An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions

Authors: Cereghetti, Gea, Kissling, Vera M., Koch, Lisa M., Arm, Alexandra, Schmidt, Claudia C., Thüringer, Yannik, Zamboni, Nicola, Afanasyev, Pavel, Linsenmeier, Miriam, Eichmann, Cédric, Kroschwald, Sonja, Zhou, Jiangtao, Cao, Yiping, Pfizenmaier, Dorota M., Wiegand, Thomas, Cadalbert, Riccardo, Gupta, Govind, Boehringer, Daniel, Knowles, Tuomas P.J., Mezzenga, Raffaele, Arosio, Paolo, Riek, Roland, Peter, Matthias

Source: In Developmental Cell 22 July 2024 59(14):1876-1891

Full-length and N-terminally truncated recombinant interleukin-38 variants are similarly inefficient in antagonizing interleukin-36 and interleukin-1 receptors.

Authors: Diaz-Barreiro, Alejandro, Talabot-Ayer, Dominique, Huard, Arnaud, Cereghetti, Gea, Tonacini, Jenna, Maillasson, Mike, Francés-Monerris, Antonio, Mortier, Erwan, Palmer, Gaby

Source: Cell Communication & Signaling; 1/20/2025, Vol. 23 Issue 1, p1-16, 16p

Subject Terms: RECOMBINANT proteins, LIFE sciences, SURFACE plasmon resonance, INTERLEUKIN-1 receptors, CYTOLOGY, KERATINOCYTE differentiation

High-throughput multiparametric imaging flow cytometry: toward diffraction-limited sub-cellular detection and monitoring of sub-cellular processes

Authors: Holzner, Gregor, Mateescu, Bogdan, van Leeuwen, Daniel, Cereghetti, Gea, Dechant, Reinhard, Stavrakis, Stavros, deMello, Andrew

Source: In Cell Reports 9 March 2021 34(10)

Comparative analysis of the intracellular responses to disease-related aggregation-prone proteins

Authors: Melnik, Andre, Cappelletti, Valentina, Vaggi, Federico, Piazza, Ilaria, Tognetti, Marco, Schwarz, Carmen, Cereghetti, Gea, Ahmed, Mennat Allah, Soste, Martin, Matlack, Kent, de Souza, Natalie, Csikasz-Nagy, Attila, Picotti, Paola

Source: In Journal of Proteomics 15 August 2020 225

TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

Authors: Griciuc, Ana, Patel, Shaun, Federico, Anthony N., Choi, Se Hoon, Innes, Brendan J., Oram, Mary K., Cereghetti, Gea, McGinty, Danielle, Anselmo, Anthony, Sadreyev, Ruslan I., Hickman, Suzanne E., El Khoury, Joseph, Colonna, Marco, Tanzi, Rudolph E.

Source: In Neuron 4 September 2019 103(5):820-835

A structural rationale for reversible vs irreversible amyloid fibril formation from a single protein.

Authors: Frey, Lukas, Zhou, Jiangtao, Cereghetti, Gea, Weber, Marco E., Rhyner, David, Pokharna, Aditya, Wenchel, Luca, Kadavath, Harindranath, Cao, Yiping, Meier, Beat H., Peter, Matthias, Greenwald, Jason, Riek, Roland, Mezzenga, Raffaele

Source: Nature Communications; 9/30/2024, Vol. 15 Issue 1, p1-11, 11p

Subject Terms: PROTEIN precursors, ATOMIC force microscopy, AMYLOID, PROTEIN folding, DENATURATION of proteins, LYSOZYMES

Oxidation-sensitive cysteines drive IL-38 amyloid formation

Authors: Diaz-Barreiro, Alejandro ^{1, 2, 3, 13, 14, ∗}, Cereghetti, Gea ^{4, 13}, Ortega Sánchez, Francisco Gabriel ^{5, 6, 7}, Tonacini, Jenna ^{1, 2, 3}, Talabot-Ayer, Dominique ^{1, 2, 3}, Kieffer-Jaquinod, Sylvie ⁸, Kissling, Vera Maria ⁹, Huard, Arnaud ^{1, 2, 3}, Swale, Christopher ¹⁰, Knowles, Tuomas P.J. ⁴, Couté, Yohann ⁸, Peter, Matthias ¹¹, Francés-Monerris, Antonio ¹², Palmer, Gaby ^{1, 2, 3}

Source: In Cell Reports 26 November 2024 43(11)

A hydrophobic low-complexity region regulates aggregation of the yeast pyruvate kinase Cdc19 into amyloid-like aggregates in vitro

Authors: Grignaschi, Erica, Cereghetti, Gea, Grigolato, Fulvio, Kopp, Marie R.G., Caimi, Stefano, Faltova, Lenka, Saad, Shady, Peter, Matthias, Arosio, Paolo

Source: In Journal of Biological Chemistry 20 July 2018 293(29):11424-11432

Reversible, functional amyloids: towards an understanding of their regulation in yeast and humans

Authors: Cereghetti, Gea, Saad, Shady, Dechant, Reinhard, Peter, Matthias

Source: Cell cycle. 17(13):1545-1558

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138420116.0x000001&indx=1&recIds=ETOCvdc_100138420116.0x000001

Mre11-Rad50 oligomerization promotes DNA double-strand break repair.

Authors: Kissling, Vera M., Reginato, Giordano, Bianco, Eliana, Kasaciunaite, Kristina, Tilma, Janny, Cereghetti, Gea, Schindler, Natalie, Lee, Sung Sik, Guérois, Raphaël, Luke, Brian, Seidel, Ralf, Cejka, Petr, Peter, Matthias

Source: Nature Communications; 5/2/2022, Vol. 13 Issue 1, p1-16, 16p

Subject Terms: DOUBLE-strand DNA breaks, EXONUCLEASES, OLIGOMERIZATION, DNA damage, DNA repair, TRANSMISSION electron microscopy

Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly

Authors: Cereghetti, Gea, Wilson-Zbinden, Caroline, Kissling, Vera M., Diether, Maren, Arm, Alexandra, Yoo, Haneul, Piazza, Ilaria, Saad, Shady, Picotti, Paola, Drummond, D. Allan, Sauer, Uwe, Dechant, Reinhard, Peter, Matthias

Source: Nature Cell Biology; October 2021, Vol. 23 Issue: 10 p1085-1094, 10p

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Author Correction: Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly

Authors: Cereghetti, Gea, Wilson-Zbinden, Caroline, Kissling, Vera M., Diether, Maren, Arm, Alexandra, Yoo, Haneul, Piazza, Ilaria, Saad, Shady, Picotti, Paola, Drummond, D. Allan, Sauer, Uwe, Dechant, Reinhard, Peter, Matthias

Source: Nature Cell Biology; 20240101, Issue: Preprints p1-1, 1p