Single-cell and spatial-resolved profiling reveals cancer-associated fibroblast heterogeneity in colorectal cancer metabolic subtypes

Authors: Youpeng Wang, Xingfeng Qiu, Qinghai Li, Jiale Qin, Lvlan Ye, Xiang Zhang, Xingxiang Huang, Xiangqiong Wen, Ziyang Wang, Weiling He, Yuqin Di, Qi Zhou

Source: Journal of Translational Medicine, Vol 23, Iss 1, Pp 1-18 (2025)

Subject Terms: Colorectal cancer, Single-cell RNA sequencing, Cancer-associated fibroblast (CAF), Chemoresistance, Medicine

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Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/e9f72ffe8bca421eb9020e0c2add3a10

Exploring the Role of Fibroblasts in Promoting Neuroblastoma Cell Migration and Invasion

Authors: Diana Corallo, Cristina Nardelli, Marcella Pantile, Sara Menegazzo, Alessandra Biffi, Sanja Aveic

Source: Journal of Nanotheranostics, Vol 5, Iss 4, Pp 212-227 (2024)

Subject Terms: cancer-associated fibroblast (CAF), neuroblastoma, metastasis, cell migration, tumor microenvironment, cancer dissemination, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://www.mdpi.com/2624-845X/5/4/13; https://doaj.org/toc/2624-845X

Access URL: https://doaj.org/article/e31e561452f3419e948d07db4a9c0216

In vitro and ex vivo evaluation of preclinical models for FAP-targeted theranostics: differences and relevance for radiotracer evaluation

Authors: Circe D. van der Heide, Joana D. Campeiro, Eline A. M. Ruigrok, Lilian van den Brink, Shashikanth Ponnala, Shawn M. Hillier, Simone U. Dalm

Source: EJNMMI Research, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: Cancer-associated fibroblast (CAF), Fibroblast activation protein (FAP), Targeted radionuclide therapy (TRT), Radionuclide theranostics, Preclinical models, Medical physics. Medical radiology. Nuclear medicine, R895-920

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Relation: https://doaj.org/toc/2191-219X

Access URL: https://doaj.org/article/3c9a4964d6cd44f694ffdf3cbf59bb8e

Editorial: Role of fibroblast in cancer

Authors: Xuezhen Zeng, Man Liu

Source: Frontiers in Molecular Biosciences, Vol 12 (2025)

Subject Terms: fibroblast, tumor microenvironment (TME, cancer, cancer associated fibroblast (CAF), therapy, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2025.1574538/full; https://doaj.org/toc/2296-889X

Access URL: https://doaj.org/article/80fc80f8d10a4ab69a86d6203a335de4

The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression

Authors: Yige Zhao, Yong Li, Panpan Wang, Mengyan Zhu, Jiaqi Wang, Bo Xie, Chenyu Tang, Yangyang Ma, Shiwen Wang, Sha Jin, Jinhui Xu, Zhao Li, Xiaoyan Zhang, Liuyu Li, Xiuzu Song, Ping Wang

Source: Frontiers in Immunology, Vol 15 (2025)

Subject Terms: mycosis fungoides (MF), cutaneous T cell lymphoma (CTCL), tissue resident memory T cell (TRM), cancer-associated fibroblast (CAF), tumor microenvironment, SOX4, Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1474564/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/bc829f311aef41ec8513514e715283ef

Deciphering the impact of aggregated autophagy-related genes TUBA1B and HSP90AA1 on colorectal cancer evolution: a single-cell sequencing study of the tumor microenvironment

Authors: Qianping Xu, Chao Liu, Hailin Wang, Shujuan Li, Hanshen Yan, Ziyang Liu, Kexin Chen, Yaoqin Xu, Runqin Yang, Jingfang Zhou, Xiaolin Yang, Jie Liu, Lexin Wang

Source: Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: Single-cell, Colorectal cancer (CRC), Tumor microenvironment (TME), Aggregated Autophagy (AA), TUBA1B and HSP90AA1, Cancer-associated fibroblast (CAF), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/24702831569b4ea5b7e0b1628b857b37

In vitro and in vivo analyses of eFAP: a novel FAP-targeting small molecule for radionuclide theranostics and other oncological interventions

Authors: Circe D. van der Heide, Hanyue Ma, Mark W.H. Hoorens, Joana D. Campeiro, Debra C. Stuurman, Corrina M.A. de Ridder, Yann Seimbille, Simone U. Dalm

Source: EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-17 (2024)

Subject Terms: Cancer-associated fibroblast (CAF), Fibroblast activation protein (FAP), Radionuclide theranostics, Small molecule inhibitor, (4-quinolinoyl)-glycyl-2-cyanopyrrolidine (QCP), Medical physics. Medical radiology. Nuclear medicine, R895-920, Therapeutics. Pharmacology, RM1-950

