Chitosan/γ-PGA nanoparticles and IFN-γ immunotherapy: A dual approach for triple-negative breast cancer treatment

Authors: Castro, Flávia ^{a, b, ⁎}, Pinto, Marta Laranjeiro ^{a, b, 1}, Leite Pereira, Catarina ^{a, b, 1}, Serre, Karine ^c, Costa, Ângela Margarida ^{a, b}, Cavadas, Bruno ^a, Barbosa, Mário Adolfo ^{a, b, d}, Vermaelen, Karim ^{e, f}, León, Sergio ^{g, h}, Serrano, Diego ^g, Gärtner, Fátima ^{a, d, i}, Calvo, Alfonso ^{g, h}, Gonçalves, Raquel Madeira ^{a, b, d, 2}, De Wever, Olivier ^{f, j, 2}, Oliveira, Maria José ^{a, b, d, 2}

Source: In Journal of Controlled Release 10 March 2025 379:621-635

Transcriptomic remodeling of gastric cells by Helicobacter pylori outer membrane vesicles.

Authors: Melo, Joana^1,2 (AUTHOR), Cavadas, Bruno¹ (AUTHOR), Pereira, Luísa^1,2,3 (AUTHOR), Figueiredo, Ceu^1,2,3 (AUTHOR), Leite, Marina^1,2,3 (AUTHOR) mleite@i3s.up.pt

Source: Helicobacter. Jan2024, Vol. 29 Issue 1, p1-11. 11p.

Subject Terms: *EXTRACELLULAR vesicles, *HELICOBACTER pylori, *TRANSCRIPTOMES, *MITOGEN-activated protein kinases, *PROTEIN kinases, *AMINO acid metabolism

Chitinase 3-like-1 and fibronectin in the cargo of extracellular vesicles shed by human macrophages influence pancreatic cancer cellular response to gemcitabine

Authors: Xavier, Cristina P.R., Castro, Inês, Caires, Hugo R., Ferreira, Dylan, Cavadas, Bruno, Pereira, Luisa, Santos, Lúcio L., Oliveira, Maria J., Vasconcelos, M. Helena

Source: In Cancer Letters 31 March 2021 501:210-223

Genomic and transcriptomic characterization of the mitochondrial-rich oncocytic phenotype on a thyroid carcinoma background

Authors: Cavadas, Bruno, Pereira, Joana B., Correia, Marcelo, Fernandes, Verónica, Eloy, Catarina, Sobrinho-Simões, Manuel, Soares, Paula, Samuels, David C., Máximo, Valdemar, Pereira, Luisa

Source: In Mitochondrion May 2019 46:123-133

Population genetics-informed meta-analysis in seven genes associated with risk to dengue fever disease

Authors: Oliveira, Marisa, Saraiva, Diana P., Cavadas, Bruno, Fernandes, Verónica, Pedro, Nicole, Casademont, Isabelle, Koeth, Fanny, Alshamali, Farida, Harich, Nourdin, Cherni, Lotfi, Sierra, Beatriz, Guzman, Maria G., Sakuntabhai, Anavaj, Pereira, Luisa

Source: In Infection, Genetics and Evolution August 2018 62:60-72

Exosomes define a local and systemic communication network in healthy pancreas and pancreatic ductal adenocarcinoma.

Authors: Adem, Bárbara, Bastos, Nuno, Ruivo, Carolina F., Sousa-Alves, Sara, Dias, Carolina, Vieira, Patrícia F., Batista, Inês A., Cavadas, Bruno, Saur, Dieter, Machado, José C., Cai, Dawen, Melo, Sonia A.

Source: Nature Communications; 2/21/2024, Vol. 15 Issue 1, p1-22, 22p

Subject Terms: PANCREATIC duct, TELECOMMUNICATION systems, EXOSOMES, LOCAL mass media, PANCREAS, ADENOCARCINOMA, BONE marrow

A unique serum IgG glycosylation signature predicts development of Crohn’s disease and is associated with pathogenic antibodies to mannose glycan

Authors: Gaifem, Joana, Rodrigues, Cláudia S., Petralia, Francesca, Alves, Inês, Leite-Gomes, Eduarda, Cavadas, Bruno, Dias, Ana M., Moreira-Barbosa, Catarina, Revés, Joana, Laird, Renee M., Novokmet, Mislav, Štambuk, Jerko, Habazin, Siniša, Turhan, Berk, Gümüş, Zeynep H., Ungaro, Ryan, Torres, Joana, Lauc, Gordan, Colombel, Jean-Frederic, Porter, Chad K., Pinho, Salomé S.

Source: Nature Immunology; 20240101, Issue: Preprints p1-12, 12p

Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival.

Authors: Poças, Juliana^1,2,3, Marques, Catarina^1,2,3, Gomes, Catarina^1,2, Otake, Andreia Hanada^4,5, Pinto, Filipe^1,2, Ferreira, Mariana^1,2, Silva, Tiago^1,2, Faria-Ramos, Isabel^1,2, Matos, Rita^1,2, Ribeiro, Ana Raquel¹, Senra, Emanuel¹, Cavadas, Bruno¹, Batista, Sílvia⁴, Maia, Joana⁴, Macedo, Joana A.^1,2, Lima, Luís⁶, Afonso, Luís Pedro⁶, Ferreira, José Alexandre⁶, Santos, Lúcio Lara⁶, Polónia, António^1,2

Source: Proceedings of the National Academy of Sciences of the United States of America; 5/16/2023, Vol. 120 Issue 20, p1-11, 45p

First insight into oral microbiome diversity in Papua New Guineans reveals a specific regional signature.

