Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel K~v1.3: Role of Conformational Dynamics

Authors: Sanchez, Karoline, Prypoten, Viktor, Chandy, K. George, Chalmers, David K., Norton, Raymond S.

Source: Journal of chemical information and modeling. 63(10):3043-3053

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632533547&indx=1&recIds=ETOCRN632533547

Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug

Authors: Tyagi, Anu, Ahmed, Tofayel, Jian, Shi, Bajaj, Saumya, Ong, Seow Theng, Goay, Stephanie Shee Min, Zhao, Yue, Vorobyov, Igor, Tian, Changlin, Chandy, K. George, Bhushan, Shashi

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 Feb 01. 119(5), 1-10.

Access URL: https://www.jstor.org/stable/27117763

Obstacles for T-lymphocytes in the tumour microenvironment: Therapeutic challenges, advances and opportunities beyond immune checkpoint

Authors: Verma, Navin Kumar, Wong, Brandon Han Siang, Poh, Zhi Sheng, Udayakumar, Aiswarya, Verma, Ritu, Goh, Ryan Kwang Jin, Duggan, Shane P., Shelat, Vishalkumar G., Chandy, K. George, Grigoropoulos, Nicholas Francis

Source: In eBioMedicine September 2022 83

Contributions of natural products to ion channel pharmacologyElectronic supplementary information (ESI) available. See DOI: 10.1039/c9np00056a

Authors: Bajaj, Saumya, Ong, Seow Theng, Chandy, K. George

Source: Natural product reports. 37(5):703-716

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100109213883.0x000001&indx=1&recIds=ETOCvdc_100109213883.0x000001

The Voltage-Gated Potassium Channel Kv1.3 Is Highly Expressed on Inflammatory Infiltrates in Multiple Sclerosis Brain

Authors: Rus, Horea, Pardo, Carlos A., Hu, Lina, Darrah, Erika, Cudrici, Cornelia, Niculescu, Teodora, Niculescu, Florin, Mullen, Katharine M., Allie, Rameeza, Guo, Liping, Wulff, Heike, Beeton, Christine, Kerr, Douglas A., Knaus, Hans-Gunther, Chandy, K. George, Calabresi, Peter A., Latorre, Ramon

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Aug 01. 102(31), 11094-11099.

Access URL: https://www.jstor.org/stable/3376222

Venom-derived peptide inhibitors of voltage-gated potassium channels

Authors: Norton, Raymond S., Chandy, K. George

Source: In Neuropharmacology December 2017 127:124-138

Peptide blockers of Kv1.3 channels in T cells as therapeutics for autoimmune disease

Authors: Chandy, K George, Norton, Raymond S

Source: In Current Opinion in Chemical Biology June 2017 38:97-107

Selective Blockade of T Lymphocyte K + Channels Ameliorates Experimental Autoimmune Encephalomyelitis, A Model for Multiple Sclerosis

Authors: Beeton, Christine, Wulff, Heike, Barbaria, Jocelyne, Clot-Faybesse, Olivier, Pennington, Michael, Bernard, Dominique, Cahalan, Michael D., Chandy, K. George, Béraud, Evelyne

Source: Proceedings of the National Academy of Sciences of the United States of America, 2001 Nov . 98(24), 13942-13947.

Access URL: https://www.jstor.org/stable/3057199

Design of a Potent and Selective Inhibitor of the Intermediate-Conductance Ca 2+ -Activated K + Channel, IKCa1: A Potential Immunosuppressant

Authors: Wulff, Heike, Miller, Mark J., Hansel, Wolfram, Grissmer, Stephan, Cahalan, Michael D., Chandy, K. George

Source: Proceedings of the National Academy of Sciences of the United States of America, 2000 Jul 01. 97(14), 8151-8156.

Access URL: https://www.jstor.org/stable/123065

International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels

Authors: Kaczmarek, Leonard K. ^*, Aldrich, Richard W., Chandy, K. George, Grissmer, Stephan, Wei, Aguan D., Wulff, Heike

Source: In Pharmacological Reviews January 2017 69(1):1-11

The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells

Authors: Pillozzi, Serena, D'Amico, Massimo, Bartoli, Gianluca, Gasparoli, Luca, Petroni, Giulia, Crociani, Olivia, Marzo, Tiziano, Guerriero, Angela, Messori, Luigi, Severi, Mirko, Udisti, Roberto, Wulff, Heike, Chandy, K George, Becchetti, Andrea, Arcangeli, Annarosa

Source: British journal of cancer. 118(2):200-212

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BPS2025 - Structural basis for the pharmacological modulation of KCa3.1 channels revealed by the cryo-EM structures

Authors: Ramanishka, Alena ¹, Nam, Young Woo ¹, Ong, Seow Theng ², Nasburg, Joshua ³, Ng, Xuan Rui ², Zhuang, Zhong ², Xu, Yang ⁴, Wulff, Heike ³, Chandy, K George ², Zhang, Miao ¹

