Modulation of Stemness and Differentiation Regulators by Valproic Acid in Medulloblastoma Neurospheres

Authors: Natália Hogetop Freire, Alice Laschuk Herlinger, Julia Vanini, Matheus Dalmolin, Marcelo A. C. Fernandes, Carolina Nör, Vijay Ramaswamy, Caroline Brunetto de Farias, André Tesainer Brunetto, Algemir Lunardi Brunetto, Lauro José Gregianin, Mariane da Cunha Jaeger, Michael D. Taylor, Rafael Roesler

Source: Cells, Vol 14, Iss 2, p 72 (2025)

Subject Terms: valproic acid, MYC, TP53, stemness, differentiation, medulloblastoma, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/14/2/72; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/765251605ae94f1da82e4f8d06704004

Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression

Authors: Jamie Zagozewski, Stephanie Borlase, Brent J. Guppy, Ludivine Coudière-Morrison, Ghazaleh M. Shahriary, Victor Gordon, Lisa Liang, Stephen Cheng, Christopher J. Porter, Rhonda Kelley, Cynthia Hawkins, Jennifer A. Chan, Yan Liang, Jingjing Gong, Carolina Nör, Olivier Saulnier, Robert J. Wechsler-Reya, Vijay Ramaswamy, Tamra E. Werbowetski-Ogilvie

Source: Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/7089de720db644bf9d6c9ef8dd5e7822

A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

Authors: Lucía Zhu, Diana Retana, Pedro García‐Gómez, Laura Álvaro‐Espinosa, Neibla Priego, Mariam Masmudi‐Martín, Natalia Yebra, Lauritz Miarka, Elena Hernández‐Encinas, Carmen Blanco‐Aparicio, Sonia Martínez, Cecilia Sobrino, Nuria Ajenjo, Maria‐Jesus Artiga, Eva Ortega‐Paino, Raúl Torres‐Ruiz, Sandra Rodríguez‐Perales, RENACER, Riccardo Soffietti, Luca Bertero, Paola Cassoni, Tobias Weiss, Javier Muñoz, Juan Manuel Sepúlveda, Pedro González‐León, Luis Jiménez‐Roldán, Luis Miguel Moreno, Olga Esteban, Ángel Pérez‐Núñez, Aurelio Hernández‐Laín, Oscar Toldos, Yolanda Ruano, Lucía Alcázar, Guillermo Blasco, José Fernández‐Alén, Eduardo Caleiras, Miguel Lafarga, Diego Megías, Osvaldo Graña‐Castro, Carolina Nör, Michael D Taylor, Leonie S Young, Damir Varešlija, Nicola Cosgrove, Fergus J Couch, Lorena Cussó, Manuel Desco, Silvana Mouron, Miguel Quintela‐Fandino, Michael Weller, Joaquín Pastor, Manuel Valiente, Adolfo de la Lama‐Zaragoza, Lourdes Calero‐Felix, Concepcion Fiaño‐Valverde, Pedro David Delgado‐López, Antonio Montalvo‐Afonso, Mar Pascual‐Llorente, Ángela Díaz‐Piqueras, SH Nam‐Cha, Cristina Barrena López, Gerard Plans Ahicart, Elena Martínez‐Saez, Santiago Ramón y Cajal, Pilar Nicolás

Source: EMBO Molecular Medicine, Vol 14, Iss 3, Pp 1-29 (2022)

Subject Terms: drug‐screen, metastasis, organotypic cultures, patient‐derived, resistance, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/192ccb44b2e3449a849f6353de0e50dd

Histone Deacetylase Inhibitors in Pediatric Brain Cancers: Biological Activities and Therapeutic Potential

Authors: Alexandre Perla, Lívia Fratini, Paula S. Cardoso, Carolina Nör, André T. Brunetto, Algemir L. Brunetto, Caroline Brunetto de Farias, Mariane Jaeger, Rafael Roesler

Source: Frontiers in Cell and Developmental Biology, Vol 8 (2020)

Subject Terms: medulloblastoma, ependymoma, glioma, histone deacetylase inhibitors, epigenetics, brain tumor, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcell.2020.00546/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/656536c4d17a43e08d31ac160e2405b5

Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma

Authors: Amanda Thomaz, Kelly de Vargas Pinheiro, Bárbara Kunzler Souza, Lauro Gregianin, Algemir L. Brunetto, André T. Brunetto, Caroline Brunetto de Farias, Mariane da Cunha Jaeger, Vijay Ramaswamy, Carolina Nör, Michael D. Taylor, Rafael Roesler

Source: Frontiers in Pharmacology, Vol 10 (2019)

