DCZ0415, a small‐molecule inhibitor targeting TRIP13, inhibits EMT and metastasis via inactivation of the FGFR4/STAT3 axis and the Wnt/β‐catenin pathway in colorectal cancer

Authors: Agarwal, Sumit, Afaq, Farrukh, Bajpai, Prachi, Kim, Hyung‐Gyoon, Elkholy, Amr, Behring, Michael, Chandrashekar, Darshan Shimoga, Diffalha, Sameer Al, Khushman, Moh'd, Sugandha, Shajan P., Varambally, Sooryanarayana, Manne, Upender

Source: Molecular oncology. 16(8):1728-1745

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154995161.0x000001&indx=1&recIds=ETOCvdc_100154995161.0x000001

UALCAN: An update to the integrated cancer data analysis platform

Authors: Chandrashekar, Darshan Shimoga, Karthikeyan, Santhosh Kumar, Korla, Praveen Kumar, Patel, Henalben, Shovon, Ahmedur Rahman, Athar, Mohammad, Netto, George J., Qin, Zhaohui S., Kumar, Sidharth, Manne, Upender, Creighton, Chad J., Varambally, Sooryanarayana

Source: In Neoplasia March 2022 25:18-27

Collagen modifying enzyme P4HA1 is overexpressed and plays a role in lung adenocarcinoma

Authors: Robinson, Alyncia D., Chakravarthi, Balabhadrapatruni V.S.K., Agarwal, Sumit, Chandrashekar, Darshan Shimoga, Davenport, Mackenzie L., Chen, Guoan, Manne, Upender, Beer, David G., Edmonds, Mick D., Varambally, Sooryanarayana

Source: In Translational Oncology August 2021 14(8)

Comparative analysis of triple-negative breast cancer transcriptomics of Kenyan, African American and Caucasian Women

Authors: Saleh, Mansoor, Chandrashekar, Darshan Shimoga, Shahin, Sayed, Agarwal, Sumit, Kim, Hyung-Gyoon, Behring, Michael, Shaikh, Asim Jamal, Moloo, Zahir, Eltoum, Isam-Eldin A, Yates, Clayton, Varambally, Sooryanarayana, Manne, Upender

Source: In Translational Oncology July 2021 14(7)

Dysregulated miRNA Expression and Androgen Receptor Loss in Racially Distinct Triple-Negative Breast Cancer.

Authors: Bhattarai, Shristi, Sugita, Bruna M., Nunes-Souza, Emanuelle, Fonseca, Aline S., Chandrashekar, Darshan Shimoga, Bhargava, Mahak, Cavalli, Luciane R., Aneja, Ritu

Source: International Journal of Molecular Sciences; Dec2024, Vol. 25 Issue 24, p13679, 20p

Subject Terms: GENE expression, ANDROGEN receptors, TRIPLE-negative breast cancer, BREAST cancer, OVERALL survival

Expression and Role of Methylenetetrahydrofolate Dehydrogenase 1 Like (MTHFD1L) in Bladder Cancer

Authors: Eich, Marie-Lisa, Rodriguez Pena, Maria Del Carmen, Chandrashekar, Darshan Shimoga, Chaux, Alcides, Agarwal, Sumit, Gordetsky, Jennifer B., Ferguson, James E., Sonpavde, Guru P., Netto, George J., Varambally, Sooryanarayana

Source: In Translational Oncology November 2019 12(11):1416-1424

Pseudogene Associated Recurrent Gene Fusion in Prostate Cancer

Authors: Chakravarthi, Balabhadrapatruni VSK ^*, Dedigama-Arachchige, Pavithra, Carskadon, Shannon, Sundaram, Shanker Kalyana, Li, Jia, Wu, Kuan-Han Hank, Chandrashekar, Darshan Shimoga ^*, Peabody, James O, Stricker, Hans, Hwang, Clara ^**, Chitale, Dhananjay A, Williamson, Sean R, Gupta, Nilesh S, Navone, Nora M, Rogers, Craig, Menon, Mani, Varambally, Sooryanarayana ^*, Palanisamy, Nallasivam ^*

Source: In Neoplasia October 2019 21(10):989-1002

MicroRNA‐mediated inflammation and coagulation effects in rats exposed to an inhaled analog of sulfur mustard

Authors: Rana, Tapasi, Ahmad, Aamir, Zafar, Iram, Mariappan, Nithya, Chandrashekar, Darshan Shimoga, Hamid, Tariq, Husain, Maroof, Varambally, Sooryanarayana, Ahmad, Shama, Ahmad, Aftab

Source: Annals of the New York Academy of Sciences. 1479(1):148-158

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100111908266.0x000001&indx=1&recIds=ETOCvdc_100111908266.0x000001

Characterization of glycine‐N‐acyltransferase like 1 (GLYATL1) in prostate cancer

Authors: Eich, Marie‐Lisa, Chandrashekar, Darshan Shimoga, Rodriguez Pen᷉a, Maria Del Carmen, Robinson, Alyncia D., Siddiqui, Javed, Daignault‐Newton, Stephanie, Chakravarthi, Balabhadrapatruni V. S. K., Kunju, Lakshmi Priya, Netto, George J., Varambally, Sooryanarayana

Source: Prostate. 79(14):1629-1639

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087709036.0x000001&indx=1&recIds=ETOCvdc_100087709036.0x000001

A novel role for KIFC1-MYH9 interaction in triple-negative breast cancer aggressiveness and racial disparity.

