Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans

Authors: Hagan, Thomas, Cortese, Mario, Rouphael, Nadine, Boudreau, Carolyn, Linde, Caitlin, Maddur, Mohan S., Das, Jishnu, Wang, Hong, Guthmiller, Jenna, Zheng, Nai-Ying, Huang, Min, Uphadhyay, Amit A., Gardinassi, Luiz, Petitdemange, Caroline, McCullough, Michele Paine, Johnson, Sara Jo, Gill, Kiran, Cervasi, Barbara, Zou, Jun, Bretin, Alexis, Hahn, Megan, Gewirtz, Andrew T., Bosinger, Steve E., Wilson, Patrick C., Li, Shuzhao, Alter, Galit, Khurana, Surender, Golding, Hana, Pulendran, Bali

Source: In Cell 5 September 2019 178(6):1313-1328

The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence.

Authors: Strongin, Zachary¹, Hoang, Timothy N.¹, Tharp, Gregory K.¹, Rahmberg, Andrew R.², Harper, Justin L.¹, Nguyen, Kevin¹, Franchitti, Lavinia¹, Cervasi, Barbara³, Lee, Max⁴, Zhang, Zhan¹, Boritz, Eli A.⁴, Silvestri, Guido^1,5,6, Marconi, Vincent C.^6,7,8,9, Bosinger, Steven E.^1,5, Brenchley, Jason M.², Kulpa, Deanna A.^1,5, Paiardini, Mirko^1,5, mirko.paiardini@emory.edu

Source: PLoS Pathogens; 7/22/2022, Vol. 18 Issue 7, p1-23, 23p

Paucity of IL-21–producing CD4+ T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques

Authors: Micci, Luca ^*, Cervasi, Barbara ^*, Ende, Zachary S., Iriele, Robin I., Reyes-Aviles, Elane, Vinton, Carol, Else, James, Silvestri, Guido, Ansari, Aftab A., Villinger, Francois, Pahwa, Savita, Estes, Jacob D., Brenchley, Jason M., Paiardini, Mirko ^*

Source: In Blood 8 November 2012 120(19):3925-3935

Antitumoral Activity of Indole-3-carbinol Cyclic tri- and Tetrameric Derivatives Mixture in Human Breast Cancer Cells: In Vitro and In Vivo Studies

Authors: Lucarini, Simone, Paiardini, Mirko, De Santi, Mauro, Cervasi, Barbara, F. Paoletti, Maria, Galluzzi, Luca, Duranti, Andrea, Magnani, Mauro, Brandi, Giorgio, Fraternale, Alessandra

Source: Anti-cancer agents in medicinal chemistry. 13(4):654-662

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083475804.0x000001&indx=1&recIds=ETOCvdc_100083475804.0x000001

Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates

Authors: Engram, Jessica C. ^*, Cervasi, Barbara ^*, Borghans, Jose A.M., Klatt, Nichole R., Gordon, Shari N., Chahroudi, Ann, Else, James G., Mittler, Robert S., Sodora, Donald L., de Boer, Rob J., Brenchley, Jason M., Silvestri, Guido, Paiardini, Mirko ^*

Source: In Blood 5 August 2010 116(5):748-758

Specific Changes in the Posttranslational Regulation of Nucleolin in Lymphocytes from Patients Infected with Human Immunodeficiency Virus [with Discussion]

Authors: Galati, Domenico, Paiardini, Mirko, Cervasi, Barbara, Albrecht, Helmut, Bocchino, Marialuisa, Costantini, Andrea, Montroni, Maria, Magnani, Mauro, Piedimonte, Giuseppe, Silvestri, Guido

Source: The Journal of Infectious Diseases, 2003 Nov . 188(10), 1483-1491.

Access URL: https://www.jstor.org/stable/30075753

Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection.

