APOE -ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals

Authors: Anna Brugulat-Serrat, Gonzalo Sánchez-Benavides, Raffaele Cacciaglia, Gemma Salvadó, Mahnaz Shekari, Lyduine E. Collij, Christopher Buckley, Bart N. M. van Berckel, Andrés Perissinotti, Aida Niñerola-Baizán, Marta Milà-Alomà, Natàlia Vilor-Tejedor, Grégory Operto, Carles Falcon, Oriol Grau-Rivera, Eider M. Arenaza-Urquijo, Carolina Minguillón, Karine Fauria, José Luis Molinuevo, Marc Suárez-Calvet, Juan Domingo Gispert, the ALFA Study

Source: EJNMMI Research, Vol 13, Iss 1, Pp 1-12 (2023)

Subject Terms: Alzheimer’s disease, Amyloid PET, Visual read, Memory, Executive function, APOE-ε4, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://doaj.org/toc/2191-219X

Access URL: https://doaj.org/article/0d4f03806f1d42348aadd1865d2552d8

Biological brain age prediction using machine learning on structural neuroimaging data: Multi-cohort validation against biomarkers of Alzheimer’s disease and neurodegeneration stratified by sex

Authors: Irene Cumplido-Mayoral, Marina García-Prat, Grégory Operto, Carles Falcon, Mahnaz Shekari, Raffaele Cacciaglia, Marta Milà-Alomà, Luigi Lorenzini, Silvia Ingala, Alle Meije Wink, Henk JMM Mutsaerts, Carolina Minguillón, Karine Fauria, José Luis Molinuevo, Sven Haller, Gael Chetelat, Adam Waldman, Adam J Schwarz, Frederik Barkhof, Ivonne Suridjan, Gwendlyn Kollmorgen, Anna Bayfield, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, Verónica Vilaplana, Juan Domingo Gispert, ALFA study, EPAD study, ADNI study, OASIS study

Source: eLife, Vol 12 (2023)

Subject Terms: brain age prediction, neuroimaging, alzheimer's disease, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/81067; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/b683f8da68144da784893d350bcd6b16

Integration of advanced 3D SPECT modelling for pinhole collimators into the open-source STIR framework

Authors: Matthew Strugari, Carles Falcon, Kjell Erlandsson, Brian F. Hutton, Kimberly Brewer, Kris Thielemans

Source: Frontiers in Nuclear Medicine, Vol 3 (2023)

Subject Terms: Image reconstruction, molecular imaging, Monte Carlo methods, nuclear medicine, open-source software, SPECT, Medical physics. Medical radiology. Nuclear medicine, R895-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnume.2023.1134774/full; https://doaj.org/toc/2673-8880

Access URL: https://doaj.org/article/a809d281e0a4417ebae92cac3e5734f2

Cognitively unimpaired individuals with a low burden of Aβ pathology have a distinct CSF biomarker profile

Authors: Marta Milà-Alomà, Mahnaz Shekari, Gemma Salvadó, Juan Domingo Gispert, Eider M. Arenaza-Urquijo, Grégory Operto, Carles Falcon, Natalia Vilor-Tejedor, Oriol Grau-Rivera, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, José Maria González-de-Echávarri, Carolina Minguillon, Karine Fauria, Aida Niñerola-Baizán, Andrés Perissinotti, Maryline Simon, Gwendlyn Kollmorgen, Henrik Zetterberg, Kaj Blennow, Marc Suárez-Calvet, José Luis Molinuevo, for the ALFA study

Source: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)

Subject Terms: Preclinical, Alzheimer’s disease, CSF, Biomarkers, Subthreshold, Cognitively unimpaired, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/f6f174b37dfb419b9a0109faee06b961

Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer’s continuum when only subtle changes in Aβ pathology are detected

Authors: Marc Suárez‐Calvet, Thomas K Karikari, Nicholas J Ashton, Juan Lantero Rodríguez, Marta Milà‐Alomà, Juan Domingo Gispert, Gemma Salvadó, Carolina Minguillon, Karine Fauria, Mahnaz Shekari, Oriol Grau‐Rivera, Eider M Arenaza‐Urquijo, Aleix Sala‐Vila, Gonzalo Sánchez‐Benavides, José Maria González‐de‐Echávarri, Gwendlyn Kollmorgen, Erik Stoops, Eugeen Vanmechelen, Henrik Zetterberg, Kaj Blennow, José Luis Molinuevo, for the ALFA Study, Annabella Beteta, Raffaele Cacciaglia, Alba Cañas, Carme Deulofeu, Irene Cumplido, Ruth Dominguez, Maria Emilio, Carles Falcon, Sherezade Fuentes, Laura Hernandez, Gema Huesa, Jordi Huguet, Paula Marne, Tania Menchón, Grégory Operto, Albina Polo, Sandra Pradas, Anna Soteras, Marc Vilanova, Natalia Vilor‐Tejedor

