The Antioxidant/Nitric Oxide-Quenching Agent Cobinamide Prevents Aortic Disease in a Mouse Model of Marfan Syndrome

Authors: Kalyanaraman, Hema, Casteel, Darren E., Cabriales, Justin A., Tat, John, Zhuang, Shunhui, Chan, Adriano, Dretchen, Kenneth L., Boss, Gerry R., Pilz, Renate B.

Source: In JACC: Basic to Translational Science January 2024 9(1):46-62

The vitamin B12 analog cobinamide ameliorates azide toxicity in cells, Drosophila melanogaster, and mice

Authors: Tat, John, Chang, Stephen C., Link, Cole D., Razo-Lopez, Suelen, Ingerto, Michael J., Katebian, Behdod, Chan, Adriano, Kalyanaraman, Hema, Pilz, Renate B., Boss, Gerry R.

Source: Clinical toxicology. 61(4):212-222

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182823024.0x000001&indx=1&recIds=ETOCvdc_100182823024.0x000001

Treatment of life-threatening H2S intoxication: Lessons from the trapping agent tetranitrocobinamide

Authors: Haouzi, Philippe, MacCann, Marissa, Brenner, Matthew, Mahon, Sari, Bebarta, Vikhyat S., Chan, Adriano, Judenherc-Haouzi, Annick, Tubbs, Nicole, Boss, Gerry R.

Source: In Environmental Toxicology and Pharmacology November 2022 96

Analysis of bisaminotetrazole cobinamide, a next-generation antidote for cyanide, hydrogen sulfide and methanethiol poisoning, in swine plasma by liquid chromatography-tandem mass spectrometry

Authors: Bhadra, Subrata, Chan, Adriano, Hendry-Hofer, Tara B., Boss, Gerry R., Bebarta, Vikhyat S., Logue, Brian A.

Source: In Journal of Chromatography B 1 October 2022 1208

Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures

Authors: Behymer, Matthew M., Mo, Huaping, Fujii, Naoaki, Suresh, Vallabh, Chan, Adriano, Lee, Jangweon, Nath, Anjali K., Saha, Kusumika, Mahon, Sari B., Brenner, Matthew

Source: Chemical research in toxicology. 35(11):1983-1996

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631525660&indx=1&recIds=ETOCRN631525660

Development of sodium tetrathionate as a cyanide and methanethiol antidote

Authors: Chan, Adriano, Lee, Jangwoen, Bhadra, Subrata, Bortey-Sam, Nesta, Hendry-Hofer, Tara B., Bebarta, Vikhyat S., Mahon, Sari B., Brenner, Matthew, Logue, Brian, Pilz, Renate B., Boss, Gerry R.

Source: Clinical toxicology. 60(3):332-341

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139860961.0x000001&indx=1&recIds=ETOCvdc_100139860961.0x000001

Methyl mercaptan gas: mechanisms of toxicity and demonstration of the effectiveness of cobinamide as an antidote in mice and rabbits

Authors: Philipopoulos, George P., Tat, John, Chan, Adriano, Jiang, Jingjing, Mukai, David, Burney, Tanya, Doosty, Melody, Mahon, Sari, Patel, Hemal H., White, Carl W., Brenner, Matthew, Lee, Jangwoen, Boss, Gerry R.

Source: Clinical toxicology. 60(5):615-622

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144749948.0x000001&indx=1&recIds=ETOCvdc_100144749948.0x000001

Intramuscular cobinamide as an antidote to methyl mercaptan poisoning

Authors: Hendry-Hofer, Tara B., Ng, Patrick C., McGrath, Alison M., Soules, Kirsten, Mukai, David S., Chan, Adriano, Maddry, Joseph K., White, Carl W., Lee, Jangwoen, Mahon, Sari B., Brenner, Matthew, Boss, Gerry R., Bebarta, Vikhyat S.

Source: Inhalation toxicology. 33(1):25-32

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116381745.0x000001&indx=1&recIds=ETOCvdc_100116381745.0x000001

Antidotal efficacies of the cyanide antidote candidate dimethyl trisulfide alone and in combination with cobinamide derivatives

Authors: Petrikovics, Ilona, Kiss, Lóránd, Chou, Ching-En, Ebrahimpour, Afshin, Kovács, Kristóf, Kiss, Márton, Logue, Brian, Chan, Adriano, Manage, Ananda B. W., Budai, Marianna, Boss, Gerry R., Rockwood, Gary A.

Source: Toxicology mechanisms and methods. 29(6):438-444

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100084298267.0x000001&indx=1&recIds=ETOCvdc_100084298267.0x000001

Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection

Authors: Bebarta, Vikhyat S., Brittain, Matthew, Chan, Adriano, Garrett, Norma, Yoon, David, Burney, Tanya, Mukai, David, Babin, Michael, Pilz, Renate B., Mahon, Sari B., Brenner, Matthew, Boss, Gerry R.

Source: In Annals of Emergency Medicine June 2017 69(6):718-725

Designed 2D protein crystals as dynamic molecular gatekeepers for a solid-state device.

Authors: Vijayakumar, Sanahan, Alberstein, Robert G., Zhang, Zhiyin, Lu, Yi-Sheng, Chan, Adriano, Wahl, Charlotte E., Ha, James S., Hunka, Deborah E., Boss, Gerry R., Sailor, Michael J., Tezcan, F. Akif

Source: Nature Communications; 7/27/2024, Vol. 15 Issue 1, p1-13, 13p

Subject Terms: MOLECULAR crystals, CRYSTALLOIDS (Botany), PROTEIN engineering, SILICON crystals, SYNTHETIC proteins, FALSE positive error

Investigating the replacement of carboxylates with carboxamides to modulate the safety and efficacy of platinum(II) thioether cyanide scavengers.

