IKK2 controls the inflammatory potential of tissue-resident regulatory T cells in a murine gain of function model

Authors: Chelisa Cardinez, Yuwei Hao, Kristy Kwong, Ainsley R. Davies, Morgan B. Downes, Nadia A. Roberts, Jason D. Price, Raquel A. Hernandez, Jessica Lovell, Rochna Chand, Zhi-Ping Feng, Anselm Enders, Carola G. Vinuesa, Bahar Miraghazadeh, Matthew C. Cook

Source: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/db07c536c7a44f49859f6963437bbf1a

Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection

Authors: Tomalika R. Ullah, Matt D. Johansen, Katherine R. Balka, Rebecca L. Ambrose, Linden J. Gearing, James Roest, Julian P. Vivian, Sunil Sapkota, W. Samantha N. Jayasekara, Daniel S. Wenholz, Vina R. Aldilla, Jun Zeng, Stefan Miemczyk, Duc H. Nguyen, Nicole G. Hansbro, Rajan Venkatraman, Jung Hee Kang, Ee Shan Pang, Belinda J. Thomas, Arwaf S. Alharbi, Refaya Rezwan, Meredith O’Keeffe, William A. Donald, Julia I. Ellyard, Wilson Wong, Naresh Kumar, Benjamin T. Kile, Carola G. Vinuesa, Graham E. Kelly, Olivier F. Laczka, Philip M. Hansbro, Dominic De Nardo, Michael P. Gantier

Source: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/780fdb67fa074e35823aa88357231e9d

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

Authors: Sarah E. Garnish, Katherine R. Martin, Maria Kauppi, Victoria E. Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C. Tovey Crutchfield, Komal M. Patel, Annette V. Jacobsen, Georgia K. Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R. Horne, Cathrine Hall, Samuel N. Young, Matthew Cook, Vicki Athanasopoulos, Carola G. Vinuesa, Kate E. Lawlor, Ian P. Wicks, Gregor Ebert, Ashley P. Ng, Charlotte A. Slade, Jaclyn S. Pearson, André L. Samson, John Silke, James M. Murphy, Joanne M. Hildebrand

Source: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/14198b0aa4ad4e93a3c3095f5a9f9cb4

The Role of Genetic Risk Factors in Pathogenesis of Childhood-Onset Systemic Lupus Erythematosus

Authors: Mario Sestan, Nastasia Kifer, Todor Arsov, Matthew Cook, Julia Ellyard, Carola G. Vinuesa, Marija Jelusic

Source: Current Issues in Molecular Biology, Vol 45, Iss 7, Pp 5981-6002 (2023)

Subject Terms: childhood-onset systemic lupus erythematosus, monogenic systemic lupus erythematosus, genetics, pathogenesis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1467-3045/45/7/378; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045

Access URL: https://doaj.org/article/f8311bdd298e4541989c1f191532cbb3

Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK

Authors: Rhiannon Morris, Yaoyuan Zhang, Julia I. Ellyard, Carola G. Vinuesa, James M. Murphy, Artem Laktyushin, Nadia J. Kershaw, Jeffrey J. Babon

Source: Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/ed728d0a0b344b1398b0296e28357e0b

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Authors: Joanne M. Hildebrand, Maria Kauppi, Ian J. Majewski, Zikou Liu, Allison J. Cox, Sanae Miyake, Emma J. Petrie, Michael A. Silk, Zhixiu Li, Maria C. Tanzer, Gabriela Brumatti, Samuel N. Young, Cathrine Hall, Sarah E. Garnish, Jason Corbin, Michael D. Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C. Josefsson, Kristin Rigbye, Holly Anderton, James A. Rickard, Anne Tripaydonis, Julie Sheridan, Thomas S. Scerri, Victoria E. Jackson, Peter E. Czabotar, Jian-Guo Zhang, Leila Varghese, Cody C. Allison, Marc Pellegrini, Gillian M. Tannahill, Esme C. Hatchell, Tracy A. Willson, Dina Stockwell, Carolyn A. de Graaf, Janelle Collinge, Adrienne Hilton, Natasha Silke, Sukhdeep K. Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M. Laxer, Alexander G. Bassuk, Benjamin W. Darbro, Maria A. Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David B. Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John Reveille, Michael S. Hildebrand, Carola G. Vinuesa, Pamela McCombe, Matthew A. Brown, Benjamin T. Kile, Catriona McLean, Melanie Bahlo, Seth L. Masters, Hiroyasu Nakano, Polly J. Ferguson, James M. Murphy, Warren S. Alexander, John Silke