Source: EMBO Molecular Medicine, Vol 12, Iss 12, Pp 1-19 (2020)

Subject Terms: Alzheimer’s disease, biomarker, cerebrospinal fluid, plasma, tau, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/fa10944cadf0424c84138b7b13f06a8e

Prediction of amyloid pathology in cognitively unimpaired individuals using voxel-wise analysis of longitudinal structural brain MRI

Authors: Paula M. Petrone, Adrià Casamitjana, Carles Falcon, Miquel Artigues, Grégory Operto, Raffaele Cacciaglia, José Luis Molinuevo, Verónica Vilaplana, Juan Domingo Gispert, for the Alzheimer’s Disease Neuroimaging Initiative

Source: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2019)

Subject Terms: Preclinical AD signature, Jacobian determinant, MRI, Machine learning, Longitudinal voxel-wise analysis, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13195-019-0526-8; https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/77e7a2ef73d44802b2d9ac40691d025a

Management and Quality Control of Large Neuroimaging Datasets: Developments From the Barcelonaβeta Brain Research Center

Authors: Jordi Huguet, Carles Falcon, David Fusté, Sergi Girona, David Vicente, José Luis Molinuevo, Juan Domingo Gispert, Grégory Operto, for the ALFA Study

Source: Frontiers in Neuroscience, Vol 15 (2021)

Subject Terms: processing workflows, neuroimaging, quality control, data management, neuroinformatics, cohort studies, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2021.633438/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/f9d5370abae849e985dadca1ed1bb94b

Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers

Authors: Gemma Salvadó, José Luis Molinuevo, Anna Brugulat-Serrat, Carles Falcon, Oriol Grau-Rivera, Marc Suárez-Calvet, Javier Pavia, Aida Niñerola-Baizán, Andrés Perissinotti, Francisco Lomeña, Carolina Minguillon, Karine Fauria, Henrik Zetterberg, Kaj Blennow, Juan Domingo Gispert, for the Alzheimer’s Disease Neuroimaging Initiative, for the ALFA Study

Source: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2019)

Subject Terms: AD pathophysiology, Biomarker concordance, Threshold, Positivity, Preclinical, Early detection, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13195-019-0478-z; https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/fbf8763755244df0852942290a33c736

Impact of urban environmental exposures on cognitive performance and brain structure of healthy individuals at risk for Alzheimer’s dementia

Authors: Marta Crous-Bou, Mireia Gascon, Juan Domingo Gispert, Marta Cirach, Gonzalo Sánchez-Benavides, Carles Falcon, Eider M. Arenaza-Urquijo, Xavier Gotsens, Karine Fauria, Jordi Sunyer, Mark J. Nieuwenhuijsen, José Luis Molinuevo

Source: Environment International, Vol 138, Iss , Pp - (2020)

Subject Terms: Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412019321130; https://doaj.org/toc/0160-4120

Access URL: https://doaj.org/article/d3e39a480ef34ac0bad9103ad846b3b0

Spatial patterns of white matter hyperintensities associated with Alzheimer’s disease risk factors in a cognitively healthy middle-aged cohort

Authors: Gemma Salvadó, Anna Brugulat-Serrat, Carole H. Sudre, Oriol Grau-Rivera, Marc Suárez-Calvet, Carles Falcon, Karine Fauria, M. Jorge Cardoso, Frederik Barkhof, José Luis Molinuevo, Juan Domingo Gispert, for the ALFA Study

Source: Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2019)

Subject Terms: Vascular, Lesions, Aging, Brain, Prevention, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13195-018-0460-1; https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/2336f348041b411fbe5533e547086076

Brain and cognitive correlates of subjective cognitive decline-plus features in a population-based cohort

Authors: Gonzalo Sánchez-Benavides, Oriol Grau-Rivera, Marc Suárez-Calvet, Carolina Minguillon, Raffaele Cacciaglia, Nina Gramunt, Carles Falcon, ALFA Study, Juan Domingo Gispert, José Luis Molinuevo

Source: Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-13 (2018)

Subject Terms: Subjective cognitive decline, Memory, Voxel-based morphometry, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13195-018-0449-9; https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/1c393e71f39e4a7b981c0bccbe74072d

White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes

Authors: Grégory Operto, Raffaele Cacciaglia, Oriol Grau-Rivera, Carles Falcon, Anna Brugulat-Serrat, Pablo Ródenas, Rubén Ramos, Sebastián Morán, Manel Esteller, Nuria Bargalló, José Luis Molinuevo, Juan Domingo Gispert, for the ALFA Study

Source: Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-18 (2018)

Subject Terms: Diffusion tensor imaging, Apolipoprotein E, White matter integrity, Aging, Cognitively normal subjects, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13195-018-0375-x; https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/deeb308a4fec42c5a252aee6fd117ebb