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Relation: https://doaj.org/toc/2365-421X

Access URL: https://doaj.org/article/faeb0767207f487993563351427f99e8

Cellular collusion: cracking the code of immunosuppression and chemo resistance in PDAC

Authors: Chiara Musiu, Francesca Lupo, Antonio Agostini, Gabriella Lionetto, Michele Bevere, Salvatore Paiella, Carmine Carbone, Vincenzo Corbo, Stefano Ugel, Francesco De Sanctis

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: PDAC - pancreatic ductal adenocarcinoma, immunotherapy, TME (tumor microenvironment), cancer associated fibroblast (CAF), MDSC (myeloid-derived suppressor cells), TILs (tumor infiltrating lymphocytes), Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1341079/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/45ea383fc8e649cc854103c3a4f8f1fd

Editorial: The role of cancer associated fibroblast (CAF) in EMT/metastasis in malignancies of epithelial tissues

Authors: Biplab Giri, Tapasree Roy Sarkar

Source: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Subject Terms: cancer associated fibroblast (CAF), tumor microenvironment (TME), metastasis, breast cancer, oral squamous cell carcinoma (OSCC), extracellular vesicles (EVs), Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2024.1384150/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/89753907a484438781b21d31c07d8948

Spatially Resolved Transcriptomics Technology Facilitates Cancer Research

Authors: Qian Wang, Yuan Zhi, Moxin Zi, Yongzhen Mo, Yumin Wang, Qianjin Liao, Shanshan Zhang, Zhaojian Gong, Fuyan Wang, Zhaoyang Zeng, Can Guo, Wei Xiong

Source: Advanced Science, Vol 10, Iss 30, Pp n/a-n/a (2023)

Subject Terms: spatially resolved transcriptomics (SRT), tumor heterogeneity, cancer‐associated fibroblast (CAF), tumor immune microenvironment, tertiary lymphoid structure (TLS), Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/7681edcb67fc484b9f457b8ea48c6ded

Cancer-associated fibroblasts in hematologic malignancies: elucidating roles and spotlighting therapeutic targets

Authors: Ziyang Ding, Run Shi, Weikang Hu, Lei Tian, Rong Sun, Yang Wu, Xiaoyan Zhang

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: cancer associated fibroblast (CAF), hematologic malignancies, crosstalk, chemoresistance, therapeutic target, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1193978/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/96e67abed2dc4c919ebd971853cde8f1

Three-dimensional heterotypic colorectal cancer spheroid models for evaluation of drug response

Authors: Jia Ning Nicolette Yau, Giulia Adriani

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: spheroid, heterotypic 3D model, colorectal cancer, cancer associated fibroblast (CAF), endothelial cell, gut microbiota, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1148930/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/78dc22fdd18c4994b05a7168c5db97a2

Cancer-associated fibroblasts and resistance to anticancer therapies: status, mechanisms, and countermeasures

Authors: Bing Feng, Jianzhong Wu, Bo Shen, Feng Jiang, Jifeng Feng

Source: Cancer Cell International, Vol 22, Iss 1, Pp 1-15 (2022)

Subject Terms: Cancer-associated fibroblast (CAF), Tumor microenvironment (TME), Resistance, Chemotherapy, Immunotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

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Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/f7d0149fcab7426b89a50fba5ead5c12

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer

Authors: Esther Strating, Mathijs P. Verhagen, Emerens Wensink, Ester Dünnebach, Liza Wijler, Itziar Aranguren, Alberto Sanchez De la Cruz, Niek A. Peters, Joris H. Hageman, Mirjam M. C. van der Net, Susanne van Schelven, Jamila Laoukili, Riccardo Fodde, Jeanine Roodhart, Stefan Nierkens, Hugo Snippert, Martijn Gloerich, Inne Borel Rinkes, Sjoerd G. Elias, Onno Kranenburg

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: colorectal cancer, CMS4, immunosuppressive, microenvironment, cancer-associated fibroblast (CAF), Immunologic diseases. Allergy, RC581-607

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Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1053920/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/90ab2b9cb2c4478f87f361dda37eab04

The Shaping of Cancer by the Tumour Microenvironment and Its Relevance for Cancer Therapy

