AUTHOR) yllin4671@tmu.edu.tw, Hsiao, Michael¹² (AUTHOR) mhsiao@gate.sinica.edu.tw, Chang, Jang-Yang³ (AUTHOR), Chang, Peter Mu-Hsin^13,14,15 (AUTHOR) ptchang@nycu.edu.tw, Lee, Hsin-Lun^5,6,7,8 (AUTHOR) leehsinlun@tmu.edu.tw, Chang, Wei-Min^1,2 (AUTHOR) leehsinlun@tmu.edu.tw

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 3, p1077. 14p.

Subject Terms: *POLYMERASE chain reaction, *CHEMOKINE receptors, *SQUAMOUS cell carcinoma, *CYTOTOXINS, *T cells

The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF-κB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation.

Authors: Jin, Chen^1,2,3,4 (AUTHOR), Zhang, Fei^1,2,3 (AUTHOR), Luo, Hailang^1,2,3 (AUTHOR), Li, Boyang^1,2,3 (AUTHOR), Jiang, Xue⁴ (AUTHOR), Pirozzi, Christopher J.⁴ (AUTHOR), Liang, Chaozhao^1,2,3 (AUTHOR) liang_chaozhao@ahmu.edu.cn, Zhang, Meng^1,2,3 (AUTHOR) zhangmeng@ahmu.edu.cn

Source: Cell Communication & Signaling. 12/5/2024, Vol. 22 Issue 1, p1-19. 19p.

Subject Terms: *CHEMOKINE receptors, *STAT proteins, *MACROPHAGE activation, *CELLULAR signal transduction, *TRANSCRIPTOMES

CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting β-catenin signaling and epithelial-to-mesenchymal transition in tubular epithelial cells.

Authors: Meng, Ping¹ (AUTHOR), Liu, Chunli¹ (AUTHOR), Li, Jingchun¹ (AUTHOR), Fang, Ping² (AUTHOR), Yang, Bo³ (AUTHOR), Sun, Wei¹ (AUTHOR) mengnini@smu.edu.cn, Zhang, Yunfang⁴ (AUTHOR) zhang_yunf@163.com

Source: Renal Failure. Dec2024, Vol. 46 Issue 2, p1-13. 13p.

Subject Terms: *CHEMOKINE receptors, *RENAL fibrosis, *EPITHELIAL-mesenchymal transition, *EPITHELIAL cells, *CHRONIC kidney failure

Atypical chemokine receptor 2 expression is directly regulated by hypoxia inducible factor-1 alpha in cancer cells under hypoxia.

Authors: Benoit, Alice¹ (AUTHOR), Lequeux, Audrey¹ (AUTHOR), Harter, Phillip¹ (AUTHOR), Berchem, Guy^1,2,3 (AUTHOR), Janji, Bassam¹ (AUTHOR) bassam.janji@lih.lu

Source: Scientific Reports. 11/4/2024, Vol. 14 Issue 1, p1-9. 9p.

Subject Terms: *TUMOR-infiltrating immune cells, *CHEMOKINE receptors, *TUMOR microenvironment, *CANCER cells, *BREAST cancer, *CHEMOKINES

Intrauterine adhesions repair with menstrual blood-derived mesenchymal stem cells via CXCL13-CXCR5 signal axis and its mechanism.

Authors: Luo, Bing^1,2 (AUTHOR), Zeng, Xun^1,2 (AUTHOR), Luo, Li^1,2 (AUTHOR) feigagasmile@163.com

Source: Stem Cell Research & Therapy. 10/25/2024, Vol. 15 Issue 1, p1-11. 11p.

Subject Terms: *MESENCHYMAL stem cells, *CHEMOKINE receptors, *TISSUE adhesions, *TREATMENT effectiveness, *FEMALE reproductive organ diseases, *ENDOMETRIUM

Evaluation of C-C Motif Chemokine Receptor 5 (CCR5) as a Sample Adequacy Control in HPV Molecular Diagnostics.

