Enhancing immune response and survival in hepatocellular carcinoma with novel oncolytic Jurona virus and immune checkpoint blockade

Authors: Tesfay, Mulu Z., Zhang, Yuguo, Ferdous, Khandoker U., Taylor, Mika A., Cios, Aleksandra, Shelton, Randal S., Simoes, Camila C., Watters, Chelsae R., Barro, Oumar, Elliott, Natalie M., Mustafa, Bahaa, Chamcheu, Jean Christopher, Graham, Alicia L., Washam, Charity L., Alkam, Duah, Gies, Allen, Byrum, Stephanie D., Giorgakis, Emmanouil, Post, Steven R., Kelly, Thomas, Ying, Jun, Moaven, Omeed, Chabu, Chiswili Y., Fernandez-Zapico, Martin E., Duda, Dan G., Roberts, Lewis R., Govindarajan, Rang, Borad, Mitesh J., Cannon, Martin J., Basnakian, Alexei G., Nagalo, Bolni M.

Source: In Molecular Therapy: Oncology 19 December 2024 32(4)

PI3K/AKT/mTOR Signaling Network in Human Health and Diseases.

Authors: Omolekan, Tolulope O.^1,2,3 (AUTHOR) tolulope.omolekan@bowen.edu.ng, Chamcheu, Jean Christopher^1,2,4 (AUTHOR) jchamcheu@lsu.edu, Buerger, Claudia⁵ (AUTHOR) jchamcheu@lsu.edu, Huang, Shile^6,7,8 (AUTHOR) jchamcheu@lsu.edu

Source: Cells (2073-4409). Sep2024, Vol. 13 Issue 17, p1500. 8p.

Subject Terms: *SCIENTIFIC literature, *PLATELET-derived growth factor receptors, *GENE expression, *TRANSCRIPTION factors, *PROTEIN kinase B, *DNA repair, *EXTRACELLULAR signal-regulated kinases, KERATINOCYTE differentiation

Characterization of Morreton virus as an oncolytic virotherapy platform for liver cancers

Authors: Nagalo, Bolni Marius, Zhou, Yumei, Loeuillard, Emilien J., Dumbauld, Chelsae, Barro, Oumar, Elliott, Natalie M., Baker, Alexander T., Arora, Mansi, Bogenberger, James M., Meurice, Nathalie, Petit, Joachim, Uson, Pedro Luiz Serrano, Aslam, Faaiq, Raupach, Elizabeth, Gabere, Musa, Basnakian, Alexei, Simoes, Camila C., Cannon, Martin J., Post, Steven R., Buetow, Kenneth, Chamcheu, Jean Christopher, Barrett, Michael T., Duda, Dan G., Jacobs, Bertram, Vile, Richard, Barry, Michael A., Roberts, Lewis R., Ilyas, Sumera, Borad, Mitesh J.

Source: Hepatology. 77(6):1943-1957

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191135458.0x000001&indx=1&recIds=ETOCvdc_100191135458.0x000001

Synthesis, inverse docking-assisted identification and in vitro biological characterization of Flavonol-based analogs of fisetin as c-Kit, CDK2 and mTOR inhibitors against melanoma and non-melanoma skin cancers

Authors: Roy, Tithi, Boateng, Samuel T., Banang-Mbeumi, Sergette, Singh, Pankaj K., Basnet, Pratik, Chamcheu, Roxane-Cherille N., Ladu, Federico, Chauvin, Isabel, Spiegelman, Vladimir S., Hill, Ronald A., Kousoulas, Konstantin G., Nagalo, Bolni Marius, Walker, Anthony L., Fotie, Jean, Murru, Siva, Sechi, Mario, Chamcheu, Jean Christopher

Source: In Bioorganic Chemistry February 2021 107

Bioactive Natural and Synthetic Products in Human Health and Diseases: Basic, Preclinical and Clinical Studies.

Authors: Noubissi, Felicite K., Omolekan, Tolulope O., Walker, Anthony L., Chamcheu, Jean Christopher

Source: Nutrients; Oct2024, Vol. 16 Issue 19, p3265, 9p

Gb3‐cSrc complex in glycosphingolipid‐enriched microdomains contributes to the expression of p53 mutant protein and cancer drug resistance via β‐catenin–activated RNA methylation

Authors: Roy, Kartik R., Uddin, Mohammad B., Roy, Sagor C., Hill, Ronald A., Marshall, John, Li, Yu‐Teh, Chamcheu, Jean Christopher, Lu, Hua, Liu, Yong‐Yu

Source: FASEB bioAdvances. 2(11):653-667

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100109316797.0x000001&indx=1&recIds=ETOCvdc_100109316797.0x000001

Enhancing Neoadjuvant Virotherapy's Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer.

