An Association between OXPHOS-Related Gene Expression and Malignant Hyperthermia Susceptibility in Human Skeletal Muscle Biopsies.

Authors: Chang, Leon¹ (AUTHOR) l.chang@leeds.ac.uk, Motley, Rebecca¹ (AUTHOR) c.p.diggle@leeds.ac.uk, Daly, Catherine L.² (AUTHOR), Diggle, Christine P.¹ (AUTHOR) p.m.hopkins@leeds.ac.uk, Hopkins, Philip M.^1,2 (AUTHOR), Shaw, Marie-Anne¹ (AUTHOR) m.shaw@leeds.ac.uk

Source: International Journal of Molecular Sciences. Mar2024, Vol. 25 Issue 6, p3489. 15p.

Subject Terms: *GENE expression, *SKELETAL muscle, *MALIGNANT hyperthermia, *RYANODINE receptors, *OXIDATIVE phosphorylation, *PHENOTYPIC plasticity

Analysis of integrated inflammatory bowel disease mouse models to assess their disease driving pathways and relevance for Crohn’s disease and Ulcerative colitis

Authors: Schultz, Weiwei, Monast, Calixte, Hesse, Mathias, Chang, Leon, Scully, Michael, Chen, Yanqing, Liu, Xuejun, Hutchins, Zachary, Pavlidis, Stelios, Baribaud, Frederic

Source: 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) Bioinformatics and Biomedicine (BIBM), 2018 IEEE International Conference on. :2806-2807 Dec, 2018

Relation: 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

Comparison of Transcriptomic Changes in Survivors of Exertional Heat Illness with Malignant Hyperthermia Susceptible Patients.

Authors: Chang, Leon¹ (AUTHOR) l.chang@leeds.ac.uk, Gardner, Lois¹ (AUTHOR) m.shaw@leeds.ac.uk, House, Carol² (AUTHOR), Daly, Catherine³ (AUTHOR) c.l.daly@leeds.ac.uk, Allsopp, Adrian² (AUTHOR), Roiz de Sa, Daniel² (AUTHOR), Shaw, Marie-Anne¹ (AUTHOR), Hopkins, Philip M.^1,3 (AUTHOR) p.m.hopkins@leeds.ac.uk

Source: International Journal of Molecular Sciences. Nov2023, Vol. 24 Issue 22, p16124. 14p.

Subject Terms: *HEAT stroke, *MALIGNANT hyperthermia, *GENE expression, *TRANSCRIPTOMES, *OXIDATIVE phosphorylation, *OCCUPATIONAL hazards

Characterization of Genetic Landscape and Novel Inflammatory Biomarkers in Patients With Adult‐Onset Still's Disease.

Authors: Topping, Joanne¹ (AUTHOR), Chang, Leon¹ (AUTHOR), Nadat, Fatima² (AUTHOR), Poulter, James A.¹ (AUTHOR), Ibbotson, Alice¹ (AUTHOR), Lara‐Reyna, Samuel¹ (AUTHOR), Watson, Christopher M.² (AUTHOR), Carter, Clive² (AUTHOR), Pournara, Linda P.¹ (AUTHOR), Zernicke, Jan³ (AUTHOR), Ross, Rebecca L.⁴ (AUTHOR), Cargo, Catherine² (AUTHOR), Lyons, Paul A.⁵ (AUTHOR), Smith, Kenneth G. C.⁵ (AUTHOR), Del Galdo, Francesco⁴ (AUTHOR), Rech, Jürgen⁶ (AUTHOR), Fautrel, Bruno⁷ (AUTHOR), Feist, Eugen⁸ (AUTHOR), McDermott, Michael F.¹ (AUTHOR), Savic, Sinisa⁹ (AUTHOR) S.Savic@leeds.ac.uk

Source: Arthritis & Rheumatology. Nov2024, p1. 14p. 6 Illustrations.