Subject Terms: brain-derived neurotrophic factor, tropomyosin receptor kinase B, neurotrophin, medulloblastoma, brain tumor, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fphar.2019.00698/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/b5b0e0b16162448d9954f355f8f89f01

Cisplatin Induces Bmi-1 and Enhances the Stem Cell Fraction in Head and Neck Cancer

Authors: Carolina Nör, Zhaocheng Zhang, Kristy A. Warner, Lisiane Bernardi, Fernanda Visioli, Joseph I. Helman, Rafael Roesler, Jacques E. Nör

Source: Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 2, Pp 137-146 (2014)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558614800134; https://doaj.org/toc/1476-5586; https://doaj.org/toc/1522-8002

Access URL: https://doaj.org/article/0cba4f9de88e4d3fb0a8133b5bd5a5c3

Polyclads (Platyhelminthes) in the southern Gulf of Mexico: unveiling biodiversity and descriptions of two new species

Authors: Daniel Cuadrado, Alejandro Hernández-Gonzalez, Carolina Noreña, Nuno Simões

Source: ZooKeys, Vol 1221, Iss , Pp 103-144 (2024)

Subject Terms: Zoology, QL1-991

File Description: electronic resource

Relation: https://zookeys.pensoft.net/article/128260/download/pdf/; https://zookeys.pensoft.net/article/128260/download/xml/; https://zookeys.pensoft.net/article/128260/; https://doaj.org/toc/1313-2970

Access URL: https://doaj.org/article/d986e7a83a7c454a853c4fb1356cf9d2

Acotylea (Platyhelminthes, Polycladida) from the southern and western Iberian Peninsula, with the description of five new species

Authors: Patricia Pérez-García, Filipa Gouveia, Gonçalo Calado, Carolina Noreña, Juan Lucas Cervera

Source: Zoosystematics and Evolution, Vol 100, Iss 4, Pp 1487-1513 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://zse.pensoft.net/article/128211/download/pdf/; https://zse.pensoft.net/article/128211/download/xml/; https://zse.pensoft.net/article/128211/; https://doaj.org/toc/1860-0743

Access URL: https://doaj.org/article/7be98c2702bc474aac74adc56904d239

Tribute to Anno Faubel (30/09/1942-20/02/2024)

Authors: Verónica N. Bulnes, Carolina Noreña, Leigh Winsor

Source: Zoologia (Curitiba), Vol 41 (2024)

Subject Terms: Zoology, QL1-991

File Description: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-46702024000100712&lng=en&tlng=en; http://www.scielo.br/pdf/zool/v41/1984-4689-zool-41-e24043.pdf; https://doaj.org/toc/1984-4689

Access URL: https://doaj.org/article/aaa2d3479c164b1d90f6aa08e5d85726

Base-substitution rates of nuclear and mitochondrial genes for polyclad flatworms

Authors: Daniel Cuadrado, Jorge Rodríguez, Annie Machordom, Carolina Noreña, Fernando Á. Fernández-Álvarez, Pat A. Hutchings, Jane E. Williamson

Source: Zoosystematics and Evolution, Vol 100, Iss 3, Pp 863-876 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://zse.pensoft.net/article/119945/download/pdf/; https://zse.pensoft.net/article/119945/download/xml/; https://zse.pensoft.net/article/119945/; https://doaj.org/toc/1860-0743

Access URL: https://doaj.org/article/b2e9ecf704244996b19c220df89460aa

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The transcriptional landscape of Shh medulloblastoma