Longitudinal structural cerebral changes related to core CSF biomarkers in preclinical Alzheimer's disease: A study of two independent datasets

Authors: Carles Falcon, Alan Tucholka, Gemma C. Monté-Rubio, Raffaele Cacciaglia, Grégory Operto, Lorena Rami, Juan Domingo Gispert, José Luis Molinuevo

Source: NeuroImage: Clinical, Vol 19, Iss , Pp 190-201 (2018)

Subject Terms: Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213158218301256; https://doaj.org/toc/2213-1582

Access URL: https://doaj.org/article/8ac713882faf44efabbeb607b0f4c6cd

A whole-brain computational modeling approach to explain the alterations in resting-state functional connectivity during progression of Alzheimer's disease

Authors: Murat Demirtaş, Carles Falcon, Alan Tucholka, Juan Domingo Gispert, José Luis Molinuevo, Gustavo Deco

Source: NeuroImage: Clinical, Vol 16, Iss , Pp 343-354 (2017)

Subject Terms: Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213158217301961; https://doaj.org/toc/2213-1582

Access URL: https://doaj.org/article/c284ee6437174565af64d742e9d8a76f

CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals

Authors: Carles Falcon, Gemma C. Monté-Rubio, Oriol Grau-Rivera, Marc Suárez-Calvet, Raquel Sánchez-Valle, Lorena Rami, Beatriz Bosch, Christian Haass, Juan Domingo Gispert, José Luis Molinuevo

Source: NeuroImage: Clinical, Vol 23, Iss , Pp - (2019)

Subject Terms: Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213158219301512; https://doaj.org/toc/2213-1582

Access URL: https://doaj.org/article/b9c5dbc3e5ce4310b7cea7b76afd7521

Mechanisms of functional compensation, delineated by eigenvector centrality mapping, across the pathophysiological continuum of Alzheimer’s disease

Authors: Stavros Skouras, Carles Falcon, Alan Tucholka, Lorena Rami, Raquel Sanchez-Valle, Albert Lladó, Juan D. Gispert, José Luís Molinuevo

Source: NeuroImage: Clinical, Vol 22, Iss , Pp - (2019)

Subject Terms: Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213158219301275; https://doaj.org/toc/2213-1582

Access URL: https://doaj.org/article/910cc532d03b4251a3d45eecb2d24062

Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects

Authors: Grégory Operto, José Luis Molinuevo, Raffaele Cacciaglia, Carles Falcon, Anna Brugulat-Serrat, Marc Suárez-Calvet, Oriol Grau-Rivera, Nuria Bargalló, Sebastián Morán, Manel Esteller, Juan Domingo Gispert

Source: NeuroImage: Clinical, Vol 24, Iss , Pp - (2019)

Subject Terms: Computer applications to medicine. Medical informatics, R858-859.7, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221315821930333X; https://doaj.org/toc/2213-1582

Access URL: https://doaj.org/article/540b90f84eab40728f5f69905ad394df

Mild developmental foreign accent syndrome and psychiatric comorbidity: Altered white matter integrity in speech and emotion regulation networks

Authors: Marcelo L Berthier, Núria Roé-Vellvé, Ignacio Moreno-Torres, Carles Falcon, Karl Thurnhofer-Hemsi, José Paredes-Pacheco, María José Torres-Prioris, Irene De Torres, Francisco Alfaro, Antonio Luis Gutierrez Cardo, Miquel Baquero, Rafael Ruiz-Cruces, Guadalupe Dávila

Source: Frontiers in Human Neuroscience, Vol 10 (2016)

Subject Terms: Diffusion Tensor Imaging, Personality, psychiatric disorders, foreign accent, Developmental speech disorders, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00399/full; https://doaj.org/toc/1662-5161

Access URL: https://doaj.org/article/7b78d99fbe7942a7971abcae42168a0d

Brain metabolism during hallucination-like auditory stimulation in schizophrenia.

Authors: Guillermo Horga, Emilio Fernández-Egea, Anna Mané, Mireia Font, Kelly C Schatz, Carles Falcon, Francisco Lomeña, Miguel Bernardo, Eduard Parellada

Source: PLoS ONE, Vol 9, Iss 1, p e84987 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3885666?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b72e5515fda2417b816b23dce80f2944

Influence of corpus callosum damage on cognition and physical disability in multiple sclerosis: a multimodal study.

Authors: Sara Llufriu, Yolanda Blanco, Eloy Martinez-Heras, Jordi Casanova-Molla, Iñigo Gabilondo, Maria Sepulveda, Carles Falcon, Joan Berenguer, Nuria Bargallo, Pablo Villoslada, Francesc Graus, Josep Valls-Sole, Albert Saiz

Source: PLoS ONE, Vol 7, Iss 5, p e37167 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22606347/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/bb38c56f411f4baab88f3fb9ef4c099b