Clinical outcomes and management following progressive disease with anti-PD-(L)1 therapy in patients with advanced Merkel Cell Carcinoma

Authors: Mo, Jeremy ^a, Zaremba, Anne ^b, Inderjeeth, Andrisha-Jade ^{c, d}, El Zeinaty, Perla ^e, Li, Ao ^f, Wicky, Alexandre ^g, Della Marta, Nicholas ^h, Marqueste, Caroline Gaudy ^{i, s}, Bohne, Ann-Sophie ^j, Matias, Margarida ^k, McNamee, Nicholas ^l, Festino, Lucia ^m, Chen, Charley ⁿ, Ch’ng, Sydney ^{h, o, p, x}, van Akkooi, Alexander C.J. ^{h, p, q}, Meda, Laetitia Da ^e, Park, John J. ^{l, r}, Ascierto, Paolo A. ^m, Hauschild, Axel ^j, Lee, Jenny H. ^{o, r}, Grob, Jean Jacques ^{i, s}, Mangana, Joanna ^t, Guminski, Alex ^u, Michielin, Olivier ^g, Xu, Wen ^{f, v}, Lebbe, Celeste ^{e, w}, Sandhu, Shahneen ^d, Zimmer, Lisa ^b, Menzies, Alexander M. ^{h, p, u, x}, Lo, Serigne N. ^{h, p, y}, Long, Georgina V. ^{h, p, u, x, y}, Carlino, Matteo S. ^{a, h, n, p}, da Silva, Ines Pires ^{h, n, p, x, y, ⁎}

Source: In European Journal of Cancer 25 February 2025 217

Outcomes following long-term disease control with immune checkpoint inhibitors in patients with advanced melanoma

Authors: Handel, Eleanor E. ^{a, ⁎}, McKeown, Janet ^b, Wei, Joe ^{a, b}, Kankaria, Roma A. ^c, Burnette, Hannah ^c, Johnson, Douglas B. ^c, Lawless, Aleigha ^d, Czapla, Juliane ^d, Sullivan, Ryan J. ^d, Albrecht, Lea Jessica ^e, Zimmer, Lisa ^e, Mangana, Joanna ^f, Dummer, Reinhard ^f, Kessels, Jolien I. ^g, Neyns, Bart ^g, Allayous, Clara ^h, Lebbe, Celeste ⁱ, Boatwright, Christina ^j, Mehnert, Janice M. ^j, Ottaviano, Margaret ^k, Ascierto, Paolo A. ^k, Czarnecka, Anna M. ^l, Rutkowski, Piotr ^l, Lo, Serigne N. ^b, Long, Georgina V. ^{b, m, n}, Menzies, Alexander M. ^{b, m, n}, Carlino, Matteo S. ^{a, b, m, ⁎⁎}

Source: In European Journal of Cancer 17 January 2025 215

Prognostic and predictive importance of body mass index and type 2 diabetes in the European Organisation for Research and Treatment of Cancer 1325/KEYNOTE-054 phase III trial of pembrolizumab versus placebo in resected high-risk stage III melanoma

Authors: Kennedy, Oliver John ^{a, b, ⁎, 1}, Glassee, Nina ^{c, 1}, Kicinski, Michal ^c, Bührer, Emanuel ^c, Valpione, Sara ^d, Gandini, Sara ^e, Suciu, Stefan ^c, Blank, Christian U. ^f, Long, Georgina V. ^g, Atkinson, Victoria G. ^h, Dalle, Stéphane ⁱ, Haydon, Andrew M. ^j, Meshcheryakov, Andrey ^k, Khattak, Adnan ^l, Carlino, Matteo S. ^m, Sandhu, Shahneen ⁿ, Larkin, James ^o, Puig, Susana ^p, Ascierto, Paolo A. ^q, Rutkowski, Piotr ^r, Schadendorf, Dirk ^s, Boers-Sonderen, Marye ^t, Di Giacomo, Anna Maria ^u, van den Eertwegh, Alfonsus J.M. ^v, Grob, Jean-Jacques ^w, Gutzmer, Ralf ^x, Jamal, Rahima ^y, van Akkooi, Alexander C.J. ^z, Robert, Caroline ^aa, Eggermont, Alexander M.M. ^{ab, ac}, Lorigan, Paul ^{a, b, 2}, Mandala, Mario ^{ad, 2}

Source: In EJC Skin Cancer 2025 3

Comparison of clinicopathological features and treatment outcomes for cutaneous melanomas of the head and neck and melanomas arising at other sites: Implications for systemic therapy

Authors: Li, Andrew T., Xu, Jessie X., Blah, Tyler R., Lo, Serigne N., Saw, Robyn PM., Varey, Alexander HR., Van Akkooi, Alexander, Carlino, Matteo S., Pires da Silva, Ines, Menzies, Alexander M., Shannon, Kerwin F., Long, Georgina V., Scolyer, Richard A., Thompson, John F., Ch'ng, Sydney

