Secreted neurofilament light chain after neuronal damage induces myeloid cell activation and neuroinflammation

Authors: Olga I. Kahn, Sara L. Dominguez, Caspar Glock, Margaret Hayne, Steve Vito, Arundhati Sengupta Ghosh, Max Adrian, Braydon L. Burgess, William J. Meilandt, Brad A. Friedman, Casper C. Hoogenraad

Source: Cell Reports, Vol 44, Iss 3, Pp 115382- (2025)

Subject Terms: CP: Neuroscience, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2211124725001536; https://doaj.org/toc/2211-1247

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Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release

Authors: Max Adrian, Martin Weber, Ming-Chi Tsai, Caspar Glock, Olga I. Kahn, Lilian Phu, Tommy K. Cheung, William J. Meilandt, Christopher M. Rose, Casper C. Hoogenraad

Source: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/07f1bdd5b8fc4c30814079f35fbb9f55

Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection

Authors: Amy E. Byrnes, Sara L. Dominguez, Chun-Wan Yen, Benjamin I. Laufer, Oded Foreman, Mike Reichelt, Han Lin, Meredith Sagolla, Kathy Hötzel, Hai Ngu, Christoffer Soendergaard, Alberto Estevez, Hsiu-Chao Lin, Alexandre Goyon, Juan Bian, Jessica Lin, Flora I. Hinz, Brad A. Friedman, Amy Easton, Casper C. Hoogenraad

Source: Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 773-793 (2023)

Subject Terms: MT: Delivery Strategies, antisense oligonucleotide, delivery, gymnosis, lipid nanoparticles, central nervous system, Therapeutics. Pharmacology, RM1-950

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Relation: http://www.sciencedirect.com/science/article/pii/S2162253123001221; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/3689714968e4460891db8a383fa60cf7

ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability

Authors: Nazmiye Özkan, Max Koppers, Inge van Soest, Alexandra van Harten, Daphne Jurriens, Nalan Liv, Judith Klumperman, Lukas C. Kapitein, Casper C. Hoogenraad, Ginny G. Farías

Source: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/cc342bac8e3b45b797d52c6e73112560

Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy

Authors: Alexander M. Rossor, James N. Sleigh, Michael Groves, Francesco Muntoni, Mary M. Reilly, Casper C. Hoogenraad, Giampietro Schiavo

Source: Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-12 (2020)

Subject Terms: Spinal muscular atrophy, SMALED2, Hereditary motor neuropathy, BICD2, DYNC1H1, Muscle, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40478-020-00909-6; https://doaj.org/toc/2051-5960

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Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau

Authors: Luca Ferrari, Riccardo Stucchi, Katerina Konstantoulea, Gerarda van de Kamp, Renate Kos, Willie J. C. Geerts, Laura S. van Bezouwen, Friedrich G. Förster, Maarten Altelaar, Casper C. Hoogenraad, Stefan G. D. Rüdiger

Source: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1e2a4433b35f46b3b264a6a1c10869f9

Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo

Authors: Lena Will, Sybren Portegies, Jasper van Schelt, Merel van Luyk, Dick Jaarsma, Casper C. Hoogenraad

Source: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-23 (2019)

Subject Terms: BICD2, Radial neuronal migration, Neocortical development, Dynein adaptor, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40478-019-0827-y; https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/370852f5a72a4276bfe0109d4ceb4764

WDR47 protects neuronal microtubule minus ends from katanin-mediated severing

Authors: Robin R. Buijs, Jessica J.A. Hummel, Mithila Burute, Xingxiu Pan, Yujie Cao, Riccardo Stucchi, Maarten Altelaar, Anna Akhmanova, Lukas C. Kapitein, Casper C. Hoogenraad

Source: Cell Reports, Vol 36, Iss 2, Pp 109371- (2021)

Subject Terms: neuron, axon, dendrite, microtubule, centrosome, WDR47, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2211124721007695; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/c8aea655c8394d87a9122b5781583d78

Wnt Signaling Directs Neuronal Polarity and Axonal Growth

Authors: Eliana Stanganello, Eitan Erez Zahavi, Mithila Burute, Jasper Smits, Ingrid Jordens, Madelon M. Maurice, Lukas C. Kapitein, Casper C. Hoogenraad

Source: iScience, Vol 13, Iss , Pp 318-327 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S258900421930063X; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/03cf1c647ee14206902981e5854f0281

Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment

Authors: Amr Abouelezz, Holly Stefen, Mikael Segerstråle, David Micinski, Rimante Minkeviciene, Lauri Lahti, Edna C. Hardeman, Peter W. Gunning, Casper C. Hoogenraad, Tomi Taira, Thomas Fath, Pirta Hotulainen

Source: iScience, Vol 23, Iss 5, Pp - (2020)

Subject Terms: Biological Sciences, Molecular Neuroscience, Cellular Neuroscience, Cell Biology, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004220302388; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/3e57b0157379454eb6ea69f71bced384

Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

Authors: Michael Dumbacher, Tom Van Dooren, Katrien Princen, Koen De Witte, Mélissa Farinelli, Sam Lievens, Jan Tavernier, Wim Dehaen, Stefaan Wera, Joris Winderickx, Sara Allasia, Amuri Kilonda, Stéphane Spieser, Arnaud Marchand, Patrick Chaltin, Casper C. Hoogenraad, Gerard Griffioen

Source: Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-21 (2018)

Subject Terms: Alzheimer’s disease, Hyperexcitability, Neuroprotection, Pde6δ, Rap1, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13024-018-0283-3; https://doaj.org/toc/1750-1326

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APC2 controls dendrite development by promoting microtubule dynamics

Authors: Olga I. Kahn, Philipp Schätzle, Dieudonnée van de Willige, Roderick P. Tas, Feline W. Lindhout, Sybren Portegies, Lukas C. Kapitein, Casper C. Hoogenraad

Source: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ade6f2219360485a9d71326ab47cd9a9

Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca2+/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites

Authors: Riccardo Stucchi, Gabriela Plucińska, Jessica J.A. Hummel, Eitan E. Zahavi, Irune Guerra San Juan, Oleg Klykov, Richard A. Scheltema, A.F. Maarten Altelaar, Casper C. Hoogenraad

Source: Cell Reports, Vol 24, Iss 3, Pp 685-700 (2018)

Subject Terms: Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2211124718309987; https://doaj.org/toc/2211-1247

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Shank Proteins Couple the Endocytic Zone to the Postsynaptic Density to Control Trafficking and Signaling of Metabotropic Glutamate Receptor 5

Authors: Nicky Scheefhals, Lisa A.E. Catsburg, Margriet L. Westerveld, Thomas A. Blanpied, Casper C. Hoogenraad, Harold D. MacGillavry

Source: Cell Reports, Vol 29, Iss 2, Pp 258-269.e8 (2019)

Subject Terms: Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2211124719311647; https://doaj.org/toc/2211-1247

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Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses

Authors: Hai Yin Hu, Dennis L.H. Kruijssen, Cátia P. Frias, Balázs Rózsa, Casper C. Hoogenraad, Corette J. Wierenga

Source: Cell Reports, Vol 27, Iss 3, Pp 666-675.e5 (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124719304176; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/6436317ff7ea449c831fa7f7df65c8cd

Probing cytoskeletal modulation of passive and active intracellular dynamics using nanobody-functionalized quantum dots

Authors: Eugene A. Katrukha, Marina Mikhaylova, Hugo X. van Brakel, Paul M. van Bergen en Henegouwen, Anna Akhmanova, Casper C. Hoogenraad, Lukas C. Kapitein

Source: Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/a471b41a01894b80a775b59d0e03eae6

Quantitative Map of Proteome Dynamics during Neuronal Differentiation

Authors: Christian K. Frese, Marina Mikhaylova, Riccardo Stucchi, Violette Gautier, Qingyang Liu, Shabaz Mohammed, Albert J.R. Heck, A.F. Maarten Altelaar, Casper C. Hoogenraad

Source: Cell Reports, Vol 18, Iss 6, Pp 1527-1542 (2017)

Subject Terms: neuronal differentiation, neuronal development, dendrite outgrowth, neuroproteomics, NCAM1, adhesion molecule, proteome, quantitative proteomics, stable isotope labeling, mass spectrometry, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2211124717300621; https://doaj.org/toc/2211-1247

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MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon

Authors: Xingxiu Pan, Yujie Cao, Riccardo Stucchi, Peter Jan Hooikaas, Sybren Portegies, Lena Will, Maud Martin, Anna Akhmanova, Martin Harterink, Casper C. Hoogenraad

Source: Cell Reports, Vol 26, Iss 8, Pp 1988-1999.e6 (2019)

Subject Terms: Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2211124719301202; https://doaj.org/toc/2211-1247

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Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture

Authors: Marta Esteves da Silva, Max Adrian, Philipp Schätzle, Joanna Lipka, Takuya Watanabe, Sukhee Cho, Kensuke Futai, Corette J. Wierenga, Lukas C. Kapitein, Casper C. Hoogenraad

Source: Cell Reports, Vol 13, Iss 5, Pp 933-943 (2015)

Subject Terms: synaptic plasticity, intracellular transport, AMPA receptors, dendritic spine, cytoskeleton, microtubule, actin, myosin, kinesin, KIF1C, myosinV, myosinVI, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2211124715011043; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/21093b42932a4bf1ba9c08b93abda438

Myosin-V Induces Cargo Immobilization and Clustering at the Axon Initial Segment

Authors: Anne F. J. Janssen, Roderick P. Tas, Petra van Bergeijk, Rosalie Oost, Casper C. Hoogenraad, Lukas C. Kapitein

Source: Frontiers in Cellular Neuroscience, Vol 11 (2017)

Subject Terms: polarized transport, motor proteins, myosin-V, kinesin, axon initial segment, motor cooperation, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fncel.2017.00260/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/7fefce74fe33457f9dbb6f93b5a597ac