Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors

Authors: Musiani, Daniele ¹, Yücel, Hatice ¹, Vallette, Marie ¹, Angrisani, Annapaola ², El Botty, Rania ³, Ouine, Bérengère ⁴, Schintu, Niccolo ¹, Adams, Caroline ¹, Chevalier, Manon ¹, Heloise, Derrien ³, El Marjou, Ahmed ⁴, Nemazanyy, Ivan ⁵, Regairaz, Marie ^{1, 6}, Marangoni, Elisabetta ³, Fachinetti, Daniele ², Ceccaldi, Raphael ^{1, 7, ∗}

Source: In Molecular Cell 20 March 2025 85(6):1072-1084

DNA damage induces nuclear envelope rupture through ATR-mediated phosphorylation of lamin A/C

Authors: Kovacs, Marton Tibor, Vallette, Marie, Wiertsema, Pauline, Dingli, Florent, Loew, Damarys, Nader, Guilherme Pedreira de Freitas, Piel, Matthieu, Ceccaldi, Raphael

Source: In Molecular Cell 19 October 2023 83(20):3659-3668

CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

Authors: Przetocka, Sara, Porro, Antonio, Bolck, Hella A., Walker, Christina, Lezaja, Aleksandra, Trenner, Anika, von Aesch, Christine, Himmels, Sarah-Felicitas, D’Andrea, Alan D., Ceccaldi, Raphael, Altmeyer, Matthias, Sartori, Alessandro A.

Source: In Molecular Cell 1 November 2018 72(3):568-582

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

Authors: Kais, Zeina, Rondinelli, Beatrice, Holmes, Amie, O’Leary, Colin, Kozono, David, D’Andrea, Alan D., Ceccaldi, Raphael

Source: In Cell Reports 14 June 2016 15(11):2488-2499

Repair Pathway Choices and Consequences at the Double-Strand Break

Authors: Ceccaldi, Raphael, Rondinelli, Beatrice, D’Andrea, Alan D.

Source: In Trends in Cell Biology January 2016 26(1):52-64

Transcriptional Repressor ZBTB1 Promotes Chromatin Remodeling and Translesion DNA Synthesis

Authors: Kim, Hyungjin, Dejsuphong, Donniphat, Adelmant, Guillaume, Ceccaldi, Raphael, Yang, Kailin, Marto, Jarrod A., D’Andrea, Alan D.

Source: In Molecular Cell 10 April 2014 54(1):107-118

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis.

Authors: Gelot, Camille, Kovacs, Marton Tibor, Miron, Simona, Mylne, Emilie, Haan, Alexis, Boeffard-Dosierre, Liza, Ghouil, Rania, Popova, Tatiana, Dingli, Florent, Loew, Damarys, Guirouilh-Barbat, Josée, Del Nery, Elaine, Zinn-Justin, Sophie, Ceccaldi, Raphael

Source: Nature; Sep2023, Vol. 621 Issue 7978, p415-422, 8p

Gene polymorphisms and cytokine plasma levels as predictive factors of complications after cardiopulmonary bypass

Authors: Jouan, Jérôme, Golmard, Lisa, Benhamouda, Nadine, Durrleman, Nicolas, Golmard, Jean-Louis, Ceccaldi, Raphaël, Trinquart, Ludovic, Fabiani, Jean-Noël, Tartour, Eric, Jeunemaitre, Xavier, Menasché, Philippe

Source: In The Journal of Thoracic and Cardiovascular Surgery August 2012 144(2):467-473

Bone Marrow Failure in Fanconi Anemia Is Triggered by an Exacerbated p53/p21 DNA Damage Response that Impairs Hematopoietic Stem and Progenitor Cells

Authors: Ceccaldi, Raphael, Parmar, Kalindi, Mouly, Enguerran, Delord, Marc, Kim, Jung Min, Regairaz, Marie, Pla, Marika, Vasquez, Nadia, Zhang, Qing-Shuo, Pondarre, Corinne, Peffault de Latour, Régis, Gluckman, Eliane, Cavazzana-Calvo, Marina, Leblanc, Thierry, Larghero, Jérôme, Grompe, Markus, Socié, Gérard, D'Andrea, Alan D., Soulier, Jean

Source: In Cell Stem Cell 6 July 2012 11(1):36-49

Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions

Authors: Quentin, Samuel ^*, Cuccuini, Wendy ^*, Ceccaldi, Raphael, Nibourel, Olivier, Pondarre, Corinne, Pagès, Marie-Pierre, Vasquez, Nadia, Dubois d'Enghien, Catherine, Larghero, Jérôme, Peffault de Latour, Régis, Rocha, Vanderson, Dalle, Jean-Hugues, Schneider, Pascale, Michallet, Mauricette, Michel, Gérard, Baruchel, André, Sigaux, François, Gluckman, Eliane, Leblanc, Thierry, Stoppa-Lyonnet, Dominique, Preudhomme, Claude, Socié, Gérard, Soulier, Jean

Source: In Blood 14 April 2011 117(15):e161-e170

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.

Authors: Ceccaldi, Raphael¹, Liu, Jessica C.², Amunugama, Ravindra³, Hajdu, Ildiko⁴, Primack, Benjamin¹, Petalcorin, Mark I. R.⁵, O'Connor, Kevin W.¹, Konstantinopoulos, Panagiotis A.⁶, Elledge, Stephen J.⁴, Boulton, Simon J.⁵, Yusufzai, Timur⁷, D'Andrea, Alan D.¹

Source: Nature. 2/12/2015, Vol. 518 Issue 7538, p258-262. 5p. 1 Diagram, 13 Graphs.

Subject Terms: *CANCER genetics, *OVARIAN cancer, *GENOMICS, *DNA repair, *DNA polymerases, TUMOR genetics

Publisher Correction: Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis.

Authors: Gelot, Camille, Kovacs, Marton Tibor, Miron, Simona, Mylne, Emilie, Haan, Alexis, Boeffard-Dosierre, Liza, Ghouil, Rania, Popova, Tatiana, Dingli, Florent, Loew, Damarys, Guirouilh-Barbat, Josée, Del Nery, Elaine, Zinn-Justin, Sophie, Ceccaldi, Raphael

Source: Nature; Feb2024, Vol. 626 Issue 7999, pE13-E13, 1p

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The Fanconi anaemia pathway: new players and new functions

Authors: Ceccaldi, Raphael, Sarangi, Prabha, D'Andrea, Alan D.

Source: Nature Reviews Molecular Cell Biology; June 2016, Vol. 17 Issue: 6 p337-349, 13p

Analysis of Rare deletional Thalassemia Using Custom CGH Array DNA Chip

Authors: Pissard, Serge ^*, Ceccaldi, Raphael ^*, Faubert-Laugé, Emmanuelle ^*, Velayoudane, Valerie ^*, Delattre, Valerie ^*, Lecerf, Laure ^*

Source: In Blood 19 November 2010 116(21):4278-4278