Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer

Authors: Inoue, Akira, Robinson, Frederick S., Minelli, Rosalba, Tomihara, Hideo, Rizi, Bahar Salimian, Rose, Johnathon L., Kodama, Takahiro, Srinivasan, Sanjana, Harris, Angela L., Zuniga, Andy M., Mullinax, Robert A., Ma, Xiaoyan, Seth, Sahil, Daniele, Joseph R., Peoples, Michael D., Loponte, Sara, Akdemir, Kadir C., Khor, Tin Oo, Feng, Ningping, Roszik, Jason, Sobieski, Mary M., Brunell, David, Stephan, Clifford, Giuliani, Virginia, Deem, Angela K., Shingu, Takashi, Deribe, Yonathan Lissanu, Menter, David G., Heffernan, Timothy P., Viale, Andrea, Bristow, Christopher A., Kopetz, Scott, Draetta, Giulio F., Genovese, Giannicola, Carugo, Alessandro

Source: In Gastroenterology July 2021 161(1):196-210

Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma

Authors: Msaouel, Pavlos, Malouf, Gabriel G., Su, Xiaoping, Yao, Hui, Tripathi, Durga N., Soeung, Melinda, Gao, Jianjun, Rao, Priya, Coarfa, Cristian, Creighton, Chad J., Bertocchio, Jean-Philippe, Kunnimalaiyaan, Selvi, Multani, Asha S., Blando, Jorge, He, Rong, Shapiro, Daniel D., Perelli, Luigi, Srinivasan, Sanjana, Carbone, Federica, Pilié, Patrick G., Karki, Menuka, Seervai, Riyad N.H., Vokshi, Bujamin H., Lopez-Terrada, Dolores, Cheng, Emily H., Tang, Ximing, Lu, Wei, Wistuba, Ignacio I., Thompson, Timothy C., Davidson, Irwin, Giuliani, Virginia, Schlacher, Katharina, Carugo, Alessandro, Heffernan, Timothy P., Sharma, Padmanee, Karam, Jose A., Wood, Christopher G., Walker, Cheryl L., Genovese, Giannicola, Tannir, Nizar M.

Source: In Cancer Cell 11 May 2020 37(5):720-734

Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors

Authors: Seth, Sahil, Li, Chieh-Yuan, Ho, I-Lin, Corti, Denise, Loponte, Sara, Sapio, Luigi, Del Poggetto, Edoardo, Yen, Er-Yen, Robinson, Frederick Scott, Peoples, Michael, Karpinets, Tatiana, Deem, Angela Kay, Kumar, Tapsi, Song, Xingzhi, Jiang, Shan, Kang, Ya’an, Fleming, Jason, Kim, Michael, Zhang, Jianhua, Maitra, Anirban, Heffernan, Timothy Paul, Giuliani, Virginia, Genovese, Giannicola, Futreal, Andrew, Draetta, Giulio Francesco, Carugo, Alessandro, Viale, Andrea

Source: In Cell Reports 5 February 2019 26(6):1518-1532

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation

Authors: Sun, Yuting, Bandi, Madhavi, Lofton, Timothy, Smith, Melinda, Bristow, Christopher A., Carugo, Alessandro, Rogers, Norma, Leonard, Paul, Chang, Qing, Mullinax, Robert, Han, Jing, Shi, Xi, Seth, Sahil, Meyers, Brooke A., Miller, Meredith, Miao, Lili, Ma, Xiaoyan, Feng, Ningping, Giuliani, Virginia, Geck Do, Mary, Czako, Barbara, Palmer, Wylie S., Mseeh, Faika, Asara, John M., Jiang, Yongying, Morlacchi, Pietro, Zhao, Shuping, Peoples, Michael, Tieu, Trang N., Warmoes, Marc O., Lorenzi, Philip L., Muller, Florian L., DePinho, Ronald A., Draetta, Giulio F., Toniatti, Carlo, Jones, Philip, Heffernan, Timothy P., Marszalek, Joseph R.

