Broussoflavonol B induces S-phase arrest and apoptosis in pancreatic cancer cells by modulating the cell cycle checkpoint through inhibition of the AURKA/PLK1 pathway

Authors: HyokChol Choe, Zhen Wang, Jianhua Huang, Yutong Yang, Zhihao Zhao, HyonSu Jo, HyonU Pak, Tanveer Ali, Kaiyue Ding, Junnan Ma, Lingzhi Li, Dong Shang, Lin Zhang

Source: Cancer Cell International, Vol 25, Iss 1, Pp 1-22 (2025)

Subject Terms: AURKA, PLK1, Cell cycle checkpoint, Pancreatic cancer, Prenylated flavonoid, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/1a0b01f424b64c0db5d6289c7f7dbdc5

Reversing regulatory safeguards: Targeting the ATR pathway to overcome PARP inhibitor resistance

Authors: Lin, Xixi ^{1, 2, ∗}, Qiu, Ye ^{1, 2}, Soni, Aashish ^{1, 2}, Stuschke, Martin ^{1, 3}, Iliakis, George ^{1, 2, ∗∗}

Source: In Molecular Therapy: Oncology 20 March 2025 33(1)

SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis

Authors: Ogawa, Akane ^{1, 16}, Izumikawa, Keiichi ^{2, 16}, Tate, Sota ^{3, 4, 16}, Isoyama, Sho ⁵, Mori, Masaru ¹, Fujiwara, Kohei ⁴, Watanabe, Soyoka ¹, Ohga, Takayuki ², Jo, Ukhyun ⁶, Taniyama, Daiki ⁶, Kitajima, Shojiro ¹, Tanaka, Soichiro ¹, Onji, Hiroshi ⁴, Kageyama, Shun-Ichiro ⁷, Yamamoto, Gaku ⁸, Saito, Hitoshi ⁸, Morita, Tomoko Yamamori ⁸, Okada, Masayasu ^{9, 10}, Natsumeda, Manabu ^{9, 11}, Nagahama, Masami ², Kobayashi, Junya ^{12, 13}, Ohashi, Akihiro ⁸, Sasanuma, Hiroyuki ¹⁴, Higashiyama, Shigeki ^{3, 4, 15}, Dan, Shingo ⁵, Pommier, Yves ^{6, ∗}, Murai, Junko ^{1, 3, 4, 12, 17, ∗∗}

Source: In Molecular Cell 6 March 2025 85(5):894-912

Cell cycle checkpoint revolution: targeted therapies in the fight against malignant tumors

Authors: Guangming Song, Jue Liu, Xing Tang, Jie Zhong, Yuhuan Zeng, Xiaodi Zhang, Jianbin Zhou, Jie Zhou, Lu Cao, Qunfeng Zhang, Yukun Li

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: malignant tumor, cell cycle, cell cycle checkpoint, cyclin, cyclin-dependent kinase, chemotherapeutic drug, Therapeutics. Pharmacology, RM1-950

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Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1459057/full; https://doaj.org/toc/1663-9812

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Isorhamnetin exerts anti-proliferative effect on cancer-associated fibroblasts by inducing cell cycle arrest

Authors: Ganbold, Munkhzul ^a, Louphrasitthiphol, Pakavarin ^{b, c}, Miyamoto, Takafumi ^{d, e}, Miyazaki, Yoshihiro ^b, Oda, Tatsuya ^b, Tominaga, Kenichi ^a, Isoda, Hiroko ^{a, f, g, ⁎}

Source: In Biomedicine & Pharmacotherapy April 2025 185

Antitumour effects of artesunate via cell cycle checkpoint controls in human oesophageal squamous carcinoma cells

Authors: Linlin Mao, Guodong Deng, Mengfan Li, Shih-Hsin Lu, Wei Jiang, Xiying Yu

Source: European Journal of Medical Research, Vol 29, Iss 1, Pp 1-14 (2024)

Subject Terms: Artesunate, DNA damage and cell cycle checkpoint controls, Oesophageal squamous cell carcinoma, Reactive oxygen species, Medicine

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Relation: https://doaj.org/toc/2047-783X

Access URL: https://doaj.org/article/a41ecad35c974634bb7d69c7ef1331b6

Minichromosome Maintenance Proteins: From DNA Replication to the DNA Damage Response

Authors: Agnes Malysa, Xiaohong Mary Zhang, Gerold Bepler

Source: Cells, Vol 14, Iss 1, p 12 (2024)