Authors: Patryk Skowron, Hamza Farooq, Florence M. G. Cavalli, A. Sorana Morrissy, Michelle Ly, Liam D. Hendrikse, Evan Y. Wang, Haig Djambazian, Helen Zhu, Karen L. Mungall, Quang M. Trinh, Tina Zheng, Shizhong Dai, Ana S. Guerreiro Stucklin, Maria C. Vladoiu, Vernon Fong, Borja L. Holgado, Carolina Nor, Xiaochong Wu, Diala Abd-Rabbo, Pierre Bérubé, Yu Chang Wang, Betty Luu, Raul A. Suarez, Avesta Rastan, Aaron H. Gillmor, John J. Y. Lee, Xiao Yun Zhang, Craig Daniels, Peter Dirks, David Malkin, Eric Bouffet, Uri Tabori, James Loukides, François P. Doz, Franck Bourdeaut, Olivier O. Delattre, Julien Masliah-Planchon, Olivier Ayrault, Seung-Ki Kim, David Meyronet, Wieslawa A. Grajkowska, Carlos G. Carlotti, Carmen de Torres, Jaume Mora, Charles G. Eberhart, Erwin G. Van Meir, Toshihiro Kumabe, Pim J. French, Johan M. Kros, Nada Jabado, Boleslaw Lach, Ian F. Pollack, Ronald L. Hamilton, Amulya A. Nageswara Rao, Caterina Giannini, James M. Olson, László Bognár, Almos Klekner, Karel Zitterbart, Joanna J. Phillips, Reid C. Thompson, Michael K. Cooper, Joshua B. Rubin, Linda M. Liau, Miklós Garami, Peter Hauser, Kay Ka Wai Li, Ho-Keung Ng, Wai Sang Poon, G. Yancey Gillespie, Jennifer A. Chan, Shin Jung, Roger E. McLendon, Eric M. Thompson, David Zagzag, Rajeev Vibhakar, Young Shin Ra, Maria Luisa Garre, Ulrich Schüller, Tomoko Shofuda, Claudia C. Faria, Enrique López-Aguilar, Gelareh Zadeh, Chi-Chung Hui, Vijay Ramaswamy, Swneke D. Bailey, Steven J. Jones, Andrew J. Mungall, Richard A. Moore, John A. Calarco, Lincoln D. Stein, Gary D. Bader, Jüri Reimand, Jiannis Ragoussis, William A. Weiss, Marco A. Marra, Hiromichi Suzuki, Michael D. Taylor

Source: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/091429a4162845e7a18371f487596c6f

Reply to Letter to the Editor Concerning 'HIPTCN: Prospective Observational Study of Hypocoagulated Head Trauma Patients with Normal Admission Computed Tomography Scan'

Authors: Pedro Duarte-Batista, José Hipólito Reis, João Silva, Samuel Sequeira Lemos, Nuno Cubas Farinha, Renata Marques, João Páscoa Pinheiro, Rui Tuna, Cristiano Antunes, Maria João Machado, Jessica Branco, Diogo Roque, Diogo Simão, Nuno Simas, Wilson Teixeira, Cátia Felício, Miguel Ferreira, Luís Rocha, Gonçalo Figueiredo, Carolina Noronha, Vasco Pinto, Filipe Silva, Ana Ferreira, Osvaldo Sousa

Source: Acta Médica Portuguesa, Vol 35, Iss 2 (2022)

Subject Terms: Anticoagulants, Brain Injuries, Traumatic, Intracranial Hemorrhage, Neurosurgical Procedures, Tomography, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/17630; https://doaj.org/toc/0870-399X; https://doaj.org/toc/1646-0758

Access URL: https://doaj.org/article/d2b3012ed0804ae0b1e22e2c4edc2d44

Complete denture hygiene solutions: antibiofilm activity and effects on physical and mechanical properties of acrylic resin

Authors: Millena Mangueira ROCHA, Adrianne Moura CARVALHO, Flávia Cristina Targa COIMBRA, Carolina Noronha Ferraz de ARRUDA, Viviane de Cássia OLIVEIRA, Ana Paula MACEDO, Cláudia Helena SILVA-LOVATO, Valéria Oliveira PAGNANO, Helena de Freitas Oliveira PARANHOS

Source: Journal of Applied Oral Science, Vol 29 (2021)

Subject Terms: Complete denture, Acrylic resin, Biofilm, Properties, Products with antimicrobial action, Dentistry, RK1-715

File Description: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572021000100435&tlng=en; https://doaj.org/toc/1678-7765

Access URL: https://doaj.org/article/35c7f5a95f574fe4bd89826cbbe84be1

HIPTCN: Prospective Observational Study of Hypocoagulated Head Trauma Patients with Normal Admission Computed Tomography Scan

Authors: Pedro Duarte-Batista, Nuno Cubas Farinha, Renata Marques, João Páscoa Pinheiro, João Silva, Rui Tuna, José Hipólito Reis, Cristiano Antunes, Maria João Machado, Samuel Sequeira Lemos, Jessica Branco, Diogo Roque, Diogo Simão, Nuno Simas, Wilson Teixeira, Cátia Felício, Miguel Ferreira, Eduardo Cunha, Luís Rocha, Gonçalo Figueiredo, Carolina Noronha, Vasco Pinto, Filipe Silva, Ana Ferreira, Osvaldo Sousa

Source: Acta Médica Portuguesa, Vol 34, Iss 6 (2021)

Subject Terms: Anticoagulants, Brain Injuries, Traumatic, Intracranial Hemorrhage, Multicenter Study, Neurosurgical Procedures, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: https://actamedicaportuguesa.com/revista/index.php/amp/article/view/13770; https://doaj.org/toc/0870-399X; https://doaj.org/toc/1646-0758

