Proteomics of immune cells from liver tumors reveals immunotherapy targets

Authors: Canale, Fernando P., Neumann, Julia, von Renesse, Janusz, Loggi, Elisabetta, Pecoraro, Matteo, Vogel, Ian, Zoppi, Giada, Antonini, Gaia, Wolf, Tobias, Jin, Wenjie, Zheng, Xiaoqin, La Barba, Giuliano, Birgin, Emrullah, Forkel, Marianne, Nilsson, Tobias, Marone, Romina, Mueller, Henrik, Pelletier, Nadege, Jeker, Lukas T., Civenni, Gianluca, Schlapbach, Christoph, Catapano, Carlo V., Seifert, Lena, Seifert, Adrian M., Gillessen, Silke, De Dosso, Sara, Cristaudi, Alessandra, Rahbari, Nuh N., Ercolani, Giorgio, Geiger, Roger

Source: In Cell Genomics 14 June 2023 3(6)

Chemoenzymatic synthesis of 2,6-disubstituted tetrahydropyrans with high σ1 receptor affinity, antitumor and analgesic activity

Authors: Kopp, Nicole, Civenni, Gianluca, Marson, Domenico, Laurini, Erik, Pricl, Sabrina, Catapano, Carlo V., Humpf, Hans-Ulrich, Almansa, Carmen, Nieto, Francisco Rafael, Schepmann, Dirk, Wünsch, Bernhard

Source: In European Journal of Medicinal Chemistry 5 July 2021 219

Novel σ1 antagonists designed for tumor therapy: Structure – activity relationships of aminoethyl substituted cyclohexanes

Authors: Kopp, Nicole, Holtschulte, Catharina, Börgel, Frederik, Lehmkuhl, Kirstin, Friedland, Kristina, Civenni, Gianluca, Laurini, Erik, Catapano, Carlo V., Pricl, Sabrina, Humpf, Hans-Ulrich, Schepmann, Dirk, Wünsch, Bernhard

Source: In European Journal of Medicinal Chemistry 15 January 2021 210

Pharmacodynamic and Pharmacokinetic Properties of Full Phosphorothioate Small Interfering RNAs for Gene Silencing In Vivo

Authors: Berk, Christian, Civenni, Gianluca, Wang, Yuluan, Steuer, Christian, Catapano, Carlo V., Hall, Jonathan

Source: Nucleic acid therapeutics. 31(3):237-244

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164313419.0x000001&indx=1&recIds=ETOCvdc_100164313419.0x000001

Preclinical Models of Neuroendocrine Prostate Cancer

Authors: Cacciatore, Alessia, Albino, Domenico, Catapano, Carlo V., Carbone, Giuseppina M.

Source: Current protocols. 3(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187361561.0x000001&indx=1&recIds=ETOCvdc_100187361561.0x000001

Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer

Authors: Civenni, Gianluca, Bosotti, Roberto, Timpanaro, Andrea, Vàzquez, Ramiro, Merulla, Jessica, Pandit, Shusil, Rossi, Simona, Albino, Domenico, Allegrini, Sara, Mitra, Abhishek, Mapelli, Sarah N., Vierling, Luca, Giurdanella, Martina, Marchetti, Martina, Paganoni, Alyssa, Rinaldi, Andrea, Losa, Marco, Mira-Catò, Enrica, D'Antuono, Rocco, Morone, Diego, Rezai, Keyvan, D'Ambrosio, Gioacchino, Ouafik, L’Houcine, Mackenzie, Sarah, Riveiro, Maria E., Cvitkovic, Esteban, Carbone, Giuseppina M., Catapano, Carlo V.

Source: In Cell Metabolism 6 August 2019 30(2):303-318

Transcriptional Reprogramming and Inhibition of Tumor-propagating Stem-like Cells by EC-8042 in ERG-positive Prostate Cancer

Authors: Shinde, Dheeraj, Albino, Domenico, Zoma, Marita, Mutti, Azzurra, Mapelli, Sarah N., Civenni, Gianluca, Kokanovic, Aleksandra, Merulla, Jessica, Perez-Escuredo, Jhudit, Costales, Paula, Morìs, Francisco, Catapano, Carlo V., Carbone, Giuseppina M.

Source: In European Urology Oncology July 2019 2(4):415-424

Lactate supports cell-autonomous ECM production to sustain metastatic behavior in prostate cancer.

Authors: Ippolito, Luigi, Duatti, Assia, Iozzo, Marta, Comito, Giuseppina, Pardella, Elisa, Lorito, Nicla, Bacci, Marina, Pranzini, Erica, Santi, Alice, Sandrini, Giada, Catapano, Carlo V, Serni, Sergio, Spatafora, Pietro, Morandi, Andrea, Giannoni, Elisa, Chiarugi, Paola

Source: EMBO Reports; Aug2024, Vol. 25 Issue 8, p3506-3531, 26p

Deciphering the complexity of human non-coding promoter-proximal transcriptome

Authors: Mapelli, Sarah N, Napoli, Sara, Pisignano, Giuseppina, Garcia-Escudero, Ramon, Carbone, Giuseppina M, Catapano, Carlo V

Source: Bioinformatics. 35(15):2529-2534

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087529886.0x000001&indx=1&recIds=ETOCvdc_100087529886.0x000001

Synthesis of Aminoethyl‐Substituted Piperidine Derivatives as σ1 Receptor Ligands with Antiproliferative Properties

Authors: Holtschulte, Catharina, Börgel, Frederik, Westphälinger, Stefanie, Schepmann, Dirk, Civenni, Gianluca, Laurini, Erik, Marson, Domenico, Catapano, Carlo V., Pricl, Sabrina, Wünsch, Bernhard

Source: ChemMedChem. 17(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100149274505.0x000001&indx=1&recIds=ETOCvdc_100149274505.0x000001

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

Authors: Genini, Davide, Brambilla, Lara, Laurini, Erik, Merulla, Jessica, Civenni, Gianluca, Pandit, Shusil, D’Antuono, Rocco, Perez, Laurent, Levy, David E., Pricl, Sabrina, Carbone, Giuseppina M., Catapano, Carlo V.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Jun . 114(25), E4924-E4933.

