Small extracellular vesicles derived from synovial fibroblasts contain distinct miRNA profiles and contribute to chondrocyte damage in osteoarthritis

Authors: Sabha Asghar, Gary J. Litherland, John J. Cole, Iain B. McInnes, R. M. D. Meek, John C. Lockhart, Carl S. Goodyear, Anne Crilly

Source: Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)

Subject Terms: Osteoarthritis, Small extracellular vesicles, Synovial fibroblasts, Chondrocytes, microRNA, miR182, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1478-6362

Access URL: https://doaj.org/article/3b5cf59e34534e7c8772f11be34ab22f

Double-negative-2 B cells are the major synovial plasma cell precursor in rheumatoid arthritis

Authors: Elinor Wing, Catherine Sutherland, Katherine Miles, David Gray, Carl S. Goodyear, Thomas D. Otto, Stefan Breusch, Graeme Cowan, Mohini Gray

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: rheumatoid arthritis, double-negative-2 (DN2) B cells, antibody secreting cells, synovium, single-cell sequencing, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1241474/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7be81bbfafaa40f7b7970a61171c4912

Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis

Authors: Oliver FitzGerald, Frank Behrens, Anne Barton, Heidi Bertheussen, Bruno Boutouyrie-Dumont, Laura Coates, Owen Davies, Maarten de Wit, Filippo Fagni, Carl S. Goodyear, Robert Gurke, Lisa Hahnefeld, Christine Huppertz, Vassilios Ioannidis, Mark Ibberson, Arnon Katz, Maximilian Klippstein, Michaela Koehm, Shimon Korish, Sina Mackay, David A. Martin, Denis O’Sullivan, Khadijah Patel, Stefan Rueping, Georg Schett, Klaus Scholich, Jochen M. Schwenk, Stefan Siebert, David Simon, Arani Vivekanantham, Stephen R. Pennington

Source: Therapeutic Advances in Musculoskeletal Disease, Vol 15 (2023)

Subject Terms: Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/1759-7218

Access URL: https://doaj.org/article/a667e6ccef804442bb02abacbd1a08bf

Human olfactory mesenchymal stromal cell transplantation ameliorates experimental autoimmune encephalomyelitis revealing an inhibitory role for IL16 on myelination

Authors: Susan L. Lindsay, Aleksandra M. Molęda, Lindsay M. MacLellan, Siew Min Keh, Daniel E. McElroy, Christopher Linington, Carl S. Goodyear, Susan C. Barnett

Source: Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-20 (2022)

Subject Terms: Human mesenchymal stromal cells, Olfactory mucosa, Multiple sclerosis, Experimental autoimmune encephalomyelitis, Myelination, Interleukin 16, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2051-5960

Access URL: https://doaj.org/article/954754aad64c4f218d94ee53a8ea3d31

Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures

Authors: Ian W. Kennedy, P. Monica Tsimbouri, Paul Campsie, Shatakshi Sood, Peter G. Childs, Stuart Reid, Peter S. Young, Dominic R. M. Meek, Carl S. Goodyear, Matthew J. Dalby

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/810f83f7a49e40a688c667b930757c1d

Searchlight: automated bulk RNA-seq exploration and visualisation using dynamically generated R scripts

Authors: John J. Cole, Bekir A. Faydaci, David McGuinness, Robin Shaw, Rose A. Maciewicz, Neil A. Robertson, Carl S. Goodyear

Source: BMC Bioinformatics, Vol 22, Iss 1, Pp 1-21 (2021)

Subject Terms: Bulk, RNA-seq, Pipeline, Automation, Visualisation, Exploration, Computer applications to medicine. Medical informatics, R858-859.7, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2105

Access URL: https://doaj.org/article/9bca106272ef4240bc9afd063a856c67

Analysis of Prostate Cancer Tumor Microenvironment Identifies Reduced Stromal CD4 Effector T-cell Infiltration in Tumors with Pelvic Nodal Metastasis

Authors: Chara Ntala, Mark Salji, Jonathan Salmond, Leah Officer, Ana Vieira Teodosio, Arnaud Blomme, Ewan J. McGhee, Ian Powley, Imran Ahmad, Marianna Kruithof-de Julio, George Thalmann, Ed Roberts, Carl S. Goodyear, Tamara Jamaspishvili, David M. Berman, Leo M. Carlin, John Le Quesne, Hing Y. Leung

Source: European Urology Open Science, Vol 29, Iss , Pp 19-29 (2021)

Subject Terms: Prostate cancer, Tumor microenvironment, Immune cells, Lymph node, Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666168321000859; https://doaj.org/toc/2666-1683

Access URL: https://doaj.org/article/ba12c3a2a624488381047889f1ca7d08

BIOlogical Factors that Limit sustAined Remission in rhEumatoid arthritis (the BIO-FLARE study): protocol for a non-randomised longitudinal cohort study

