Novel insights into the regulation of cellular catabolic metabolism in macrophages through nuclear receptors

Authors: Stifel, Ulrich, Caratti, Giorgio, Tuckermann, Jan

Source: FEBS letters. 596(20):2617-2629

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Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle

Authors: Stifel, Ulrich, Wolfschmitt, Eva-Maria, Vogt, Josef, Wachter, Ulrich, Vettorazzi, Sabine, Tews, Daniel, Hogg, Melanie, Zink, Fabian, Koll, Nora Maria, Winning, Sandra, Mounier, Rémi, Chazaud, Bénédicte, Radermacher, Peter, Fischer-Posovszky, Pamela, Caratti, Giorgio, Tuckermann, Jan

Source: In Molecular Metabolism March 2022 57

A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis

Authors: Loft, Anne, Schmidt, Søren Fisker, Caratti, Giorgio, Stifel, Ulrich, Havelund, Jesper, Sekar, Revathi, Kwon, Yun, Sulaj, Alba, Chow, Kan Kau, Alfaro, Ana Jimena, Schwarzmayr, Thomas, Rittig, Nikolaj, Svart, Mads, Tsokanos, Foivos-Filippos, Maida, Adriano, Blutke, Andreas, Feuchtinger, Annette, Møller, Niels, Blüher, Matthias, Nawroth, Peter, Szendrödi, Julia, Færgeman, Nils J., Zeigerer, Anja, Tuckermann, Jan, Herzig, Stephan

Source: In Cell Metabolism 1 March 2022 34(3):473-486

Macrophagic AMPKα1 orchestrates regenerative inflammation induced by glucocorticoids

Authors: Caratti, Giorgio, Desgeorges, Thibaut, Juban, Gaëtan, Stifel, Ulrich, Fessard, Aurélie, Koenen, Mascha, Caratti, Bozhena, Théret, Marine, Skurk, Carsten, Chazaud, Bénédicte, Tuckermann, Jan P, Mounier, Rémi

Source: EMBO reports. 24(2)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194584836.0x000001&indx=1&recIds=ETOCvdc_100194584836.0x000001

Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad?

Authors: Pofi, Riccardo, Caratti, Giorgio, Ray, David W, Tomlinson, Jeremy W

Source: Endocrine Reviews; Dec2023, Vol. 44 Issue 6, p975-1011, 37p

Subject Terms: GLUCOCORTICOIDS, TYPE 2 diabetes, OSTEOPOROSIS

Unique Gene Expression Signature in Periadrenal Adipose Tissue Identifies a High Blood Pressure Group in Patients With Cushing Syndrome.

Authors: Stifel, Ulrich, Vogel, Frederick, Caratti, Giorgio, Reincke, Martin, Tuckermann, Jan

Source: Hypertension (0194911X); Nov2023, Vol. 80 Issue 11, p2333-2344, 12p

Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the GoodFrom the Bad?

Authors: Pofi, Riccardo, Caratti, Giorgio, Ray, David W, Tomlinson, Jeremy W

Source: Endocrine Reviews; December 2023, Vol. 44 Issue: 6 p975-1011, 37p

Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance.

Authors: Caratti, Giorgio, Stifel, Ulrich, Caratti, Bozhena, Jamil, Ali J. M., Chung, Kyoung-Jin, Kiehntopf, Michael, Gräler, Markus H., Blüher, Matthias, Rauch, Alexander, Tuckermann, Jan P.

Source: Nature Communications; 4/20/2023, Vol. 14 Issue 1, p1-16, 16p

Subject Terms: INSULIN resistance, LIPOLYSIS, KUPFFER cells, MACROPHAGE activation, ADIPOSE tissues, MYELOID cells, INSULIN receptors

The glucocorticoid receptor associates with RAS complexes to inhibit cell proliferation and tumor growth.

Authors: Caratti, Bozhena, Fidan, Miray, Caratti, Giorgio, Breitenecker, Kristina, Engler, Melanie, Kazemitash, Naser, Traut, Rebecca, Wittig, Rainer, Casanova, Emilio, Ahmadian, Mohammad Reza, Tuckermann, Jan P., Moll, Herwig P., Cirstea, Ion Cristian

Source: Science Signaling; 3/22/2022, Vol. 15 Issue 726, p1-13, 13p

Subject Terms: GLUCOCORTICOID receptors, INHIBITION of cellular proliferation, TUMOR growth, RAS proteins, NUCLEAR receptors (Biochemistry), CANCER cells

HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling.

Authors: Giroud, Maude, Tsokanos, Foivos-Filippos, Caratti, Giorgio, Kotschi, Stefan, Khani, Sajjad, Jouffe, Céline, Vogl, Elena S., Irmler, Martin, Glantschnig, Christina, Gil-Lozano, Manuel, Hass, Daniela, Khan, Asrar Ali, Garcia, Marcos Rios, Mattijssen, Frits, Maida, Adriano, Tews, Daniel, Fischer-Posovszky, Pamela, Feuchtinger, Annette, Virtanen, Kirsi A., Beckers, Johannes

Source: Diabetologia; Aug2021, Vol. 64 Issue 8, p1850-1865, 16p

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Fighting the Fire: Mechanisms of Inflammatory Gene Regulation by the Glucocorticoid Receptor.

Authors: Escoter-Torres, Laura, Caratti, Giorgio, Mechtidou, Aikaterini, Tuckermann, Jan, Uhlenhaut, Nina Henriette, Vettorazzi, Sabine

Source: Frontiers in Immunology; 8/7/2019, p1-17, 17p

Subject Terms: GENETIC regulation, GLUCOCORTICOID receptors, OSTEOPOROSIS, FIREFIGHTING, GLUCOCORTICOID regulation, GENE expression

Glucocorticoids Shape Macrophage Phenotype for Tissue Repair.

Authors: Desgeorges, Thibaut, Caratti, Giorgio, Mounier, Rémi, Tuckermann, Jan, Chazaud, Bénédicte

Source: Frontiers in Immunology; 7/9/2019, p1-12, 12p

Subject Terms: GLUCOCORTICOIDS, ANTI-inflammatory agents, DEMAND function, PHENOTYPES

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Serum cholesterol selectively regulates glucocorticoid sensitivity through activation of JNK.

Authors: Nan Yang, Caratti, Giorgio, Ince, Louise M., Poolman, Toryn M., Trebble, Peter J., Holt, Cathy M., Ray, David W., Matthews, Laura C.

Source: Journal of Endocrinology; Nov2014, Vol. 223 Issue 2, p155-166, 11p

Subject Terms: GLUCOCORTICOIDS, ADRENOCORTICAL hormones, ISOPENTENOIDS, BLOOD plasma, HIGH cholesterol diet

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