Access URL: https://doaj.org/article/ad6c37d7c51c4f18ae00aad62e352b67

Color change of composites on substrates treated with 0.2% chlorhexidine

Authors: Cristian SBARDELOTTO, Fernanda de Carvalho Panzeri PIRES-DE-SOUZA, Rafaella Tonani TORRIERI, Carolina Noronha Ferraz de ARRUDA

Source: RGO: Revista Gaúcha de Odontologia, Vol 69 (2021)

Subject Terms: Chlorhexidine, Composite resins, Color, Dentistry, RK1-715

File Description: electronic resource

Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1981-86372021000100301&tlng=en; https://doaj.org/toc/1981-8637

Access URL: https://doaj.org/article/58014bbb15034897bd6683b782295c53

Polycladida (Platyhelminthes, Rhabditophora) from Cape Verde and related regions of Macaronesia

Authors: Daniel Cuadrado, Jorge Rodríguez, Leopoldo Moro, Cristina Grande, Carolina Noreña

Source: European Journal of Taxonomy, Vol 736, Iss 1 (2021)

Subject Terms: flatworms, distribution, Acotylea, Cotylea, 28S, Zoology, QL1-991, Botany, QK1-989

File Description: electronic resource

Relation: https://europeanjournaloftaxonomy.eu/index.php/ejt/article/view/1249; https://doaj.org/toc/2118-9773