Authors: Njoku, Ruth C.^1,2 (AUTHOR) chiara.giubbi@unimib.it, Martinelli, Marianna² (AUTHOR) marianna.martinelli@unimib.it, Giubbi, Chiara² (AUTHOR) barbara.torsello@unimib.it, De Marco, Sofia² (AUTHOR) manuela.sironi@unimib.it, Torsello, Barbara² (AUTHOR) cristina.bianchi@unimib.it, d'Avenia, Morena³ (AUTHOR) morena.davenia@asl.bari.it, Sironi, Manuela² (AUTHOR) clementina.cocuzza@unimib.it, Bianchi, Cristina² (AUTHOR), Cocuzza, Clementina E.² (AUTHOR)

Source: Diagnostics (2075-4418). Oct2024, Vol. 14 Issue 19, p2194. 11p.

Subject Terms: *CHEMOKINE receptors, *HUMAN papillomavirus, *HUMAN papillomavirus vaccines, *DISEASE management, *QUALITY control

Causal Relationship Between Post‐Traumatic Stress Disorder and Immune Cell Traits: A Mendelian Randomization Study.

Authors: Wang, Jian¹ (AUTHOR), Shao, Yuan¹ (AUTHOR), Deng, Xianhua¹ (AUTHOR), Du, Jianbin² (AUTHOR) dujianbin1987@163.com

Source: Brain & Behavior. Oct2024, Vol. 14 Issue 10, p1-8. 8p.

Subject Terms: *DENDRITIC cells, *CHEMOKINE receptors, *ODDS ratio, *POST-traumatic stress disorder, *GENOME-wide association studies

The CXCR6-CXCL16 axis mediates T cell control of polyomavirus infection in the kidney.

Authors: Lauver, Matthew D.¹, Katz, Zoe E.¹, Markus, Havell², Derosia, Nicole M.¹, Jin, Ge¹, Ayers, Katelyn N.¹, Butic, Arrienne B.¹, Bushey, Kaitlyn³, Abendroth, Catherine S.⁴, Liu, Dajiang J.², Lukacher, Aron E.¹, ael17@psu.edu

Source: PLoS Pathogens; 3/5/2025, Vol. 21 Issue 3, p1-20, 20p

CCR2 signaling regulates anti-chlamydia T cell immune responses in the airway.

Authors: Yang, Shuaini¹, Yu, Jinxi¹, Dong, Xue², Zeng, Jiajia¹, Tan, Lu¹, Zhang, Hong¹, Sun, Ruoyuan¹, Tuo, Yuqing¹, Yang, Jing³, jingyang@nankai.edu.cn, Wan, Chunxiao², jingyang@nankai.edu.cn, Bai, Hong¹, wcx22226@163.com

Source: PLoS Pathogens; 2/4/2025, Vol. 21 Issue 2, p1-23, 23p

Genetic variations in PADI4 and CCR6: a comprehensive meta-analysis on rheumatoid arthritis susceptibility.

Authors: Muruganantham, Jethendra Kumar¹ (AUTHOR), Thomas, Sheena Mariyam¹ (AUTHOR), Kalarani, Iyshwarya Bhaskar¹ (AUTHOR), Veerabathiran, Ramakrishnan¹ (AUTHOR) rkgenes@gmail.com

Source: Egyptian Journal of Medical Human Genetics. 9/27/2024, Vol. 25 Issue 1, p1-11. 11p.

Subject Terms: *CHEMOKINE receptors, *GENETIC models, *CHEMOKINES, *GENETIC variation, *GENETIC polymorphisms

The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune Microenvironment.

Authors: Huang, Tao¹ (AUTHOR), Zhu, Gang¹ (AUTHOR), Chen, Fan¹ (AUTHOR) professorchen@foxmail.com, Siddiqui, Arif¹ (AUTHOR) ar.siddiqui@uoh.edu.sa

Source: Journal of Immunology Research. 9/5/2024, Vol. 2024, p1-21. 21p.

Subject Terms: *KILLER cells, *CHEMOKINE receptors, *IMMUNOHISTOCHEMISTRY techniques, *IMMUNE checkpoint proteins, *GENETIC translation

New insights into sperm physiology regulation: Enlightenment from G‐protein‐coupled receptors.

Authors: Dai, Pengyuan¹ (AUTHOR), Chen, Chen¹ (AUTHOR), Yu, Jingyan¹ (AUTHOR), Ma, Chaoye¹ (AUTHOR), Zhang, Xiaoning¹ (AUTHOR) zhangxn@ntu.edu.cn

Source: Andrology. Sep2024, Vol. 12 Issue 6, p1253-1271. 19p.

