Development of cell lines with increased susceptibility to diverse adeno-associated viral vectors to enable in vitro potency assays

Authors: Zengel, James ^{1, 3}, Esterman, Emma S. ^{1, 3}, Ponnuswami, Anitha ², Wall, Nicholas R. ², Carette, Jan E. ^{1, ∗}

Source: In Molecular Therapy - Methods & Clinical Development 13 March 2025 33(1)

Activation of the helper NRC4 immune receptor forms a hexameric resistosome

Authors: Liu, Furong, Yang, Zhenlin, Wang, Chao, You, Zhang, Martin, Raoul, Qiao, Wenjie, Huang, Jian, Jacob, Pierre, Dangl, Jeffery L., Carette, Jan E., Luan, Sheng, Nogales, Eva, Staskawicz, Brian J.

Source: In Cell 5 September 2024 187(18):4877-4889

Lysosomal enzyme trafficking: from molecular mechanisms to human diseases

Authors: Braulke, Thomas, Carette, Jan E., Palm, Wilhelm

Source: In Trends in Cell Biology March 2024 34(3):198-210

Small RNAs are modified with N-glycans and displayed on the surface of living cells

Authors: Flynn, Ryan A., Pedram, Kayvon, Malaker, Stacy A., Batista, Pedro J., Smith, Benjamin A.H., Johnson, Alex G., George, Benson M., Majzoub, Karim, Villalta, Peter W., Carette, Jan E., Bertozzi, Carolyn R.

Source: In Cell 10 June 2021 184(12):3109-3124

Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions

Authors: Flynn, Ryan A., Belk, Julia A., Qi, Yanyan, Yasumoto, Yuki, Wei, Jin, Alfajaro, Mia Madel, Shi, Quanming, Mumbach, Maxwell R., Limaye, Aditi, DeWeirdt, Peter C., Schmitz, Cameron O., Parker, Kevin R., Woo, Elizabeth, Chang, Howard Y., Horvath, Tamas L., Carette, Jan E., Bertozzi, Carolyn R., Wilen, Craig B., Satpathy, Ansuman T.

Source: In Cell 29 April 2021 184(9):2394-2411

Improved Genome Editing through Inhibition of FANCM and Members of the BTR Dissolvase Complex

Authors: de Alencastro, Gustavo, Puzzo, Francesco, Pavel-Dinu, Mara, Zhang, Feijie, Pillay, Sirika, Majzoub, Karim, Tiffany, Matthew, Jang, Hagoon, Sheikali, Adam, Cromer, M. Kyle, Meetei, Ruhikanta, Carette, Jan E., Porteus, Matthew H., Pekrun, Katja, Kay, Mark A.

Source: In Molecular Therapy 3 March 2021 29(3):1016-1027

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

Authors: Wang, Ruofan, Simoneau, Camille R., Kulsuptrakul, Jessie, Bouhaddou, Mehdi, Travisano, Katherine A., Hayashi, Jennifer M., Carlson-Stevermer, Jared, Zengel, James R., Richards, Christopher M., Fozouni, Parinaz, Oki, Jennifer, Rodriguez, Lauren, Joehnk, Bastian, Walcott, Keith, Holden, Kevin, Sil, Anita, Carette, Jan E., Krogan, Nevan J., Ott, Melanie, Puschnik, Andreas S.

Source: In Cell 7 January 2021 184(1):106-119

GOLPH3 and GOLPH3L maintain Golgi localization of LYSET and a functional mannose 6-phosphate transport pathway.

Authors: Brauer, Berit K, Chen, Zilei, Beirow, Felix, Li, Jiaran, Meisinger, Daniel, Capriotti, Emanuela, Schweizer, Michaela, Wagner, Lea, Wienberg, Jascha, Hobohm, Laura, Blume, Lukas, Qiao, Wenjie, Narimatsu, Yoshiki, Carette, Jan E, Clausen, Henrik, Winter, Dominic, Braulke, Thomas, Jabs, Sabrina, Voss, Matthias

Source: EMBO Journal; Dec2024, Vol. 43 Issue 24, p6264-6290, 27p

Subject Terms: MEMBRANE proteins, LIFE sciences, GOLGI apparatus, RF values (Chromatography), MANNOSE, ADAPTOR proteins

GPR108 Is a Highly Conserved AAV Entry Factor

Authors: Dudek, Amanda M., Zabaleta, Nerea, Zinn, Eric, Pillay, Sirika, Zengel, James, Porter, Caryn, Franceschini, Jennifer Santos, Estelien, Reynette, Carette, Jan E., Zhou, Guo Ling, Vandenberghe, Luk H.

Source: In Molecular Therapy 5 February 2020 28(2):367-381

GluA4-Targeted AAV Vectors Deliver Genes Selectively to Interneurons while Relying on the AAV Receptor for Entry

Authors: Hartmann, Jessica, Thalheimer, Frederic B., Höpfner, Felix, Kerzel, Thomas, Khodosevich, Konstantin, García-González, Diego, Monyer, Hannah, Diester, Ilka, Büning, Hildegard, Carette, Jan E., Fries, Pascal, Buchholz, Christian J.

