Temporal phosphoproteomics reveals circuitry of phased propagation in insulin signaling.

Authors: Turewicz, Michael, Skagen, Christine, Hartwig, Sonja, Majda, Stephan, Thedinga, Kristina, Herwig, Ralf, Binsch, Christian, Altenhofen, Delsi, Ouwens, D. Margriet, Förster, Pia Marlene, Wachtmeister, Thorsten, Köhrer, Karl, Stermann, Torben, Chadt, Alexandra, Lehr, Stefan, Marschall, Tobias, Thoresen, G. Hege, Al-Hasani, Hadi

Source: Nature Communications; 2/12/2025, Vol. 16 Issue 1, p1-19, 19p

Subject Terms: ALTERNATIVE RNA splicing, LIFE sciences, INSULIN regulation, SATELLITE cells, CYTOLOGY, INSULIN receptors, RNA splicing

Nudix hydrolase NUDT19 regulates mitochondrial function and ATP production in murine hepatocytes

Authors: Görigk, Sarah, Ouwens, D. Margriet, Kuhn, Tanja, Altenhofen, Delsi, Binsch, Christian, Damen, Mareike, Khuong, Jenny Minh-An, Kaiser, Katharina, Knebel, Birgit, Vogel, Heike, Schürmann, Annette, Chadt, Alexandra, Al-Hasani, Hadi

Source: In BBA - Molecular and Cell Biology of Lipids June 2022 1867(6)

AKT/AMPK-mediated phosphorylation of TBC1D4 disrupts the interaction with insulin-regulated aminopeptidase

Authors: Eickelschulte, Samaneh, Hartwig, Sonja, Leiser, Ben, Lehr, Stefan, Joschko, Viola, Chokkalingam, Manopriya, Chadt, Alexandra, Al-Hasani, Hadi

Source: In Journal of Biological Chemistry January-June 2021 296

Inhibition of proline‐rich tyrosine kinase 2 restores cardioprotection by remote ischaemic preconditioning in type 2 diabetes.

Authors: Erkens, Ralf, Duse, Dragos Andrei, Brum, Amanda, Chadt, Alexandra, Becher, Stefanie, Siragusa, Mauro, Quast, Christine, Müssig, Johanna, Roden, Michael, Cortese‐Krott, Miriam, Ibáñez, Borja, Lammert, Eckhard, Fleming, Ingrid, Jung, Christian, Al‐Hasani, Hadi, Heusch, Gerd, Kelm, Malte

Source: British Journal of Pharmacology; Nov2024, Vol. 181 Issue 21, p4174-4194, 21p

Subject Terms: TYPE 2 diabetes, ISCHEMIC preconditioning, NITRIC-oxide synthases, MYOCARDIAL infarction, PROTEIN-tyrosine kinases

A novel 3D imaging approach for quantification of GLUT4 levels across the intact myocardium.

Authors: Geiser, Angéline, Currie, Susan, Al-Hasani, Hadi, Chadt, Alexandra, McConnell, Gail, Gould, Gwyn W.

Source: Journal of Cell Science; Oct2024, Vol. 137 Issue 20, p1-12, 12p

Subject Terms: HEART septum, MICROSCOPY, THREE-dimensional imaging, OPTICAL images, MYOCARDIUM

Skeletal muscle p53‐depletion uncovers a mechanism of fuel usage suppression that enables efficient energy conservation.

Authors: Lenihan‐Geels, Georgia, Garcia Carrizo, Francisco, Leer, Marina, Gohlke, Sabrina, Oster, Moritz, Pöhle‐Kronawitter, Sophie, Ott, Christiane, Chadt, Alexandra, Reinisch, Isabel N., Galhuber, Markus, Li, Chen, Jonas, Wenke, Jähnert, Markus, Klaus, Susanne, Al‐Hasani, Hadi, Grune, Tilman, Schürmann, Annette, Madl, Tobias, Prokesch, Andreas, Schupp, Michael

Source: Journal of Cachexia, Sarcopenia & Muscle; Oct2024, Vol. 15 Issue 5, p1772-1784, 13p

Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle

Authors: Klymenko, Oleksiy, Brecklinghaus, Tim, Dille, Matthias, Springer, Christian, de Wendt, Christian, Altenhofen, Delsi, Binsch, Christian, Knebel, Birgit, Scheller, Jürgen, Hardt, Christopher, Herwig, Ralf, Chadt, Alexandra, Pfluger, Paul T., Al-Hasani, Hadi, Kabra, Dhiraj G.