Access URL: https://www.jstor.org/stable/26484947

Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)

Authors: Brambilla, Lara, Genini, Davide, Laurini, Erik, Merulla, Jessica, Perez, Laurent, Fermeglia, Maurizio, Carbone, Giuseppina M., Pricl, Sabrina, Catapano, Carlo V.

Source: In Molecular Oncology June 2015 9(6):1194-1206

Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer

Authors: Albino, Domenico, Falcione, Martina, Uboldi, Valeria, Temilola, Dada Oluwaseyi, Sandrini, Giada, Merulla, Jessica, Civenni, Gianluca, Kokanovic, Aleksandra, Stürchler, Alessandra, Shinde, Dheeraj, Garofalo, Mariangela, Mestre, Ricardo Pereira, Constâncio, Vera, Wium, Martha, Burrello, Jacopo, Baranzini, Nicolò, Grimaldi, Annalisa, Theurillat, Jean-Philippe, Bossi, Daniela, Barile, Lucio, Henrique, Rui M., Jeronimo, Carmen, Zerbini, Luiz Fernando, Catapano, Carlo V., Carbone, Giuseppina M.

Source: Communications biology. 4(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193170128.0x000001&indx=1&recIds=ETOCvdc_100193170128.0x000001

Chemoenzymatic synthesis of 2, 6-disubstituted tetrahydropyrans with high σ1 receptor affinity, antitumor and analgesic activity

Authors: Kopp, Nicole, Civenni, Gianluca, Marson, Domenico, Laurini, Erik, Pricl, Sabrina, Catapano, Carlo V., Humpf, Hans-Ulrich, Almansa, Carmen, Nieto, Francisco Rafael, Schepmann, Dirk, Wünsch, Bernhard

Source: European journal of medicinal chemistry. 219

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156214842.0x000001&indx=1&recIds=ETOCvdc_100156214842.0x000001

Natural antisense transcripts drive a regulatory cascade controlling c-MYC transcription

Authors: Napoli, Sara, Piccinelli, Valentina, Mapelli, Sarah N., Pisignano, Giuseppina, Catapano, Carlo V.

Source: RNA biology. 14(12):1742-1755

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100053415182.0x000001&indx=1&recIds=ETOCvdc_100053415182.0x000001

Enhancing Chemotherapy Efficacy in Pten-Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

Authors: Toso, Alberto, Revandkar, Ajinkya, Di Mitri, Diletta, Guccini, Ilaria, Proietti, Michele, Sarti, Manuela, Pinton, Sandra, Zhang, Jiangwen, Kalathur, Madhuri, Civenni, Gianluca, Jarrossay, David, Montani, Erica, Marini, Camilla, Garcia-Escudero, Ramon, Scanziani, Eugenio, Grassi, Fabio, Pandolfi, Pier Paolo, Catapano, Carlo V., Alimonti, Andrea

Source: In Cell Reports 9 October 2014 9(1):75-89

Molecular Determinants for Unphosphorylated STAT3 Dimerization Determined by Integrative Modeling

Authors: Sgrignani, Jacopo, Olsson, Simon, Ekonomiuk, Dariusz, Genini, Davide, Krause, Rolf, Catapano, Carlo V., Cavalli, Andrea

Source: Biochemistry. 54(35):5489-5501

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN602885675&indx=1&recIds=ETOCRN602885675

Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer

Authors: Civenni, Gianluca, Carbone, Giuseppina M., Catapano, Carlo V.

Source: Molecular & cellular oncology. 6(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100088860321.0x000001&indx=1&recIds=ETOCvdc_100088860321.0x000001

Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts

Authors: Previdi, Sara, Malek, Anastasia, Albertini, Veronica, Riva, Cristina, Capella, Carlo, Broggini, Massimo, Carbone, Giuseppina M., Rohr, Jurgen, Catapano, Carlo V.

Source: In Gynecologic Oncology 2010 118(2):182-188

Pharmacological inhibition of Lin28 promotes ketogenesis and restores lipid homeostasis in models of non-alcoholic fatty liver disease.

Authors: Lekka, Evangelia, Kokanovic, Aleksandra, Mosole, Simone, Civenni, Gianluca, Schmidli, Sandro, Laski, Artur, Ghidini, Alice, Iyer, Pavithra, Berk, Christian, Behera, Alok, Catapano, Carlo V., Hall, Jonathan

Source: Nature Communications; 12/26/2022, Vol. 13 Issue 1, p1-17, 17p

Subject Terms: NON-alcoholic fatty liver disease, FATTY liver, RNA-binding proteins, MALE models, LIVER cells, SOX2 protein