Bioenergetic defects in muscle fibers of RYR1 mutant knock-in mice associated with malignant hyperthermia

Authors: Chang, Leon, Liu, Xiaochen, Diggle, Christine P., Boyle, John P., Hopkins, Philip M., Shaw, Marie-Anne, Allen, Paul D. ^*

Source: In Journal of Biological Chemistry 6 November 2020 295(45):15226-15235

Efecto 2020 en la siniestralidad laboral de la República del Ecuador: un año atípico por COVID-19

Authors: Alywin I. Hacay-Chang Leon, Antonio Ramón Gómez García

Source: Revista Colombiana de Salud Ocupacional, Vol 11, Iss 1 (2022)

Subject Terms: accidentes de trabajo, COVID-19, Ecuador, incidencia, tasa de incidencia, Public aspects of medicine, RA1-1270, Psychology, BF1-990

File Description: electronic resource

Relation: https://revistas.unilibre.edu.co/index.php/rc_salud_ocupa/article/view/7381; https://doaj.org/toc/2322-634X

Access URL: https://doaj.org/article/444d16303fa5490ba763b8414d888031

Adaptive Complex Contagions and Threshold Dynamical Systems

Authors: Chang, Leon, Cochran, Jeffrey, Mortveit, Henning S., Raval, Siddharth, Schroeder, Matthew

Subject Terms: Mathematics - Dynamical Systems

Access URL: http://arxiv.org/abs/1305.4599

Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals

Authors: Chang, Leon, Daly, Catherine, Miller, Dorota M., Allen, Paul D., Boyle, John P., Hopkins, Philip M., Shaw, Marie-Anne

Source: In British Journal of Anaesthesia May 2019 122(5):613-621

Anti‐MDA5‐associated dermatomyositis

Authors: Gupta, Rajiv, Kumar, Sunil, Gow, Peter, (Hsien‐Cheng) Chang, Leon, Yen, Linda

Source: Internal medicine journal. 50(4):484-487

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100106880630.0x000001&indx=1&recIds=ETOCvdc_100106880630.0x000001

The mode of action of IL-23 in experimental inflammatory arthritic pain and disease.

Authors: Lee, Kevin M.-C., Lupancu, Tanya, Chang, Leon, Manthey, Carl L., Zeeman, Martha, Fourie, Anne M., Hamilton, John A.

Source: Arthritis Research & Therapy; 8/6/2024, Vol. 26 Issue 1, p1-13, 13p

IL-23 regulation of myeloid cell biology during inflammation

Authors: Lee, Kevin M.-C., Lupancu, Tanya, Chang, Leon, Manthey, Carl L., Zeeman, Martha, Fourie, Anne M., Hamilton, John A.

Source: In Cytokine July 2024 179

Mo1504: IN SILICO EVALUATION AND PRE-CLINICAL EFFICACY OF ANTI-TNF AND ANTI-IL-23 COMBINATION THERAPY IN INFLAMMATORY BOWEL DISEASE

Authors: Perrigoue, Jacqueline, Muniz-Bongers, Luciana R., Ong, Luvena L., Chen, Yanqing, Chang, Leon, Ngo, Karen, Stojmirovic, Aleksandar, O'Brien, Christopher D., Germinaro, Matthew, Rao, Rajesh, Vetter, Marion, Towne, Jennifer

Source: Gastroenterology. 162(7):S-794-S-794

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100167643887.0x000001&indx=1&recIds=ETOCvdc_100167643887.0x000001

A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors

Alternate Title: Differential Pharmacology of Novel FLAP Inhibitors (English)

Authors: Blevitt, Jonathan M., Hack, Michael D., Herman, Krystal, Chang, Leon, Keith, John M., Mirzadegan, Tara, Rao, Navin L., Lebsack, Alec D., Milla, Marcos E.