Authors: Ferdous, Khandoker Usran, Tesfay, Mulu Z., Cios, Aleksandra, Shelton, Randal S., Hartupee, Conner, Urbaniak, Alicja, Chamcheu, Jean Christopher, Mavros, Michail N., Giorgakis, Emmanouil, Mustafa, Bahaa, Simoes, Camila C., Miousse, Isabelle R., Basnakian, Alexei G., Moaven, Omeed, Post, Steven R., Cannon, Martin J., Kelly, Thomas, Nagalo, Bolni Marius

Source: Biomedicines; Jul2024, Vol. 13 Issue 7, p1596, 19p

Subject Terms: ONCOLYTIC virotherapy, PROTEOLYTIC enzymes, PANCREATIC duct, SURGICAL margin, SURGICAL excision

Bipiperidinyl Derivatives of Cannabidiol Enhance Its Antiproliferative Effects in Melanoma Cells.

Authors: Lyu, Peihong, Li, Huifang, Wan, Junzhao, Chen, Ying, Zhang, Zhen, Wu, Panpan, Wan, Yinsheng, Seeram, Navindra P., Chamcheu, Jean Christopher, Liu, Chang, Ma, Hang

Source: Antioxidants; Apr2024, Vol. 13 Issue 4, p478, 15p

Subject Terms: CANNABINOID receptors, CANNABIDIOL, MELANOMA, CANNABINOIDS, CYTOTOXINS, LACTATE dehydrogenase

Multifaceted approach toward mapping out the anticancer properties of small molecules via in vitro evaluation on melanoma and nonmelanoma skin cancer cells, and in silico target fishing.

Authors: Boateng, Samuel T., Roy, Tithi, Agbo, Mercy E., Mahmud, Md Ashiq, Banang‐Mbeumi, Sergette, Chamcheu, Roxane‐Cherille N., Yadav, Rajesh K., Bramwell, Marion, Pham, Long K., Dang, Danny D., Jackson, Keith E., Nagalo, Bolni Marius, Hill, Ronald A., Efimova, Tatiana, Fotie, Jean, Chamcheu, Jean Christopher

Source: Chemical Biology & Drug Design; Jan2024, Vol. 103 Issue 1, p1-29, 29p

Subject Terms: SKIN cancer, SMALL molecules, CANCER cells, MELANOMA, WESTERN immunoblotting

Identification of new fisetin analogs as kinase inhibitors: Data on synthesis and anti-skin cancer activities evaluation

Authors: Roy, Tithi, Boateng, Samuel T., Banang-Mbeumi, Sergette, Singh, Pankaj K., Basnet, Pratik, Chamcheu, Roxane-Cherille N., Ladu, Federico, Chauvin, Isabel, Spiegelman, Vladimir S., Hill, Ronald A., Kousoulas, Konstantin G., Nagalo, Bolni Marius, Walker, Anthony L., Fotie, Jean, Murru, Siva, Sechi, Mario, Chamcheu, Jean Christopher

Source: Data in brief. 35

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134404705.0x000001&indx=1&recIds=ETOCvdc_100134404705.0x000001

Involvement of ER stress and activation of apoptotic pathways in fisetin induced cytotoxicity in human melanoma

Authors: Syed, Deeba N., Lall, Rahul K., Chamcheu, Jean Christopher, Haidar, Omar, Mukhtar, Hasan

Source: In Archives of Biochemistry and Biophysics 1 December 2014 563:108-117

Excellent anti-proliferative and pro-apoptotic effects of (−)-epigallocatechin-3-gallate encapsulated in chitosan nanoparticles on human melanoma cell growth both in vitro and in vivo

Authors: Siddiqui, Imtiaz A., Bharali, Dhruba J., Nihal, Minakshi, Adhami, Vaqar M., Khan, Naghma, Chamcheu, Jean Christopher, Khan, Mohammad Imran, Shabana, Sameh, Mousa, Shaker A., Mukhtar, Hasan

Source: In Nanomedicine: Nanotechnology, Biology, and Medicine November 2014 10(8):1619-1626

Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: Findings from 3-D melanoma skin equivalents and computational modeling

Authors: Syed, Deeba N., Chamcheu, Jean-Christopher, Khan, Mohammad Imran, Sechi, Mario, Lall, Rahul K., Adhami, Vaqar M., Mukhtar, Hasan

Source: In Biochemical Pharmacology 1 June 2014 89(3):349-360

α-Glucosidase inhibition by green, white and oolong teas: in vitro activity and computational studies.