Authors: Pedro, Nicole, Brucato, Nicolas, Cavadas, Bruno, Lisant, Valentine, Camacho, Rui, Kinipi, Christopher, Leavesley, Matthew, Pereira, Luisa, Ricaut, François‐Xavier

Source: Molecular Ecology; May2023, Vol. 32 Issue 10, p2551-2564, 14p

Subject Terms: ABORIGINAL Australians, HUMAN microbiota, BIODIVERSITY, HUMAN body, BACTERIAL population, PUBLIC spaces

Geographic Terms: PAPUA New Guinea

Extracellular Vesicles from Pancreatic Cancer Stem Cells Lead an Intratumor Communication Network (EVNet) to fuel tumour progression.

Authors: Ruivo, Carolina F., Bastos, Nuno, Adem, Barbara, Batista, Ines, Duraes, Cecilia, Melo, Carlos A., Castaldo, Stephanie A., Campos-Laborie, Francisco, Moutinho-Ribeiro, Pedro, Morão, Barbara, Costa-Pinto, Ana, Silva, Soraia, Osorio, Hugo, Ciordia, Sergio, Costa, Jose Luis, Goodrich, David, Cavadas, Bruno, Pereira, Luisa, Kouzarides, Tony, Macedo, Guilherme

Source: Gut; Oct2022, Vol. 71 Issue 10, p2043-2068, 171p

Subject Terms: CANCER stem cells, TELECOMMUNICATION systems, EXTRACELLULAR vesicles, PANCREATIC intraepithelial neoplasia, PANCREATIC cancer, CYTOSKELETAL proteins

Projecting Ancient Ancestry in Modern-Day Arabians and Iranians: A Key Role of the Past Exposed Arabo-Persian Gulf on Human Migrations.

Authors: Ferreira, Joana C, Alshamali, Farida, Montinaro, Francesco, Cavadas, Bruno, Torroni, Antonio, Pereira, Luisa, Raveane, Alessandro, Fernandes, Veronica

Source: Genome Biology & Evolution; Sep2021, Vol. 13 Issue 9, p1-12, 12p

Subject Terms: HUMAN migrations, IRANIANS, HUMAN DNA, FOSSIL DNA, GENEALOGY, NEANDERTHALS

Geographic Terms: ARABIAN Peninsula, IRAN

Sub-Saharan African information potential to unveil adaptations to infectious disease.

Authors: Pedro, Nicole, Pinto, Ricardo J, Cavadas, Bruno, Pereira, Luisa

Source: Human Molecular Genetics; Mar2021, Vol. 30 Issue R1, pR138-R145, 8p

A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis.

Authors: Lopes, Nair, Bergsland, Christian, Bruun, Jarle, Bjørnslett, Merete, Vieira, André Filipe, Mesquita, Patrícia, Pinto, Rita, Gomes, Rosa, Cavadas, Bruno, Bennett, Eric, Pereira, Luisa, Lothe, Ragnhild A., Almeida, Raquel, David, Leonor

Source: Gastric Cancer; Sep2020, Vol. 23 Issue 5, p811-823, 13p

Subject Terms: STOMACH cancer, CANCER patients, CANCER-related mortality, DIGITAL images, PROTEIN expression, ATROPHIC gastritis

The mitogenome portrait of Umbria in Central Italy as depicted by contemporary inhabitants and pre-Roman remains.

Authors: Modi, Alessandra, Lancioni, Hovirag, Cardinali, Irene, Capodiferro, Marco R., Rambaldi Migliore, Nicola, Hussein, Abir, Strobl, Christina, Bodner, Martin, Schnaller, Lisa, Xavier, Catarina, Rizzi, Ermanno, Bonomi Ponzi, Laura, Vai, Stefania, Raveane, Alessandro, Cavadas, Bruno, Semino, Ornella, Torroni, Antonio, Olivieri, Anna, Lari, Martina, Pereira, Luisa

Source: Scientific Reports; 7/1/2020, Vol. 10 Issue 1, p1-12, 12p

Subject Terms: MITOCHONDRIAL DNA, POPULATION genetics, NEOLITHIC Period

Geographic Terms: UMBRIA (Italy)

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OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed CUBANS.

Authors: Sierra, Beatriz¹, Siebet@ipk.sld.cu, Triska, Petr^2,3,4, Soares, Pedro³, Garcia, Gissel¹, Perez, Ana B.¹, Aguirre, Eglys¹, Oliveira, Marisa^2,3,4,5,6, Cavadas, Bruno^2,3, Regnault, Béatrice⁵, Alvarez, Mayling¹, Ruiz, Didye¹, Samuels, David C.⁷, Sakuntabhai, Anavaj⁶, Pereira, Luisa^2,3,8, luisap@ipatimup.pt, Guzman, Maria G.¹

Source: PLoS Pathogens; 2/27/2017, Vol. 13 Issue 2, p1-21, 21p

P481: FAILURE OF BONE MARROW ERYTHROPOIESIS IN ACUTE MYELOID LEUKEMIA IS DRIVEN BY LOSS OF ERYTHROBLASTIC ISLANDS.

Authors: Mosteo, Laura, Rocha, Lidia, Raquel Maceiras, Ana, Cavadas, Bruno, Pereira, Carolina, Lopes, Marta, Chacim, Sérgio, Ramos, Inês, Hawkins, Edwin, Mário Mariz, José, Porto, Graça, Duarte, Delfim

Source: HemaSphere; 2023 Supplement 3, Vol. 7, p1-2, 2p

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