Subject Terms: *CXCR4 receptors, *CHEMOKINE receptors, *G protein coupled receptors, *TESTIS physiology, *OLFACTORY receptors

Inducing Receptor Degradation as a Novel Approach to Target CC Chemokine Receptor 2 (CCR2).

Authors: Ortiz Zacarías, Natalia V.¹ (AUTHOR) jeremybroekhuis@outlook.com, Röth, Sascha² (AUTHOR) sascha.roth@astrazeneca.com, Broekhuis, Jeremy D.^1,3 (AUTHOR) d.van.der.es@lacdr.leidenuniv.nl, van der Es, Daan¹ (AUTHOR) l.h.heitman@lacdr.leidenuniv.nl, Moreau, Kevin² (AUTHOR) kevin.moreau@astrazeneca.com, Heitman, Laura H.^1,3 (AUTHOR)

Source: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p8984. 22p.

Subject Terms: *CHIMERIC proteins, *CHEMOKINE receptors, *PROTEOLYSIS, *DRUG target, *CELL physiology

C-C Motif Chemokine Ligand 2 and Chemokine Receptor 2 in Cardiovascular and Neural Aging and Aging-Related Diseases.

Authors: Guo, David¹ (AUTHOR) dguo9@arizona.edu, Zhu, Wuqiang² (AUTHOR) zhu.wuqiang@mayo.edu, Qiu, Hongyu^1,3 (AUTHOR) hqiu@arizona.edu

Source: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p8794. 16p.

Subject Terms: *IMMUNOMODULATORS, *CHEMOKINE receptors, *AGE factors in disease, *DRUG target, *CHRONIC diseases, *AGING

Modulating neuroinflammation and cognitive function in postoperative cognitive dysfunction via CCR5‐GPCRs‐Ras‐MAPK pathway targeting with microglial EVs.

Authors: Qi, Zheng¹ (AUTHOR), Peng, Junlin¹ (AUTHOR), Wang, Haitao¹ (AUTHOR), Wang, Li² (AUTHOR), Su, Yu³ (AUTHOR), Ding, Lan⁴ (AUTHOR), Cao, Bin¹ (AUTHOR), Zhao, Yingying¹ (AUTHOR), Xing, Qinghe³ (AUTHOR) qhxing@fudan.edu.cn, Yang, Jian‐jun¹ (AUTHOR) jianjunyangzzu@hotmail.com

Source: CNS Neuroscience & Therapeutics. Aug2024, Vol. 30 Issue 8, p1-15. 15p.

Subject Terms: *CHEMOKINE receptors, *COGNITIVE testing, *EXTRACELLULAR vesicles, *DENDRITIC spines, *COGNITIVE ability

Targeting CCL2-CCR2 signaling pathway alleviates macrophage dysfunction in COPD via PI3K-AKT axis.

Authors: Dong, Yue^1,2,3,4 (AUTHOR), Dong, Ying⁴ (AUTHOR), Zhu, Chengyue^1,2,3 (AUTHOR), Yang, Lan⁵ (AUTHOR), Wang, Hanlin⁴ (AUTHOR), Li, Junqing^1,2 (AUTHOR), Zheng, Zixuan⁶ (AUTHOR), Zhao, Hanwei⁶ (AUTHOR), Xie, Wanji⁷ (AUTHOR), Chen, Meiting⁸ (AUTHOR), Jie, Zhijun^1,2 (AUTHOR), Li, Jia^4,5,8,9,10 (AUTHOR), Zang, Yi³ (AUTHOR) yzang@lglab.ac.cn, Shi, Jindong^1,2 (AUTHOR) shijindong@fudan.edu.cn

Source: Cell Communication & Signaling. 7/17/2024, Vol. 22 Issue 1, p1-19. 19p.

Subject Terms: *CHRONIC obstructive pulmonary disease, *CHEMOKINE receptors, *MACROPHAGE activation, *KNOCKOUT mice, *EPITHELIAL cells

Correction: Trypsin, Tryptase, and Thrombin Polarize Macrophages towards a Pro-Fibrotic M2a Phenotype.

Authors: White, Michael J. V. (AUTHOR), Gomer, Richard H. (AUTHOR)

Source: PLoS ONE. 11/20/2024, Vol. 19 Issue 11, p1-3. 3p.

Subject Terms: *PHENOTYPES, *CHEMOKINE receptors, *TRYPSIN, *THROMBIN, *TRYPTASE