Inherited C-terminal TREX1 variants disrupt homology-directed repair to cause senescence and DNA damage phenotypes in Drosophila, mice, and humans

Authors: Samuel D. Chauvin, Shoichiro Ando, Joe A. Holley, Atsushi Sugie, Fang R. Zhao, Subhajit Poddar, Rei Kato, Cathrine A. Miner, Yohei Nitta, Siddharth R. Krishnamurthy, Rie Saito, Yue Ning, Yuya Hatano, Sho Kitahara, Shin Koide, W. Alexander Stinson, Jiayuan Fu, Nehalee Surve, Lindsay Kumble, Wei Qian, Oleksiy Polishchuk, Prabhakar S. Andhey, Cindy Chiang, Guanqun Liu, Ludovic Colombeau, Raphaël Rodriguez, Nicolas Manel, Akiyoshi Kakita, Maxim N. Artyomov, David C. Schultz, P. Toby Coates, Elisha D. O. Roberson, Yasmine Belkaid, Roger A. Greenberg, Sara Cherry, Michaela U. Gack, Tristan Hardy, Osamu Onodera, Taisuke Kato, Jonathan J. Miner

Source: Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ca3eac3b209b443bb4c3882b9c20a335

The IFN-γ receptor promotes immune dysregulation and disease in STING gain-of-function mice

Authors: W. Alexander Stinson, Cathrine A. Miner, Fang R. Zhao, Annena Jane Lundgren, Subhajit Poddar, Jonathan J. Miner

Source: JCI Insight, Vol 7, Iss 17 (2022)

Subject Terms: Autoimmunity, Inflammation, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/a4c4e4bbfe444775954246d3e433d51c

STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice

Authors: Brock G. Bennion, Carys A. Croft, Teresa L. Ai, Wei Qian, Amber M. Menos, Cathrine A. Miner, Marie-Louis Frémond, Jean-Marc Doisne, Prabhakar S. Andhey, Derek J. Platt, Jennifer K. Bando, Erin R. Wang, Hella Luksch, Thierry J. Molina, Elisha D.O. Roberson, Maxim N. Artyomov, Angela Rösen-Wolff, Marco Colonna, Frédéric Rieux-Laucat, James P. Di Santo, Bénédicte Neven, Jonathan J. Miner

Source: Cell Reports, Vol 31, Iss 11, Pp 107771- (2020)

Subject Terms: STING, ILC, lymphoid tissue organogenesis, lymphopoiesis, SAVI, LTi cell, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124720307518; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/f1e6b14586b644339c225d5a7c1cd1ea