Source: In Molecular Therapy - Methods & Clinical Development 13 September 2019 14:252-260

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

Authors: Cao, Jennifer Yinuo, Poddar, Aunoy, Magtanong, Leslie, Lumb, Jennifer H., Mileur, Trevor R., Reid, Michael A., Dovey, Cole M., Wang, Jin, Locasale, Jason W., Stone, Everett, Cole, Susan P.C., Carette, Jan E., Dixon, Scott J.

Source: In Cell Reports 5 February 2019 26(6):1544-1556

A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity

Authors: Shah, Jimit, Rouaud, Florian, Guerrera, Diego, Vasileva, Ekaterina, Popov, Lauren M., Kelley, William L., Rubinstein, Eric, Carette, Jan E., Amieva, Manuel R., Citi, Sandra

Source: In Cell Reports 20 November 2018 25(8):2132-2147

MLKL Requires the Inositol Phosphate Code to Execute Necroptosis

Authors: Dovey, Cole M., Diep, Jonathan, Clarke, Bradley P., Hale, Andrew T., McNamara, Dan E., Guo, Hongyan, Brown, Nathaniel W., Jr., Cao, Jennifer Yinuo, Grace, Christy R., Gough, Peter J., Bertin, John, Dixon, Scott J., Fiedler, Dorothea, Mocarski, Edward S., Kaiser, William J., Moldoveanu, Tudor, York, John D., Carette, Jan E.

Source: In Molecular Cell 7 June 2018 70(5):936-948

DDX6 Represses Aberrant Activation of Interferon-Stimulated Genes

Authors: Lumb, Jennifer H., Li, Qin, Popov, Lauren M., Ding, Siyuan, Keith, Marie T., Merrill, Bryan D., Greenberg, Harry B., Li, Jin Billy, Carette, Jan E.

Source: In Cell Reports 25 July 2017 20(4):819-831

Host determinants of adeno-associated viral vector entry

Authors: Pillay, Sirika, Carette, Jan E

Source: In Current Opinion in Virology June 2017 24:124-131

CRISPR Screen Reveals PACT as a Pro-Viral Factor for Dengue Viral Replication.

Authors: Shivaprasad, Shwetha, Qiao, Wenjie, Weng, Kuo-Feng, Umashankar, Pavithra, Carette, Jan E., Sarnow, Peter

Source: Viruses (1999-4915); May2024, Vol. 16 Issue 5, p725, 13p

Subject Terms: DENGUE viruses, VIRAL replication, MEDICAL screening, CRISPRS, GENE expression, DENGUE, CUCUMBER mosaic virus, FENITROTHION

MYADM binds human parechovirus 1 and is essential for viral entry.

Authors: Wenjie Qiao, Richards, Christopher M., Youlim Kim, Zengel, James R., Siyuan Ding, Greenberg, Harry B., Carette, Jan E.

Source: Nature Communications; 4/24/2024, Vol. 15 Issue 1, p1-14, 14p, 1 Color Photograph, 4 Graphs

Gene essentiality and synthetic lethality in haploid human cells

Authors: Blomen, Vincent A., Májek, Peter, Jae, Lucas T., Bigenzahn, Johannes W., Nieuwenhuis, Joppe, Staring, Jacqueline, Sacco, Roberto, van Diemen, Ferdy R., Olk, Nadine, Stukalov, Alexey, Marceau, Caleb, Janssen, Hans, Carette, Jan E., Bennett, Keiryn L., Colinge, Jacques, Superti-Furga, Giulio, Brummelkamp, Thijn R.

Source: Science, 2015 Nov . 350(6264), 1092-1096.

Access URL: http://www.jstor.org/stable/24740939

The adherens junctions control susceptibility to Staphylococcus aureus α-toxin

Authors: Popov, Lauren M., Marceau, Caleb D., Starkl, Philipp M., Lumb, Jennifer H., Shah, Jimit, Guerrera, Diego, Cooper, Rachel L., Merakou, Christina, Bouley, Donna M., Meng, Wenxiang, Kiyonari, Hiroshi, Takeichi, Masatoshi, Galli, Stephen J., Bagnoli, Fabio, Citi, Sandra, Carette, Jan E., Amieva, Manuel R.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Nov . 112(46), 14337-14342.

Access URL: https://www.jstor.org/stable/26466450

Nuclear accumulation of host transcripts during Zika Virus Infection.

Authors: Leon, Kristoffer E.^1,2,3,4, Khalid, Mir M.¹, Flynn, Ryan A.^5,6, Fontaine, Krystal A.¹, Nguyen, Thong T.¹, Kumar, G. Renuka¹, Simoneau, Camille R.^1,2,4, Tomar, Sakshi¹, Jimenez-Morales, David^1,7, Dunlap, Mariah¹, Kaye, Julia¹, Shah, Priya S.⁸, Finkbeiner, Steven^1,9,10, Krogan, Nevan J.^1,11,12, Bertozzi, Carolyn^5,13, Carette, Jan E.¹⁴, Ott, Melanie^1,2,15, melanie.ott@gladstone.ucsf.edu

Source: PLoS Pathogens; 1/5/2023, Vol. 18 Issue 1, p1-21, 21p