The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia

Authors: Cara E. Toscan, Hannah McCalmont, Amir Ashoorzadeh, Xiaojing Lin, Zhe Fu, Louise Doculara, Hansen J. Kosasih, Roxanne Cadiz, Anthony Zhou, Sarah Williams, Kathryn Evans, Faezeh Khalili, Ruilin Cai, Kristy L. Yeats, Andrew J. Gifford, Russell Pickford, Chelsea Mayoh, Jinhan Xie, Michelle J. Henderson, Toby N. Trahair, Adam V. Patterson, Jeff B. Smaill, Charles E. de Bock, Richard B. Lock

Source: Blood Cancer Journal, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2044-5385

Access URL: https://doaj.org/article/6345a011fd5e4b7dbeced8196c76971a

PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia

Authors: Dominik Beck, Honghui Cao, Feng Tian, Yizhou Huang, Miao Jiang, Han Zhao, Xiaolu Tai, Wenqian Xu, Hansen J. Kosasih, David J. Kealy, Weiye Zhao, Samuel J. Taylor, Timothy A. Couttas, Gaoxian Song, Diego Chacon-Fajardo, Yashna Walia, Meng Wang, Adam A. Dowle, Andrew N. Holding, Katherine S. Bridge, Chao Zhang, Jin Wang, Jian-Qing Mi, Richard B. Lock, Charles E. de Bock, Duohui Jing

Source: Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/5435731f29bf4866b65f5821ed78136d

In vitro and in vivo modelling of mutant JAK3/STAT5 signaling in leukemia

Authors: Sofia A. Omari, Hansen J. Kosasih, Thomas Chung, Charles E. de Bock

Source: Heliyon, Vol 9, Iss 11, Pp e22085- (2023)

Subject Terms: Bone marrow transplant, JAK3, STAT5, T-cell acute lymphoblastic leukemia, Retroviral transduction, Transfection, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844023092939; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/6a03e7aa03c54534a97e5458b746fd59

Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma

Authors: Stien De Coninck, Renate De Smedt, Beatrice Lintermans, Lindy Reunes, Hansen J. Kosasih, Alexandra Reekmans, Lauren M. Brown, Nadine Van Roy, Bruno Palhais, Juliette Roels, Malaika Van der Linden, Jo Van Dorpe, Panagiotis Ntziachristos, Frederik W. van Delft, Marc R. Mansour, Tim Pieters, Tim Lammens, Barbara De Moerloose, Charles E. de Bock, Steven Goossens, Pieter Van Vlierberghe

Source: Haematologica, Vol 109, Iss 5 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/11338; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/a08f66779ce943b3bf87b6b00741dfb3

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

Authors: Quentin Van Thillo, Jolien De Bie, Janith A. Seneviratne, Sofie Demeyer, Sofia Omari, Anushree Balachandran, Vicki Zhai, Wai L. Tam, Bram Sweron, Ellen Geerdens, Olga Gielen, Sarah Provost, Heidi Segers, Nancy Boeckx, Glenn M. Marshall, Belamy B. Cheung, Kiyotaka Isobe, Itaru Kato, Junko Takita, Timothy G. Amos, Ira W. Deveson, Hannah McCalmont, Richard B. Lock, Ethan P. Oxley, Maximilian M. Garwood, Ross A. Dickins, Anne Uyttebroeck, Daniel R. Carter, Jan Cools, Charles E. de Bock

Source: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/097bfb27edca4477bb37a09172ff1f71

The Promise of Single-cell Technology in Providing New Insights Into the Molecular Heterogeneity and Management of Acute Lymphoblastic Leukemia

Authors: Holly C.L. Pearson, Kooper V. Hunt, Toby N. Trahair, Richard B. Lock, Heather J. Lee, Charles E. de Bock

Source: HemaSphere, Vol 6, Iss 6, p e734 (2022)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000734; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/71869efe7d01412fa75e2cd2ed105ff7

The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models

Authors: Carmen Vicente, Rocco Stirparo, Sofie Demeyer, Charles E. de Bock, Olga Gielen, Mardelle Atkins, Jiekun Yan, Georg Halder, Bassem A. Hassan, Jan Cools

Source: Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-16 (2018)

Subject Terms: CCR4-NOT, Leukemia, mRNA stability, Tumor suppressor, Drosophila melanogaster, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13045-018-0650-0; https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/d2b4f3970332452b81f7d13001aa3d14

Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia

Authors: Patrick Connerty, Ernest Moles, Charles E. de Bock, Nisitha Jayatilleke, Jenny L. Smith, Soheil Meshinchi, Chelsea Mayoh, Maria Kavallaris, Richard B. Lock

Source: Pharmaceutics, Vol 13, Iss 10, p 1681 (2021)

Subject Terms: lipid-based nanoparticles, long non-coding RNA, RNA interference, nanomedicine, nanoparticle-assisted siRNA delivery, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/13/10/1681; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/2b83fb439aaf40ae8845b777116b0c33

Long Non-coding RNAs: Major Regulators of Cell Stress in Cancer

Authors: Patrick Connerty, Richard B. Lock, Charles E. de Bock

Source: Frontiers in Oncology, Vol 10 (2020)

Subject Terms: lncRNA, metabolism, cell stress, oxidative stress, cancer, tumor suppressor gene, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fonc.2020.00285/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/cff0f15d7aaf4ceb896459c32960bfea

T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development

Authors: Charles E. de Bock, Michelle Down, Kinsha Baidya, Bram Sweron, Andrew W. Boyd, Mark Fiers, Gordon F. Burns, Timothy J. Molloy, Richard B. Lock, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Jan Cools, Jeff Holst, Rick F. Thorne

Source: Haematologica, Vol 104, Iss 5 (2019)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8909; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/917739d4aa2b4d259a4011e995e0cec1

A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing

Authors: Karen Verboom, Wouter Van Loocke, Pieter-Jan Volders, Bieke Decaesteker, Francisco Avila Cobos, Simon Bornschein, Charles E. de Bock, Zeynep Kalender Atak, Emmanuelle Clappier, Stein Aerts, Jan Cools, Jean Soulier, Tom Taghon, Pieter Van Vlierberghe, Jo Vandesompele, Frank Speleman, Kaat Durinck

Source: Haematologica, Vol 103, Iss 12 (2018)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/8715; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/20376f51afbd42e3b908c9d13fd65995

JAK3 mutations and HOXA9 expression are important cooperating events in T-cell acute lymphoblastic leukemia

Authors: Charles E. de Bock, Jan Cools

Source: Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)

Subject Terms: signaling, transcription factor, leukemia, retroviral vector, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2372-3556

Access URL: https://doaj.org/article/075a8fb483254be799caaec4fb329185

A soluble form of the giant cadherin Fat1 is released from pancreatic cancer cells by ADAM10 mediated ectodomain shedding.

Authors: Nathalie Wojtalewicz, Elham Sadeqzadeh, Jakob V Weiß, Mahnaz Moradian Tehrani, Susanne Klein-Scory, Stephan Hahn, Wolff Schmiegel, Uwe Warnken, Martina Schnölzer, Charles E de Bock, Rick F Thorne, Irmgard Schwarte-Waldhoff

Source: PLoS ONE, Vol 9, Iss 3, p e90461 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3953070?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/7d58260ac5714f1bb343e4550925c852