EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function

Authors: Isshiki, Yusuke ¹, Chen, Xi ^{1, 10}, Teater, Matt ^{1, 2, 10}, Karagiannidis, Ioannis ¹, Nam, Henna ¹, Cai, Winson ³, Meydan, Cem ^{2, 4}, Xia, Min ¹, Shen, Hao ¹, Gutierrez, Johana ¹, Easwar Kumar, Vigneshwari ¹, Carrasco, Sebastián E. ^{5, 6}, Ouseph, Madhu M. ⁵, Yamshon, Samuel ¹, Martin, Peter ¹, Griess, Ofir ⁷, Shema, Efrat ⁷, Porazzi, Patrizia ⁸, Ruella, Marco ⁸, Brentjens, Renier J. ^{3, 9}, Inghirami, Giorgio ⁵, Zappasodi, Roberta ¹, Chadburn, Amy ⁵, Melnick, Ari M. ¹, Béguelin, Wendy ^{1, 11, ∗}

Source: In Cancer Cell 13 January 2025 43(1):49-68

Characterizing the heterogeneity of Castleman disease and oligocentric subtype: findings from the ACCELERATE registry

Authors: Pierson, Sheila K. ¹, Brandstadter, Joshua D. ², Torigian, Drew A. ³, Bagg, Adam ⁴, Lechowicz, Mary Jo ⁵, Alapat, Daisy ⁶, Casper, Corey ^{7, 8, 9}, Chadburn, Amy ¹⁰, Chandrakasan, Shanmuganathan ¹¹, Dispenzieri, Angela ¹², Fosså, Alexander ^{13, 14}, Hoffmann, Christian ¹⁵, Ide, Makoto ¹⁶, Kurzrock, Razelle ¹⁷, Mukherjee, Sudipto ¹⁸, Nasta, Sunita ¹⁹, Navarro, José-Tomás ²⁰, Noy, Ariela ²¹, Oksenhendler, Eric ²², Bustamante, Mateo Sarmiento ¹, Shyamsundar, Saishravan ¹, Streetly, Matthew ^{23, 24}, Wong, Raymond S. M. ²⁵, Zhang, Lu ²⁶, Lim, Megan S. ²⁷, Srkalovic, Gordan ²⁸, van Rhee, Frits ²⁹, Fajgenbaum, David C. ^{1, ∗}

Source: In Blood Advances January 2025

ARID1A orchestrates SWI/SNF-mediated sequential binding of transcription factors with ARID1A loss driving pre-memory B cell fate and lymphomagenesis

Authors: Barisic, Darko, Chin, Christopher R., Meydan, Cem, Teater, Matt, Tsialta, Ioanna, Mlynarczyk, Coraline, Chadburn, Amy, Wang, Xuehai, Sarkozy, Margot, Xia, Min, Carson, Sandra E., Raggiri, Santo, Debek, Sonia, Pelzer, Benedikt, Durmaz, Ceyda, Deng, Qing, Lakra, Priya, Rivas, Martin, Steidl, Christian, Scott, David W., Weng, Andrew P., Mason, Christopher E., Green, Michael R., Melnick, Ari

Source: In Cancer Cell 8 April 2024 42(4):583-604

SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions

Authors: Deng, Qing, Lakra, Priya, Gou, Panhong, Yang, Haopeng, Meydan, Cem, Teater, Matthew, Chin, Christopher, Zhang, Wenchao, Dinh, Tommy, Hussein, Usama, Li, Xubin, Rojas, Estela, Liu, Weiguang, Reville, Patrick K., Kizhakeyil, Atish, Barisic, Darko, Parsons, Sydney, Wilson, Ashley, Henderson, Jared, Scull, Brooks, Gurumurthy, Channabasavaiah, Vega, Francisco, Chadburn, Amy, Cuglievan, Branko, El-Mallawany, Nader Kim, Allen, Carl, Mason, Christopher, Melnick, Ari, Green, Michael R.

