miR-204-5p Protects Nephrin from Enzymatic Degradation in Cultured Mouse Podocytes Treated with Nephrotoxic Serum.

Authors: Haddad, George¹ (AUTHOR), Blaine, Judith^1,2 (AUTHOR) judith.blaine@cuanschutz.edu

Source: Cells (2073-4409). Mar2025, Vol. 14 Issue 5, p364. 17p.

Subject Terms: *CATHEPSIN D, *FOCAL segmental glomerulosclerosis, *GENE expression, *LINCRNA, *GENETIC regulation

α-Synuclein Degradation in Brain Pericytes Is Mediated via Akt, ERK, and p38 MAPK Signaling Pathways.

Authors: Yokoya, Miki¹ (AUTHOR), Takata, Fuyuko^1,2 (AUTHOR), Iwao, Takuro¹ (AUTHOR), Matsumoto, Junichi^1,2 (AUTHOR), Tanaka, Yasuyoshi¹ (AUTHOR), Aridome, Hisataka¹ (AUTHOR), Yasunaga, Miho¹ (AUTHOR), Mizoguchi, Junko¹ (AUTHOR), Sano, Kazunori² (AUTHOR), Dohgu, Shinya¹ (AUTHOR) dohgu@fukuoka-u.ac.jp

Source: International Journal of Molecular Sciences. Feb2025, Vol. 26 Issue 4, p1615. 21p.

Subject Terms: *CATHEPSIN D, *PARKINSON'S disease, *ENDOTHELIAL cells, *PERICYTES, *PROTEASOME inhibitors

Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy 21 human cellular and mouse models.

Authors: Wu, Yixing^1,2 (AUTHOR) yixing.wu@ucl.ac.uk, Cleverley, Karen³ (AUTHOR), Wiseman, Frances K.^1,2 (AUTHOR) yixing.wu@ucl.ac.uk

Source: PLoS ONE. 1/22/2025, Vol. 20 Issue 1, p1-13. 13p.

Subject Terms: *CATHEPSIN B, *DISEASE risk factors, *PROTEIN precursors, *HUMAN chromosomes, *ALZHEIMER'S disease

Co-Localized in Amyloid Plaques Cathepsin B as a Source of Peptide Analogs Potential Drug Candidates for Alzheimer's Disease.

Authors: Theodoropoulou, Marilena K.¹ (AUTHOR), Vraila, Konstantina D.¹ (AUTHOR), Papandreou, Nikos C.¹ (AUTHOR) mtheod@biol.uoa.gr, Nasi, Georgia I.¹ (AUTHOR), Iconomidou, Vassiliki A.¹ (AUTHOR) veconom@biol.uoa.gr

Source: Biomolecules (2218-273X). Jan2025, Vol. 15 Issue 1, p28. 18p.

Subject Terms: *CATHEPSIN B, *PEPTIDES, *ALZHEIMER'S disease, *AMYLOID plaque, *MOLECULAR dynamics

Benzalkonium chloride initiates proinflammatory responses via NLRP3 inflammasome activation.

Authors: Tomohiro Kagi¹ takuya.noguchi.a7@tohoku.ac.jp, Maoko Tan¹, Wakana Suzuki¹, Kohei Otani¹, Sara Suzuki¹, Yusuke Hirata¹, Takuya Noguchi¹, Atsushi Matsuzaw¹ atsushi.matsuzawa.c6@tohoku.ac.jp

Source: Journal of Toxicological Sciences. 2025, Vol. 50 Issue 1, p11-21. 11p.

Subject Terms: *CATHEPSIN B, *CALCIUM antagonists, *BENZALKONIUM chloride, *CHELATING agents, *PULMONARY fibrosis

Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer's drug discovery.

Authors: Alrouji, Mohammed¹ (AUTHOR), Yasmin, Sabina² (AUTHOR), Alshammari, Mohammed S.³ (AUTHOR), Alhumaydhi, Fahad A.⁴ (AUTHOR), Sharaf, Sharaf E.⁵ (AUTHOR), Shahwan, Moyad⁶ (AUTHOR), Shamsi, Anas⁶ (AUTHOR) anas.shamsi18@gmail.com

Source: PLoS ONE. 12/19/2024, Vol. 19 Issue 12, p1-19. 19p.

Subject Terms: *AMYLOID beta-protein precursor, *CATHEPSIN B, *DRUG discovery, *PROTEOLYSIS, *VIRTUAL high-throughput screening (Drug development)

Improved recombinant expression of soluble cathepsin B and L in Escherichia coli.

