Type I interferon receptor (IFNAR2) deficiency reveals Zika virus cytopathicity in human macrophages and microglia

Authors: Aidan T. Hanrath, Catherine F. Hatton, Florian Gothe, Cathy Browne, Jane Vowles, Peter Leary, Simon J. Cockell, Sally A. Cowley, William S. James, Sophie Hambleton, Christopher J. A. Duncan

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: Zika virus, IFNAR2 deficiency, inborn errors of immunity, macrophages, type I interferons, cell death, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1035532/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7b7909c2b1294e159f14f7444c6593f6

RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes

Authors: Heather D.E. Booth, Frank Wessely, Natalie Connor-Robson, Federica Rinaldi, Jane Vowles, Cathy Browne, Samuel G. Evetts, Michele T. Hu, Sally A. Cowley, Caleb Webber, Richard Wade-Martins

Source: Neurobiology of Disease, Vol 129, Iss , Pp 56-66 (2019)

Subject Terms: Induced pluripotent stem cells, Astrocytes, Neurodegeneration, Parkinson's disease, LRRK2, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996119301202; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/2c53914889f24f2e84b456f7cc9c2d65

An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2

Authors: Natalie Connor-Robson, Heather Booth, Jeffrey G. Martin, Benbo Gao, Kejie Li, Natalie Doig, Jane Vowles, Cathy Browne, Laura Klinger, Peter Juhasz, Christine Klein, Sally A. Cowley, Paul Bolam, Warren Hirst, Richard Wade-Martins

Source: Neurobiology of Disease, Vol 127, Iss , Pp 512-526 (2019)

Subject Terms: LRRK2, Parkinson's disease, Endocytosis, Clathrin, Endophilin, Rabs, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996119300968; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/2474a4c8f24f45c393a0062ca0f93f99

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

Authors: Jamie Toombs, Lindsay Panther, Loren Ornelas, Chunyan Liu, Emilda Gomez, Raquel Martín-Ibáñez, Simon R. Cox, Stuart J. Ritchie, Sarah E. Harris, Adele Taylor, Paul Redmond, Tom C. Russ, Lee Murphy, James D. Cooper, Karen Burr, Bhuvaneish T. Selvaraj, Cathy Browne, Clive N. Svendsen, Sally A. Cowley, Ian J. Deary, Siddharthan Chandran, Tara L. Spires-Jones, Dhruv Sareen

Source: Stem Cell Research, Vol 46, Iss , Pp 101851- (2020)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1873506120301525; https://doaj.org/toc/1873-5061

Access URL: https://doaj.org/article/2ec95fdbbd9044aca4c3416f0ee6b4db

Efficient, long term production of monocyte-derived macrophages from human pluripotent stem cells under partly-defined and fully-defined conditions.

Authors: Bonnie van Wilgenburg, Cathy Browne, Jane Vowles, Sally A Cowley

Source: PLoS ONE, Vol 8, Iss 8, p e71098 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3741356?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6b3f28871bde4010aa43150bc18464ef

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The 5′–3′ exoribonuclease pacman is required for epithelial sheet sealing in Drosophila and genetically interacts with the phosphatase puckered.

Authors: Dominic P. Grima, Melanie Sullivan, Maria V. Zabolotskaya, Cathy Browne, Julian Seago, Kay Chong Wan, Yoshio Okada, Sarah F. Newbury

Source: Biology of the Cell (Wiley-Blackwell); Dec2008, Vol. 100 Issue 12, p687-701, 15p

Subject Terms: RIBONUCLEASES, DROSOPHILA, PHOSPHATASES, RNA, GENETIC mutation, MESSENGER RNA, CELLULAR signal transduction, WOUND healing