Source: In Journal of the American Academy of Dermatology January 2025 92(1):58-67

Nature and management of melanoma recurrences following adjuvant anti-PD-1 based therapy

Authors: Woodford, Rachel ^a, McKeown, Janet ^a, Hoeijmakers, Lotte L. ^b, Mangana, Johanna ^c, Dimitriou, Florentia ^c, Allayous, Clara ^d, Zaman, Farzana ^e, Aya, Francisco ^f, Marsiglio, John ^g, Goodman, Rachel ^h, Rayson, Victoria ⁱ, Placzke, Joanna ^j, Kessels, Jolien ^k, Ramalyte, Egle ^l, Haque, Waqas ^m, Wilson, Isabella ⁿ, Trojaniello, Claudia ^o, Benannoune, Naima ^p, Roberts-Thomson, Rachel ^q, Robert, Caroline ^p, Blank, Christian U. ^b, Dummer, Reinhard ^c, Lebbe, Celeste ^{d, r}, Haydon, Andrew ^e, Arance, Ana ^f, Hu-Lieskovan, Siwen ^g, Johnson, Douglas B. ^h, Mcarthur, Grant A. ⁱ, Rutkowski, Piotr ^j, Neyns, Bart ^k, Sullivan, Ryan J. ^l, Weber, Jeffrey ^m, Carlino, Matteo S. ^{a, n}, Ascierto, Paolo A. ^o, Lo, Serigne ^a, Long, Georgina V. ^{a, s}, Menzies, Alexander M. ^{a, s, ⁎}

Source: In European Journal of Cancer November 2024 212

Seven-year analysis of adjuvant pembrolizumab versus placebo in stage III melanoma in the EORTC1325 / KEYNOTE-054 trial

Authors: Eggermont, Alexander MM, Kicinski, Michal, Blank, Christian U., Mandala, Mario, Long, Georgina V., Atkinson, Victoria, Dalle, Stéphane, Haydon, Andrew, Meshcheryakov, Andrey, Khattak, Adnan, Carlino, Matteo S., Sandhu, Shahneen, Larkin, James, Puig, Susana, Ascierto, Paolo A., Rutkowski, Piotr, Schadendorf, Dirk, Boers-Sonderen, Marye, Di Giacomo, Anna Maria, van den Eertwegh, Alfonsus JM, Grob, Jean-Jacques, Gutzmer, Ralf, Jamal, Rahima, van Akkooi, Alexander C.J., Lorigan, Paul, Grebennik, Dmitri, Kreplere, Clemens, Marreaud, Sandrine, Suciu, Stefan, Robert, Caroline

Source: In European Journal of Cancer November 2024 211

Adjuvant pembrolizumab versus placebo in resected stage III melanoma (EORTC 1325-MG/KEYNOTE-054): long-term, health-related quality-of-life results from a double-blind, randomised, controlled, phase 3 trial

Authors: Bührer, Emanuel ^*, Kicinski, Michal, Mandala, Mario, Pe, Madeline, Long, Georgina V, Atkinson, Victoria, Blank, Christian U, Haydon, Andrew, Dalle, Stéphane, Khattak, Adnan, Carlino, Matteo S, Meshcheryakov, Andrey, Sandhu, Shahneen, Puig, Susana, Schadendorf, Dirk, Jamal, Rahima, Rutkowski, Piotr, van den Eertwegh, Alfonsus J M, Coens, Corneel, Grebennik, Dmitri, Krepler, Clemens, Robert, Caroline, Eggermont, Alexander M M

Source: In The Lancet Oncology September 2024 25(9):1202-1212

Safety of pembrolizumab as adjuvant therapy in a pooled analysis of phase 3 clinical trials of melanoma, non–small cell lung cancer, and renal cell carcinoma

Authors: Luke, Jason J., Long, Georgina V., Robert, Caroline, Carlino, Matteo S., Choueiri, Toni K., Haas, Naomi B., O’Brien, Mary, Paz-Ares, Luis, Peters, Solange, Powles, Thomas, Leiby, Melanie A., Lin, Jianxin, Zhao, Yujie, Krepler, Clemens, Perini, Rodolfo F., Catherine Pietanza, M., Samkari, Ayman, Gruber, Todd, Ibrahim, Nageatte, Eggermont, Alexander M.M.

Source: In European Journal of Cancer August 2024 207

Anti-PD-1 alone or in combination with anti-CTLA-4 for advanced melanoma patients with liver metastases

Authors: Pires da Silva, Ines, Li, Isabel, Ugurel, Selma, Serra-Bellver, Patricio, Andhale, Avanti, Burnette, Hannah, Aya, Francisco, Conway, Jordan W., Braden, Jorja, Carlino, Matteo S., Menzies, Alexander M., Weichenthal, Michael, Mohr, Peter, Gutzmer, Ralf, Arance, Ana M., Johnson, Douglas B., Lorigan, Paul, Schadendorf, Dirk, Lo, Serigne N., Long, Georgina V.