Source: In Journal of Biological Chemistry 10 June 2016 291(24):12724-12731

Phenotyping drug polypharmacology via eicosanoid profiling of blood

Authors: Song, Jiao ^*, Liu, Xuejun ^†, Rao, Tadimeti S. ^†, Chang, Leon ^†, Meehan, Michael J. ^§, Blevitt, Jonathan M. ^*, Wu, Jiejun ^*, Dorrestein, Pieter C. ^§, Milla, Marcos E. ^*

Source: In Journal of Lipid Research August 2015 56(8):1492-1500

Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.

Authors: Babbe, Holger, Sundberg, Thomas B., Tichenor, Mark, Seierstad, Mark, Bacani, Genesis, Berstler, James, Wenying Chai, Chang, Leon, De Michael Chung, Coe, Kevin, Collins, Bernard, Finley, Michael, Guletsky, Alexander, Lemke, Christopher T., Puiying A. Mak, Mathur, Ashok, Mercado-Marin, Eduardo V., Metkar, Shailesh, Raymond, Donald D., Rives, Marie-Laure

Source: Proceedings of the National Academy of Sciences of the United States of America; 1/2/2024, Vol. 121 Issue 1, p1-11, 49p

Subject Terms: INTERNALLY displaced persons, MYELOID cells, CARRIER proteins, INFLAMMATORY bowel diseases, INFLAMMATION, INTESTINES

Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase

Authors: Keith, John M., Jones, William, Pierce, Joan M., Seierstad, Mark, Palmer, James A., Webb, Michael, Karbarz, Mark, Scott, Brian P., Wilson, Sandy J., Luo, Lin, Wennerholm, Michelle, Chang, Leon, Rizzolio, Michele, Rynberg, Raymond, Chaplan, Sandra, Guy Breitenbucher, J.

Source: Bioorganic & medicinal chemistry letters. 30(20)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121268514.0x000001&indx=1&recIds=ETOCvdc_100121268514.0x000001

The mitochondrial bioenergetics in primary myotubes from mouse models of malignant hyperthermia are not directly related to increased sarcoplasmic calcium concentrations

Authors: Kaura, Vikas, Chang, Leon, Hopkins, Phil M., Shaw, Marie-Anne

Source: In British Journal of Anaesthesia August 2024 133(2):462-462

Su1738 JNJ-77242113, AN ORAL PEPTIDE SELECTIVELY TARGETING THE IL-23 RECEPTOR, DEMONSTRATES PHARMACODYNAMIC ACTIVITY IN RAT AND HUMAN COLON TISSUE EXPLANTS FOLLOWING ORAL DOSING

Authors: de Leon-Tabaldo, Aimee, Strawn, David, Chang, Leon, Cheng, Xiaoli, Greving, Carrie, Knight, Beverly, Sendecki, Jocelyn, Sherlock, Jonathan, Modi, Nishit B., Kannan, Arun K., Fourie, Anne M.

Source: In Gastroenterology 18-21 May 2024 166(5) Supplement:S

Lessons learned from the institution of the Surgical Care Improvement Project at a teaching medical center

Authors: Potenza, Bruce, Deligencia, Michelle, Estigoy, Brenda, Faraday, Eema, Snyder, Andrea, Angle, Niren, Schwartz, Alexandra, Chang, Leon, Hackett, James, Minokadeh, Anushirvan, Madani, Michael, MacAulay, Kathryn, Ramamoorthy, Sonia, Blaner, Lynn, James, Charles, Bansal, Vishal, Torriani, Francesca, Coimbra, Raul

Source: In The American Journal of Surgery 2009 198(6):881-888

Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.

Authors: Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Bacani, Genesis M., Wei, Jianmei, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Chang, Leon, Clancy, Kathleen W., Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, Jiejun, Rui, Haopeng, Sepassi, Kia, Gaudiano, Marcello

Source: Journal of Medicinal Chemistry; 11/10/2022, Vol. 65 Issue 21, p14326-14336, 11p