Replicating Dynamic Immune Responses at Single‐Cell Resolution within a Microfluidic Human Skin Equivalent.

Authors: Hindle, Sarah A.¹, Bachas Brook, Holly^1,2, Chrysanthou, Alexandra¹, Chambers, Emma S.³, Caley, Matthew P.¹, Connelly, John T.¹, j.connelly@qmul.ac.uk

Source: Advanced Science; 3/13/2025, Vol. 12 Issue 10, p1-14, 14p

The impact of ageing on monocytes and macrophages

Authors: De Maeyer, Roel P.H., Chambers, Emma S. ^*

Source: In Immunology Letters February 2021 230:1-10

Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging

Authors: Chambers, Emma S., Vukmanovic-Stejic, Milica, Shih, Barbara B., Trahair, Hugh, Subramanian, Priya, Devine, Oliver P., Glanville, James, Gilroy, Derek, Rustin, Malcolm H. A., Freeman, Tom C., Mabbott, Neil A., Akbar, Arne N.

Source: Nature aging. 1(1):101-113

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191451133.0x000001&indx=1&recIds=ETOCvdc_100191451133.0x000001

Can blocking inflammation enhance immunity during aging?

Authors: Chambers, Emma S., Akbar, Arne N.

Source: In The Journal of Allergy and Clinical Immunology May 2020 145(5):1323-1331

Skin barrier immunity and ageing

Authors: Chambers, Emma S., Vukmanovic‐Stejic, Milica

Source: Immunology. 160(2):116-125

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107546077.0x000001&indx=1&recIds=ETOCvdc_100107546077.0x000001

Immunogenicity of biologics used in the treatment of asthma.

Authors: Neunie, Omario A.M., Rabbani, Wardah, Baker, David, Chambers, Emma S., Pfeffer, Paul E., Kang, Angray S.

Source: Human Antibodies; 2024, Vol. 32 Issue 3, p121-128, 8p

Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen–Specific Challenge

Authors: Patel, Neil P., Vukmanovic-Stejic, Milica, Suarez-Farinas, Mayte, Chambers, Emma S., Sandhu, Daisy, Fuentes-Duculan, Judilyn, Mabbott, Neil A., Rustin, Malcolm H.A., Krueger, James, Akbar, Arne N.

Source: The Journal of Infectious Diseases, 2018 Nov 01. 218, S88-S98.

Access URL: https://www.jstor.org/stable/26508538

Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation

Authors: Vukmanovic-Stejic, Milica, Chambers, Emma S. ^∗, Suárez-Fariñas, Mayte ^∗, Sandhu, Daisy, Fuentes-Duculan, Judilyn, Patel, Neil, Agius, Elaine, Lacy, Katie E., Turner, Carolin T., Larbi, Anis, Birault, Veronique, Noursadeghi, Mahdad, Mabbott, Neil A., Rustin, Malcolm H.A., Krueger, James G., Akbar, Arne N.

Source: In The Journal of Allergy and Clinical Immunology September 2018 142(3):844-856

Influence of individuals' determinants including vaccine type on cellular and humoral responses to SARS-CoV-2 vaccination.

Authors: Chambers, Emma S., Cai, Weigang, Vivaldi, Giulia, Jolliffe, David A., Perdek, Natalia, Li, Wenhao, Faustini, Sian E., Gibbons, Joseph M., Pade, Corinna, Richter, Alex G., Coussens, Anna K., Martineau, Adrian R.

Source: NPJ Vaccines; 5/22/2024, Vol. 9 Issue 1, p1-9, 9p

Subject Terms: HUMORAL immunity, BODY mass index, VACCINE immunogenicity, T cells, VACCINATION, SARS-CoV-2, VACCINE effectiveness

Geographic Terms: UNITED Kingdom

Company/Entity: UNIVERSITY of Oxford, ASTRAZENECA PLC

Vitamin D3 inhibits p38 MAPK and senescence‐associated inflammatory mediator secretion by senescent fibroblasts that impacts immune responses during ageing.

Authors: Sayegh, Souraya, Fantecelle, Carlos Henrique, Laphanuwat, Phatthamon, Subramanian, Priya, Rustin, Malcom H. A., Gomes, Daniel C. O., Akbar, Arne N., Chambers, Emma S.

Source: Aging Cell; Apr2024, Vol. 23 Issue 4, p1-7, 7p

Subject Terms: INFLAMMATORY mediators, CHOLECALCIFEROL, MITOGEN-activated protein kinases, IMMUNOSENESCENCE, IMMUNE response, DIETARY supplements, SKIN aging

Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol

Authors: Chambers, Emma S., Nanzer, Alexandra M., Pfeffer, Paul E., Richards, David F., Timms, Peter M., Martineau, Adrian R., Griffiths, Christopher J., Corrigan, Christopher J., Hawrylowicz, Catherine M.

