The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion

Authors: Ugur Uslu, Lijun Sun, Sofia Castelli, Amanda V. Finck, Charles-Antoine Assenmacher, Regina M. Young, Zhijian J. Chen, Carl H. June

Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/0776d7dc8ea14173bb63673e70265732

Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation

Authors: Abdulla Berjis, Deeksha Muthumani, Oscar A. Aguilar, Oz Pomp, Omar Johnson, Amanda V. Finck, Nils W. Engel, Linhui Chen, Nicolas Plachta, John Scholler, Lewis L. Lanier, Carl H. June, Neil C. Sheppard

Source: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3fd910c3f98f4e43883f2a9ab9531d8c

ZFP36 disruption is insufficient to enhance the function of mesothelin-targeting human CAR-T cells

Authors: David Mai, Tifara Boyce, Aakash Mehta, Jordan Reff, John Scholler, Neil C. Sheppard, Carl H. June

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/43e2928bff434cb489ee369a6bdcb722

Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors

Authors: Zebin Xiao, Leslie Todd, Li Huang, Estela Noguera-Ortega, Zhen Lu, Lili Huang, Meghan Kopp, Yue Li, Nimisha Pattada, Wenqun Zhong, Wei Guo, John Scholler, Maria Liousia, Charles-Antoine Assenmacher, Carl H. June, Steven M. Albelda, Ellen Puré

Source: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/8293ae22274440439fe76629503609b5

Long-term stability of clinical-grade lentiviral vectors for cell therapy

Authors: Julie K. Jadlowsky, Rachel Leskowitz, Stephen McKenna, Jayashree Karar, Yujie Ma, Anlan Dai, Gabriela Plesa, Fang Chen, Kathleen Alexander, Jennifer Petrella, Nan Gong, Wei-Ting Hwang, Olivia Farrelly, Julie Barber-Rotenberg, Shannon Christensen, Vanessa E. Gonzalez, Anne Chew, Joseph A. Fraietta, Carl H. June

Source: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101186- (2024)

Subject Terms: titer stability, potency, transduction efficiency, lentiviral vector, cell therapy, Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050124000020; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/7bc0c17d5d0e4617bc7ee7d437b08ef4

Enhancing Chimeric Antigen Receptor T Cell Anti-tumor Function through Advanced Media Design

Authors: Saba Ghassemi, Francisco J. Martinez-Becerra, Alyssa M. Master, Sarah A. Richman, David Heo, John Leferovich, Yitao Tu, Juan Carlos García-Cañaveras, Asma Ayari, Yinan Lu, Ai Wang, Joshua D. Rabinowitz, Michael C. Milone, Carl H. June, Roddy S. O’Connor

Source: Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 595-606 (2020)

Subject Terms: Genetics, QH426-470, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050120301571; https://doaj.org/toc/2329-0501

Access URL: https://doaj.org/article/3c8878a6387c4c229e27c84bfdffb1ba

Cancer immunotherapy comes of age and looks for maturity

Authors: Amanda Finck, Saar I. Gill, Carl H. June

Source: Nature Communications, Vol 11, Iss 1, Pp 1-4 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b79c612e2f44404b8f5683d98f5ab4b9

A phase I trial of cyclosporine for hospitalized patients with COVID-19

Authors: Emily A. Blumberg, Julia Han Noll, Pablo Tebas, Joseph A. Fraietta, Ian Frank, Amy Marshall, Anne Chew, Elizabeth A. Veloso, Alison Carulli, Walter Rogal, Avery L. Gaymon, Aliza H. Schmidt, Tiffany Barnette, Renee Jurek, Rene Martins, Briana M. Hudson, Kalyan Chavda, Christina M. Bailey, Sarah E. Church, Hooman Noorchashm, Wei-Ting Hwang, Carl H. June, Elizabeth O. Hexner

Source: JCI Insight, Vol 7, Iss 11 (2022)

Subject Terms: COVID-19, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/6597f6dab218404fa9ecd0f6232979e4

CAR T-cell therapy is effective for CD19-dim B-lymphoblastic leukemia but is impacted by prior blinatumomab therapy

Authors: Vinodh Pillai, Kavitha Muralidharan, Wenzhao Meng, Asen Bagashev, Derek A. Oldridge, Jaclyn Rosenthal, John Van Arnam, Jos J. Melenhorst, Diwakar Mohan, Amanda M. DiNofia, Minjie Luo, Sindhu Cherian, Jonathan R. Fromm, Gerald Wertheim, Andrei Thomas-Tikhonenko, Michele Paessler, Carl H. June, Eline T. Luning Prak, Vijay G. Bhoj, Stephan A. Grupp, Shannon L. Maude, Susan R. Rheingold

Source: Blood Advances, Vol 3, Iss 22, Pp 3539-3549 (2019)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952920317535; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/e70ab1bdc076485da3ba01a3a1e59b84

T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma

Authors: Alfred L. Garfall, Ehren K. Dancy, Adam D. Cohen, Wei-Ting Hwang, Joseph A. Fraietta, Megan M. Davis, Bruce L. Levine, Don L. Siegel, Edward A. Stadtmauer, Dan T. Vogl, Adam Waxman, Aaron P. Rapoport, Michael C. Milone, Carl H. June, J. Joseph Melenhorst

Source: Blood Advances, Vol 3, Iss 19, Pp 2812-2815 (2019)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952920318437; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/c2b1211d1c304b2d96f08de44dae0f46

