Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

Authors: Marselli, Lorella, Piron, Anthony, Suleiman, Mara, Colli, Maikel L., Yi, Xiaoyan, Khamis, Amna, Carrat, Gaelle R., Rutter, Guy A., Bugliani, Marco, Giusti, Laura, Ronci, Maurizio, Ibberson, Mark, Turatsinze, Jean-Valery, Boggi, Ugo, De Simone, Paolo, De Tata, Vincenzo, Lopes, Miguel, Nasteska, Daniela, De Luca, Carmela, Tesi, Marta, Bosi, Emanuele, Singh, Pratibha, Campani, Daniela, Schulte, Anke M., Solimena, Michele, Hecht, Peter, Rady, Brian, Bakaj, Ivona, Pocai, Alessandro, Norquay, Lisa, Thorens, Bernard, Canouil, Mickaël, Froguel, Philippe, Eizirik, Decio L., Cnop, Miriam, Marchetti, Piero

Source: In Cell Reports 1 December 2020 33(9)

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis

Authors: Carrat, Gaelle R., Haythorne, Elizabeth, Tomas, Alejandra, Haataja, Leena, Müller, Andreas, Arvan, Peter, Piunti, Alexandra, Cheng, Kaiying, Huang, Mutian, Pullen, Timothy J., Georgiadou, Eleni, Stylianides, Theodoros, Amirruddin, Nur Shabrina, Salem, Victoria, Distaso, Walter, Cakebread, Andrew, Heesom, Kate J., Lewis, Philip A., Hodson, David J., Briant, Linford J., Fung, Annie C.H., Sessions, Richard B., Alpy, Fabien, Kong, Alice P.S., Benke, Peter I., Torta, Federico, Teo, Adrian Kee Keong, Leclerc, Isabelle, Solimena, Michele, Wigley, Dale B., Rutter, Guy A.

Source: In Molecular Metabolism October 2020 40

Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice

Authors: Carrat, Gaelle R., Hu, Ming, Nguyen-Tu, Marie-Sophie, Chabosseau, Pauline, Gaulton, Kyle J., van de Bunt, Martijn, Siddiq, Afshan, Falchi, Mario, Thurner, Matthias, Canouil, Mickaël, Pattou, Francois, Leclerc, Isabelle, Pullen, Timothy J., Cane, Matthew C., Prabhala, Priyanka, Greenwald, William, Schulte, Anke, Marchetti, Piero, Ibberson, Mark, MacDonald, Patrick E., Manning Fox, Jocelyn E., Gloyn, Anna L., Froguel, Philippe, Solimena, Michele, McCarthy, Mark I., Rutter, Guy A.

Source: In The American Journal of Human Genetics 2 February 2017 100(2):238-256

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Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn²⁺ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart.

Authors: Tuncay, Erkan, Bitirim, Verda C., Durak, Aysegul, Carrat, Gaelle R. J., Taylor, Kathryn M., Rutter, Guy A., Turan, Belma, Taylor, Kathryn

Source: Diabetes; May2017, Vol. 66 Issue 5, p1346-1358, 13p, 2 Diagrams, 5 Graphs

Subject Terms: ENDOPLASMIC reticulum, HEART cells, HYPERGLYCEMIA, PEOPLE with diabetes, FLUORESCENCE resonance energy transfer, CELL metabolism, RNA metabolism, ZINC metabolism, ANIMAL experimentation, ANIMALS, CARRIER proteins, CYTOPLASM, DIABETES, HEART ventricles, TYPE 1 diabetes, PHOSPHORYLATION, POLYMERASE chain reaction, RATS, RESEARCH funding, TRANSFERASES, WESTERN immunoblotting, REVERSE transcriptase polymerase chain reaction, PRECIPITIN tests

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