Harnessing the Power of Generative Artificial Intelligence in Pathology Education: Opportunities, Challenges, and Future Directions.

Authors: Cecchini, Matthew J.¹, Borowitz, Michael J.², Glassy, Eric F.³, Gullapalli, Rama R.⁴, Hart, Steven N.⁵, Hassell, Lewis A.⁶, Homer, Robert J.⁷, Jackups Jr., Ronald⁸, McNeal, Jeffrey L.⁹, Anderson, Scott R.¹⁰ scott.anderson@uvmhealth.org

Source: Archives of Pathology & Laboratory Medicine. Feb2025, Vol. 149 Issue 2, p142-151. 10p.

Subject Terms: *GENERATIVE artificial intelligence, *SCHOOL environment, *PATHOLOGY, *MEDICAL education, *CONTENT analysis, *NATURAL language processing, *EDUCATIONAL technology, *CURRICULUM planning, *LEARNING strategies, *ACCESS to information

Concurrent Neoadjuvant Chemotherapy and Radiation in Locally Advanced Breast Cancer: Impact on Locoregional Recurrence Rates.

Authors: Grindrod, Natalie^1,2 (AUTHOR), Cecchini, Matthew^1,2 (AUTHOR), Brackstone, Muriel^1,3 (AUTHOR) muriel.brackstone@lhsc.on.ca

Source: Current Oncology. Feb2025, Vol. 32 Issue 2, p85. 11p.

Subject Terms: *NEOADJUVANT chemotherapy, *RADIOTHERAPY, *CLINICAL trials, *TUMOR-infiltrating immune cells, *TREATMENT effectiveness, *HISTOPATHOLOGY, *DISEASE relapse, *METASTATIC breast cancer

Predicting cancer content in tiles of lung squamous cell carcinoma tumours with validation against pathologist labels

Authors: Dammak, Salma ^{a, b}, Cecchini, Matthew J. ^c, Coats, Jennifer ^c, Baranova, Katherina ^c, Ward, Aaron D. ^{a, b, d, e, ⁎}

Source: In Computers in Biology and Medicine February 2025 185

Cellular blueprint of healthy and diseased human epiglottis and subglottis—a study of the Canadian Airways Research (CARE) group

Authors: Lin, R. Jun, Fung, Kevin, Hu, Amanda, Anderson, Jennifer, Coburn, Bryan, Mymryk, Joe S., Zeng, Peter Y.F., Cecchini, Matthew J., Ying, Shengjie, Khan, Halema, Barrett, John W., Nichols, Anthony C., Woo, Elissa ^b, MacInnis, Patrick ^c, Jarycki, Laura ^a, Karimi, Amir ^{a, b}, Al Jawhri, MohdWessam ^{a, b}, Lin, Sherman ^{a, b}, Shaikh, Mushfiq ^{a, b, i}, Pan, Harrison ^{a, b}, Inculet, Richard ^h

Source: In eBioMedicine April 2025 114

Cohort-level clinical trajectory and molecular landscape of idiopathic subglottic stenosis for precision laryngology—a study of the Canadian Airways Research (CARE) group

Authors: Lin, R. Jun, Fung, Kevin, Hu, Amanda, Anderson, Jennifer, Coburn, Bryan, Mymryk, Joe S., Zeng, Peter Y.F., Cecchini, Matthew J., Ying, Shengjie, Khan, Halema, Barrett, John W., Nichols, Anthony C., Woo, Elissa ^c, MacInnis, Patrick ^a, Karimi, Amir ^{b, c}, Al Jawhri, MohdWessam ^{b, c}, Lin, Sherman ^{b, c}, Jarycki, Laura ^b, Shaikh, Mushfiq H. ^{b, c, i}, Pan, Harrison ^{b, c}, Inculet, Richard ^h

Source: In eBioMedicine April 2025 114

Spatially resolved gene expression profiles of fibrosing interstitial lung diseases.