Subject Terms: minichromosome maintenance (MCM), DNA replication, origin recognition complex (ORC), pre-replication complex (pre-RC), cell cycle checkpoint, replication stress, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/14/1/12; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/0e467442bb9a4545bd526184f6645220

Inhibition of DNA Repair Enzymes as a Valuable Pharmaceutical Approach

Contributors: Volcho, Konstantin, Lavrik, Olga

Subject Terms: poly (ADP-ribose) polymerase inhibitor, non-small cell lung cancer, DNA damage, radiotherapy, chemotherapy, combination therapy, coumarin, neoflavone, DNA repair enzymes, Tdp1 inhibitor, cancer, tumor, topotecan, topoisomerase 1 inhibitors, molecular modeling, chemical space, morpholino nucleosides, NAD+ analogs, DNA repair, PARP, 7-methylguanine, poly(ADP-ribose) polymerase 1, inhibitor, nucleosome, trapping, docking, molecular dynamics, fluorescence anisotropy, spFRET microscopy, DNA glycosylases, drug targets, APE1, protein–protein interactions, base excision repair, multifunctional disordered protein, fluorescence techniques, cell cycle checkpoint, cancer therapy, DNA repair inhibitors, synthetic lethality, fused in sarcoma, poly(ADP-ribose) polymerase, poly(ADP-ribose), protein phase separation, berberine, tetrahydroberberine, DNA repair enzyme, SAR, poly(ADP-ribosylation), PARP-1, Olaparib, KU55933, KU-0060648, SCR7 pyrazine, VERO cells, synergism, resistance, CDKN2A, soft tissue sarcomas (STS), gastrointestinal stromal tumors (GIST), AKT signaling, Rad51 recombinase, homology-mediated DNA repair, apoptosis, sensitization, XPA, ERCC1-XPF, CSB, UVB radiation, UVB mutagenesis, nucleotide excision repair (NER), cyclobutane–pyrimidine dimer (CPD) photolesion, veliparib, resveratrol, arsenic trioxide, spironolactone, usnic acid, thioether, tyrosyl-DNA phosphodiesterase 1, TDP1 inhibitor, inhibiting activity, TDP2, PARP1, synergy, HEK293 knockout cell line, polyphenols, PARP-1 inhibitors, Research and information: general, Biology, life sciences

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Access URL: https://directory.doabooks.org/handle/20.500.12854/101373
https://mdpi.com/books/pdfview/book/7469

Transcriptomic correlates of cell cycle checkpoints with distinct prognosis, molecular characteristics, immunological regulation, and therapeutic response in colorectal adenocarcinoma

Authors: Heng Wang, Wei Wang, Zhen Wang, Xu Li

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: colorectal adenocarcinoma, cell cycle checkpoint, CCCs signature, overall survival, molecular characteristics, immunological regulation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1291859/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/305e255bebec44578e7ce0fcf3eaef8c

Myt1 overexpression mediates resistance to cell cycle and DNA damage checkpoint kinase inhibitors

Authors: Sargun Sokhi, Cody W. Lewis, Amirali B. Bukhari, Joanne Hadfield, Edric J. Xiao, Jeremy Fung, Yea Jin Yoon, Wen-Hsin Hsu, Armin M. Gamper, Gordon K. Chan

Source: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Subject Terms: cell cycle, cell cycle checkpoint kinase inhibitors, DNA damage checkpoint kinase inhibitors, Myt1 overexpression, resistance, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2023.1270542/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/bb42fe2ab7be453fa00e30cc0aa196a6

The synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment

Authors: Shuangying Li, Liangliang Wang, Yuanyuan Wang, Changyi Zhang, Zhenya Hong, Zhiqiang Han

Source: Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-32 (2022)

Subject Terms: Cell cycle checkpoint, PARP inhibitors, Drug resistance, Synthetic lethality, Targeted therapy, Cancer, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/4effe64b8756463d91fc308a868b8202

Combined evaluation of both WEE1 and phosphorylated cyclin dependent kinase 1 expressions in oral squamous cell carcinomas predicts cancer recurrence and progression

Authors: Yu-Hsueh Wu, Julia Yu-Fong Chang, Chun-Pin Chiang, Yi-Ping Wang

Source: Journal of Dental Sciences, Vol 17, Iss 4, Pp 1780-1787 (2022)

Subject Terms: WEE1, Cyclin-dependent kinase 1, Oral squamous cell carcinoma, Cell cycle checkpoint, Immunohisto-chemistry, Dentistry, RK1-715

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1991790222001921; https://doaj.org/toc/1991-7902