Source: In Cancer Cell 8 April 2024 42(4):605-622

Fifth Edition of the World Health Classification of Tumors of the Hematopoietic and Lymphoid Tissues: B-cell Neoplasms

Authors: Medeiros, L. Jeffrey ^{a, ∗}, Chadburn, Amy ^b, Natkunam, Yasodha ^c, Naresh, Kikkeri N. ^{d, e}

Source: In Modern Pathology April 2024 37(4)

Immune deficiency/dysregulation -associated lymphoproliferative disorders. Revised classification and management

Authors: Carbone, Antonino, Chadburn, Amy, Gloghini, Annunziata, Vaccher, Emanuela, Bower, Mark

Source: In Blood Reviews March 2024 64

Primary Effusion Lymphoma in an HIV-Negative Patient with Chronic Myeloid Leukemia Treated with Dasatinib

Authors: SahBandar, Ivo N., Sy, Chandler B., van den Akker, Tayler, Kim, David, Geyer, Julia T., Chadburn, Amy, Cesarman, Ethel, Inghirami, Giorgio, Allan, John N, Siddiqui, Momin T., Ouseph, Madhu M.

Source: PATHOBIOLOGY. 90(5):356-364

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196471068.0x000001&indx=1&recIds=ETOCvdc_100196471068.0x000001

EBV-positive PCNSL in older patients: incidence, characteristics, tumor pathology, and outcomes across a large multicenter cohort

Authors: Agrawal, Prashasti, David, Kevin A., Chen, Zhengming, Sundaram, Suchitra, Kim, Seo-Hyun, Vaca, Ryan, Lin, Yong, Singer, Samuel, Malecek, Mary-Kate, Carter, Jordan, Zayac, Adam, Kim, Myung Sun, Reddy, Nishitha, Ney, Douglas, Habib, Alma, Strouse, Christopher, Graber, Jerome, Bachanova, Veronika, Salman, Sidra, Vendiola, Jean A., Hossain, Nasheed, Tsang, Mazie, Major, Ajay, Gandhi, Maher K., Keane, Colm, Bond, David A., Folstad, Matthew, Chang, Julie, Mier-Hicks, Angel, Torka, Pallawi, Rajakumar, Priya, Venugopal, Parameswaran, Berg, Stephanie, Glantz, Michael, Goldlust, Samuel A., Matnani, Rahul, Kumar, Pallavi, Ollila, Thomas A., Cai, Johnny, Spurgeon, Stephen E., Sieg, Alex G., Cleveland, Joseph, Epperla, Narendranath, Karmali, Reem, Naik, Seema, Smith, Sonali M., Rubenstein, James L., Kahl, Brad S., Chadburn, Amy, Evens, Andrew M., Martin, Peter

Source: Leukemia & lymphoma. 64(5):1026-1034

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190362980.0x000001&indx=1&recIds=ETOCvdc_100190362980.0x000001

Building the Model: Challenges and Considerations of Developing and Implementing Machine Learning Tools for Clinical Laboratory Medicine Practice

Authors: Yang, He S., Rhoads, Daniel D., Sepulveda, Jorge, Zang, Chengxi, Chadburn, Amy, Wang, Fei

Source: Archives of pathology & laboratory medicine. 147(7):826-836

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632865932&indx=1&recIds=ETOCRN632865932

Epigenetic memory of coronavirus infection in innate immune cells and their progenitors

Authors: Cheong, Jin-Gyu, Ravishankar, Arjun, Sharma, Siddhartha, Parkhurst, Christopher N., Grassmann, Simon A., Wingert, Claire K., Laurent, Paoline, Ma, Sai, Paddock, Lucinda, Miranda, Isabella C., Karakaslar, Emin Onur, Nehar-Belaid, Djamel, Thibodeau, Asa, Bale, Michael J., Kartha, Vinay K., Yee, Jim K., Mays, Minh Y., Jiang, Chenyang, Daman, Andrew W., Martinez de Paz, Alexia, Ahimovic, Dughan, Ramos, Victor, Lercher, Alexander, Nielsen, Erik, Alvarez-Mulett, Sergio, Zheng, Ling, Earl, Andrew, Yallowitz, Alisha, Robbins, Lexi, LaFond, Elyse, Weidman, Karissa L., Racine-Brzostek, Sabrina, Yang, He S., Price, David R., Leyre, Louise, Rendeiro, André F., Ravichandran, Hiranmayi, Kim, Junbum, Borczuk, Alain C., Rice, Charles M., Jones, R. Brad, Schenck, Edward J., Kaner, Robert J., Chadburn, Amy, Zhao, Zhen, Pascual, Virginia, Elemento, Olivier, Schwartz, Robert E., Buenrostro, Jason D., Niec, Rachel E., Barrat, Franck J., Lief, Lindsay, Sun, Joseph C., Ucar, Duygu, Josefowicz, Steven Z.