Contributors: Madureira, Patrícia Alexandra Saraiva

Subject Terms: hypoxia, macrophages, colon cancer, tumor microenvironment, immune cell infiltration, prognosis, feline mammary carcinoma, PD-1, PD-L1, CTLA-4, TNF-α, biomarkers, immunotherapy, cancer, histone modification, inhibitor, KDM5B, molecular docking, repurposing, cancer acidity, hyperosmolarity, cross-presentation, tumour microenvironment, syngeneic model, prostate cancer, radiotherapy, preclinical modelling, myeloid-derived suppressor cells, biomarker, stroma, cancer-associated fibroblast (CAF), extracellular matrix (ECM), cytokine/chemokine, growth factors, pro- and anti-tumor immune cells, immunomodulatory roles, radiotherapy dose fractionation, radioresistance, radiosensitivity, breast cancer, S100A10 (p11), tumor growth, tumor progression, metastasis, carcinoma, mammary gland, triple negative, pre-metastatic niche, pro-inflammatory cytokines, clinical trials, evolutionary therapy, darwinian evolution, cancer cells subpopulations, diclofenac, koningic acid, spheroid, 3D co-culture, microenvironment, resistance, myeloid cells, cancer development, molecular subtypes of pancreatic cancer, chemotherapy response, pancreatic stellate cells, regulatory T cells, tumor-associated macrophages, myeloid derived suppressor cells, glioblastoma (GB), Hypoxia Inducible Factor (HIF), glioma stem cells (GSC), oxidative stress, reactive oxygen species, plasmin, plasminogen, S100A10, uPA, uPAR, PAI-1, PAI-2, cancer stem cells, cancer recurrence, therapeutic resistance, signaling pathways, targeted therapy, head and neck cancer, lung cancer, bladder cancer, Medicine and Nursing

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Access URL: https://directory.doabooks.org/handle/20.500.12854/76822
https://mdpi.com/books/pdfview/book/4271

The origins, roles and therapies of cancer associated fibroblast in liver cancer

Authors: Natasha Zulaziz, San Jiun Chai, Kue Peng Lim

Source: Frontiers in Oncology, Vol 13 (2023)

Subject Terms: cancer-associated fibroblast (CAF), liver cancer, hepatocellular carcinoma (HCC), immunotherapy, immune-modulating, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2023.1151373/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/e662a9183c9b427c99cad035fa3ec1cd

Deciphering the temporal heterogeneity of cancer-associated fibroblast subpopulations in breast cancer

Authors: Freja Albjerg Venning, Kamilla Westarp Zornhagen, Lena Wullkopf, Jonas Sjölund, Carmen Rodriguez-Cupello, Pontus Kjellman, Mikkel Morsing, Morteza Chalabi Hajkarim, Kyoung Jae Won, Janine Terra Erler, Chris Denis Madsen

Source: Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-21 (2021)

Subject Terms: Cancer-associated fibroblast (CAF), CAF heterogeneity, CAF subpopulations, Flow cytometry analysis, Breast cancer progression, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/a5982df9dfdb4c37a2ed3833290a7ddd

Contribution of MMP14-expressing cancer-associated fibroblasts in the tumor immune microenvironment to progression of colorectal cancer

Authors: Yusuke Makutani, Hisato Kawakami, Takahiro Tsujikawa, Kanako Yoshimura, Yasutaka Chiba, Akihiko Ito, Junichiro Kawamura, Koji Haratani, Kazuhiko Nakagawa

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: colorectal cancer, matrix metalloproteinase 14 (MMP14), multiplex immunohistochemistry (mIHC), cancer-associated fibroblast (CAF), M2 tumor-associated macrophages (M2-TAMs), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.956270/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/78158ca296c0489e8e6d30126d7284b8

Gold nanoparticles inhibit activation of cancer-associated fibroblasts by disrupting communication from tumor and microenvironmental cells

Authors: Yushan Zhang, Chandra Kumar Elechalawar, Md Nazir Hossen, Emmy R. Francek, Anindya Dey, Stefan Wilhelm, Resham Bhattacharya, Priyabrata Mukherjee

Source: Bioactive Materials, Vol 6, Iss 2, Pp 326-332 (2021)

Subject Terms: Gold nanoparticle (GNP), Cancer-associated fibroblast (CAF), Tumor microenvironment (TME), Fibroblast activation, Morphology, Migration, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2452199X20301651; https://doaj.org/toc/2452-199X

Access URL: https://doaj.org/article/53d69094348c43c2b5156d4e478fe68a

Monocarboxylate Transporter 4 in Cancer-Associated Fibroblasts Is a Driver of Aggressiveness in Aerodigestive Tract Cancers

Authors: Marina Domingo-Vidal, Diana Whitaker-Menezes, Mehri Mollaee, Zhao Lin, Madalina Tuluc, Nancy Philp, Jennifer M. Johnson, Tingting Zhan, Joseph Curry, Ubaldo Martinez-Outschoorn

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: aerodigestive tract cancer, non-small cell lung cancer, head and neck squamous cell carcinoma, cancer-associated fibroblast (CAF), metabolic compartmentalization, monocarboxylate transporter 4 (MCT4), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

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Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.906494/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/1a27894c72f64f59ae35937ec8c95bed