Authors: Lee, Michelle Y.-H.¹, Upadhyay, Amit A.¹, Walum, Hasse¹, Chan, Chi N.², Dawoud, Reem A.¹, Grech, Christine¹, Harper, Justin L.¹, Karunakaran, Kirti A.¹, Nelson, Sydney A.¹, Mahar, Ernestine A.¹, Goss, Kyndal L.¹, Carnathan, Diane G.¹, Cervasi, Barbara³, Gill, Kiran³, Tharp, Gregory K.⁴, Wonderlich, Elizabeth R.⁵, Velu, Vijayakumar^1,6, Barratt-Boyes, Simon M.⁷, Paiardini, Mirko^1,6, Silvestri, Guido^1,6

Source: PLoS Pathogens; 6/28/2021, Vol. 17 Issue 6, p1-32, 32p

T-cell phenotypic and functional changes associated with social subordination and gene polymorphisms in the serotonin reuptake transporter in female rhesus monkeys

Authors: Paiardini, Mirko, Hoffman, Jackie, Cervasi, Barbara, Ortiz, Alexandra M., Stroud, Fawn, Silvestri, Guido, Wilson, Mark E.

Source: In Brain Behavior and Immunity February 2009 23(2):286-293

Bone marrow–based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis

Authors: Paiardini, Mirko ^*, Cervasi, Barbara ^*, Engram, Jessica C., Gordon, Shari N., Klatt, Nichole R., Muthukumar, Alagarraju, Else, James, Mittler, Robert S., Staprans, Silvija I., Sodora, Donald L., Silvestri, Guido ^*

Source: In Blood 15 January 2009 113(3):612-621

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

Authors: Brenchley, Jason M., Paiardini, Mirko ^*, Knox, Kenneth S., Asher, Ava I., Cervasi, Barbara, Asher, Tedi E., Scheinberg, Phillip, Price, David A., Hage, Chadi A., Kholi, Lisa M., Khoruts, Alexander, Frank, Ian, Else, James, Schacker, Timothy, Silvestri, Guido ^*, Douek, Daniel C.

Source: In Blood 1 October 2008 112(7):2826-2835

Limited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques.

Authors: Pino, Maria, Pagliuzza, Amélie, Pampena, M. Betina, Deleage, Claire, Viox, Elise G., Nguyen, Kevin, Shim, Inbo, Zhang, Adam, Harper, Justin L., Samer, Sadia, King, Colin T., Cervasi, Barbara, Gill, Kiran P., Ehnert, Stephanie, Jean, Sherrie M., Freeman, Michael L., Lifson, Jeffrey D., Kulpa, Deanna, Betts, Michael R., Chomont, Nicolas

Source: Nature Communications; 8/27/2022, Vol. 13 Issue 1, p1-12, 12p

Subject Terms: RHESUS monkeys, T helper cells, LYMPHOID tissue, FINGOLIMOD, KILLER cells, HIV-positive persons, PLASMA frequencies

Fingolimod retains cytolytic T cells and limits T follicular helper cell infection in lymphoid sites of SIV persistence.

Authors: Pino, Maria¹, Paganini, Sara¹, Deleage, Claire², Padhan, Kartika³, Harper, Justin L.¹, King, Colin T.¹, Micci, Luca¹, Cervasi, Barbara⁴, Mudd, Joseph C.⁵, Gill, Kiran P.⁴, Jean, Sherrie M.⁶, Easley, Kirk⁷, Silvestri, Guido^1,8, Estes, Jacob D.⁹, Petrovas, Constantinos³, Lederman, Michael M.⁵, MXL6@case.edu, Paiardini, Mirko^1,8, MXL6@case.edu

Source: PLoS Pathogens; 10/18/2019, Vol. 15 Issue 10, p1-24, 24p

Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression.