Source: In Cell Reports 8 January 2019 26(2):469-482

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

Authors: Cascone, Tina, McKenzie, Jodi A., Mbofung, Rina M., Punt, Simone, Wang, Zhe, Xu, Chunyu, Williams, Leila J., Wang, Zhiqiang, Bristow, Christopher A., Carugo, Alessandro, Peoples, Michael D., Li, Lerong, Karpinets, Tatiana, Huang, Lu, Malu, Shruti, Creasy, Caitlin, Leahey, Sara E., Chen, Jiong, Chen, Yuan, Pelicano, Helen, Bernatchez, Chantale, Gopal, Y.N. Vashisht, Heffernan, Timothy P., Hu, Jianhua, Wang, Jing, Amaria, Rodabe N., Garraway, Levi A., Huang, Peng, Yang, Peiying, Wistuba, Ignacio I., Woodman, Scott E., Roszik, Jason, Davis, R. Eric, Davies, Michael A., Heymach, John V., Hwu, Patrick, Peng, Weiyi

Source: In Cell Metabolism 1 May 2018 27(5):977-987

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer

Authors: Carugo, Alessandro, Genovese, Giannicola, Seth, Sahil, Nezi, Luigi, Rose, Johnathon Lynn, Bossi, Daniela, Cicalese, Angelo, Shah, Parantu Krushnakant, Viale, Andrea, Pettazzoni, Piergiorgio Francesco, Akdemir, Kadir Caner, Bristow, Christopher Aaron, Robinson, Frederick Scott, Tepper, James, Sanchez, Nora, Gupta, Sonal, Estecio, Marcos Roberto, Giuliani, Virginia, Dellino, Gaetano Ivan, Riva, Laura, Yao, Wantong, Di Francesco, Maria Emilia, Green, Tessa, D’Alesio, Carolina, Corti, Denise, Kang, Ya’an, Jones, Philip, Wang, Huamin, Fleming, Jason Bates, Maitra, Anirban, Pelicci, Pier Giuseppe, Chin, Lynda, DePinho, Ronald Anthony, Lanfrancone, Luisa, Heffernan, Timothy Paul, Draetta, Giulio Francesco

Source: In Cell Reports 28 June 2016 16(1):133-147

Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

Authors: Colla, Simona, Ong, Derrick Sek Tong, Ogoti, Yamini, Marchesini, Matteo, Mistry, Nipun A., Clise-Dwyer, Karen, Ang, Sonny A., Storti, Paola, Viale, Andrea, Giuliani, Nicola, Ruisaard, Kathryn, Ganan Gomez, Irene, Bristow, Christopher A., Estecio, Marcos, Weksberg, David C., Ho, Yan Wing, Hu, Baoli, Genovese, Giannicola, Pettazzoni, Piergiorgio, Multani, Asha S., Jiang, Shan, Hua, Sujun, Ryan, Michael C., Carugo, Alessandro, Nezi, Luigi, Wei, Yue, Yang, Hui, D’Anca, Marianna, Zhang, Li, Gaddis, Sarah, Gong, Ting, Horner, James W., Heffernan, Timothy P., Jones, Philip, Cooper, Laurence J.N., Liang, Han, Kantarjian, Hagop, Wang, Y. Alan, Chin, Lynda, Bueso-Ramos, Carlos, Garcia-Manero, Guillermo, DePinho, Ronald A.

Source: In Cancer Cell 11 May 2015 27(5):644-657

Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy.

Authors: Shapiro, Daniel D., Zacharias, Niki Millward, Tripathi, Durga N., Karki, Menuka, Bertocchio, Jean‐Philippe, Soeung, Melinda, He, Rong, Westerman, Mary E., Gao, Jianjun, Rao, Priya, Lam, Truong N. A., Jonasch, Eric, Perelli, Luigi, Cheng, Emily H., Carugo, Alessandro, Heffernan, Timothy P., Walker, Cheryl L., Genovese, Giannicola, Tannir, Nizar M., Karam, Jose A.

Source: Clinical & Translational Medicine; May2023, Vol. 13 Issue 5, p1-18, 18p

Subject Terms: CANCER chemotherapy, PLATINUM, DNA damage, CARCINOMA, COMBINATION drug therapy, ANGIOTENSIN II

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ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer.

Authors: Manshouri, Roxsan, Coyaud, Etienne, Kundu, Samrat T., Peng, David H., Stratton, Sabrina A., Alton, Kendra, Bajaj, Rakhee, Fradette, Jared J., Minelli, Rosalba, Peoples, Michael D., Carugo, Alessandro, Chen, Fengju, Bristow, Christopher, Kovacs, Jeffrey J., Barton, Michelle C., Heffernan, Tim, Creighton, Chad J., Raught, Brian, Gibbons, Don L.

Source: Nature Communications; 11/12/2019, Vol. 10 Issue 1, p1-15, 15p

Subject Terms: NON-small-cell lung carcinoma, CADHERINS, METASTASIS, LUNG cancer, TRANSCRIPTION factors

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Academic Discovery of Anticancer Drugs: Historic and Future Perspectives.

Authors: Carugo, Alessandro, Draetta, Giulio F.

Source: Annual Review of Cancer Biology; 2019, Vol. 3, p385-408, 24p

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