Optogenetic stimulation of dynorphinergic neurons within the dorsal raphe activate kappa opioid receptors in the ventral tegmental area and ablation of dorsal raphe prodynorphin or kappa receptors in dopamine neurons blocks stress potentiation of cocaine reward

Authors: Abraham, Antony D., Casello, Sanne M., Land, Benjamin B., Chavkin, Charles

Source: In Addiction Neuroscience March 2022 1

Regulation of Kappa Opioid Receptor Inactivation Depends on Sex and Cellular Site of Antagonist Action

Authors: Reichard, Kathryn L., Newton, Keionna A., Rivera, Zeena M.G., Sotero de Menezes, Paulo M., Schattauer, Selena S., Land, Benjamin B., Chavkin, Charles ^*

Source: In Molecular Pharmacology November 2020 98(5):548-558

Synergy of Distinct Dopamine Projection Populations in Behavioral Reinforcement

Authors: Heymann, Gabriel, Jo, Yong S., Reichard, Kathryn L., McFarland, Naomi, Chavkin, Charles, Palmiter, Richard D., Soden, Marta E., Zweifel, Larry S.

Source: In Neuron 4 March 2020 105(5):909-920

Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation

Authors: Schattauer, Selena S., Bedini, Andrea, Summers, Floyd, Reilly-Treat, Aiden, Andrews, Mackenzie M., Land, Benjamin B., Chavkin, Charles

Source: In Journal of Biological Chemistry 8 November 2019 294(45):16884-16896

Will biased ligands be the opioids of the future?

Authors: Ballantyne, Jane C., Chavkin, Charles

Source: Pain. 161(9):1945-1948

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174998560.0x000001&indx=1&recIds=ETOCvdc_100174998560.0x000001

Nalfurafine is a G-protein biased agonist having significantly greater bias at the human than rodent form of the kappa opioid receptor

Authors: Schattauer, Selena S., Kuhar, Jamie R., Song, Allisa, Chavkin, Charles

Source: In Cellular Signalling April 2017 32:59-65

Abnormal Neurotransmission in Mice Lacking Synaptic Vesicle Protein 2A (SV2A)

Authors: Crowder, Kelly M., Gunther, Jane M., Jones, Theresa A., Hale, Brian D., Zhang, Hai Zhuan, Peterson, Michael R., Scheller, Richard H., Chavkin, Charles, Bajjalieh, Sandra M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1999 Dec . 96(26), 15268-15273.

Access URL: https://www.jstor.org/stable/121243

GIRK1 Immunoreactivity is Present Predominantly in Dendrites, Dendritic Spines, and Somata in the CA1 Region of the Hippocampus

Authors: Drake, Carrie T., Bausch, Suzanne B., Milner, Teresa A., Chavkin, Charles

Source: Proceedings of the National Academy of Sciences of the United States of America, 1997 Feb 01. 94(3), 1007-1012.

Access URL: https://www.jstor.org/stable/41426

N-Methyl-D-Aspartate Receptor-Induced Proteolytic Conversion of Postsynaptic Class C L-Type Calcium Channels in Hippocampal Neurons

Authors: Hell, Johannes W., Westenbroek, Ruth E., Breeze, Liam J., Chavkin, Charles, Catterall, William A.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1996 Apr . 93(8), 3362-3367.

Access URL: https://www.jstor.org/stable/38965

Mu opioid receptor stimulation activates c-Jun N-terminal kinase 2 by distinct arrestin-dependent and independent mechanisms

Authors: Kuhar, Jamie Rose, Bedini, Andrea, Melief, Erica J., Chiu, Yen-Chen, Striegel, Heather N., Chavkin, Charles

Source: In Cellular Signalling September 2015 27(9):1799-1806

Role of G Protein–Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

Authors: Lowe, Janet D., Sanderson, Helen S., Cooke, Alexandra E., Ostovar, Mehrnoosh, Tsisanova, Elena, Withey, Sarah L., Chavkin, Charles, Husbands, Stephen M., Kelly, Eamonn, Henderson, Graeme, Bailey, Chris P. ^*

Source: In Molecular Pharmacology August 2015 88(2):347-356

Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase

Authors: Schattauer, Selena, Land, Benjamin, Reichard, Kathryn, Abraham, Antony, Burgeno, Lauren, Kuhar, Jamie, Phillips, Paul, Ong, Shao En, Chavkin, Charles

Source: Nature communications. 8(1):1-14

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Κ-Opioid Receptor Activation in Dopamine Neurons Disrupts Behavioral Inhibition

Authors: Abraham, Antony D, Fontaine, Harrison M, Song, Allisa J, Andrews, Mackenzie M, Baird, Madison A, Kieffer, Brigitte L, Land, Benjamin B, Chavkin, Charles

Source: Neuropsychopharmacology. 43(2):362-372

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Ketamine Pharmacodynamics Entangled: Comment

Authors: Bowdle, T. Andrew, Sackett, Nathan, Strassman, Rick, Murray, Thomas F., Jelacic, Srdjan, Chavkin, Charles

Source: Anesthesiology. 137(6):747-748

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Disruption of Dopamine Neuron Activity Pattern Regulation through Selective Expression of a Human KCNN3 Mutation

Authors: Soden, Marta E., Jones, Graham L., Sanford, Christina A., Chung, Amanda S., Güler, Ali D., Chavkin, Charles, Luján, Rafael, Zweifel, Larry S.

Source: In Neuron 20 November 2013 80(4):997-1009

Regulation of µ-Opioid Receptors: Desensitization, Phosphorylation, Internalization, and Tolerance

Authors: Williams, John T., Ingram, Susan L., Henderson, Graeme, Chavkin, Charles, von Zastrow, Mark, Schulz, Stefan, Koch, Thomas, Evans, Christopher J., Christie, MacDonald J. ^*

Source: In Pharmacological Reviews January 2013 65(1):223-254

Ligand Directed Signaling Differences between Rodent and Human κ-Opioid Receptors

Authors: Schattauer, Selena S., Miyatake, Mayumi, Shankar, Haripriya, Zietz, Chad, Levin, Jamie R., Liu-Chen, Lee-Yuan, Gurevich, Vsevolod V., Rieder, Mark J., Chavkin, Charles

Source: In Journal of Biological Chemistry 7 December 2012 287(50):41595-41607

Long-term effects of neonatal stress on adult conditioned place preference (CPP) and hippocampal neurogenesis

Authors: Hays, Sarah L., McPherson, Ronald J., Juul, Sandra E., Wallace, Gerard, Schindler, Abigail G., Chavkin, Charles, Gleason, Christine A.

Source: In Behavioural Brain Research 2012 227(1):7-11

α-Dystrobrevin-1 recruits α-catulin to the α 1D -adrenergic receptor/dystrophin-associated protein complex signalosome

Authors: Lyssand, John S., Whiting, Jennifer L., Lee, Kyung-Soon, Kasti, Ryan, Wacker, Jennifer L., Bruchas, Michael R., Miyatake, Mayumi, Langeberg, Lorene K., Chavkin, Charles, Scott, John D., Gardner, Richard G., Adams, Marvin E., Hague, Chris, Lefkowitz, Robert J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2010 Dec . 107(50), 21854-21859.

Access URL: https://www.jstor.org/stable/25756973

Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling

Authors: Melief, Erica J., Miyatake, Mayumi, Bruchas, Michael R., Chavkin, Charles, Amara, Susan G.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2010 Jun . 107(25), 11608-11613.

Access URL: https://www.jstor.org/stable/20724115