Authors: Kim, Seung J.^1,2 (AUTHOR) seung.kim@lhsc.on.ca, Cecchini, Matthew J.³ (AUTHOR), Woo, Elissa³ (AUTHOR), Jayawardena, Nathashi^1,2 (AUTHOR), Passos, Daniel T.^2,3,4 (AUTHOR), Dick, Frederick A.^2,3,4 (AUTHOR), Mura, Marco^1,5 (AUTHOR)

Source: Scientific Reports. 11/2/2024, Vol. 14 Issue 1, p1-15. 15p.

Subject Terms: *INTERSTITIAL lung diseases, *GENE expression profiling, *IDIOPATHIC pulmonary fibrosis, *HYPERSENSITIVITY pneumonitis, *PULMONARY fibrosis

Eye tracking in digital pathology: A comprehensive literature review

Authors: Lopes, Alana, Ward, Aaron D., Cecchini, Matthew

Source: In Journal of Pathology Informatics December 2024 15

Loss of MACROD2 drives radioresistance but not cisplatin resistance in HPV-positive head and neck cancer

Authors: Dawson, Alice, Karimi, Amir Hossein, Shaikh, Mushfiq H., Gazala, Walid, Zeng, Peter Y.F., Ryan, Sarah E.B., Pan, Harrison, Khan, Halema, Cecchini, Matthew, Mendez, Adrian, Palma, David A., Mymryk, Joe S., Barrett, John W., Nichols, Anthony C.

Source: In Oral Oncology December 2024 159

Association between synovial tissue damage and pain in late-stage knee osteoarthritis: A cross-sectional study

Authors: Philpott, Holly T. ^{#, †}, Birmingham, Trevor B. ^{#, †}, Carter, McKenzie M. ^{†, ‡}, Cecchini, Matthew J. ^§, Giffin, J. Robert ^¶, Vasarhelyi, Edward M. ^{†, ¶}, MacDonald, Steven J. ^¶, Lanting, Brent A. ^{†, ¶}, Appleton, C. Thomas ^{†, ‡, ∥, *}

Source: In Osteoarthritis and Cartilage November 2024 32(11):1503-1512

The genomic and evolutionary landscapes of anaplastic thyroid carcinoma

Authors: Zeng, Peter Y.F. ^{1, 2, 3, 4, 47}, Prokopec, Stephenie D. ^{5, 45, 46, 47}, Lai, Stephen Y. ^{6, 47}, Pinto, Nicole ¹, Chan-Seng-Yue, Michelle A. ⁵, Clifton-Bligh, Roderick ⁷, Williams, Michelle D. ⁸, Howlett, Christopher J. ⁹, Plantinga, Paul ⁹, Cecchini, Matthew J. ¹⁰, Lam, Alfred K. ¹⁰, Siddiqui, Iram ¹¹, Wang, Jianxin ⁵, Sun, Ren X. ⁵, Watson, John D. ^{5, 45, 46}, Korah, Reju ¹², Carling, Tobias ¹², Agrawal, Nishant ¹³, Cipriani, Nicole ¹⁴, Ball, Douglas ¹⁵, Nelkin, Barry ¹⁶, Rooper, Lisa M. ¹⁷, Bishop, Justin A. ¹⁸, Garnis, Cathie ¹⁹, Berean, Ken ¹⁹, Nicolson, Norman G. ¹², Weinberger, Paul ^{20, 21}, Henderson, Ying C. ⁶, Lalansingh, Christopher M. ⁵, Tian, Mao ^{45, 46}, Yamaguchi, Takafumi N. ^{5, 45, 46}, Livingstone, Julie ^{5, 45, 46}, Salcedo, Adriana ^{5, 22, 42}, Patel, Krupal ^{1, 5}, Vizeacoumar, Frederick ²³, Datti, Alessandro ^{24, 25}, Xi, Liu ²⁶, Nikiforov, Yuri E. ²⁷, Smallridge, Robert ²⁸, Copland, John A. ²⁹, Marlow, Laura A. ²⁹, Hyrcza, Martin D. ³⁰, Delbridge, Leigh ^{31, 32}, Sidhu, Stan ^{31, 32}, Sywak, Mark ^{31, 32}, Robinson, Bruce ^{32, 33}, Fung, Kevin ^{1, 4}, Ghasemi, Farhad ¹, Kwan, Keith ⁹, MacNeil, S. Danielle ^{1, 4}, Mendez, Adrian ^{1, 4}, Palma, David A. ^{2, 3, 4}, Khan, Mohammed I. ¹, Shaikh, Mushfiq ¹, Ruicci, Kara M. ¹, Wehrli, Bret ⁹, Winquist, Eric ^{2, 3, 4}, Yoo, John ^{1, 4}, Mymryk, Joe S. ^{1, 2, 4, 34}, Rocco, James W. ³⁵, Wheeler, David ²⁶, Scherer, Steve ²⁶, Giordano, Thomas J. ³⁶, Barrett, John W. ¹, Faquin, William C. ³⁷, Gill, Anthony J. ^{32, 38, 39}, Clayman, Gary ^{40, 47}, Boutros, Paul C. ^{22, 41, 42, 43, 44, 45, 46, 47, ∗}, Nichols, Anthony C. ^{1, 2, 3, 4, 47, 48, ∗∗}