Authors: Möller, Christina¹ (AUTHOR), Rimkus, Niklas¹ (AUTHOR), Skala, Ferdinand F. O.¹ (AUTHOR), Merouze, Maëlle¹ (AUTHOR), Böttcher, Dominique¹ (AUTHOR), Dörr, Mark¹ (AUTHOR), Bornscheuer, Uwe T.¹ (AUTHOR) uwe.bornscheuer@uni-greifswald.de

Source: Applied Microbiology & Biotechnology. 12/16/2024, Vol. 108 Issue 1, p1-9. 9p.

Subject Terms: *CATHEPSIN B, *ESCHERICHIA coli, *GENE expression, *SITE-specific mutagenesis, *CATHEPSINS

The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons.

Authors: Jones-Tabah, Jace^1,2 (AUTHOR), He, Kathy¹ (AUTHOR), Karpilovsky, Nathan¹ (AUTHOR), Senkevich, Konstantin^1,2 (AUTHOR), Deyab, Ghislaine¹ (AUTHOR), Pietrantonio, Isabella¹ (AUTHOR), Goiran, Thomas¹ (AUTHOR), Cousineau, Yuting² (AUTHOR), Nikanorova, Daria³ (AUTHOR), Goldsmith, Taylor⁴ (AUTHOR), del Cid Pellitero, Esther¹ (AUTHOR), Chen, Carol X.-Q.⁴ (AUTHOR), Luo, Wen⁴ (AUTHOR), You, Zhipeng⁴ (AUTHOR), Abdian, Narges⁴ (AUTHOR), Ahmad, Jamil^1,2 (AUTHOR), Ruskey, Jennifer A.^1,2 (AUTHOR), Asayesh, Farnaz^1,5 (AUTHOR), Spiegelman, Dan¹ (AUTHOR), Fahn, Stanley⁶ (AUTHOR)

Source: Molecular Neurodegeneration. 11/25/2024, Vol. 19 Issue 1, p1-21. 21p.

Subject Terms: *CATHEPSIN B, *PARKINSON'S disease, *GENETIC regulation, *PROTEOLYSIS, *ALPHA-synuclein

Cysteine protease cathepsin B promotes lysosome integrity to extend the lifespan of alternative day fasting worms.

Authors: Yin, Xue¹ (AUTHOR), Dai, Fangzhou¹ (AUTHOR), Ran, Dongyang¹ (AUTHOR), Zhang, Yutong¹ (AUTHOR), Qu, Zhi² (AUTHOR) 10210056@henu.edu.cn, Zheng, Shanqing^1,3,4 (AUTHOR) zhengshanqing@henu.edu.cn

Source: Aging Cell. Nov2024, Vol. 23 Issue 11, p1-17. 17p.

Subject Terms: *CATHEPSIN B, *DELAYED onset of disease, *CAENORHABDITIS elegans, *NEURODEGENERATION, *LIPID metabolism

Cleistanthin A derivative disrupts autophagy and suppresses head and neck squamous cell carcinoma progression via targeted vacuolar ATPase.

Authors: Wongpan, Anongnat¹ (AUTHOR), Panvongsa, Wittaya² (AUTHOR), Krobthong, Sucheewin³ (AUTHOR), Nutho, Bodee⁴ (AUTHOR), Kanjanasirirat, Phongthon^5,6 (AUTHOR), Jearawuttanakul, Kedchin⁵ (AUTHOR), Khumpanied, Tanawadee⁵ (AUTHOR), Phlaetita, Sureeporn⁷ (AUTHOR), Chabang, Napason⁸ (AUTHOR), Munyoo, Bamroong^5,9 (AUTHOR), Tuchinda, Patoomratana^5,9 (AUTHOR), Ponpuak, Marisa⁷ (AUTHOR), Borwornpinyo, Suparerk^5,10 (AUTHOR), Chairoungdua, Arthit^1,5,11 (AUTHOR) arthit.chi@mahidol.ac.th

Source: Scientific Reports. 9/29/2024, Vol. 14 Issue 1, p1-20. 20p.

Subject Terms: *CATHEPSIN D, *SQUAMOUS cell carcinoma, *CELL migration, *ANTINEOPLASTIC agents, *CISPLATIN

Association between various cathepsins and uterine leiomyoma: A Mendelian randomization analysis.