Source: In The Journal of Allergy and Clinical Immunology September 2015 136(3):628-637

Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion

Authors: Nanzer, Alexandra M., Chambers, Emma S., Ryanna, Kimuli, Richards, David F., Black, Cheryl, Timms, Peter M., Martineau, Adrian R., Griffiths, Christopher J., Corrigan, Christopher J., Hawrylowicz, Catherine M.

Source: In The Journal of Allergy and Clinical Immunology August 2013 132(2):297-304

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

Authors: Pereira, Branca I., Devine, Oliver P., Vukmanovic-Stejic, Milica, Chambers, Emma S., Subramanian, Priya, Patel, Neil, Virasami, Alex, Sebire, Neil J., Kinsler, Veronica, Valdovinos, Alexis, LeSaux, Claude Jourdan, Passos, João F., Antoniou, Antony, Rustin, Malcom H. A., Campisi, Judith, Akbar, Arne N.

Source: Nature communications. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130639461.0x000001&indx=1&recIds=ETOCvdc_100130639461.0x000001

Reply

Authors: Chambers, Emma S., Akbar, Arne N.

Source: Journal of allergy and clinical immunology. 146(4):922-923

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100117029711.0x000001&indx=1&recIds=ETOCvdc_100117029711.0x000001

Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study.

Authors: Vivaldi, Giulia, Jolliffe, David A, Faustini, Sian, Shields, Adrian M, Holt, Hayley, Perdek, Natalia, Talaei, Mohammad, Tydeman, Florence, Chambers, Emma S, Cai, Weigang, Li, Wenhao, Gibbons, Joseph M, Pade, Corinna, McKnight, Áine, Shaheen, Seif O, Richter, Alex G, Martineau, Adrian R

Source: Journal of Infectious Diseases; 12/1/2022, Vol. 226 Issue 11, p1903-1908, 6p

Subject Terms: COVID-19, SARS-CoV-2, ANTIBODY titer, BREAKTHROUGH infections

Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial.

Authors: Jolliffe, David A., Vivaldi, Giulia, Chambers, Emma S., Cai, Weigang, Li, Wenhao, Faustini, Sian E., Gibbons, Joseph M., Pade, Corinna, Coussens, Anna K., Richter, Alex G., McKnight, Áine, Martineau, Adrian R.

Source: Nutrients; Sep2022, Vol. 14 Issue 18, pN.PAG-N.PAG, 16p

Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes

Authors: Peckham, Hannah, Radziszewska, Anna, Sikora, Justyna, de Gruijter, Nina M., Restuadi, Restuadi, Kartawinata, Melissa, Martin-Gutierrez, Lucia, Robinson, George A., Deakin, Claire T., Wedderburn, Lucy R., Jury, Elizabeth C., Butler, Gary, Chambers, Emma S., Rosser, Elizabeth C., Ciurtin, Coziana

Source: The Journal of Experimental Medicine; April 2025, Vol. 222 Issue: 4 pe20241253-e20241253, 1p

1 α,25-dihydroxyvitamin D3 acts via transforming growth factor- β to up-regulate expression of immunosuppressive CD73 on human CD4⁺ Foxp3^- T cells.

Authors: Mann, Elizabeth H.¹, Chambers, Emma S.¹, Chen, Yin‐Huai¹, Richards, David F.¹, Hawrylowicz, Catherine M.¹

Source: Immunology. Nov2015, Vol. 146 Issue 3, p423-431. 9p.

Subject Terms: *VITAMIN D deficiency, *CHOLECALCIFEROL, *TRANSFORMING growth factors, *IMMUNOSUPPRESSION, *CD4 antigen, *T cells

1 α,25-dihydroxyvitamin D3 in combination with transforming growth factor- β increases the frequency of Foxp3⁺ regulatory T cells through preferential expansion and usage of interleukin-2.

Authors: Chambers, Emma S.¹, Suwannasaen, Duangchan^1,2, Mann, Elizabeth H.¹, Urry, Zoe¹, Richards, David F.¹, Lertmemongkolchai, Ganjana², Hawrylowicz, Catherine M.¹

Source: Immunology. Sep2014, Vol. 143 Issue 1, p52-60. 9p.

Subject Terms: *TRANSFORMING growth factors-beta, *T cells, *INTERLEUKIN-2, *VITAMIN D deficiency, *IMMUNOLOGIC diseases, *CHOLECALCIFEROL, *IMMUNOREGULATION, *IN vitro studies

Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma.

Authors: Mann, Elizabeth H.¹, Chambers, Emma S.¹, Pfeffer, Paul E.¹, Hawrylowicz, Catherine M.¹ catherine.hawrylowicz@kcl.ac.uk

Source: Annals of the New York Academy of Sciences. May2014, Vol. 1317, p57-69. 13p.

Subject Terms: *IMMUNOMODULATORS, *ASTHMA treatment, *VITAMIN D deficiency, *AUTOIMMUNE diseases, *GLUCOCORTICOIDS, *PREVENTION, TREATMENT of respiratory diseases