Source: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/eb684694de314067aac5b53c9a7c86cd

TFR Cells Express Functional CCR6 But It Is Dispensable for Their Development and Localization During Splenic Humoral Immune Responses

Authors: Cameron R. Bastow, Ervin E. Kara, Timona S. Tyllis, Carola G. Vinuesa, Shaun R. McColl, Iain Comerford

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: germinal center T cell, T follicular helper (Tfh) cell, CCR6, T follicular regulatory (Tfr) cells, chemokine receptor, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.873586/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a0e35c22794d47cdb9314e6c4850a5b4

Extrafollicular Plasmablasts Present in the Acute Phase of Infections Express High Levels of PD-L1 and Are Able to Limit T Cell Response

Authors: Melisa Gorosito Serrán, Facundo Fiocca Vernengo, Laura Almada, Cristian G. Beccaria, Yamila Gazzoni, Pablo F. Canete, Jonathan A. Roco, Jimena Tosello Boari, Maria Cecilia Ramello, Ellen Wehrens, Yeping Cai, Elina I. Zuniga, Carolina L. Montes, Ian A. Cockburn, Eva V. Acosta Rodriguez, Carola G. Vinuesa, Adriana Gruppi

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: plasmablasts/plasma cells, B cell, PD-L1, Trypanosoma cruzi, Plasmodium, LCMV, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.828734/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e2cf7f337a5340039ee73c984b6bf218

Genomic test ends a long diagnostic odyssey in a patient with resistance to thyroid hormones

Authors: Todor Arsov, Chengmei Xie, Nan Shen, Dan Andrews, Carola G. Vinuesa, Olivija Vaskova

Source: Thyroid Research, Vol 12, Iss 1, Pp 1-5 (2019)

Subject Terms: Resistance to thyroid hormones, Hashimoto thyroiditis, Genomic testing, Whole exome sequencing, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13044-019-0068-y; https://doaj.org/toc/1756-6614

Access URL: https://doaj.org/article/680b37bce8954636b07dfd9e7f20bb6f

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus

Authors: Simon H. Jiang, Vicki Athanasopoulos, Julia I. Ellyard, Aaron Chuah, Jean Cappello, Amelia Cook, Savit B. Prabhu, Jacob Cardenas, Jinghua Gu, Maurice Stanley, Jonathan A. Roco, Ilenia Papa, Mehmet Yabas, Giles D. Walters, Gaetan Burgio, Kathryn McKeon, James M. Byers, Charlotte Burrin, Anselm Enders, Lisa A. Miosge, Pablo F. Canete, Marija Jelusic, Velibor Tasic, Adrian C. Lungu, Stephen I. Alexander, Arthur R. Kitching, David A. Fulcher, Nan Shen, Todor Arsov, Paul A. Gatenby, Jeff J. Babon, Dominic F. Mallon, Carmen de Lucas Collantes, Eric A. Stone, Philip Wu, Matthew A. Field, Thomas D. Andrews, Eun Cho, Virginia Pascual, Matthew C. Cook, Carola G. Vinuesa

Source: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/78a180011b6f49c096a0159adcd221f4

STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles

Authors: Jalila Alshekaili, Rochna Chand, Cindy Eunhee Lee, Susan Corley, Kristy Kwong, Ilenia Papa, David A. Fulcher, Katrina L. Randall, Jennifer W. Leiding, Cindy S. Ma, Marc R. Wilkins, Gulbu Uzel, Chris C. Goodnow, Carola G. Vinuesa, Stuart G. Tangye, Matthew C. Cook

Source: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e2eb94b50da340409764c3fb20783667

Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center

Authors: Hu Yan, Longyan Wu, Changming Shih, Shiyue Hou, Jingwen Shi, Tianyang Mao, Wenbin Chen, Bhavani Melvin, Robert J. Rigby, Yingjia Chen, Haochen Jiang, Roland H. Friedel, Carola G. Vinuesa, Hai Qi

Source: Cell Reports, Vol 19, Iss 5, Pp 995-1007 (2017)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124717304977; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/8ba257eb967e40d490f16b2b4c43930d

Non-parametric Heat Map Representation of Flow Cytometry Data: Identifying Cellular Changes Associated With Genetic Immunodeficiency Disorders

Authors: Julia I. Ellyard, Robert Tunningley, Ayla May Lorenzo, Simon H. Jiang, Amelia Cook, Rochna Chand, Dipti Talaulikar, Ann-Maree Hatch, Anastasia Wilson, Carola G. Vinuesa, Matthew C. Cook, David A. Fulcher

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: flow cytometry, immunodeficiency, common variable immunodeficiency, TACI, CTLA4, TNFSF13B, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.02134/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0b6ff66eb1ef4b62bb850289385bfead

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

Authors: Jian Tan, Craig McKenzie, Peter J. Vuillermin, Gera Goverse, Carola G. Vinuesa, Reina E. Mebius, Laurence Macia, Charles R. Mackay

Source: Cell Reports, Vol 15, Iss 12, Pp 2809-2824 (2016)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716306301; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/007fe71e36a64e44a8b4820eb54f9198

Synaptic Interactions in Germinal Centers

Authors: Ilenia Papa, Carola G. Vinuesa

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: T follicular helper (TFH) cell, germinal center, germinal centre B cells, immunological synapse, dense core granules, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2018.01858/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/3eb7734bf2bc4dcda0ff8c4197f022db

Unconventional Pro-inflammatory CD4+ T Cell Response in B Cell-Deficient Mice Infected with Trypanosoma cruzi

Authors: Melisa Gorosito Serrán, Jimena Tosello Boari, Facundo Fiocca Vernengo, Cristian G. Beccaría, María C. Ramello, Daniela A. Bermejo, Amelia G. Cook, Carola G. Vinuesa, Carolina L. Montes, Eva V. Acosta Rodriguez, Adriana Gruppi

Source: Frontiers in Immunology, Vol 8 (2017)

Subject Terms: Trypanosoma cruzi, Chagas disease, B cell, CD4+ T cells, inflammation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.01548/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/b227416f13764d8c86e92c05631e1f2b

Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation

Authors: Roybel R Ramiscal, Ian A Parish, Robert S Lee-Young, Jeffrey J Babon, Julianna Blagih, Alvin Pratama, Jaime Martin, Naomi Hawley, Jean Y Cappello, Pablo F Nieto, Julia I Ellyard, Nadia J Kershaw, Rebecca A Sweet, Christopher C Goodnow, Russell G Jones, Mark A Febbraio, Carola G Vinuesa, Vicki Athanasopoulos

Source: eLife, Vol 4 (2015)

Subject Terms: T follicular helper cell, germinal center, stress granule, ROQUIN, AMPK, mTOR, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/08698; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/7bf1a7c862fb4da5805e2cb6c10ee4a4

Inflammation: gone with translation.

Authors: Carola G Vinuesa, Thomas Preiss

Source: PLoS Genetics, Vol 10, Iss 6, p e1004442 (2014)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4063730?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/deaf51a4eccd4c7688f96ff61981c74e