Matrix stiffness regulates the protein profile of extracellular vesicles of pancreatic cancer cell lines.

Authors: Ferrara, Benedetta, Bourgoin‐Voillard, Sandrine, Habert, Damien, Vallée, Benoit, Nicolas‐Boluda, Alba, Simanic, Isidora, Seve, Michel, Vingert, Benoit, Gazeau, Florence, Castellano, Flavia, Cohen, José, Courty, José, Cascone, Ilaria

Source: Proteomics; Dec2024, Vol. 24 Issue 23/24, p1-16, 16p

Identification of inhibitors of the immunosuppressive enzyme IL4I1

Authors: Presset, Marc, Djordjevic, Diana, Dupont, Aurélie, Le Gall, Erwan, Molinier-Frenkel, Valérie, Castellano, Flavia

Source: In Bioorganic Chemistry January 2020 94

Emerging Role of IL-4–Induced Gene 1 as a Prognostic Biomarker Affecting the Local T-Cell Response in Human Cutaneous Melanoma

Authors: Ramspott, Jan Philipp, Bekkat, Fériel, Bod, Lloyd, Favier, Maryline, Terris, Benoit, Salomon, Anne, Djerroudi, Lounes, Zaenker, Kurt S., Richard, Yolande, Molinier-Frenkel, Valérie, Castellano, Flavia, Avril, Marie-Françoise, Prévost-Blondel, Armelle

Source: In Journal of Investigative Dermatology December 2018 138(12):2625-2634

Quantitative Analysis of Proteome Modulations in Alveolar Epithelial Type II Cells in Response to Pulmonary Aspergillus fumigatus Infection

Authors: Seddigh, Pegah ^‡, Bracht, Thilo ^¶, Molinier-Frenkel, Válerie ^**, Castellano, Flavia ^**, Kniemeyer, Olaf ^‖, Schuster, Marc ^‡, Weski, Juliane ^‡, Hasenberg, Anja ^‡, Kraus, Andreas ^‡, Poschet, Gernot ^§§, Hager, Thomas ^¶¶, Theegarten, Dirk ^¶¶, Opitz, Christiane A. ^‡‡, Brakhage, Axel A. ^‖, Sitek, Barbara ^{¶, ‖‖}, Hasenberg, Mike ^{§, ‖‖}, Gunzer, Matthias ^{‡, ‖‖}

Source: In Molecular & Cellular Proteomics December 2017 16(12):2184-2198

Upregulation of IL4‐induced gene 1 enzyme by B2 cells during melanoma progression impairs their antitumor properties.

Authors: Bekkat, Fériel, Seradj, Malvina, Lengagne, Renée, Fiore, Frédéric, Kato, Masashi, Lucas, Bruno, Castellano, Flavia, Molinier‐Frenkel, Valérie, Richard, Yolande, Prévost‐Blondel, Armelle

Source: European Journal of Immunology; Apr2024, Vol. 54 Issue 4, p1-16, 16p

IL-4—Induced Gene 1: A Negative Immune Checkpoint Controlling B Cell Differentiation and Activation

Authors: Bod, Lloyd, Douguet, Laetitia, Auffray, Cédric, Lengagne, Renée, Bekkat, Fériel, Rondeau, Elena, Molinier-Frenkel, Valérie, Castellano, Flavia, Richard, Yolande, Prévost-Blondel, Armelle

Source: Journal of immunology. 200(3):1027-1038

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN614834649&indx=1&recIds=ETOCRN614834649

ARL5b inhibits human rhinovirus 16 propagation and impairs macrophage-mediated bacterial clearance.

Authors: Faure-Dupuy, Suzanne, Jubrail, Jamil, Depierre, Manon, Africano-Gomez, Kshanti, Öberg, Lisa, Israelsson, Elisabeth, Thörn, Kristofer, Delevoye, Cédric, Castellano, Flavia, Herit, Floriane, Guilbert, Thomas, Russell, David G, Mayer, Gaell, Cunoosamy, Danen M, Kurian, Nisha, Niedergang, Florence

Source: EMBO Reports; Mar2024, Vol. 25 Issue 3, p1156-1175, 20p

Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma

Authors: Ritz, Olga, Guiter, Chrystelle, Castellano, Flavia, Dorsch, Karola, Melzner, Julia, Jais, Jean-Philippe, Dubois, Gwendoline, Gaulard, Philippe, Möller, Peter, Leroy, Karen

Source: In Blood 6 August 2009 114(6):1236-1242

Human IL4I1 is a secreted l-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation

Authors: Boulland, Marie-Laure, Marquet, Jeanine, Molinier-Frenkel, Valérie, Möller, Peter, Guiter, Chrystelle, Lasoudris, Fanette, Copie-Bergman, Christiane, Baia, Maryse, Gaulard, Philippe, Leroy, Karen, Castellano, Flavia ^*

Source: In Blood 1 July 2007 110(1):220-227

An Overview of L-Amino Acid Oxidase Functions from Bacteria to Mammals: Focus on the Immunoregulatory Phenylalanine Oxidase IL4I1.

