Chemoenzymatic synthesis of both enantiomers of propafenone hydrochloride through lipase-catalyzed process

Authors: Bezerra, Francisco de Aquino, Lima, Gabriella de Castro, Carvalho, Ana Caroline Lustosa de Melo, Vega, Kimberly Benedetti, Oliveira, Maria Conceição Ferreira, de Lemos, Telma Leda Gomes, Sousa dos Santos, Jose Cleiton, Gonçalves, Luciana Rocha Barros, Rios, Nathalia Saraiva, Fernandez-Lafuente, Roberto, Molinari, Francesco, Zanatta, Geancarlo, de Mattos, Marcos Carlos

Source: In Molecular Catalysis August 2022 529

Resolution of Racemic Aryloxy-Propan-2-yl Acetates via Lipase-Catalyzed Hydrolysis: Preparation of Enantiomerically Pure/Enantioenriched Mexiletine Intermediates and Analogs.

Authors: Carvalho, Ana Caroline Lustosa de Melo¹ (AUTHOR), de Oliveira, Bruna Rocha¹ (AUTHOR), Lima, Gledson Vieira¹ (AUTHOR), Negreiro, Jonatas Martins¹ (AUTHOR), Oliveira, Maria Conceição Ferreira¹ (AUTHOR), de Lemos, Telma Leda Gomes¹ (AUTHOR), da Silva, Marcos Reinaldo² (NURSE), Fonseca, Thiago de Sousa³ (AUTHOR), Bezerra, Rayanne Mendes⁴ (AUTHOR), dos Santos, Jose Cleiton Sousa⁴ (AUTHOR), Gonçalves, Luciana Rocha Barros⁵ (AUTHOR), Rios, Nathalia Saraiva⁶ (NURSE), Zanatta, Geancarlo⁷ (AUTHOR), de Mattos, Marcos Carlos¹ (AUTHOR) mcdmatto@ufc.br

Source: Catalysts (2073-4344). Dec2022, Vol. 12 Issue 12, p1566. 21p.

Subject Terms: *ENANTIOMERIC purity, *HYDROLYSIS, *ACETATES, *MEXILETINE, *KINETIC resolution, *PSEUDOMONAS fluorescens, *NUCLEAR magnetic resonance spectroscopy

Recent Advances in Lipase-Mediated Preparation of Pharmaceuticals and Their Intermediates.

Authors: Carvalho, Ana Caroline Lustosa de Melo¹ carol.luz@hotmail.com, Fonseca, Thiago de Sousa¹ thiagofonseka@hotmail.com, de Mattos, Marcos Carlos¹ mcfo@ufc.br, de Oliveira, Maria da Conceição Ferreira¹ mcdmatto@ufc.br, de Lemos, Telma Leda Gomes¹ tlemos@dqoi.ufc.br, Molinari, Francesco² francesco.molinari@unimi.it, Romano, Diego² diego.romano@unimi.it, Serra, Immacolata² Immacolata.serra@unimi.it

Source: International Journal of Molecular Sciences. 2015, Vol. 16 Issue 12, p29682-29716. 35p. 46 Diagrams, 6 Charts.

Subject Terms: *LIPASES, *CHIRAL drugs, *BIOCATALYSIS, *ENZYMES, *CHEMICAL synthesis