Authors: Behymer, Matthew M, Mo, Huaping, Fujii, Naoaki, Suresh, Vallabh, Arzumanian, Ari S, Chan, Adriano, Nath, Anjali K, McCain, Robyn, MacRae, Calum A, Peterson, Randall, Boss, Gerry R, Davisson, Vincent Jo, Knipp, Gregory T

Source: Toxicological Sciences; Feb2024, Vol. 197 Issue 2, p197-210, 14p

Subject Terms: CYANIDES, CARBOXAMIDES, BODY surface area, PLATINUM, SAFETY factor in engineering, AMIDES, CARBOXYLATES

Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity

Authors: Wahwah, Nisreen, Dhar, Debanjan, Chen, Hui, Zhuang, Shunhui, Chan, Adriano, Casteel, Darren E., Kalyanaraman, Hema, Pilz, Renate B., Boss, Gerry R.

Source: Scientific reports. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187024005.0x000001&indx=1&recIds=ETOCvdc_100187024005.0x000001

Cyanide Produced by Human Isolates of Pseudomonas aeruginosa Contributes to Lethality in Drosophila melanogaster

Authors: Broderick, Kate E., Chan, Adriano, Balasubramanian, Maheswari, Feala, Jake, Reed, Sharon L., Panda, Markandeswar, Sharma, Vijay S., Pilz, Renate B., Bigby, Timothy D., Boss, Gerry R.

Source: The Journal of Infectious Diseases, 2008 Feb 01. 197(3), 457-464.

Access URL: https://www.jstor.org/stable/30087712

The vitamin B12 analog cobinamide ameliorates azide toxicity in cells, Drosophila melanogaster, and mice.

Authors: Tat, John, Chang, Stephen C., Link, Cole D., Razo-Lopez, Suelen, Ingerto, Michael J., Katebian, Behdod, Chan, Adriano, Kalyanaraman, Hema, Pilz, Renate B., Boss, Gerry R.

Source: Clinical Toxicology (15563650); Apr2023, Vol. 61 Issue 4, p212-222, 11p

Subject Terms: DROSOPHILA melanogaster, BODY temperature, CYTOCHROME oxidase, BLOOD pressure, ADENOSINE triphosphate, WEAPONS of mass destruction, NITRIC oxide, CYTOCHROME c

INTRATRACHEAL SALINE BOLUS INCREASES SURVIVABILITY IN RABBITS EXPOSED TO LETHAL DOSE OF INHALED HYDROGEN SULFIDE

Authors: Doosty, Melina, Philipopoulos, George, Lee, Jangwoen, Mukai, David, Burney, Tanya, Bebarta, Vikhyat, Hendry-Hofer, Tara, Mahon, Sari, Chan, Adriano, Haouzi, Philippe, Boss, Gerry, Brenner, Matthew

Source: Chest. 158(S):A1864-A1865

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115090729.0x000001&indx=1&recIds=ETOCvdc_100115090729.0x000001

IM COBINAMIDE (A VITAMIN B12 ANALOG) IS EFFECTIVE FOR INCREASING SURVIVABILITY TO INHALED LETHAL DOSE OF METHYL MERCAPTAN IN RABBITS

Authors: Philipopoulos, George, Doosty, Melina, Lee, Jangwoen, Mukai, David, Veress, Livia, White, Carl, Bebarta, Vikhyat, Burney, Tanya, Mahon, Sari, Chan, Adriano, Boss, Gerry, Brenner, Matthew

Source: Chest. 158(S):A1866-A1867

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115090725.0x000001&indx=1&recIds=ETOCvdc_100115090725.0x000001

Cisplatin Analogs Confer Protection against Cyanide Poisoning

Authors: Nath, Anjali K., Shi, Xu, Harrison, Devin L., Morningstar, Jordan E., Mahon, Sari, Chan, Adriano, Sips, Patrick, Lee, Jangwoen, MacRae, Calum A., Boss, Gerry R., Brenner, Matthew, Gerszten, Robert E., Peterson, Randall T.

Source: Cell chemical biology. 24(5):565-575.e4

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100051490545.0x000001&indx=1&recIds=ETOCvdc_100051490545.0x000001

This result is not displayed to guests.
Login for full access.

Glyoxylate protects against cyanide toxicity through metabolic modulation.

Authors: Nielson, Jason R., Nath, Anjali K., Doane, Kim P., Shi, Xu, Lee, Jangwoen, Tippetts, Emily G., Saha, Kusumika, Morningstar, Jordan, Hicks, Kevin G., Chan, Adriano, Zhao, Yanbin, Kelly, Amy, Hendry-Hofer, Tara B., Witeof, Alyssa, Sips, Patrick Y., Mahon, Sari, Bebarta, Vikhyat S., Davisson, Vincent Jo, Boss, Gerry R., Rutter, Jared

Source: Scientific Reports; 3/23/2022, Vol. 12 Issue 1, p1-16, 16p

Subject Terms: CYANIDES, CYTOCHROME oxidase, POISONS, LACTATE dehydrogenase, SMALL molecules, MONOCARBOXYLATE transporters