Authors: Liu, Tingxiu^1,2 (AUTHOR), Ren, Yuehan^1,2 (AUTHOR), Zhang, Junning^2,3 (AUTHOR), Yin, Hechun⁴ (AUTHOR), Zheng, Zheng¹ (AUTHOR), Zhang, Mingyue¹ (AUTHOR), Liao, Yan^1,2 (AUTHOR), Yang, Liangliang^1,2 (AUTHOR), Liu, Chang^1,2 (AUTHOR), Liu, Xinmin¹ (AUTHOR) XinminLIU9626@126.com, Yan, Peiyu^5,6 (AUTHOR) teamzhang@126.com

Source: PLoS ONE. 9/12/2024, Vol. 19 Issue 9, p1-11. 11p.

Subject Terms: *CATHEPSIN B, *GENOME-wide association studies, *CATHEPSINS, *UTERINE fibroids, *SCIENTIFIC observation

Correction: CD147 promotes collective invasion through cathepsin B in hepatocellular carcinoma.

Authors: Wang, Shi-Jie¹ (AUTHOR), Chao, Dong² (AUTHOR), Wei, Wei¹ (AUTHOR), Nan, Gang¹ (AUTHOR), Li, Jia-Yue¹ (AUTHOR), Liu, Fen-Ling¹ (AUTHOR), Li, Ling¹ (AUTHOR), Jiang, Jian-Li¹ (AUTHOR) jiangjl@fmmu.edu.cn, Cui, Hong-Yong¹ (AUTHOR) cui-hongyong@163.com, Chen, Zhi-Nan¹ (AUTHOR) znchen@fmmu.edu.cn

Source: Journal of Experimental & Clinical Cancer Research (17569966). 12/16/2024, Vol. 43 Issue 1, p1-3. 3p.

Subject Terms: *CATHEPSIN B, *WESTERN immunoblotting, *IMMUNOSTAINING, *ONE-way analysis of variance, *PROTEIN analysis

Downregulation of Protease Cathepsin D and Upregulation of Pathologic α-Synuclein Mediate Paucity of DNAJC6-Induced Degeneration of Dopaminergic Neurons.

Authors: Chiu, Ching-Chi^1,2,3 (AUTHOR) ccchei@mail.cgu.edu.tw, Chen, Ying-Ling⁴ (AUTHOR) ylchen@gw.cgust.edu.tw, Weng, Yi-Hsin^2,5,6 (AUTHOR), Liu, Shu-Yu⁷ (AUTHOR) a0934188711@gmail.com, Li, Hon-Lun⁸ (AUTHOR) h4567980@gmail.com, Yeh, Tu-Hsueh⁹ (AUTHOR) do2739@tmu.edu.tw, Wang, Hung-Li^2,3,5,7 (AUTHOR) do2739@tmu.edu.tw

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 12, p6711. 22p.

Subject Terms: *CATHEPSIN D, *DOPAMINERGIC neurons, *ALPHA-synuclein, *UNFOLDED protein response, *NEURODEGENERATION, *RECESSIVE genes, *PRESENILINS, *DOPAMINE receptors

Lysosome-Disrupting Agents in Combination with Venetoclax Increase Apoptotic Response in Primary Chronic Lymphocytic Leukemia (CLL) Cells Mediated by Lysosomal Cathepsin D Release and Inhibition of Autophagy.

Authors: Manivannan, Madhumita S.¹ (AUTHOR) msubram1@ualberta.ca, Yang, Xiaoyan¹ (AUTHOR) xiaoyan3@ualberta.ca, Patel, Nirav¹ (AUTHOR) nkpatel1@ualberta.ca, Peters, Anthea^1,2 (AUTHOR) anthea.peters@albertahealthservices.ca, Johnston, James B.³ (AUTHOR) jjohnsto@cancercare.mb.ca, Gibson, Spencer B.^1,4,5 (AUTHOR) sgibson2@ualberta.ca

Source: Cells (2073-4409). Jun2024, Vol. 13 Issue 12, p1041. 18p.

Subject Terms: *CATHEPSIN D, *CHRONIC lymphocytic leukemia, *VENETOCLAX, *AUTOPHAGY, *REACTIVE oxygen species

Involvement of Endolysosomes and Aurora Kinase A in the Regulation of Amyloid β Protein Levels in Neurons.

Authors: Afghah, Zahra¹ (AUTHOR) zahra.afghah@ndus.edu, Khan, Nabab¹ (AUTHOR), Datta, Gaurav¹ (AUTHOR), Halcrow, Peter W.¹ (AUTHOR), Geiger, Jonathan D.¹ (AUTHOR), Chen, Xuesong¹ (AUTHOR) xuesong.chen@und.edu

Source: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p6200. 11p.