Source: In Molecular Metabolism December 2020 42

Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation

Authors: Schwerbel, Kristin, Kamitz, Anne, Krahmer, Natalie, Hallahan, Nicole, Jähnert, Markus, Gottmann, Pascal, Lebek, Sandra, Schallschmidt, Tanja, Arends, Danny, Schumacher, Fabian, Kleuser, Burkhard, Haltenhof, Tom, Heyd, Florian, Gancheva, Sofiya, Broman, Karl W., Roden, Michael, Joost, Hans-Georg, Chadt, Alexandra, Al-Hasani, Hadi, Vogel, Heike, Jonas, Wenke, Schürmann, Annette

Source: In Journal of Hepatology October 2020 73(4):771-782

Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease

Authors: Chadt, Alexandra, Al-Hasani, Hadi

Source: Pflügers Archiv. 472(9):1273-1298

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168028409.0x000001&indx=1&recIds=ETOCvdc_100168028409.0x000001

AKT and AMP-activated protein kinase regulate TBC1D1 through phosphorylation and its interaction with the cytosolic tail of insulin-regulated aminopeptidase IRAP

Authors: Mafakheri, Samaneh, Flörke, Ralf R., Kanngießer, Sibylle, Hartwig, Sonja, Espelage, Lena, De Wendt, Christian, Schönberger, Tina, Hamker, Nele, Lehr, Stefan, Chadt, Alexandra, Al-Hasani, Hadi

Source: In Journal of Biological Chemistry 16 November 2018 293(46):17853-17862

FGF21 regulates insulin sensitivity following long-term chronic stress

Authors: Jelenik, Tomas, Dille, Matthias, Müller-Lühlhoff, Sabrina, Kabra, Dhiraj G., Zhou, Zhou, Binsch, Christian, Hartwig, Sonja, Lehr, Stefan, Chadt, Alexandra, Peters, Eva M.J., Kruse, Johannes, Roden, Michael, Al-Hasani, Hadi, Castañeda, Tamara R.

Source: In Molecular Metabolism October 2018 16:126-138

Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation

Authors: Weimershaus, Mirjana, Mauvais, François-Xavier, Saveanu, Loredana, Adiko, Cézaire, Babdor, Joël, Abramova, Anastasia, Montealegre, Sebastian, Lawand, Myriam, Evnouchidou, Irini, Huber, Katharina Julia, Chadt, Alexandra, Zwick, Markus, Vargas, Pablo, Dussiot, Michael, Lennon-Dumenil, Ana Maria, Brocker, Thomas, Al-Hasani, Hadi, van Endert, Peter

Source: In Cell Reports 25 September 2018 24(13):3568-3581

AMPK and Beyond: The Signaling Network Controlling RabGAPs and Contraction-Mediated Glucose Uptake in Skeletal Muscle.

Authors: Peifer-Weiß, Leon, Al-Hasani, Hadi, Chadt, Alexandra

Source: International Journal of Molecular Sciences; Feb2024, Vol. 25 Issue 3, p1910, 18p

Subject Terms: INSULIN, SKELETAL muscle, AMP-activated protein kinases, GTPASE-activating protein, GLUCOSE, TYPE 2 diabetes

Impact of physical fitness and exercise training on subcutaneous adipose tissue beiging markers in humans with and without diabetes and a high‐fat diet‐fed mouse model.

Authors: Bódis, Kálmán, Breuer, Saida, Crepzia‐Pevzner, Assja, Zaharia, Oana‐Patricia, Schön, Martin, Saatmann, Nina, Altenhofen, Delsi, Springer, Christian, Szendroedi, Julia, Wagner, Robert, Al‐Hasani, Hadi, Roden, Michael, Pesta, Dominik, Chadt, Alexandra

Source: Diabetes, Obesity & Metabolism; Jan2024, Vol. 26 Issue 1, p339-350, 12p

Subject Terms: HIGH-fat diet, EXERCISE therapy, OXYGEN consumption, ADIPOSE tissues, WHITE adipose tissue, TYPE 2 diabetes, PHYSICAL fitness, LABORATORY mice

Re-patterning of Skeletal Muscle Energy Metabolism by Fat Storage-inducing Transmembrane Protein 2

Authors: Miranda, Diego A., Koves, Timothy R., Gross, David A., Chadt, Alexandra, Al-Hasani, Hadi, Cline, Gary W., Schwartz, Gary J. ^**, Muoio, Deborah M., Silver, David L.