Authors: Castellano, Flavia^1,2,3 valerie.frenkel@inserm.fr, Molinier-Frenkel, Valérie^1,2,4 flavia.castellano@inserm.fr

Source: Molecules. Dec2017, Vol. 22 Issue 12, p2151. 11p. 3 Diagrams.

Subject Terms: *AMINO acid oxidase, *BACTERIA, *MAMMALS, *PHENYLALANINE, *IMMUNOREGULATION, *IMMUNOSUPPRESSION

IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike.

Authors: Gatineau, Jérôme, Nidercorne, Charlotte, Dupont, Aurélie, Puiffe, Marie-Line, Cohen, JoséL., Molinier-Frenkel, Valérie, Niedergang, Florence, Castellano, Flavia

Source: Frontiers in Immunology; 9/5/2022, Vol. 13, p1-13, 13p

Subject Terms: SARS-CoV-2, CARRIER proteins, VIRAL proteins, ADAPTIVE control systems, PROTEIN binding, GRANZYMES

IL4-induced gene 1 promotes tumor growth by shaping the immune microenvironment in melanoma

Authors: Bod, Lloyd, Lengagne, Renée, Wrobel, Ludovic, Ramspott, Jan Philipp, Kato, Masashi, Avril, Marie-Françoise, Castellano, Flavia, Molinier-Frenkel, Valérie, Prévost-Blondel, Armelle

Source: Oncoimmunology. 6(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100059303505.0x000001&indx=1&recIds=ETOCvdc_100059303505.0x000001

Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma

Authors: Guiter, Chrystelle, Dusanter-Fourt, Isabelle, Copie-Bergman, Christiane, Boulland, Marie-Laure, le Gouvello, Sabine, Gaulard, Philippe, Leroy, Karen, Castellano, Flavia ^*

Source: In Blood 15 July 2004 104(2):543-549

Actin dynamics during phagocytosis

Authors: Castellano, Flavia, Chavrier, Philippe, Caron, Emmanuelle

Source: In Seminars in Immunology December 2001 13(6):347-355

Inducible membrane recruitment of small GTP-binding proteins by rapamycin-based system in living cells

Authors: Castellano, Flavia, Chavrier, Philippe

Source: In Methods in Enzymology 2000 325:285-295

What role for AHR activation in IL4I1-mediated immunosuppression?

Authors: Castellano, Flavia^1,2 flavia.castellano@inserm.fr, Prevost-Blondel, Armelle³, Cohen, José L.^1,4, Molinier-Frenkel, Valérie^1,2 valerie.frenkel@inserm.fr

Source: OncoImmunology. 2021, Vol. 10 Issue 1, p1-8. 8p.

Subject Terms: *CYTOTOXIC T cells, *T cell differentiation, *T cells, *DENDRITIC cells, *SYNAPTOGENESIS, *TRYPTOPHAN, *T cell receptors

IL4I1 Accelerates the Expansion of Effector CD8⁺ T Cells at the Expense of Memory Precursors by Increasing the Threshold of T-Cell Activation.

Authors: Puiffe, Marie-Line, Dupont, Aurélie, Sako, Nouhoum, Gatineau, Jérôme, Cohen, José L., Mestivier, Denis, Lebon, Agnès, Prévost-Blondel, Armelle, Castellano, Flavia, Molinier-Frenkel, Valérie

Source: Frontiers in Immunology; 12/4/2020, Vol. 11, pN.PAG-N.PAG, 15p

Subject Terms: T cells, ACTIVATION energy, LYMPHOCYTIC choriomeningitis virus, T cell differentiation, CLONE cells, PSYCHONEUROIMMUNOLOGY

Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation

Authors: Castellano, Flavia, Montcourrier, Philippe, Guillemot, Jean-Claude, Gouin, Edith, Machesky, Laura, Cossart, Pascale, Chavrier, Philippe ^*

Source: In Current Biology 8 April 1999 9(7):351-361

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