Source: In European Journal of Cancer July 2024 205

Prognostic and predictive value of non-steroidal anti-inflammatory drugs in the EORTC 1325/KEYNOTE-054 phase III trial of pembrolizumab versus placebo in resected high-risk stage III melanoma

Authors: Kennedy, Oliver John, Glassee, Nina, Kicinski, Michal, Blank, Christian U., Long, Georgina V., Atkinson, Victoria G., Dalle, Stéphane, Haydon, Andrew M., Meshcheryakov, Andrey, Khattak, Adnan, Carlino, Matteo S., Sandhu, Shahneen, Larkin, James, Puig, Susana, Ascierto, Paolo A., Rutkowski, Piotr, Schadendorf, Dirk, Boers-Sonderen, Marye, Giacomo, Anna Maria Di, van den Eertwegh, Alfonsus J.M., Grob, Jean-Jacques, Gutzmer, Ralf, Jamal, Rahima, van Akkooi, Alexander C.J., Gandini, Sara, Buhrer, Emanuel, Suciu, Stefan, Robert, Caroline, Eggermont, Alexander M.M., Mandala, Mario, Lorigan, Paul, Valpione, Sara

Source: In European Journal of Cancer April 2024 201

Efficacy and safety of ‘Second Adjuvant’ therapy with BRAF/MEK inhibitors after local therapy for recurrent melanoma following adjuvant PD-1 based immunotherapy

Authors: Taylor, Amelia M., McKeown, Janet, Dimitriou, Florentia, Jacques, Sarah K., Zimmer, Lisa, Allayous, Clara, Yeoh, Hui-Ling, Haydon, Andrew, Ressler, Julia M., Galea, Claire, Woodford, Rachel, Kahler, Katharina, Hauschild, Axel, Festino, Lucia, Hoeller, Christoph, Schwarze, Julia K., Neyns, Bart, Wicky, Alexandre, Michielin, Olivier, Placzke, Joanna, Rutkowski, Piotr, Johnson, Douglas B., Lebbe, Celeste, Dummer, Reinhard, Ascierto, Paolo A., Lo, Serigne, Long, Georgina V., Carlino, Matteo S., Menzies, Alexander M.

Source: In European Journal of Cancer March 2024 199

Outcomes of patients with resected stage III/IV acral or mucosal melanoma, treated with adjuvant anti-PD-1 based therapy

Authors: Jacques, Sarah K., McKeown, Janet, Grover, Piyush, Johnson, Douglas B., Zaremba, Anne, Dimitriou, Florentia, Weiser, Roi, Farid, Mohamad, Namikawa, Kenjiro, Sullivan, Ryan J., Rutkowski, Piotr, Lebbe, Celeste, Hamid, Omid, Zager, Jonathan S., Michielin, Olivier, Neyns, Bart, Nakamura, Yasuhiro, Robert, Caroline, Mehnert, Janice, Ascierto, Paolo A., Bhave, Prachi, Park, Benjamin, Zimmer, Lisa, Mangana, Joanna, Mooradian, Megan, Placzke, Joanna, Allayous, Clare, Glitza Oliva, Isabella C., Mehmi, Inderjit, Depalo, Danielle, Wicky, Alexandre, Schwarze, Julia K., Roy, Severine, Boatwright, Christina, Vanella, Vito, Long, Georgina V., Menzies, Alexander M., Lo, Serigne N., Carlino, Matteo S.

Source: In European Journal of Cancer March 2024 199

Individualised neoantigen therapy mRNA-4157 (V940) plus pembrolizumab versus pembrolizumab monotherapy in resected melanoma (KEYNOTE-942): a randomised, phase 2b study

Authors: Weber, Jeffrey S ^*, Carlino, Matteo S, Khattak, Adnan, Meniawy, Tarek, Ansstas, George, Taylor, Matthew H, Kim, Kevin B, McKean, Meredith, Long, Georgina V, Sullivan, Ryan J, Faries, Mark, Tran, Thuy T, Cowey, C Lance, Pecora, Andrew, Shaheen, Montaser, Segar, Jennifer, Medina, Theresa, Atkinson, Victoria, Gibney, Geoffrey T, Luke, Jason J, Thomas, Sajeve, Buchbinder, Elizabeth I, Healy, Jane A, Huang, Mo, Morrissey, Manju, Feldman, Igor, Sehgal, Vasudha, Robert-Tissot, Celine, Hou, Peijie, Zhu, Lili, Brown, Michelle, Aanur, Praveen, Meehan, Robert S, Zaks, Tal

Source: In The Lancet 17-23 February 2024 403(10427):632-644

Seasonal patterns of toxicity in melanoma patients treated with combination anti-PD-1 and anti-CTLA-4 immunotherapy

Authors: Rogiers, Aljosja, Dimitriou, Florentia, Lobon, Irene, Harvey, Catriona, Vergara, Ismael A., Pires da Silva, Ines, Lo, Serigne N., Scolyer, Richard A., Carlino, Matteo S., Menzies, Alexander M., Long, Georgina V.