Source: In Cell Reports 26 March 2024 43(3)

The protective role of postoperative radiation therapy in low and intermediate grade major salivary gland malignancies: A study of the Canadian Head and Neck Collaborative Research Initiative

Authors: Morand, Grégoire B., Eskander, Antoine, Fu, Rui, Almeida, John, Goldstein, David, Noroozi, Hesameddin, Hosni, Ali, Seikaly, Hadi, Tabet, Paul, Pyne, Justin M., Matthews, T. Wayne, Dort, Joseph, Nakoneshny, Steve, Christopoulos, Apostolos, Bahig, Houda, Johnson‐Obaseki, Stephanie, Hua, Nadia, Gaudet, Marc, Jooya, Alborz, Nichols, Anthony, Laxague, Francisco, Cecchini, Matthew, Du, Jenny, Shapiro, Justin, Karam, Irene, Dziegielewski, Peter T., Hanubal, Krishna, Erovic, Boban, Grasl, Stefan, Davies, Joel, Monteiro, Eric, Gete, Maru, Witterick, Ian, Sadeghi, Nader, Richardson, Keith, Shenouda, George, Maniakas, Anastasios, Landry, Vivianne, Gupta, Michael, Zhou, Kelvin, Mlynarek, Alex M., Pusztaszeri, Marc, Sultanem, Khalil, Hier, Michael P.

Source: Cancer. 129(20):3263-3274

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193690621.0x000001&indx=1&recIds=ETOCvdc_100193690621.0x000001

Loss of LRP1B expression drives acquired chemo and radio-resistance in HPV-positive head and neck cancer

Authors: Shaikh, Mushfiq H., Dawson, Alice, Prokopec, Stephenie D., Barrett, John W., Y.F. Zeng, Peter, Khan, Mohammed I., Ryan, Sarah E.B., Cecchini, Matthew, Palma, David A., Mymryk, Joe S., Boutros, Paul C., Nichols, Anthony C.

Source: In Oral Oncology November 2023 146

Digital Quantification of Tumor Cellularity as a Novel Prognostic Feature of Non–Small Cell Lung Carcinoma

Authors: Lin, Sherman, Samsoondar, Joshua P., Bandari, Ela, Keow, Samantha, Bikash, Binit, Tan, Djarren, Martinez-Acevedo, Jacobo, Loggie, John, Pham, Michelle, Wu, Nina J., Misra, Tanya, Lam, Victor H.K., Sansano, Irene, Cecchini, Matthew J.

Source: In Modern Pathology March 2023 36(3)

Pathways to Precision.

Authors: Cecchini, Matthew J.¹ Matthew.Cecchini@lhsc.on.ca

Source: Archives of Pathology & Laboratory Medicine. Jul2024, Vol. 148 Issue 7, p754-756. 3p.