Authors: Paiardini, Mirko, Cervasi, Barbara, Reyes-Aviles, Elane

Source: Nature Medicine; July 2011, Vol. 17 Issue 7, p830-836, 7p

Mechanisms of Action and Antiproliferative Properties of Brassica oleracea Juice in Human Breast Cancer Cell Lines

Authors: Brandi, Giorgio ^{*, †}, Schiavano, Giuditta F. ^*, Zaffaroni, Nadia ^‡, De Marco, Cinzia ^‡, Paiardini, Mirko ^**, Cervasi, Barbara ^**, Magnani, Mauro ^{†, **}

Source: In The Journal of Nutrition June 2005 135(6):1503-1509

Abnormal intracellular kinetics of cell-cycle–dependent proteins in lymphocytes from patients infected with human immunodeficiency virus: a novel biologic link between immune activation, accelerated T-cell turnover, and high levels of apoptosis

Authors: Cannavo', Giuseppe, Paiardini, Mirco, Galati, Domenico, Cervasi, Barbara, Montroni, Maria, De Vico, Gionata, Guetard, Denise, Bocchino, Maria L., Picerno, Isa, Magnani, Mauro, Silvestri, Guido ^*, Piedimonte, Giuseppe

Source: In Blood 15 March 2001 97(6):1756-1764

Low levels of SIV infection in sooty mangabey central memory CD4⁺ T cells are associated with limited CCR5 expression.

Authors: Paiardini, Mirko¹ mirko.paiardini@emory.edu, Cervasi, Barbara¹, Reyes-Aviles, Elane², Micci, Luca³, Ortiz, Alexandra M⁴, Chahroudi, Ann⁵, Vinton, Carol⁶, Gordon, Shari N.⁴, Bosinger, Steven E.⁵, Francella, Nicholas², Hallberg, Paul L.², Cramer, Elizabeth², Schlub, Timothy⁷, Chan, Ming Liang⁷, Riddick, Nadeene E.⁸, Collman, Ronald G.⁸, Apetrei, Cristian¹, Pandrea, Ivona¹, Else, James⁵, Munch, Jan⁸

Source: Nature Medicine. Jul2011, Vol. 17 Issue 7, p830-836. 7p. 6 Graphs.

Subject Terms: *SIMIAN immunodeficiency virus, *MANGABEYS, *T cells, *GENE expression, *VIRUS diseases, *ANIMAL diseases

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells.

Authors: McBrien, Julia Bergild, Mavigner, Maud, Franchitti, Lavinia, Smith, S. Abigail, White, Erick, Tharp, Gregory K., Walum, Hasse, Busman-Sahay, Kathleen, Aguilera-Sandoval, Christian R., Thayer, William O., Spagnuolo, Rae Ann, Kovarova, Martina, Wahl, Angela, Cervasi, Barbara, Margolis, David M., Vanderford, Thomas H., Carnathan, Diane G., Paiardini, Mirko, Lifson, Jeffrey D., Lee, John H.

Source: Nature; 2/6/2020, Vol. 578 Issue 7793, p154-159, 6p, 1 Chart, 13 Graphs

Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21.

Authors: Pallikkuth, Suresh¹, Micci, Luca², Ende, Zachary S.², Iriele, Robin I.², Cervasi, Barbara², Lawson, Benton², McGary, Colleen S.², Rogers, Kenneth A.², Else, James G.², Silvestri, Guido^2,3, Easley, Kirk⁴, Estes, Jacob D.⁵, Villinger, Francois², Pahwa, Savita¹, Paiardini, Mirko^2,3, mirko.paiardini@emory.edu

Source: PLoS Pathogens; Jul2013, Vol. 9 Issue 7, p1-15, 15p

CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

Authors: Harper, Justin, Gordon, Shari, Chan, Chi Ngai, Wang, Hong, Lindemuth, Emily, Galardi, Cristin, Falcinelli, Shane D., Raines, Samuel L. M., Read, Jenna L., Nguyen, Kevin, McGary, Colleen S, Nekorchuk, Michael, Busman-Sahay, Kathleen, Schawalder, James, King, Colin, Pino, Maria, Micci, Luca, Cervasi, Barbara, Jean, Sherrie, Sanderson, Andrew, Johns, Brian, Koblansky, A. Alicia, Amrine-Madsen, Heather, Lifson, Jeffrey, Margolis, David M., Silvestri, Guido, Bar, Katharine J., Favre, David, Estes, Jacob D., Paiardini, Mirko

Source: Nature Medicine; April 2020, Vol. 26 Issue: 4 p519-528, 10p

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