Source: In Cell 31 August 2023 186(18):3882-3902

Brentuximab vedotin with AVD for stage II–IV HIV-related Hodgkin lymphoma (AMC 085): phase 2 results from an open-label, single arm, multicentre phase 1/2 trial

Authors: Barta, Stefan K., Hamdan, Ayad, Boué, François, Delobel, Pierre, Galicier, Lionel, Coppo, Paul, Ghesquières, Hervé, Rubinstein, Paul G ^*, Moore, Page C, Bimali, Milan, Lee, Jeanette Y, Rudek, Michelle A, Chadburn, Amy, Ratner, Lee, Henry, David H, Cesarman, Ethel, DeMarco, Camille E, Costagliola, Dominique, Taoufik, Yassine, Ramos, Juan Carlos, Sharon, Elad, Reid, Erin G, Ambinder, Richard F, Mitsuyasu, Ronald, Mounier, Nicolas, Besson, Caroline, Noy, Ariela

Source: In The Lancet Haematology August 2023 10(8):e624-e632

Genetic subgroups inform on pathobiology in adult and pediatric Burkitt lymphoma

Authors: Thomas, Nicole, Dreval, Kostiantyn, Gerhard, Daniela S., Hilton, Laura K., Abramson, Jeremy S., Ambinder, Richard F., Barta, Stefan, Bartlett, Nancy L., Bethony, Jeffrey, Bhatia, Kishor, Bowen, Jay, Bryan, Anthony C., Cesarman, Ethel, Casper, Corey, Chadburn, Amy, Cruz, Manuela, Dittmer, Dirk P., Dyer, Maureen A., Farinha, Pedro, Gastier-Foster, Julie M., Gerrie, Alina S., Grande, Bruno M., Greiner, Timothy, Griner, Nicholas B., Gross, Thomas G., Harris, Nancy L., Irvin, John D., Jaffe, Elaine S., Henry, David, Huppi, Rebecca, Leal, Fabio E., Lee, Michael S., Martin, Jean Paul, Martin, Marie-Reine, Mbulaiteye, Sam M., Mitsuyasu, Ronald, Morris, Vivian, Mullighan, Charles G., Mungall, Andrew J., Mungall, Karen, Mutyaba, Innocent, Nokta, Mostafa, Namirembe, Constance, Noy, Ariela, Ogwang, Martin D., Omoding, Abraham, Orem, Jackson, Ott, German, Petrello, Hilary, Pittaluga, Stefania, Phelan, James D., Ramos, Juan Carlos, Ratner, Lee, Reynolds, Steven J., Rubinstein, Paul G., Sissolak, Gerhard, Slack, Graham, Soudi, Shaghayegh, Swerdlow, Steven H., Traverse-Glehen, Alexandra, Wilson, Wyndham H., Wong, Jasper, Yarchoan, Robert, ZenKlusen, Jean C., Marra, Marco A., Staudt, Louis M., Scott, David W., Morin, Ryan D.

Source: In Blood 23 February 2023 141(8):904-916

KSHV/HHV8-mediated hematologic diseases

Authors: Cesarman, Ethel, Chadburn, Amy, Rubinstein, Paul G.

Source: Blood. 139(7):1013-1025

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183249442.0x000001&indx=1&recIds=ETOCvdc_100183249442.0x000001

Genetic profiling and biomarkers in peripheral T-cell lymphomas: current role in the diagnostic work-up

Authors: Vega, Francisco, Amador, Catalina, Chadburn, Amy, Hsi, Eric D., Slack, Graham, Medeiros, L. Jeffrey, Feldman, Andrew L.