Authors: Garlapati, Chakravarthy, Joshi, Shriya, Yang, Chunhua, Chandrashekar, Darshan Shimoga, Rida, Padmashree, Aneja, Ritu

Source: Cell Communication & Signaling; 6/6/2024, Vol. 22 Issue 1, p1-17, 17p

Molecular pathology as basis for timely cancer diagnosis and therapy.

Authors: Mackinnon Jr, A. Craig, Chandrashekar, Darshan Shimoga, Suster, David I.

Source: Virchows Archiv: European Journal of Pathology; Feb2024, Vol. 484 Issue 2, p155-168, 14p

Spatial Transcriptomics Resolve an Emphysema-Specific Lymphoid Follicle B Cell Signature in Chronic Obstructive Pulmonary Disease.

Authors: Rojas-Quintero, Joselyn, Ochsner, Scott A., New, Felicia, Divakar, Prajan, Chen Xi Yang, Wu, Tianshi David, Robinson, Jerid, Chandrashekar, Darshan Shimoga, Banovich, Nicholas E., Rosas, Ivan O., Sauler, Maor, Kheradmand, Farrah, Gaggar, Amit, Margaroli, Camilla, Estepar, Raul San Jose, McKenna, Neil J., Polverino, Francesca

Source: American Journal of Respiratory & Critical Care Medicine; 1/1/2024, Vol. 209 Issue 1, p48-58, 30p

Subject Terms: CHRONIC obstructive pulmonary disease, B cells, TRANSCRIPTOMES, GENE regulatory networks, GENE expression

Fermentable fiber-induced hepatocellular carcinoma in mice recapitulates gene signatures found in human liver cancer.

Authors: Chandrashekar, Darshan Shimoga¹ (AUTHOR), Golonka, Rachel M.² (AUTHOR), Yeoh, Beng San² (AUTHOR), Gonzalez, David J.³ (AUTHOR), Heikenwälder, Mathias⁴ (AUTHOR), Gerwirtz, Andrew T.⁵ (AUTHOR), Varambally, Sooryanarayana^1,6 (AUTHOR) MatamVijay.Kumar@UToledo.edu, Vijay-Kumar, Matam^2,7 (AUTHOR) MatamVijay.Kumar@UToledo.edu

Source: PLoS ONE. 6/19/2020, Vol. 15 Issue 6, p1-18. 18p.

Subject Terms: *LIVER cancer, *HEPATOCELLULAR carcinoma, *CELL adhesion molecules, *PROTEOLYSIS, *FOCAL adhesions

RNA splicing: a dual-edged sword for hepatocellular carcinoma.

Authors: Kashyap, Anjali, Tripathi, Greesham, Tripathi, Avantika, Rao, Rashmi, Kashyap, Manju, Bhat, Anjali, Kumar, Deepak, Rajhans, Anjali, Kumar, Pravindra, Chandrashekar, Darshan Shimoga, Mahmood, Riaz, Husain, Amjad, Zayed, Hatem, Bharti, Alok Chandra, Kashyap, Manoj Kumar

Source: Medical Oncology; 9/1/2022, Vol. 39 Issue 11, p1-31, 31p

GREAM: A Web Server to Short-List Potentially Important Genomic Repeat Elements Based on Over-/Under-Representation in Specific Chromosomal Locations, Such as the Gene Neighborhoods, within or across 17 Mammalian Species.

Authors: Chandrashekar, Darshan Shimoga^1,2, Dey, Poulami^1,2, Acharya, Kshitish K.^1,3 kshitish@ibab.ac.in

Source: PLoS ONE. 7/24/2015, Vol. 10 Issue 7, p1-17. 17p.

Subject Terms: *MAMMAL genomes, *NUCLEOTIDE sequence, *GENETIC transcription regulation, *DNA methylation, *RETROTRANSPOSONS, *GENE expression

Subcellular localization of EZH2 phosphorylated at T367 stratifies metaplastic breast carcinoma subtypes.

Authors: McMullen, Emily R., Skala, Stephanie L., Gonzalez, Maria E., Djomehri, Sabra, Chandrashekar, Darshan Shimoga, Varambally, Sooryanarayana, Kleer, Celina G.

Source: Breast Cancer (13406868); Mar2021, Vol. 28 Issue 2, p496-505, 10p

Fermentable fibers induce rapid macro- and micronutrient depletion in Toll-like receptor 5-deficient mice.

Authors: Golonka, Rachel M., Beng San Yeoh, Yaqi Li, Piu Saha, Abokor, Ahmed A., Xi Cheng, Xia Xiao, Chandrashekar, Darshan Shimoga, Varambally, Sooryanarayana, Gonzalez, David J., Ross, A. Catharine, Vijay-Kumar, Matam

Source: American Journal of Physiology: Gastrointestinal & Liver Physiology; May2020, Vol. 318 Issue 5, pG955-G965, 11p, 6 Graphs

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