Access URL: https://doaj.org/article/286d702530c04ee980196b8ace2ce872

Global Perspectives on Task Shifting and Task Sharing in Neurosurgery

Authors: Faith C. Robertson, Ignatius N. Esene, Angelos G. Kolias, Tariq Khan, Gail Rosseau, William B. Gormley, Kee B. Park, Marike L.D. Broekman, Jeffrey Rosenfeld, Naci Balak, Ahmed Ammar, Magnus Tisel, Michael Haglund, Timothy Smith, Ivar Mendez, Jannick Brennum, Stephen Honeybul, Akira Matsumara, Severien Muneza, Andres Rubiano, Patrick Kamalo, Graham Fieggen, Basant Misra, Gene Bolles, David Adelson, Robert Dempsey, Peter Hutchinson, Alexandrina Nikova, Osama Ghazala, Elubabor Buno, Shibashish Bhattacharjee, Takahiro Iizuka, Jafri Malin Abdullah, Bipin Chaurasia, Eghosa Morgan, Rodolfo E. Alcedo-Guardia, Lynne Lourdes N. Lucena, Kadir Oktay, Omar Ibrahim AbdAllah, Ahlem Saihi, Gacem Abdeldjalil, Mahi Asmaa, Claudio Yampolsky, Laura P. Saladino, Francisco Mannara, Sonal Sachdev, Benjamin Price, Vincent Joris, Nourou Dine Adeniran Bankole, Edgar M. Carrasco, Mirsad Hodzic, Marcos Wagner de Sousa Porto, Robson Amorim, Igor Lima Maldonado, Bizoza Yves, Gonzalo Suarez, Felipe Constanzo, Johanna Cecilia Valdeblanquez Atencio, Karen Alexa Ruiz Mora, Juan Manuel Rodriguez Gil, Kiriakos Paraskeva, Emrah Egemen, Trevcsor Ngamasata, Jeff Ntalaja, Antoine Beltchika, Glennie Ntsambi, Goertz Mirenge Dunia, Mahmoud M. Taha, Mohamed Arnaout, Ramez Kirollos, Mohamed Kassem, Omar Elwardany, Ahmed Negida, Birhanu Dolango, Mikael Aseged, Alemu Adise Mldie, Tsegazeab Laeke, Abenezer Aklilu, Esayas Adefris, Teemu Luoto, Rezai Jahromi Behnam, Emmanuel De Schlichting, Bougaci Nassim, Pierre Bourdillon, Martin N. Stienen, Stephan Lackermair, Franziska Anna Schmidt, Juergen Konczalla, Adrien Holzgreve, Andre Sagerer, Dieter M. Weinert, Paulette Kumi, Aaron Lawson McLean, James Loan, Julian Cahill, Simon Dockrell, Fardad T. Afshari, Paul May, Alkinoos Athanasiou, Steven Papadopoulos, Edroulfo-Georgios Espinoza, Athanasios Chatzisotiriou, Pavlos Vlachogiannis, Konstantina Karabatsou, Thanasis Paschalis, Christos Tsitsipanis, Gabriel Mauricio Longo Calderan, Ronny Leiva, Harsh Deora, Sreenivas Mukkamala, Dipesh Batra, Arvind Sukumaran, Kanishk Parmar, Anuj Bahl, Amit Agrawal, Nirankar Dev, Nikhil Thakur, Sanjay Behari, Chandrasekhar B.V.K. Yandrapati, Ritesh Bhoot, Pragnesh Bhatt, Uday Bhaumik, Manish Agrawal, Antony Thomas, Harish Chandrappa, Ankit Mathur, Petra Wahjoepramono, Selfy Oswari, Rafid Al-Mahfoudh, Abbas Alnaji, Nidal Abuhadrous, Bakr Abo Jarad, Ibrahim Nour, Or Cohen-Inbar, Roberto Colasanti, Alfredo Conti, Giovanni Raffa, Corrado Castrioto, Matteo M. Baccanelli, Santino Ottavio Tomasi, Matteo Zoli, Andrea Veroni, Andrea Di Cristofori, Luigi Giannachi, Laura Lippa, Donatella Sgubin, Morgan Broggi, Marcello Barbato, Francesco Restelli, Mario Ganau, Graziano Taddei, Hamzeh Albadawi, Mohammed Salameh, Madieyva Gulmira, Muffaq Lashhab, Walid El Gaddafi, Mohammad Altoumi, S.M. Manvinder, Davendran Kanesen, Mario Teo, Prabu Rau Sriram, Sarah Atiqah M. Zamri, Vayara Perumall Vinodh, Moussa Denou, Adyl Melhaoui, Oumaima Outani, Mahjouba Boutarbouch, Armin Gretschel, Pradhumna Yadav, Balgopal Karmacharya, Fatih Incekara, Hugo den Boogert, Buccket Argvoello Lopez, Hassane Ali Amadou, Danjuma Sale, Sanusi Bello, Poluyi Edward, Alvan-Emeka Ukachukwu, Evaristus Nwaribe, Ikechukwu Aniaku, Aliyu Baba Ndajiwo, Olabamidele Ayodele, Gyang Markus Bot, Sunday David Ndubuisu Achebe, Bakht Jamal, Muhammad Tariq, Ghulam Farooq, Danyal Zaman Khan, Ahtesham Khizar, Zahid Hussain, Anisa Nazir, Marco Gonzales-Portillo, Jhosep Silvestre Bautista, Roland A. Torres, Abigail Javier-Lizan, Isagani Jodl G. de los Santos, Jr., Nuno Morais, Lydia Dias, Carolina Noronha, Jovelo Monteiro Silva, Alexandra Seromenho-Santos, Kiril Lozanche, Ionut Negoi, Alexandru Tascu, Danil A. Kozyrev, Dr. Menelas Nkeshimana, Claire Karekezi, Marcel Didier Ndayishyigikiye, Faisal Alabbass, Faisal Farrash, Rawan Alhazmi, Jagos Golubovic, Milan Lepifá, Rosanda Ilifá, Aleksandar Stanimirovifá, Sergio Garcia-Garcia, Carlos A. Rodriguez Arias, Ruth Lau, Juan Delgado-Fernandez, Miguel A. Arraez, C. Fernandez Mateos, Ana M. Castano Leon, Saman Wadanamby, David Bervini, Hamisi K. Shabani, Kriengsak Limpastan, Khalil Ayadi, Altay Sencer, Ali Yalcinkaya, Elif Eren, Recep Basaran, Abdulkerim Gokoglu, Vyval Mykola, Felicita Tayong, Mario Zuccarello, Carolyn Quinsey, Michael C. Dewan, Paul H. Young, Edward Laws, Jack Rock, David B. Kurland, Carrie R. Muh, Eri Dario Delgado Aguilar, Kenneth Burns, Jacob Low, Conor Keogh, Chris Uff, Alfio Spina, Fayez Alelyani

Source: World Neurosurgery: X, Vol 6, Iss , Pp - (2020)

Subject Terms: Surgery, RD1-811, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2590139719301012; https://doaj.org/toc/2590-1397

Access URL: https://doaj.org/article/6b988bca432f443c92cd973e5c055ba7

Cadherin Expression and EMT: A Focus on Gliomas

Authors: Carolina Noronha, Ana Sofia Ribeiro, Ricardo Taipa, Diogo S. Castro, Joaquim Reis, Cláudia Faria, Joana Paredes

Source: Biomedicines, Vol 9, Iss 10, p 1328 (2021)

Subject Terms: cadherins, EMT, gliomas, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/9/10/1328; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/3ceb49b1646640f9a7cf029fdb765b14

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