Source: In Modern Pathology March 2022 35(3):306-318

Synergistic efficacy of the dual PI3K-δ/γ inhibitor duvelisib with the Bcl-2 inhibitor venetoclax in Richter syndrome PDX models

Authors: Iannello, Andrea, Vitale, Nicoletta, Coma, Silvia, Arruga, Francesca, Chadburn, Amy, Di Napoli, Arianna, Laudanna, Carlo, Allan, John N., Furman, Richard R., Pachter, Jonathan A., Deaglio, Silvia ^**, Vaisitti, Tiziana ^*

Source: In Blood 17 June 2021 137(24):3378-3389

ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient–derived xenograft mouse models

Authors: Vaisitti, Tiziana ^**, Arruga, Francesca, Vitale, Nicoletta, Lee, Thanh-Trang, Ko, Mira, Chadburn, Amy, Braggio, Esteban, Di Napoli, Arianna, Iannello, Andrea, Allan, John N., Miller, Langdon L., Lannutti, Brian J., Furman, Richard R., Jessen, Katti A., Deaglio, Silvia ^*

Source: In Blood 17 June 2021 137(24):3365-3377

Testing-on-a-probe biosensors reveal association of early SARS-CoV-2 total antibodies and surrogate neutralizing antibodies with mortality in COVID-19 patients

Authors: Yang, He S., Racine-Brzostek, Sabrina E., Karbaschi, Mohsen, Yee, Jim, Dillard, Alicia, Steel, Peter A.D., Lee, William T., McDonough, Kathleen A., Qiu, Yuqing, Ketas, Thomas J., Francomano, Erik, Klasse, P.J., Hatem, Layla, Westblade, Lars, Wu, Heng, Chen, Haode, Zuk, Robert, Tan, Hong, Girardin, Roxanne C., Dupuis, Alan P., II, Payne, Anne F., Moore, John P., Cushing, Melissa M., Chadburn, Amy, Zhao, Zhen

Source: In Biosensors and Bioelectronics 15 April 2021 178

Targeted reduction of cholesterol uptake in cholesterol-addicted lymphoma cells blocks turnover of oxidized lipids to cause ferroptosis

Authors: Rink, Jonathan S., Lin, Adam Yuh, McMahon, Kaylin M., Calvert, Andrea E., Yang, Shuo, Taxter, Tim, Moreira, Jonathan, Chadburn, Amy, Behdad, Amir, Karmali, Reem, Thaxton, C. Shad, Gordon, Leo I.

Source: In Journal of Biological Chemistry January-June 2021 296

Mast cell sarcoma transdifferentiated from clonally-related T-lymphoblastic leukemia upon acquisition of TP53 mutation and genetic complexity

Authors: Gao, Juehua, Fu, Lucy, Lu, Xinyan, Sukhanova, Madina, Frankfurt, Olga, Mohtashamian, Arash, Chadburn, Amy, Jennings, Lawrence, Aqil, Barina, Chen, Qing, Chen, Yi-Hua

Source: Leukemia & lymphoma. 62(13):3304-3307

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135648612.0x000001&indx=1&recIds=ETOCvdc_100135648612.0x000001

Postconvalescent SARS-CoV-2 IgG and Neutralizing Antibodies are Elevated in Individuals with Poor Metabolic Health

Authors: Racine-Brzostek, Sabrina E, Yang, He S, Jack, Gwendolyne A, Chen, Zhengming, Chadburn, Amy, Ketas, Thomas J, Francomano, Erik, Klasse, P J, Moore, John P, McDonough, Kathleen A, Girardin, Roxanne C, Dupuis, Alan P, Payne, Anne F, Ma, Lucy X, Sweeney, Jacob, Zhong, Elaine, Yee, Jim, Cushing, Melissa M, Zhao, Zhen

Source: Journal of clinical endocrinology & metabolism. 106(5):e2025-e2034

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100133336140.0x000001&indx=1&recIds=ETOCvdc_100133336140.0x000001