Subject Terms: *AURORA kinases, *CATHEPSIN D, *AMYLOID, *NEURONS, *AMYLOID plaque, *TUBULINS, *AMYLOID beta-protein precursor

PDX proteins from Arabidopsis thaliana as novel substrates of cathepsin B: implications for vitamin B6 biosynthesis regulation.

Authors: Parra, Marcelina¹ (AUTHOR), Coppola, Marianna² (AUTHOR), Hellmann, Hanjo¹ (AUTHOR) hellmann@wsu.edu

Source: FEBS Journal. Jun2024, Vol. 291 Issue 11, p2372-2387. 16p.

Subject Terms: *ARABIDOPSIS proteins, *CATHEPSIN B, *BIOSYNTHESIS, *VITAMIN B complex, *VITAMIN B6

Exploring the Association between Cathepsin B and Parkinson's Disease.

Authors: Lu, Changhao^1,2 (AUTHOR) c.lu@studenti.uniss.it, Cai, Xinyi³ (AUTHOR) 16xycai@stu.edu.cn, Zhi, Shilin⁴ (AUTHOR) zhishl@mail2.sysu.edu.cn, Wen, Xiaofen⁵ (AUTHOR) x.wen@studenti.uniss.it, Shen, Jiaxin⁶ (AUTHOR) j.shen@studenti.uniss.it, Ercoli, Tommaso⁷ (AUTHOR) ercolitommaso@me.com, Simula, Elena Rita² (AUTHOR) sechila@uniss.it, Masala, Carla⁸ (AUTHOR) cmasala@unica.it, Sechi, Leonardo A.^2,9 (AUTHOR), Solla, Paolo^1,7 (AUTHOR) ercolitommaso@me.com

Source: Brain Sciences (2076-3425). May2024, Vol. 14 Issue 5, p482. 11p.

Subject Terms: *CATHEPSIN B, *PARKINSON'S disease, *GENOME-wide association studies

Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis.

Authors: Terron, Heather M.¹ (AUTHOR), Parikh, Sagar J.¹ (AUTHOR), Abdul-Hay, Samer O.² (AUTHOR), Sahara, Tomoko² (AUTHOR), Kang, Dongcheul² (AUTHOR), Dickson, Dennis W.² (AUTHOR), Saftig, Paul³ (AUTHOR), LaFerla, Frank M.^1,4 (AUTHOR), Lane, Shelley¹ (AUTHOR), Leissring, Malcolm A.^1,2 (AUTHOR) m.leissring@uci.edu

Source: Alzheimer's Research & Therapy. 4/4/2024, Vol. 16 Issue 1, p1-12. 12p.

Subject Terms: *CATHEPSIN D, *TAUOPATHIES, *NEUROBLASTOMA, *ALZHEIMER'S disease, *CHRONIC traumatic encephalopathy, *AMYLOID plaque, *AMYLOID beta-protein precursor, *TRANSGENIC mice

Deciphering the Involvement of Chronic Inflammation in Osteoarthritis: Evaluation of Complement 3 and Cathepsin D in Osteoarthritic Patients--A Retrospective Case Study.

Authors: Dhilip, Ashita¹, Parameswari, R. P.² parameswarirp.sdc@saveetha.com

Source: Journal of Pharmacy & Bioallied Sciences. 2024 Supplement, Vol. 16, pS1221-S1325. 5p.

Subject Terms: *CATHEPSIN D, *KNEE, *COMPLEMENT (Immunology), *OSTEOARTHRITIS, *KNEE osteoarthritis, *COMPLEMENT activation

Enhancement of Acetate-Induced Apoptosis of Colorectal Cancer Cells by Cathepsin D Inhibition Depends on Oligomycin A-Sensitive Respiration.

Authors: Alves, Sara¹ (AUTHOR), Santos-Pereira, Cátia¹ (AUTHOR), Oliveira, Cláudia S. F.¹ (AUTHOR), Preto, Ana¹ (AUTHOR) sara.csa@gmail.com, Chaves, Susana R.¹ (AUTHOR) suchaves@bio.uminho.pt, Côrte-Real, Manuela¹ (AUTHOR) suchaves@bio.uminho.pt

Source: Biomolecules (2218-273X). Apr2024, Vol. 14 Issue 4, p473. 13p.

Subject Terms: *CATHEPSIN D, *COLORECTAL cancer, *CANCER cells, *APOPTOSIS, *SHORT-chain fatty acids, *APOPTOSIS inhibition