Experimental validation of a parenteral permitted daily exposure value for cleaning-induced degradants from recombinant therapeutic proteins with in vitro immunogenicity assays

Authors: Cohen, Joseph R. ^{a, ⁎}, Joubert, Marisa K. ^a, Tabassum, Syeda ^a, Capili, Allyson ^a, Carreon, Julia ^a, Xiang, Cathie ^a, Prabhu, Siddharth ^a, Merlo, Anthony ^a, Mytych, Dan ^b, Dolan, David G. ^c, Kouda, Ram ^{a, ⁎}

Source: In Journal of Pharmaceutical Sciences February 2025 114(2):866-877

Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

Authors: Price, David R., Benedetti, Elisa, Hoffman, Katherine L., Gomez-Escobar, Luis, Alvarez-Mulett, Sergio, Capili, Allyson, Sarwath, Hina, Parkhurst, Christopher N., Lafond, Elyse, Weidman, Karissa, Ravishankar, Arjun, Cheong, Jin Gyu, Batra, Richa, Büyüközkan, Mustafa, Chetnik, Kelsey, Easthausen, Imaani, Schenck, Edward J., Racanelli, Alexandra C., Outtz Reed, Hasina, Laurence, Jeffrey, Josefowicz, Steven Z., Lief, Lindsay, Choi, Mary E., Schmidt, Frank, Borczuk, Alain C., Choi, Augustine M.K., Krumsiek, Jan, Rafii, Shahin

Source: American journal of pathology. 192(7):1001-1015

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100166553705.0x000001&indx=1&recIds=ETOCvdc_100166553705.0x000001

Conditional deletion of myeloid-specific mitofusin 2 but not mitofusin 1 promotes kidney fibrosis

Authors: Bhatia, Divya, Capili, Allyson, Nakahira, Kiichi, Muthukumar, Thangamani, Torres, Lisa K., Choi, Augustine M.K., Choi, Mary E.

Source: Kidney international. 101(5):963-986

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100161111808.0x000001&indx=1&recIds=ETOCvdc_100161111808.0x000001

Cytokine response over the course of COVID-19 infection in pregnant women

Authors: Rosen, Daniel B., Murphy, Elisabeth A., Gejman, Ron S., Capili, Allyson, Friedlander, Rachel L., Rand, Sophie, Cagino, Kristen A., Glynn, Shannon M., Matthews, Kathy C., Kubiak, Jeff M., Yee, Jim, Prabhu, Malavika, Riley, Laura E., Yang, Yawei J.

Source: In Cytokine June 2022 154

High-Throughput CRISPR Screening Identifies Genes Involved in Macrophage Viability and Inflammatory Pathways

Authors: Covarrubias, Sergio, Vollmers, Apple Cortez, Capili, Allyson, Boettcher, Michael, Shulkin, Aaron, Correa, Michele Ramos, Halasz, Haley, Robinson, Elektra K., O’Briain, Laura, Vollmers, Christopher, Blau, James, Katzman, Sol, McManus, Michael T., Carpenter, Susan

Source: In Cell Reports 29 December 2020 33(13)

Macrophage Exosomes Resolve Atherosclerosis by Regulating Hematopoiesis and Inflammation via MicroRNA Cargo

Authors: Bouchareychas, Laura, Duong, Phat, Covarrubias, Sergio, Alsop, Eric, Phu, Tuan Anh, Chung, Allen, Gomes, Michael, Wong, David, Meechoovet, Bessie, Capili, Allyson, Yamamoto, Ryo, Nakauchi, Hiromitsu, McManus, Michael T., Carpenter, Susan, Van Keuren-Jensen, Kendall, Raffai, Robert L.

Source: In Cell Reports 14 July 2020 32(2)

A High Threshold of Biotherapeutic Aggregate Numbers is Needed to Induce an Immunogenic Response In Vitro, In Vivo, and in the Clinic.

Authors: Cohen, Joseph R., Brych, Stephen R., Prabhu, Siddharth, Bi, Vivian, Elbaradei, Ahmed, Tokuda, Joshua M., Xiang, Cathie, Hokom, Martha, Cui, Xiaohong, Ly, Claudia, Amos, Nathan, Sun, Jilin, Calamba, Dominador, Herskovitz, Jonathan, Capili, Allyson, Nourbakhsh, Kimya, Merlo, Anthony, Carreon, Julia, Wypych, Jette, Narhi, Linda O.

Source: Pharmaceutical Research; Apr2024, Vol. 41 Issue 4, p651-672, 22p

Subject Terms: CLINICAL trials, IMMUNE response, ACTIVATION energy, DISEASE progression, RHEUMATOID arthritis

LincRNA-Cox2 Regulates Smoke-induced Inflammation in Murine Macrophages.

Authors: Salih, Mays Mohammed, Robinson, Elektra Kantzari, Malekos, Eric, Perez, Elizabeth, Capili, Allyson, Kihwan Kim, Zhang, William Z., Cloonan, Suzanne M., Carpenter, Susan

Source: American Journal of Respiratory Cell & Molecular Biology; May2023, Vol. 68 Issue 5, p511-522, 25p

Subject Terms: LINCRNA, CHRONIC obstructive pulmonary disease, GENETIC engineering, CIGARETTE smoke, REGULATOR genes

Reversal of emphysema by restoration of pulmonary endothelial cells

Authors: Hisata, Shu, Racanelli, Alexandra C., Kermani, Pouneh, Schreiner, Ryan, Houghton, Sean, Palikuqi, Brisa, Kunar, Balvir, Zhou, Aiyuan, McConn, Keith, Capili, Allyson

Source: Journal of experimental medicine. 218(8):e20200938-e20200938

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627221987&indx=1&recIds=ETOCRN627221987

Abstract 13066: Alternatively Activated Macrophage Exosomes: New Mediators to Control Hematopoiesis & Atherosclerosis

Authors: Bouchareychas, Laura, Duong, Phat, Covarrubias, Sergio, Alsop, Eric, Chung, Allen, Gomes, Michael, Wong, David, Meechoovet, Bessie, Capili, Allyson, Yamamoto, Ryo, Nakauchi, Hiromitsu, McManus, Michael, Carpenter, Susan, Van Keuren-Jensen, Kendall, Raffai, Robert

Source: Circulation (Ovid); November 2019, Vol. 140 Issue: Supplement 1 pA13066-A13066, 1p