Source: In Biophysical Journal 13 February 2025 124(3) Supplement 1:292a-293a

Augmenting the activity of calcium-activated potassium channel KCa3.1 revitalizes T-cell function in the immunosuppressive tumor microenvironment

Authors: Verma, Navin K., Siang Wong, Brandon Han, Theng Ong, Seow, Min Goay, Stephanie Shee, Swan Ho, Ying, Chen, Shuwen, Bi, Xuezhi, Shim, Heesung, Wulff, Heike, Webster, Richard D., Shelat, Vishalkumar G., Chandy, K. George

Source: Biophysical journal. 122(S1):256a-256a

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185964295.0x000001&indx=1&recIds=ETOCvdc_100185964295.0x000001

Structure of the voltage-gated potassium channel KV1.3: Insights into the inactivated conformation and binding to therapeutic leads.

Authors: Chandy, K. George, Sanches, Karoline, Norton, Raymond S.

Source: Channels (19336950); Dec2023, Vol. 17 Issue 1, p1-20, 20p

Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance

Authors: Upadhyay, Sanjeev Kumar, Eckel-Mahan, Kristin L., Mirbolooki, M. Reza, Tjong, Indra, Griffey, Stephen M., Schmunk, Galina, Koehne, Amanda, Halbout, Briac, Iadonato, Shawn, Pedersen, Brian, Borrelli, Emiliana, Wang, Ping H., Mukherjee, Jogeshwar, Sassone-Corsi, Paolo, Chandy, K. George

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Jun 01. 110(24), 9632-9632.

Access URL: https://www.jstor.org/stable/42706055

Modulation of voltage-gated K⁺ channels by the sodium channel β1 subunit

Authors: Nguyen, Hai M., Miyazaki, Haruko, Hoshi, Naoto, Smith, Brian J., Nukina, Nobuyuki, Goldin, Alan L., Chandy, K. George

Source: Proceedings of the National Academy of Sciences of the United States of America, 2012 Nov 01. 109(45), 18577-18582.

Access URL: https://www.jstor.org/stable/41829954

Durable Pharmacological Responses from the Peptide ShK-186, a Specific Kv1.3 Channel Inhibitor That Suppresses T Cell Mediators of Autoimmune Disease

Authors: Tarcha, Eric J. ^*, Chi, Victor, Muñoz-Elías, Ernesto J., Bailey, David, Londono, Luz M., Upadhyay, Sanjeev K., Norton, Kayla, Banks, Amy, Tjong, Indra, Nguyen, Hai, Hu, Xueyou, Ruppert, Greg W., Boley, Scott E., Slauter, Richard, Sams, James, Knapp, Brian, Kentala, Dustin, Hansen, Zachary, Pennington, Michael W., Beeton, Christine, Chandy, K. George, Iadonato, Shawn P.

Source: In The Journal of Pharmacology and Experimental Therapeutics September 2012 342(3):642-653

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

Authors: Chi, Victor, Pennington, Michael W., Norton, Raymond S., Tarcha, Eric J., Londono, Luz M., Sims-Fahey, Brian, Upadhyay, Sanjeev K., Lakey, Jonathan T., Iadonato, Shawn, Wulff, Heike, Beeton, Christine, Chandy, K. George

Source: In Toxicon 15 March 2012 59(4):529-546

Kv1.3 Channels Are a Therapeutic Target for T Cell-Mediated Autoimmune Diseases

Authors: Beeton, Christine, Wulff, Heike, Standifer, Nathan E., Azam, Philippe, Mullen, Katherine M., Pennington, Michael W., Kolski-Andreaco, Aaron, Wei, Eric, Grino, Alexandra, Counts, Debra R., Wang, Ping H., LeeHealey, Christine J., Andrews, Brian S., Sankaranarayanan, Ananthakrishnan, Homerick, Daniel, Roeck, Werner W., Tehranzadeh, Jamshid, Stanhope, Kimber L., Zimin, Pavel, Havel, Peter J., Griffey, Stephen, Knaus, Hans-Guenther, Nepom, Gerald T., Gutman, George A., Calabresi, Peter A., Chandy, K. George

Source: Proceedings of the National Academy of Sciences of the United States of America, 2006 Nov . 103(46), 17414-17419.

Access URL: https://www.jstor.org/stable/30052446

Interaction of the Inhibitory Peptides ShK and HmK with the Voltage-Gated Potassium Channel KV1.3: Role of Conformational Dynamics.

Authors: Sanches, Karoline, Prypoten, Viktor, Chandy, K. George, Chalmers, David K., Norton, Raymond S.

Source: Journal of Chemical Information & Modeling; 5/22/2023, Vol. 63 Issue 10, p3043-3053, 11p