Source: In European Journal of Cancer February 2024 198

The features and management of acquired resistance to PD1-based therapy in metastatic melanoma

Authors: Hepner, Adriana, Versluis, Judith M., Wallace, Roslyn, Allayous, Clara, Brown, Lauren Julia, Trojaniello, Claudia, Gerard, Camille Lea, Jansen, Yanina JL, Bhave, Prachi, Neyns, Bart, Haydon, Andrew, Michielin, Olivier, Mangana, Joanna, Klein, Oliver, Shoushtari, Alexander N., Warner, Allison Betof, Ascierto, Paolo Antonio, McQuade, Jennifer Leigh, Carlino, Matteo S., Zimmer, Lisa, Lebbe, Celeste, Johnson, Douglas B., Sandhu, Shahneen, Atkinson, Victoria, Blank, Christian U., Lo, Serigne N., Long, Georgina V., Menzies, Alexander M.

Source: In European Journal of Cancer January 2024 196

Has the advent of modern adjuvant systemic therapy for melanoma rendered sentinel node biopsy unnecessary?

Authors: Varey, Alexander H.R., Thompson, John F., Howle, Julie R., Lo, Serigne N., Ch'ng, Sydney, Carlino, Matteo S.

Source: European journal of cancer. 186:166-171

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194198364.0x000001&indx=1&recIds=ETOCvdc_100194198364.0x000001

Durability of response to immune checkpoint inhibitors in metastatic Merkel cell carcinoma after treatment cessation

Authors: Weppler, Alison M., Da Meda, Laetitia, Pires da Silva, Ines, Xu, Wen, Grignani, Giovanni, Menzies, Alexander M., Carlino, Matteo S., Long, Georgina V., Lo, Serigne N., Nordman, Ina, Steer, Christopher B., Lyle, Megan, Trojaniello, Claudia, Ascierto, Paolo A., Lebbe, Celeste, Sandhu, Shahneen

Source: European journal of cancer. 183:109-118

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190699390.0x000001&indx=1&recIds=ETOCvdc_100190699390.0x000001

Lichen sclerosus and immune checkpoint inhibitors: A case and review of the literature

Authors: Truong, Kelvin, Jones‐Caballero, Maria, Chou, Shaun, Carlino, Matteo S., Consuegra‐Romero, Germana, Araujo, Raquel Ruiz

Source: Australasian journal of dermatology. 64(1):158-161

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181483787.0x000001&indx=1&recIds=ETOCvdc_100181483787.0x000001

Efficacy and safety of immune checkpoint inhibitors in young adults with metastatic melanoma

Authors: Wong, Selina K., Blum, Steven M., Sun, Xiaopeng, Da Silva, Inês P., Zubiri, Leyre, Ye, Fei, Bai, Kun, Zhang, Kevin, Ugurel, Selma, Zimmer, Lisa, Livingstone, Elisabeth, Schadendorf, Dirk, Serra-Bellver, Patricio, Muñoz-Couselo, Eva, Ortiz, Carolina, Lostes, Julia, Huertas, Roberto M., Arance, Ana, Pickering, Lisa, Long, Georgina V., Carlino, Matteo S., Buchbinder, Elizabeth I., Vázquez-Cortés, Leticia, Jara-Casas, Diego, Márquez-Rodas, Iván, González-Espinoza, Iván R., Balko, Justin M., Menzies, Alexander M., Sullivan, Ryan J., Johnson, Douglas B.

Source: European journal of cancer. 181:188-197

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BRAF inhibitor cessation prior to disease progression in metastatic melanoma: Long-term outcomes

Authors: Lee, Joanna, Ahmed, Tasnia, Maurichi, Andrea, Di Guardo, Lorenza, Stagno, Anna M., Warburton, Lydia, Taylor, Amelia. M., Livingstone, Elisabeth, Rehman, Saba, Khattak, Adnan, Kahler, Katharina C., Vanella, Vito, Atkinson, Victoria, Millward, Michael, Schadendorf, Dirk, Johnson, Douglas B., Ascierto, Paolo A., Hauschild, Axel, Lo, Serigne N., Long, Georgina V., Menzies, Alexander M., Carlino, Matteo S.

Source: European journal of cancer. 179:87-97

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100178898531.0x000001&indx=1&recIds=ETOCvdc_100178898531.0x000001