Access URL: https://doaj.org/article/c5c9e51aac554a04817a2bd340eea140

The DDR-related gene signature with cell cycle checkpoint function predicts prognosis, immune activity, and chemoradiotherapy response in lung adenocarcinoma

Authors: Quan Li, Pan Zhang, Huixiao Hu, Hang Huang, Dong Pan, Guangyun Mao, Burong Hu

Source: Respiratory Research, Vol 23, Iss 1, Pp 1-17 (2022)

Subject Terms: Lung adenocarcinoma, Cancer prognosis, DNA damage repair, Cell cycle checkpoint, Gene signature, Diseases of the respiratory system, RC705-779

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Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/0630163dc96d4a8cb8fd7ef8b9cb351f

Cyclin-dependent kinases in DNA damage response

Authors: Kciuk, Mateusz ^{a, b, ⁎}, Gielecińska, Adrianna ^a, Mujwar, Somdutt ^c, Mojzych, Mariusz ^d, Kontek, Renata ^a

Source: In BBA - Reviews on Cancer May 2022 1877(3)

Mec1-independent activation of the Rad53 checkpoint kinase revealed by quantitative analysis of protein localization dynamics

Authors: Brandon Ho, Ethan J Sanford, Raphael Loll-Krippleber, Nikko P Torres, Marcus B Smolka, Grant W Brown

Source: eLife, Vol 12 (2023)

Subject Terms: DNA repair, protein localization, cell cycle checkpoint, protein kinase, retrograde signaling, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/82483; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/237e6447f30d4f348e1780f7a1ef4b11

Cell cycle checkpoint signaling through the ATR and ATM kinases

Authors: Ming Liu, Wen-Xiang Hu

Source: The 2nd International Conference on Information Science and Engineering Information Science and Engineering (ICISE), 2010 2nd International Conference on. :1-4 Dec, 2010

Relation: 2010 2nd International Conference on Information Science and Engineering (ICISE)

Overexpression of claspin promotes docetaxel resistance and is associated with prostate‐specific antigen recurrence in prostate cancer

Authors: Takashi Babasaki, Kazuhiro Sentani, Yohei Sekino, Go Kobayashi, Quoc Thang Pham, Narutaka Katsuya, Shintaro Akabane, Daiki Taniyama, Tetsutaro Hayashi, Masaki Shiota, Naohide Oue, Jun Teishima, Akio Matsubara, Wataru Yasui

Source: Cancer Medicine, Vol 10, Iss 16, Pp 5574-5588 (2021)

Subject Terms: cell cycle checkpoint, claspin, DNA damage repair, docetaxel resistance, prostate cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/e27c82e0d2d144ce81b5740eabe5b976

Elevated TAB182 enhances the radioresistance of esophageal squamous cell carcinoma through G2‐M checkpoint modulation

Authors: Yuandong Cao, Aidi Gao, Xiaoqing Li, Han Min, Chao He, Xinchen Sun, Wei‐Qun Ding, Jundong Zhou

Source: Cancer Medicine, Vol 10, Iss 9, Pp 3101-3112 (2021)

Subject Terms: esophageal squamous cell carcinoma, FHL2, G2‐M cell cycle checkpoint, radioresistance, TAB182, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://doaj.org/toc/2045-7634

Access URL: https://doaj.org/article/765c4a42965c4ae69f52c6c6ec7b320f

Cell Cycle Checkpoint Kinase and Drug Resistance of Lung Cancer

Authors: Zhiyin KE, Ailing LIANG, Yongjun LIU

Source: Chinese Journal of Lung Cancer, Vol 24, Iss 4, Pp 265-270 (2021)

Subject Terms: cell cycle checkpoint kinase, lung neoplasms, drug resistance, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1009-3419; https://doaj.org/toc/1999-6187

Access URL: https://doaj.org/article/27738a0497b94163affc2d964fa29454

Impairment of RAD17 Functions by miR-506-3p as a Novel Synthetic Lethal Approach Targeting DNA Repair Pathways in Ovarian Cancer

Authors: Marina Bagnoli, Roberta Nicoletti, Monica Valitutti, Andrea Rizzo, Alessandra Napoli, Rafaela Montalvão De Azevedo, Antonella Tomassetti, Delia Mezzanzanica

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: miR-506-3p, ChrXq27.3 miRNA cluster, RAD17, cell cycle checkpoint inhibitors, DNA damage and repair, ovarian cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.923508/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/4803c9df65ad40f0932e2028409870de