Source: In Journal of Biological Chemistry 9 December 2011 286(49):42188-42199

Over-expression of PRAS40 enhances insulin sensitivity in skeletal muscle

Authors: Wiza, Claudia, Chadt, Alexandra, Blumensatt, Marcel, Kanzleiter, Timo, Herzfeld De Wiza, Daniella, Horrighs, Angelika, Mueller, Heidi, Nascimento, Emmani B.M., Schürmann, Annette, Al-Hasani, Hadi, Ouwens, D. Margriet

Source: Archives of physiology and biochemistry. 120(2):64-72

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125407490.0x000001&indx=1&recIds=ETOCvdc_100125407490.0x000001

Overexpressing high levels of human vaspin limits high fat diet-induced obesity and enhances energy expenditure in a transgenic mouse.

Authors: Rapöhn, Inka, Elias, Ivet, Weiner, Juliane, Pujol, Anna, Kehr, Stephanie, Chadt, Alexandra, Al-Hasani, Hadi, Burkhardt, Ralph, Klöting, Nora, Stumvoll, Michael, Bosch, Fatima, Kovacs, Peter, Heiker, John T., Breitfeld, Jana

Source: Frontiers in Endocrinology; 2023, p1-9, 9p

Subject Terms: TRANSGENIC mice, NON-alcoholic fatty liver disease, WEIGHT gain, ADIPOSE tissues, HIGH-fat diet

E96V Mutation in the Kdelr3 Gene Is Associated with Type 2 Diabetes Susceptibility in Obese NZO Mice.

Authors: Altenhofen, Delsi, Khuong, Jenny Minh-An, Kuhn, Tanja, Lebek, Sandra, Görigk, Sarah, Kaiser, Katharina, Binsch, Christian, Griess, Kerstin, Knebel, Birgit, Belgardt, Bengt-Frederik, Cames, Sandra, Eickelschulte, Samaneh, Stermann, Torben, Rasche, Axel, Herwig, Ralf, Weiss, Jürgen, Vogel, Heike, Schürmann, Annette, Chadt, Alexandra, Al-Hasani, Hadi

Source: International Journal of Molecular Sciences; Jan2023, Vol. 24 Issue 1, p845, 18p

Subject Terms: TYPE 2 diabetes, LOCUS (Genetics), GENETIC variation, GENETIC mutation, PANCREATIC beta cells

Geographic Terms: NEW Zealand

Two Novel Candidate Genes for Insulin Secretion Identified by Comparative Genomics of Multiple Backcross Mouse Populations.

Authors: Schallschmidt, Tanja^1,2, Lebek, Sandra^1,2, Altenhofen, Delsi^1,2, Damen, Mareike^1,2, Schulte, Yvonne^1,2, Knebel, Birgit^1,2, Stermann, Torben^1,2, Chadt, Alexandra^1,2, Al-Hasani, Hadi^1,2, Kamitz, Anne^2,3, Hallahan, Nicole^2,3, Jähnert, Markus^2,3, Vogel, Heike^2,3, Schürmann, Annette^2,3, Herwig, Ralf⁴, Rasche, Axel⁴

Source: Genetics; Dec2018, Vol. 210 Issue 4, p1527-1542, 17p

Comparative genomic analyses of multiple backcross mouse populations suggest SGCG as a novel potential obesity-modifier gene.

Authors: Kuhn, Tanja, Kaiser, Katharina, Lebek, Sandra, Altenhofen, Delsi, Knebel, Birgit, Herwig, Ralf, Rasche, Axel, Pelligra, Angela, Görigk, Sarah, Khuong, Jenny Minh-An, Vogel, Heike, Schürmann, Annette, Blüher, Matthias, Chadt, Alexandra, Al-Hasani, Hadi

Source: Human Molecular Genetics; Dec2022, Vol. 31 Issue 23, p4019-4033, 15p