Authors: Fiona Rayner, Amy E. Anderson, Kenneth F. Baker, Christopher D. Buckley, Bernard Dyke, Sally Fenton, Andrew Filer, Carl S. Goodyear, Catharien M. U. Hilkens, Shaun Hiu, Sean Kerrigan, Mariola Kurowska-Stolarska, Fiona Matthews, Iain McInnes, Wan-Fai Ng, Arthur G. Pratt, Jonathan Prichard, Karim Raza, Stefan Siebert, Deborah Stocken, M. Dawn Teare, Stephen Young, John D. Isaacs

Source: BMC Rheumatology, Vol 5, Iss 1, Pp 1-10 (2021)

Subject Terms: Rheumatoid arthritis, Flare, Remission, Pathogenesis, DMARD withdrawal, DMARD cessation, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: https://doaj.org/toc/2520-1026

Access URL: https://doaj.org/article/7bbdfdc9383c46daab23a559ec6892ed

Chromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritis

Authors: Claudio Carini, Ewan Hunter, Scottish Early Rheumatoid Arthritis Inception cohort Investigators, Aroul S. Ramadass, Jayne Green, Alexandre Akoulitchev, Iain B. McInnes, Carl S. Goodyear

Source: Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-11 (2018)

Subject Terms: Early rheumatoid arthritis, Methotrexate, Rheumatoid arthritis, DMARDs (synthetic), Precision medicine drug response biomarkers, Methotrexate (MTX), Medicine

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12967-018-1387-9; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/33b575a6daa44a989aa398d7c8ad6949

Changes in Plasma Itaconate Elevation in Early Rheumatoid Arthritis Patients Elucidates Disease Activity Associated Macrophage Activation

Authors: Rónán Daly, Gavin Blackburn, Cameron Best, Carl S. Goodyear, Manikhandan Mudaliar, Karl Burgess, Anne Stirling, Duncan Porter, Iain B. McInnes, Michael P. Barrett, James Dale

Source: Metabolites, Vol 10, Iss 6, p 241 (2020)

Subject Terms: rheumatoid arthritis, DMARD, macrophage, itaconate, inflammation, liquid chromatography–mass spectrometry (LC-MS), Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.mdpi.com/2218-1989/10/6/241; https://doaj.org/toc/2218-1989

Access URL: https://doaj.org/article/5e35c46d3e0b43d5828fdb46fd292b77

Essential Domain-Dependent Roles Within Soluble IgG for in vivo Superantigen Properties of Staphylococcal Protein A: Resolving the B-Cell Superantigen Paradox

Authors: Alejandro J. Ulloa-Morales, Carl S. Goodyear, Gregg J. Silverman

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: B cells, superantigens, protein A, antibodies, host-pathogen, anaphylaxis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2018.02011/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/e456ea4ff58347a18c8434867510377f

Rheumatic Disease: Protease-Activated Receptor-2 in Synovial Joint Pathobiology

Authors: Kendal McCulloch, Sarah McGrath, Carmen Huesa, Lynette Dunning, Gary Litherland, Anne Crilly, Leif Hultin, William R. Ferrell, John C. Lockhart, Carl S. Goodyear

Source: Frontiers in Endocrinology, Vol 9 (2018)

Subject Terms: protease-activated receptor-2, rheumatoid arthritis, osteoarthritis, bone, cartilage, synovium, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fendo.2018.00257/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/170af33040924b10a099670146961922

Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

Authors: Patricia Riedlova, author¹, Shatakshi Sood, author¹, Carl S. Goodyear, author¹, Cecilia Ansalone, author¹

Source: Journal of Visualized Experiments. (191)

Availability: http://www.jove.com/video/64698

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Authors: Lynette Dunning, author¹, Kendal McCulloch, author¹, John C. Lockhart, author¹, Carl S. Goodyear, author², Carmen Huesa, author²

Source: Journal of Visualized Experiments. (185)

Availability: http://www.jove.com/video/64159

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Analysis of lectin binding to glycolipid complexes using combinatorial glycoarrays.

Authors: Simon Rinaldi, Kathryn M Brennan, Carl S Goodyear, Colin O’Leary, Giampietro Schiavo, Paul R Crocker, Hugh J Willison

Source: Glycobiology; Jul2009, Vol. 19 Issue 7, p789-789, 1p

Subject Terms: GLYCOLIPIDS, GLYCOCONJUGATES, LIPIDS, GLYCOSPHINGOLIPIDS, BIOMOLECULES

JAK inhibitors disrupt T cell-induced proinflammatory macrophage activation

Authors: Iain B McInnes, Duncan Porter, Stefan Siebert, Carl S Goodyear, Jagtar Singh Nijjar, Derek S Gilchrist, Marina Frleta-Gilchrist, Mukanthu H Nyirenda

Source: RMD Open, Vol 9, Iss 1 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://rmdopen.bmj.com/content/9/1/e002671.full; https://doaj.org/toc/2056-5933

Access URL: https://doaj.org/article/c6ea63591bb54974a375054d26f2c305