Authors: Esposito, Fabio, Pala, Nicolino, Carcelli, Mauro, Boateng, Samuel T., D'Aquila, Paolo S., Mariani, Alberto, Satta, Sandro, Chamcheu, Jean Christopher, Sechi, Mario, Sanna, Vanna

Source: Journal of Enzyme Inhibition & Medicinal Chemistry; Dec2023, Vol. 38 Issue 1, p1-10, 10p

Subject Terms: GREEN tea, TEA, CATECHIN, ACARBOSE

Company/Entity: UNITED States. Food & Drug Administration

Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents.

Authors: Boateng, Samuel T., Roy, Tithi, Torrey, Kara, Owunna, Uchechi, Banang-Mbeumi, Sergette, Basnet, David, Niedda, Eleonora, Alexander, Alexis D., Hage, Denzel El, Atchimnaidu, Siriki, Nagalo, Bolni Marius, Aryal, Dinesh, Findley, Ann, Seeram, Navindra P., Efimova, Tatiana, Sechi, Mario, Hill, Ronald A., Ma, Hang, Chamcheu, Jean Christopher, Murru, Siva

Source: Journal of Enzyme Inhibition & Medicinal Chemistry; Dec2023, Vol. 38 Issue 1, p1-27, 27p

Subject Terms: BIOCHEMISTRY, PYRAZOLE derivatives, MOLECULAR docking, NUCLEAR magnetic resonance, ANTIOXIDANTS, MELANINS

Pomegranate Extracts and Cancer Prevention: Molecular and Cellular Activities

Authors: Syed, Deeba N., Chamcheu, Jean-Christopher, Adhami, Vaqar M., Mukhtar, Hasan

Source: Anti-cancer agents in medicinal chemistry. 13(8):1149-1161

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCETOCvdc_100027187202.0x000001&indx=1&recIds=ETOCETOCvdc_100027187202.0x000001

Chemical Chaperones Protect Epidermolysis Bullosa Simplex Keratinocytes from Heat Stress–Induced Keratin Aggregation: Involvement of Heat Shock Proteins and MAP Kinases

Authors: Chamcheu, Jean Christopher, Navsaria, Harshad, Pihl-Lundin, Inger, Liovic, Mirjana, Vahlquist, Anders, Törmä, Hans ^*

Source: In Journal of Investigative Dermatology August 2011 131(8):1684-1691

Keratin gene mutations in disorders of human skin and its appendages

Authors: Chamcheu, Jean Christopher, Siddiqui, Imtiaz A., Syed, Deeba N., Adhami, Vaqar M., Liovic, Mirjana, Mukhtar, Hasan

Source: In Archives of Biochemistry and Biophysics 2011 508(2):123-137

The PI3K-Akt-mTOR and Associated Signaling Pathways as Molecular Drivers of Immune-Mediated Inflammatory Skin Diseases: Update on Therapeutic Strategy Using Natural and Synthetic Compounds.

Authors: Roy, Tithi, Boateng, Samuel T., Uddin, Mohammad B., Banang-Mbeumi, Sergette, Yadav, Rajesh K., Bock, Chelsea R., Folahan, Joy T., Siwe-Noundou, Xavier, Walker, Anthony L., King, Judy A., Buerger, Claudia, Huang, Shile, Chamcheu, Jean Christopher

Source: Cells (2073-4409); Jun2023, Vol. 12 Issue 12, p1671, 66p

Subject Terms: SKIN diseases, CELLULAR signal transduction, THERAPEUTICS, NATURAL products, ATOPIC dermatitis, FILAGGRIN, COMPREHENSION in children

The Genus Dacryodes Vahl.: Ethnobotany, Phytochemistry and Biological Activities.

Authors: Swana, Leseho, Tsakem, Bienvenu, Tembu, Jacqueline V., Teponno, Rémy B., Folahan, Joy T., Kalinski, Jarmo-Charles, Polyzois, Alexandros, Kamatou, Guy, Sandjo, Louis P., Chamcheu, Jean Christopher, Siwe-Noundou, Xavier

Source: Pharmaceuticals (14248247); May2023, Vol. 16 Issue 5, p775, 20p

Subject Terms: ETHNOBOTANY, BOTANICAL chemistry, SCIENTIFIC knowledge, METABOLITES, SCIENCE databases, NEUROLOGICAL disorders