Tisagenlecleucel Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor–T Cells

Authors: Andrew M. Stein, Stephan A. Grupp, John E. Levine, Theodore W. Laetsch, Michael A. Pulsipher, Michael W. Boyer, Keith J. August, Bruce L. Levine, Lori Tomassian, Sweta Shah, Mimi Leung, Pai‐Hsi Huang, Rakesh Awasthi, Karen Thudium Mueller, Patricia A. Wood, Carl H. June

Source: CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 5, Pp 285-295 (2019)

Subject Terms: Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2163-8306

Access URL: https://doaj.org/article/e1eac9e64fa4445bbb240eabb2a86beb

Bispecific Antibody Armed Metabolically Enhanced Headless CAR T Cells

Authors: Archana Thakur, John Scholler, Ewa Kubicka, Edwin T. Bliemeister, Dana L. Schalk, Carl H. June, Lawrence G. Lum

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: breast cancer, pancreatic cancer, activated T cells, co-activated T cells, bispecific antibody, headless CAR T cells, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.690437/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/44fc3950d1424b9fb6857b674cd72b67

Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma

Authors: Joseph S. Durgin, Fraser Henderson, MacLean P. Nasrallah, Suyash Mohan, Sumei Wang, Simon F. Lacey, Jan Joseph Melenhorst, Arati S. Desai, John Y. K. Lee, Marcela V. Maus, Carl H. June, Steven Brem, Roddy S. O’Connor, Zev Binder, Donald M. O’Rourke

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: CAR T cell therapy, glioblastoma, EGFRvIII, recurrent glioblastoma (rGBM), CAR (chimeric antigen receptor), perfusion imaging, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.669071/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/28e7edd3d6b7457386c94ed075c82476

Engineered T Cell Therapies from a Drug Development Viewpoint

Authors: Fang Chen, Joseph A. Fraietta, Carl H. June, Zhongwei Xu, J. Joseph Melenhorst, Simon F. Lacey

Source: Engineering, Vol 5, Iss 1, Pp 140-149 (2019)

Subject Terms: Engineering (General). Civil engineering (General), TA1-2040

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2095809918306647; https://doaj.org/toc/2095-8099

Access URL: https://doaj.org/article/efc3dde1d79240f08fcbd718400b5236

iGUIDE: an improved pipeline for analyzing CRISPR cleavage specificity

Authors: Christopher L. Nobles, Shantan Reddy, January Salas-McKee, Xiaojun Liu, Carl H. June, J. Joseph Melenhorst, Megan M. Davis, Yangbing Zhao, Frederic D. Bushman

Source: Genome Biology, Vol 20, Iss 1, Pp 1-6 (2019)

Subject Terms: Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13059-019-1625-3; https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/029e894e495a48feb0359649b71e6498

Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas

Authors: Yibo Yin, Alina C. Boesteanu, Zev A. Binder, Chong Xu, Reiss A. Reid, Jesse L. Rodriguez, Danielle R. Cook, Radhika Thokala, Kristin Blouch, Bevin McGettigan-Croce, Logan Zhang, Christoph Konradt, Alexandria P. Cogdill, M. Kazim Panjwani, Shuguang Jiang, Denis Migliorini, Nadia Dahmane, Avery D. Posey, Jr., Carl H. June, Nicola J. Mason, Zhiguo Lin, Donald M. O’Rourke, Laura A. Johnson

Source: Molecular Therapy: Oncolytics, Vol 11, Iss , Pp 20-38 (2018)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2372770518300202; https://doaj.org/toc/2372-7705

Access URL: https://doaj.org/article/c4f59e6339ce4efa84b3ecf00abab181

Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance

Authors: Michael M. Boyiadzis, Madhav V. Dhodapkar, Renier J. Brentjens, James N. Kochenderfer, Sattva S. Neelapu, Marcela V. Maus, David L. Porter, David G. Maloney, Stephan A. Grupp, Crystal L. Mackall, Carl H. June, Michael R. Bishop

Source: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-12 (2018)

Subject Terms: Chimeric antigen receptor, Tisagenlecleucel, Axicabtagene ciloleucel, Leukemia, Lymphoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40425-018-0460-5; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/5a568f9326c844da8f86b218c9098847

Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence

Authors: Stefanie R. Bailey, Michelle H. Nelson, Kinga Majchrzak, Jacob S. Bowers, Megan M. Wyatt, Aubrey S. Smith, Lillian R. Neal, Keisuke Shirai, Carmine Carpenito, Carl H. June, Michael J. Zilliox, Chrystal M. Paulos

Source: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/63f1a5f94c67463f9202a2a71250b8b7

Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18

Authors: Biliang Hu, Jiangtao Ren, Yanping Luo, Brian Keith, Regina M. Young, John Scholler, Yangbing Zhao, Carl H. June

Source: Cell Reports, Vol 20, Iss 13, Pp 3025-3033 (2017)

Subject Terms: IL-18, cancer, immunotherapy, chimeric antigen receptor, T cell, adoptive transfer, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124717312639; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/752ee465a8f44ba2800654c883ebc4e5

Novel T cells with improved in vivo anti-tumor activity generated by RNA electroporation

Authors: Xiaojun Liu, Shuguang Jiang, Chongyun Fang, Hua Li, Xuhua Zhang, Fuqin Zhang, Carl H. June, Yangbing Zhao

Source: Protein & Cell, Vol 8, Iss 7, Pp 514-526 (2017)

Subject Terms: T lymphocytes, CAR, manufacture, gene transfer, RNA electroporation, Cytology, QH573-671, Animal biochemistry, QP501-801

File Description: electronic resource

Relation: http://link.springer.com/article/10.1007/s13238-017-0422-6; https://doaj.org/toc/1674-800X; https://doaj.org/toc/1674-8018

Access URL: https://doaj.org/article/b570ad5c0750454a91e622293ba7ac79