Subject Terms: *MEDICAL protocols, *SERIAL publications, *PROGRAMMED death-ligand 1, *IMMUNOTHERAPY, *CANCER patients, *TUMOR markers, *DECISION making in clinical medicine, *IMMUNOHISTOCHEMISTRY, *IMMUNE checkpoint inhibitors, *LUNG tumors, *INDIVIDUALIZED medicine, *GENETIC mutation, *GENETIC testing

Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification

Authors: Zeng, Peter Y.F., Cecchini, Matthew J., Barrett, John W., Shammas-Toma, Matthew, De Cecco, Loris, Serafini, Mara S., Cavalieri, Stefano, Licitra, Lisa, Hoebers, Frank, Brakenhoff, Ruud H., Leemans, C. René, Scheckenbach, Kathrin, Poli, Tito, Wang, Xiaowei, Liu, Xinyi, Laxague, Francisco, Prisman, Eitan, Poh, Catherine, Bose, Pinaki, Dort, Joseph C., Shaikh, Mushfiq H., Ryan, Sarah E.B., Dawson, Alice, Khan, Mohammed I., Howlett, Christopher J., Stecho, William, Plantinga, Paul, Daniela da Silva, Sabrina, Hier, Michael, Khan, Halema, MacNeil, Danielle, Mendez, Adrian, Yoo, John, Fung, Kevin, Lang, Pencilla, Winquist, Eric, Palma, David A., Ziai, Hedyeh, Amelio, Antonio L., Li, Shawn S-C., Boutros, Paul C., Mymryk, Joe S., Nichols, Anthony C.

Source: In eBioMedicine December 2022 86

Giant Cell, Giant Problems: A Case of Giant Cell Myocarditis Complicated by Cardiogenic Shock and Refractory Ventricular Tachycardia Managed With a Mechanical Circulatory Support Device

Authors: Goulbourne, Clive A., Sharma, Navneet, Cecchini, Matthew J., Bloom, Michelle, Singh, Abhijeet, Skopicki, Hal, Pyo, Robert

Source: Cardiovascular revascularization medicine. 28(S):180-185

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135893187.0x000001&indx=1&recIds=ETOCvdc_100135893187.0x000001

Pathology, Radiology, and Genetics of Interstitial Lung Disease in Patients With Shortened Telomeres

Authors: Cecchini, Matthew J., Tarmey, Tara, Ferreira, Allison, Mangaonkar, Abhishek A., Ferrer, Alejandro, Patnaik, Mrinal M., Wylam, Mark E., Jenkins, Sarah M., Spears, Grant M., Yi, Eunhee S., Hartman, Thomas E., Scott, John P., Roden, Anja C.

Source: American journal of surgical pathology. 45(7):871-884

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185885519.0x000001&indx=1&recIds=ETOCvdc_100185885519.0x000001

Update on Practical Management of Early-Stage Non-Small Cell Lung Cancer (NSCLC): A Report from the Ontario Forum.

Authors: Cheema, Parneet K., Wheatley-Price, Paul F., Cecchini, Matthew J., Ellis, Peter M., Louie, Alexander V., Moore, Sara, Sheffield, Brandon S., Spicer, Jonathan D., Villeneuve, Patrick James, Leighl, Natasha B.

Source: Current Oncology; Nov2024, Vol. 31 Issue 11, p6979-6999, 21p

Subject Terms: ANAPLASTIC lymphoma kinase, NON-small-cell lung carcinoma, EPIDERMAL growth factor receptors, MEDICAL personnel, IMMUNE checkpoint inhibitors

SMARCA4-Deficient Undifferentiated Tumor of the Esophagus: Diagnostic Pitfalls in Immunohistochemical Profiles.

Authors: Chakrabarti, Rana, Lin, Sherman, Wang, Hui, Cecchini, Matthew

Source: International Journal of Surgical Pathology; Oct2024, Vol. 32 Issue 7, p1292-1302, 11p

Subject Terms: CANCER chemotherapy, ESOPHAGEAL tumors, CHEST (Anatomy), GASTROINTESTINAL tumors

Using deep learning to predict tumor mutational burden in lung squamous cell carcinoma from 20 centers
Medical Imaging 2022: Digital and Computational Pathology

Authors: Dammak, Salma, Cecchini, Matthew J., Ward, Aaron D.

Source: Proceedings of SPIE, the International Society for Optical Engineering. 12039:120390T-120390T-8

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN900045250&indx=1&recIds=ETOCCN900045250